Acquired methemoglobinemia due to nitrobenzene poisoning: An unusual acquaintance
Key Clinical MessageNitrobenzene poisoning is a rare yet life-threatening contention. The ensuing acute methemoglobinemia has a high fatality rate, hence early prompt intervention is required. Methylene blue (intravenous or oral) and ascorbic acid are the cornerstones of management. They must be administered to suspected patients without tardiness.AbstractAn aromatic organic chemical used in paints and the printing industry is nitrobenzene. Its poisoning causes potentially fatal methemoglobinemia. One aspect of its management involves reducing the iron moiety from its ferric to ferrous form by administering intravenous met...
Source: Clinical Case Reports - April 9, 2024 Category: General Medicine Authors: Sunil Bhatta,
Pusp Raj Awasthi Tags: CASE REPORT Source Type: research
Vitamin C Supplementation Among Pregnant Smokers and Offspring Airway Function
This secondary analysis of a randomized clinical trial analyzes the association of vitamin C supplementation in women who smoked during pregnancy with airway function trajectory in their offspring at 4 to 6 years of age. (Source: JAMA Pediatrics)
Source: JAMA Pediatrics - April 8, 2024 Category: Pediatrics Source Type: research
Molecules, Vol. 29, Pages 1675: Citrus limon Wastes from Part of the Eastern Cape Province in South Africa: Medicinal, Sustainable Agricultural, and Bio-Resource Potential
This study obtained the chemical profiles of the essential oils (EOs) of C. limon wastes (the peel and leaves), evaluated their medicinal value as antioxidants, their potential for sustainable use in agriculture as an insecticide for post-harvest preservation of grains, and their potential as a bioresource in livestock feed formulations. The EOs were isolated from C. limon leaves and peel using a hydro-distillation method on a Clevenger apparatus. The oil constituents were identified using the gas chromatography-mass spectrometry (GC-MS) hyphenated technique. The oils were evaluated for their in vitro antioxidant activity ...
Source: Molecules - April 8, 2024 Category: Chemistry Authors: Phumelele Nodola Gugulethu M. Miya Vuyokazi Mazwi Ayodeji O. Oriola Opeoluwa O. Oyedeji Yiseyon S. Hosu Simon K. Kuria Adebola O. Oyedeji Tags: Article Source Type: research
Acute oxalate nephropathy: exploring the role of excess dietary oxalate intake
We report here two cases presenting as unexplained AKI which were confirmed histologically to be due to acute oxalate nephropathy. Dietary oxalate or its precursor vitamin C was the cause of oxalate exposure in both of these cases. While one patient recovered, another continued to need dialysis and succumbed to underlying metastatic cancer. This cause should be suspected in all patients presenting with unexplained AKI, and detailed history about dietary intake of oxalate or vitamin C should be inquired. (Source: CEN Case Reports)
Source: CEN Case Reports - April 8, 2024 Category: Urology & Nephrology Source Type: research
Vitamin C enhances co-localization of novel TET1 nuclear bodies with both Cajal and PML bodies in colorectal cancer cells
Volume 19, Issue 1, December 2024 . (Source: Epigenetics)
Source: Epigenetics - April 7, 2024 Category: Genetics & Stem Cells Authors: Nour El OsmaniCorinne Pr évostelLaurence Picque LasorsaMohammad El HarakehZeina RadwanHiba MawlawiMarwan El SabbanMargret ShirinianZeina Dassoukia IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, Franceb Université de Montpellie Source Type: research
Influence of intensity ultrasound on rheological properties and bioactive compounds of araticum (Annona crassiflora) juice
Ultrason Sonochem. 2024 Apr 3;105:106868. doi: 10.1016/j.ultsonch.2024.106868. Online ahead of print.ABSTRACTThe use of extracts rich in bioactive compounds is becoming increasingly common in the food, cosmetics, and pharmaceutical industries for the production of functional products. Araticum is a potential fruit to be analyzed due to its content of phenolic compounds, carotenoids and vitamins, with antioxidant properties. Therefore, this study aimed to investigate the effect of ultrasound on total phenolic compounds, total carotenoids, ascorbic acid, color, turbidity and rheology in araticum juice. Response surface metho...
Source: Ultrasonics Sonochemistry - April 6, 2024 Category: Chemistry Authors: Jhenifer Cristina Carvalho Santos Jefferson Luiz Gomes Correa Maria Luiza Bianchetti Furtado Larissa Carolina de Morais Soraia Vilela Borges Cassiano Rodrigues de Oliveira Jaime Vilela de Resende Let ícia Fernandes de Oliveira Source Type: research
Influence of intensity ultrasound on rheological properties and bioactive compounds of araticum (Annona crassiflora) juice
Ultrason Sonochem. 2024 Apr 3;105:106868. doi: 10.1016/j.ultsonch.2024.106868. Online ahead of print.ABSTRACTThe use of extracts rich in bioactive compounds is becoming increasingly common in the food, cosmetics, and pharmaceutical industries for the production of functional products. Araticum is a potential fruit to be analyzed due to its content of phenolic compounds, carotenoids and vitamins, with antioxidant properties. Therefore, this study aimed to investigate the effect of ultrasound on total phenolic compounds, total carotenoids, ascorbic acid, color, turbidity and rheology in araticum juice. Response surface metho...
Source: Ultrasonics Sonochemistry - April 6, 2024 Category: Chemistry Authors: Jhenifer Cristina Carvalho Santos Jefferson Luiz Gomes Correa Maria Luiza Bianchetti Furtado Larissa Carolina de Morais Soraia Vilela Borges Cassiano Rodrigues de Oliveira Jaime Vilela de Resende Let ícia Fernandes de Oliveira Source Type: research
Influence of intensity ultrasound on rheological properties and bioactive compounds of araticum (Annona crassiflora) juice
Ultrason Sonochem. 2024 Apr 3;105:106868. doi: 10.1016/j.ultsonch.2024.106868. Online ahead of print.ABSTRACTThe use of extracts rich in bioactive compounds is becoming increasingly common in the food, cosmetics, and pharmaceutical industries for the production of functional products. Araticum is a potential fruit to be analyzed due to its content of phenolic compounds, carotenoids and vitamins, with antioxidant properties. Therefore, this study aimed to investigate the effect of ultrasound on total phenolic compounds, total carotenoids, ascorbic acid, color, turbidity and rheology in araticum juice. Response surface metho...
Source: Ultrasonics Sonochemistry - April 6, 2024 Category: Chemistry Authors: Jhenifer Cristina Carvalho Santos Jefferson Luiz Gomes Correa Maria Luiza Bianchetti Furtado Larissa Carolina de Morais Soraia Vilela Borges Cassiano Rodrigues de Oliveira Jaime Vilela de Resende Let ícia Fernandes de Oliveira Source Type: research
Influence of intensity ultrasound on rheological properties and bioactive compounds of araticum (Annona crassiflora) juice
Ultrason Sonochem. 2024 Apr 3;105:106868. doi: 10.1016/j.ultsonch.2024.106868. Online ahead of print.ABSTRACTThe use of extracts rich in bioactive compounds is becoming increasingly common in the food, cosmetics, and pharmaceutical industries for the production of functional products. Araticum is a potential fruit to be analyzed due to its content of phenolic compounds, carotenoids and vitamins, with antioxidant properties. Therefore, this study aimed to investigate the effect of ultrasound on total phenolic compounds, total carotenoids, ascorbic acid, color, turbidity and rheology in araticum juice. Response surface metho...
Source: Ultrasonics Sonochemistry - April 6, 2024 Category: Chemistry Authors: Jhenifer Cristina Carvalho Santos Jefferson Luiz Gomes Correa Maria Luiza Bianchetti Furtado Larissa Carolina de Morais Soraia Vilela Borges Cassiano Rodrigues de Oliveira Jaime Vilela de Resende Let ícia Fernandes de Oliveira Source Type: research
Tris buffer-accelerated ligand exchange rate for instant fluorescence detection of trivalent chromium ion
In this study, we report that the good's buffers containing amino and polyhydroxy groups greatly increase the ligand exchange rate of Cr3+. Using EDTA as a model coordinate ligand, the Tris buffer (100 mM, pH 7.0) showed the best acceleration effect among the eight buffers. It improved the rate constant ∼20-fold, shorten the half-time 19-fold, and lowered the activation energy ∼70% at 40 °C. The Tris buffer was then applied for sensor based on the Cr3+-binding induced fluorescence quenching of fluorescein (FAM)-labeled and single-stranded DNA (ssDNA), which shortened the assay time from 1 h to 1 min. The Tris buffer a...
Source: Analytica Chimica Acta - April 5, 2024 Category: Chemistry Authors: Nan Wang Qianni Gao Xiaoqi Li Jinming Li Xinhui Lou Source Type: research
Differential effects of theasinensins and epigallocatechin-3-O-gallate on phospholipid bilayer structure and liposomal aggregation
This study presents a differential analysis of intact and oxidized EGCg regarding their interactions with phosphatidylcholine liposomes, serving as a simple biomembrane model. In the presence of ascorbic acid, pre-oxidized EGCg induced liposomal aggregation in a dose-dependent manner, whereas intact EGCg did not. Toxicity evaluation using calcein-loaded liposomes revealed that liposomal aggregation is associated with minimal membrane damage. Through fractionation of the oxidized EGCg sample, the fraction containing theasinensins showed high liposomal aggregation activity. Overall, these results suggest that oxidatively con...
Source: Biochimica et Biophysica Acta - April 5, 2024 Category: Biochemistry Authors: Asako Narai-Kanayama Sumio Hayakawa Takayuki Yoshino Futa Honda Hiroko Matsuda Yumiko Oishi Source Type: research
The Hepatocurative Effects of < em > Zanthoxylum zanthoxyloides < /em > Alkaloids on Tetrachloromethane-Induced Hepatotoxicity on Albino Rats
Indian J Clin Biochem. 2024 Apr;39(2):188-196. doi: 10.1007/s12291-022-01095-z. Epub 2022 Nov 12.ABSTRACTThe study investigated the hepatocurative activity of the bulk alkaloids of Zanthoxylum zanthoxyloides in a tetrachloromethane (CCl4)-induced hepatotoxicity model in rats. The hepatocurative activity of the alkaloids at 200, 400 and 600 mg/kg doses was demonstrated by the assay of both enzymic and non-enzymic parameters. Sections of the liver were also subjected to histological examinations. Mapping techniques and data visualization approaches were adopted in finding relationships between the enzymic and non-enzymic par...
Source: Clinical Biochemistry - April 5, 2024 Category: Biochemistry Authors: Thecla Okeahunwa Ayoka Ngwu Nwachukwu Aloysius Chinedu Ene Chidi Uzoma Igwe Charles Okeke Nnadi Source Type: research
Use of complementary medicine and its association with SARS-CoV-2 vaccination during the COVID-19 pandemic: a longitudinal cohort study
CONCLUSION: While complementary medicine is increasingly used, it is rarely discussed with primary care physicians. Complementary medicine use, especially for COVID-19 prevention, is associated with COVID-19 vaccination status. Communication between physicians, patients, and complementary medicine therapists is encouraged to facilitate a truly holistic approach to making a shared decision based on the best available information.PMID:38579302 | DOI:10.57187/s.3505 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Mayssam Nehme Olivia Braillard Pierre-Yves Rodondi Idris Guessous Source Type: research
Tris buffer-accelerated ligand exchange rate for instant fluorescence detection of trivalent chromium ion
In this study, we report that the good's buffers containing amino and polyhydroxy groups greatly increase the ligand exchange rate of Cr3+. Using EDTA as a model coordinate ligand, the Tris buffer (100 mM, pH 7.0) showed the best acceleration effect among the eight buffers. It improved the rate constant ∼20-fold, shorten the half-time 19-fold, and lowered the activation energy ∼70% at 40 °C. The Tris buffer was then applied for sensor based on the Cr3+-binding induced fluorescence quenching of fluorescein (FAM)-labeled and single-stranded DNA (ssDNA), which shortened the assay time from 1 h to 1 min. The Tris buffer a...
Source: Analytica Chimica Acta - April 5, 2024 Category: Chemistry Authors: Nan Wang Qianni Gao Xiaoqi Li Jinming Li Xinhui Lou Source Type: research
Differential effects of theasinensins and epigallocatechin-3-O-gallate on phospholipid bilayer structure and liposomal aggregation
This study presents a differential analysis of intact and oxidized EGCg regarding their interactions with phosphatidylcholine liposomes, serving as a simple biomembrane model. In the presence of ascorbic acid, pre-oxidized EGCg induced liposomal aggregation in a dose-dependent manner, whereas intact EGCg did not. Toxicity evaluation using calcein-loaded liposomes revealed that liposomal aggregation is associated with minimal membrane damage. Through fractionation of the oxidized EGCg sample, the fraction containing theasinensins showed high liposomal aggregation activity. Overall, these results suggest that oxidatively con...
Source: Biochimica et Biophysica Acta - April 5, 2024 Category: Biochemistry Authors: Asako Narai-Kanayama Sumio Hayakawa Takayuki Yoshino Futa Honda Hiroko Matsuda Yumiko Oishi Source Type: research
