Assessing the impact of non-pharmaceutical interventions on SARS-CoV-2 transmission in Switzerland.
Abstract Following the rapid dissemination of COVID-19 cases in Switzerland, large-scale non-pharmaceutical interventions (NPIs) were implemented by the cantons and the federal government between 28 February and 20 March 2020. Estimates of the impact of these interventions on SARS-CoV-2 transmission are critical for decision making in this and future outbreaks. We here aim to assess the impact of these NPIs on disease transmission by estimating changes in the basic reproduction number (R0) at national and cantonal levels in relation to the timing of these NPIs. We estimated the time-varying R0 nationally and in el...
Source: Swiss Medical Weekly - May 18, 2020 Category: General Medicine Authors: Lemaitre JC, Perez-Saez J, Azman AS, Rinaldo A, Fellay J Tags: Swiss Med Wkly Source Type: research

Statin treatment and LDL target value achievement in Swiss general practice - a retrospective observational study.
CONCLUSIONS: Although over half of patients were at a high or very high risk of fatal CVD, the majority did not receive high-intensity statin treatment. Only a third of very high-risk patients achieved LDL target values, and there was a gender gap in LDL target achievement disadvantaging female patients. Results from this study suggest that current treatment may warrant reconsideration in a large proportion of patients treated with statins in Swiss general practice. PMID: 32459361 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - May 18, 2020 Category: General Medicine Authors: Rachamin Y, Meier R, Rosemann T, Langenegger S, Markun S Tags: Swiss Med Wkly Source Type: research

D-dimer and mortality in COVID-19: a self-fulfilling prophecy or a pathophysiological clue?
We present the case of a patient who was diagnosed with a pulmonary thrombotic complication during inpatient care for COVID-19. The haemostasis parameters we observed, including increased levels of von Willebrand factor and factor VIII, point towards a relevant involvement of endothelial cells in patients with severe COVID-19. We suggest that it is possible to hypothesise a spectrum of secondarily acquired, prothrombotic coagulopathy mediated by the endothelial interaction with SARS-CoV-2 as a cause of mortality in a subset of patients with a complicated clinical course of COVID-19. We support the recommendation of thrombo...
Source: Swiss Medical Weekly - May 18, 2020 Category: General Medicine Authors: Breakey N, Escher R Tags: Swiss Med Wkly Source Type: research

Reasons for admission in asylum-seeking and non-asylum-seeking patients in a paediatric tertiary care centre.
CONCLUSION: Asylum-seeking children represent a small number of total admissions. Age distribution and main reason for admission being diseases of the respiratory system were comparable in asylum-seeking and non-asylum-seeking children. Rare infections and mental health disorders are important diseases in asylum-seeking children and require special attention and training of staff working with paediatric asylum seekers. PMID: 32459858 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - May 18, 2020 Category: General Medicine Authors: Gmünder M, Brandenberger J, Buser S, Pohl C, Ritz N Tags: Swiss Med Wkly Source Type: research

Time trend of suicide in Swiss male farmers and comparison with other men: a cohort study.
CONCLUSION: The study shows a higher rate of suicide in farmers compared to non-farmers in Switzerland, with the gap widening increasingly after 2006. It underlines the importance of identifying the difficulties and concerns of male farmers at an early stage in order to make appropriate structural adjustments and to offer low-threshold assistance tailored to their needs and preferences. PMID: 32459859 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - May 18, 2020 Category: General Medicine Authors: Steck N, Junker C, Bopp M, Egger M, Zwahlen M Tags: Swiss Med Wkly Source Type: research

Comment on: Mumme M, et al. Tissue engineering for paediatric patients. Swiss Med Wkly. 2019.149.w20032.
PMID: 32453857 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - May 18, 2020 Category: General Medicine Authors: Rose K, Grant-Kels JM, Neubauer D, Fumi L Tags: Swiss Med Wkly Source Type: research

Reply to comment on: Mumme M, et al. Tissue engineering for paediatric patients. Swiss Med Wkly. 2019.149.w20032.
PMID: 32453858 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - May 18, 2020 Category: General Medicine Authors: Mumme M, Wixmerten A, Martin I Tags: Swiss Med Wkly Source Type: research

Heavy energy drink consumption is associated with risky substance use in young Swiss men.
CONCLUSION: Chronic heavy energy drink consumers are a significant population subgroup in Switzerland and are relevant for public health due to the co-occurrence of unhealthy substance use. This link and the close relationship between chronic heavy energy drink use and social class indicate the role of lifestyle in the emergence and distribution of energy drink consumption. Interventions that encourage chronic heavy energy drink consumers to make positive lifestyle changes may contribute to the prevention of unhealthy substance use. PMID: 32455436 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - May 18, 2020 Category: General Medicine Authors: Benkert R, Abel T Tags: Swiss Med Wkly Source Type: research

Digital health and the COVID-19 epidemic: an assessment framework for apps from an epidemiological and legal perspective.
Abstract As COVID-19 spreads across the globe, crowdsourced digital technology harbours the potential to improve surveillance and epidemic control, primarily through increased information coverage, higher information speed, fast case tracking and improved proximity tracing. Targeting those aims, COVID-19-related smartphone and web-based health applications are continuously emerging, leading to a multitude of options, raising ethical and legal challenges and potentially overwhelming end users. Building on an existing trustworthiness checklist for digital health applications, we searched the literature and developed...
Source: Swiss Medical Weekly - May 4, 2020 Category: General Medicine Authors: Vokinger KN, Nittas V, Witt CM, Fabrikant SI, von Wyl V Tags: Swiss Med Wkly Source Type: research

Swiss experience of atezolizumab for platinum-pretreated urinary tract carcinoma: the SAUL study in real-world practice.
CONCLUSIONS: Atezolizumab is an active treatment option for platinum-pretreated urinary tract carcinoma, including patients with conditions that typically exclude them from clinical trials. (Trial registration no.: NCT02928406). PMID: 32399958 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - May 4, 2020 Category: General Medicine Authors: Cathomas R, Schardt J, Pless M, Llado A, Mach N, Riklin C, Haefeli J, Fear S, Stenner F Tags: Swiss Med Wkly Source Type: research

COVID-19 and telehealth: a window of opportunity and its challenges.
PMID: 32400882 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - May 4, 2020 Category: General Medicine Authors: Nittas V, von Wyl V Tags: Swiss Med Wkly Source Type: research

Early off-label treatment during pandemics? A dilemma.
PMID: 32391568 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - May 4, 2020 Category: General Medicine Authors: Roth JA, Ballouz T, Kouyos RD, Battegay M Tags: Swiss Med Wkly Source Type: research

icumonitoring.ch: a platform for short-term forecasting of intensive care unit occupancy during the COVID-19 epidemic in Switzerland.
Abstract In Switzerland, the COVID-19 epidemic is progressively slowing down owing to “social distancing” measures introduced by the Federal Council on 16 March 2020. However, the gradual ease of these measures may initiate a second epidemic wave, the length and intensity of which are difficult to anticipate. In this context, hospitals must prepare for a potential increase in intensive care unit (ICU) admissions of patients with acute respiratory distress syndrome. Here, we introduce icumonitoring.ch, a platform providing hospital-level projections for ICU occupancy. We combined current data on...
Source: Swiss Medical Weekly - May 4, 2020 Category: General Medicine Authors: Zhao C, Tepekule B, Criscuolo NG, Wendel Garcia PD, Hilty MP, Risc-Icu Consortium Investigators In Switzerland, Fumeaux T, Van Boeckel T Tags: Swiss Med Wkly Source Type: research

Copeptin-based diagnosis of diabetes insipidus.
Abstract Polyuria-polydipsia syndrome consists of the three main entities: central or nephrogenic diabetes insipidus and primary polydipsia. Reliable distinction between these diagnoses is essential as treatment differs substantially, with the wrong treatment potentially leading to serious complications. Past diagnostic measures using the classical water deprivation test had several pitfalls and clinicians were often left with uncertainity concerning the diagnosis. With the establishment of copeptin, a stable and reliable surrogate marker for arginine vasopressin, diagnosis of the polyuria-polydipsia syndrome has ...
Source: Swiss Medical Weekly - May 4, 2020 Category: General Medicine Authors: Refardt J, Christ-Crain M Tags: Swiss Med Wkly Source Type: research

Individualised nutritional support in medical inpatients - a practical guideline.
PMID: 32374888 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - May 4, 2020 Category: General Medicine Authors: Ballmer PE Tags: Swiss Med Wkly Source Type: research

Five reasons why data on compassionate use of remdesivir deserved publication (and are worth reading).
PMID: 32364611 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - May 4, 2020 Category: General Medicine Authors: Lapadula G Tags: Swiss Med Wkly Source Type: research

How to test trust in   clinical competence.
How to test trust in  clinical competence. Swiss Med Wkly. 2020 May 04;150:w20270 Authors: Seiler C PMID: 32364612 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - May 4, 2020 Category: General Medicine Authors: Seiler C Tags: Swiss Med Wkly Source Type: research

Guideline of the Swiss Society of Gynaecology and Obstetrics (SSGO) on acute and recurrent urinary tract infections in women, including pregnancy.
Abstract Acute and recurrent urinary tract infections (UTIs) are common auto-infectious diseases transmitted from the intestinal tract. They affect the urinary tract either through recurrence or through persistence. The incidence of UTIs increases with age and comorbidities. In this guideline from the Swiss Society of Gynaecology and Obstetrics (SSGO), diagnosis and treatment of UTIs are grouped into uncomplicated and complicated cases. This is to our knowledge the first guideline that specifically considers UTIs in pregnancy and breastfeeding, and the prevention of UTIs in the context of urogynaecological diagnos...
Source: Swiss Medical Weekly - May 4, 2020 Category: General Medicine Authors: Betschart C, Albrich WC, Brandner S, Faltin D, Kuhn A, Surbek D, Geissbuehler V Tags: Swiss Med Wkly Source Type: research

Reproductive number of the COVID-19 epidemic in Switzerland with a focus on the Cantons of Basel-Stadt and Basel-Landschaft.
, Kübler W, Bingisser R, Battegay M, Tschudin-Sutter S, Stadler T Abstract The reproductive number in Switzerland was between 1.5 and 2 during the first third of March, and has consistently decreased to around 1. After the announcement of the latest strict measure on 20 March 2020, namely that gatherings of more than five people in public spaces are prohibited, the reproductive number dropped significantly below 1; the authors of this study estimate the reproductive number to be between 0.6 and 0.8 in the first third of April. PMID: 32365217 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - May 4, 2020 Category: General Medicine Authors: Scire J, Nadeau S, Vaughan T, Brupbacher G, Fuchs S, Sommer J, Koch KN, Misteli R, Mundorff L, Götz T, Eichenberger T, Quinto C, Savic M, Meienberg A, Burkard T, Mayr M, Meier CA, Widmer A, Kuehl R, Egli A, Hirsch HH, Bassetti S, Nickel CH, Rentsch KS, K Tags: Swiss Med Wkly Source Type: research

The ecology of medical care in Switzerland: prevalence of illness in the community and healthcare utilisation in Switzerland.
CONCLUSIONS: This study represented an attempt to map the healthcare utilisation of the Swiss population. These results may be useful for further delineation of healthcare policies and medical education to meet the demand and needs of people in Switzerland. They indicate that general practitioners are the most important healthcare resource in Switzerland. Compared with specialists, they provide twice as much health advice at less costs. To optimise the health care system in Switzerland, we suggest to allocate resources where they are most needed. PMID: 32365218 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - May 4, 2020 Category: General Medicine Authors: Giezendanner S, Bretschneider W, Fischer R, Diaz Hernandez L, Zeller A Tags: Swiss Med Wkly Source Type: research

An independent appraisal and re-analysis of hydroxychloroquine treatment trial for COVID-19.
PMID: 32347963 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 20, 2020 Category: General Medicine Authors: Intson K, Kumar S, Botta A, Neckles R, Leung C, Jawaid A Tags: Swiss Med Wkly Source Type: research

Chromobacterium violaceum bacteraemia: a new entity in Switzerland.
We report the uncommon clinical case of our patient, an 83-year-old woman with Alzheimer disease, who acquired a potentially fatal tropical infection in an open-air swimming pool in the Alps. Chromobacterium violaceum is a rare gram-negative anaerobe bacillus, generally associated with serious waterborne infections in tropical and subtropical regions. The patient presented to our emergency department with a 2-day history of fever and a small non-necrotic wound on the right leg after a minor injury 9 days before. It turned out to be the first infection in Switzerland due to C. violaceum, a deadly bacterium typical of tropic...
Source: Swiss Medical Weekly - April 20, 2020 Category: General Medicine Authors: Moretti E, Baggi Menozzi F, Elzi L, Lepori M Tags: Swiss Med Wkly Source Type: research

Age, comorbidity, frailty status: effects on disposition and resource allocation during the COVID-19 pandemic.
PMID: 32352150 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 20, 2020 Category: General Medicine Authors: Nickel CH, Rueegg M, Pargger H, Bingisser R Tags: Swiss Med Wkly Source Type: research

The global COVID-19 response must include refugees and migrants.
PMID: 32343357 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 20, 2020 Category: General Medicine Authors: Brandenberger JR, Baauw A, Kruse A, Ritz N Tags: Swiss Med Wkly Source Type: research

Transmission risk of SARS-CoV-2 to healthcare workers -observational results of a primary care hospital contact tracing.
CONCLUSION: We found a low risk of SARS-CoV-2 transmission in a primary care setting. These findings are compatible with previous reports of the highest transmission probability in household settings with prolonged close contacts. The current protective measures for healthcare workers, including strict adherence to basic standard hygiene and facemasks, offer considerable protection during short periods of contact with symptomatic COVID-19 cases by diminishing the risk of direct and indirect transmission. PMID: 32333603 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 20, 2020 Category: General Medicine Authors: Canova V, Lederer Schläpfer H, Piso RJ, Droll A, Fenner L, Hoffmann T, Hoffmann M Tags: Swiss Med Wkly Source Type: research

Gout management in Swiss primary care - a retrospective observational study.
CONCLUSION: Swiss gout patients received comprehensive treatment, which is reflected in a high number of patients treated with ULT, laboratory tests per person and a high treatment success rate, although there is no systematic approach to the treatment of gout. PMID: 32329802 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 20, 2020 Category: General Medicine Authors: Meier R, di Gangi S, Valeri F, Rosemann T, Zechmann S Tags: Swiss Med Wkly Source Type: research

Management of neurosurgical implant-associated infections.
Abstract With the technical developments in neurosurgery, increasing numbers of neurosurgical implants are used in an increasingly aged population of patients with several comorbidities. Consequently, the number of neurosurgical implant-associated infections is continuously raising, resulting in significant morbidity and mortality, including disfiguring skull deformities and lack of brain protection. In this article we review infections associated with craniotomy, cranioplasty, neurostimulators, internal cerebrospinal fluid shunts, and external ventricular and lumbar cerebrospinal fluid drainages. In all implant-a...
Source: Swiss Medical Weekly - April 20, 2020 Category: General Medicine Authors: Conen A, Raabe A, Schaller K, Fux CA, Vajkoczy P, Trampuz A Tags: Swiss Med Wkly Source Type: research

Pain - the fifth vital sign.
PMID: 32329804 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 20, 2020 Category: General Medicine Authors: Christ M Tags: Swiss Med Wkly Source Type: research

Quality of sleep in patients with nocturnal leg cramps and validity of a single-item measure of cramp-related sleep disturbance: an observational study.
CONCLUSIONS: In this primary care sample, poor sleep quality was not associated with suffering from a higher number of nocturnal cramps, and a single-item mean score was not a valid instrument to screen for sleep disturbance among these patients. PMID: 32329805 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 20, 2020 Category: General Medicine Authors: Sebo P, Haller DM, Maisonneuve H Tags: Swiss Med Wkly Source Type: research

Recommendations on the use of anticoagulants for the treatment of patients with heparin-induced thrombocytopenia in Switzerland.
Abstract Heparin-induced thrombocytopenia (HIT) is an immune-mediated adverse drug effect that occurs in 0.1–5% of heparin treated patients. Management of acute HIT currently involves (1) cessation of heparin exposure, and (2) inhibition of coagulation with an anticoagulant other than heparin. Several anticoagulants can be considered for the treatment of HIT. Anticoagulant monitoring, management of drug-induced adverse events including bleeding, and therapeutic dosing schedules in selected clinical settings represent challenges to the clinician treating HIT patients. Moreover, the fact that not all regis...
Source: Swiss Medical Weekly - April 20, 2020 Category: General Medicine Authors: Alberio L, Angelillo-Scherrer A, Asmis L, Casini A, Fontana P, Graf L, Hegemann I, Kremer Hovinga JA, Korte W, Lecompte T, Martinez M, Nagler M, Studt JD, Tsakiris DA, Wuillemin W Tags: Swiss Med Wkly Source Type: research

Bioethics: stop to think, but don't stop thinking.
PMID: 32329807 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 20, 2020 Category: General Medicine Authors: Biller-Andorno N Tags: Swiss Med Wkly Source Type: research

The cellular prion protein beyond prion diseases.
Abstract The cellular prion protein (PrPC), a cell surface glycoprotein originally identified for its central role in prion diseases (also called transmissible spongiform encephalopathies), has recently been implicated in the pathogenesis of other neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases, by acting as a toxicity-transducing receptor for different misfolded protein isoforms, or in some case by exerting neuroprotective effects. Interestingly, PrPC has also been reported to play unexpected functions outside the nervous system, for example by contributing to myelin ...
Source: Swiss Medical Weekly - April 20, 2020 Category: General Medicine Authors: Manni G, Lewis V, Senesi M, Spagnolli G, Fallarino F, Collins SJ, Mouillet-Richard S, Biasini E Tags: Swiss Med Wkly Source Type: research

Interventional radiology workflow during the COVID-19 pandemic: recommendations of the Swiss Society of Vascular and Interventional Radiology.
Abstract Given the importance of continuum in providing services and exigence of protecting health care professionals during this period, the Swiss Society of Vascular and Interventional Radiology (SSVIR) is releasing guidance for interventional radiologists as preparedness to manage COVID-19 patients, the workflow of non-COVID-19 patients and optimize interactions with other healthcare professionals. PMID: 32330285 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 20, 2020 Category: General Medicine Authors: Qanadli SD, Zech CL, Monnard E, Binkert C, Denys A, Pfammater T Tags: Swiss Med Wkly Source Type: research

Individualised nutritional support in medical inpatients - a practical guideline.
z P Abstract Malnutrition has been defined as a “state resulting from lack of uptake or intake of nutrition, leading to altered body composition and body cell mass, as well as to diminished physical and mental function and impaired clinical outcome from disease.” Particularly for the multimorbid medical inpatient, there are multiple research studies linking malnutrition to adverse clinical outcomes independent of type of acute and chronic illnesses. Importantly, recent trials have shown that malnutrition is indeed a modifiable risk factor with specific individualised nutritional support interve...
Source: Swiss Medical Weekly - April 6, 2020 Category: General Medicine Authors: Baumgartner A, Kägi-Braun N, Tribolet P, Gomes F, Stanga Z, Schuetz P Tags: Swiss Med Wkly Source Type: research

Uranium exposure of the Swiss population based on 24-hour urinary excretion.
CONCLUSIONS: On the basis of uranium exposure, assessed via 24-hour urinary uranium excretion, and current knowledge of the toxicity of naturally occurring uranium, a substantial corresponding health risk for the general adult population is unlikely. However, as long as no specific sensitive biomarker for the biological impact of low-dose chronic uranium exposure has been identified and validated, assessing subtle health impact of such exposure will remain difficult. PMID: 32294221 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 6, 2020 Category: General Medicine Authors: Jenny-Burri J, Blanc A, Aubert R, Haldimann M, Zürcher U, Burnier M, Paccaud F, Bochud M, Dudler V Tags: Swiss Med Wkly Source Type: research

Characteristics and opinions of MD-PhD students and graduates from different European countries: a study from the European MD-PhD Association.
CONCLUSION: The MD-PhD workforce in Europe is highly diverse in their demographics, programme characteristics and career paths but does not differ in opinions related to the challenges faced. The results of this study may be helpful for implementation and improvement of MD-PhD programmes. PMID: 32294222 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 6, 2020 Category: General Medicine Authors: Dos Santos Rocha A, Scherlinger M, Ostermann L, Mehler DMA, Nadiradze A, Schulze F, Feldmeyer L, de Koning M, Berbecar VT, Buijs R, Kijlstra JD, Jawaid A Tags: Swiss Med Wkly Source Type: research

Nationwide introduction of a new competency framework for undergraduate medical curricula: a collaborative approach.
Abstract Switzerland recently introduced PROFILES, a revised version of its national outcomes reference framework for the undergraduate medical curriculum. PROFILES is based on a set of competencies adapted from the CanMEDS framework and nine entrustable professional activities (EPAs) that students have to be able to perform autonomously in the context of a predefined list of clinical situations. The nationwide implementation of such a competency- and EPA-based approach to medical education is a complex process that represents an important change to the organisation of undergraduate training in the various medical...
Source: Swiss Medical Weekly - April 6, 2020 Category: General Medicine Authors: Sohrmann M, Berendonk C, Nendaz M, Bonvin R, Swiss Working Group For Profiles Implementation Tags: Swiss Med Wkly Source Type: research

A review of HLA allele and SNP associations with highly prevalent infectious diseases in human populations.
Abstract Human leucocyte antigen (HLA) alleles and single nucleotide polymorphisms (SNPs) lying in the HLA region are known to be associated with several infectious diseases among which acquired immunodeficiency syndrome, hepatitis B, hepatitis C, tuberculosis, leprosy and malaria are highly prevalent in many human populations worldwide. Distinct approaches such as case-control comparisons, immunogenetic analyses, bioinformatic peptide-binding predictions, ancient DNA and genome-wide association studies (GWAS) have contributed to improving this knowledge during the last decade, although many results still need str...
Source: Swiss Medical Weekly - April 6, 2020 Category: General Medicine Authors: Sanchez-Mazas A Tags: Swiss Med Wkly Source Type: research

HLA studies in the context of coronavirus outbreaks.
PMID: 32297958 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 6, 2020 Category: General Medicine Authors: Sanchez-Mazas A Tags: Swiss Med Wkly Source Type: research

Is antibody-dependent enhancement playing a role in COVID-19 pathogenesis?
PMID: 32298458 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 6, 2020 Category: General Medicine Authors: Negro F Tags: Swiss Med Wkly Source Type: research

Thromboprophylaxis and laboratory monitoring for in-hospital patients with Covid-19 - a Swiss consensus statement by the Working Party Hemostasis.
PMID: 32277760 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 6, 2020 Category: General Medicine Authors: Casini A, Alberio L, Angelillo-Scherrer A, Fontana P, Gerber B, Graf L, Hegemann I, Korte W, Kremer Hovinga J, Lecompte T, Martinez M, Nagler M, Studt JD, Tsakiris D, Wuillemin W, Asmis L Tags: Swiss Med Wkly Source Type: research

Benign COVID-19 in an immunocompromised cancer patient -   the case of a married couple.
Benign COVID-19 in an immunocompromised cancer patient -  the case of a married couple. Swiss Med Wkly. 2020 Apr 06;150:w20246 Authors: Spezzani V, Piunno A, Iselin HU Abstract Respiratory failure in COVID-19 is a common feature in fatal cases and has been considered as a failure of the immune system to control the virus. Here we report the case of COVID-19 affecting an immunocompromised women and her presumably immunocompetent spouse. A married couple (age 60 years) was simultaneously admitted to the emergency department on 10 March 2020 because of dyspnoea and fever, consistent with COVID-19. T...
Source: Swiss Medical Weekly - April 6, 2020 Category: General Medicine Authors: Spezzani V, Piunno A, Iselin HU Tags: Swiss Med Wkly Source Type: research

Response of a European surgical department to the COVID-19 crisis.
PMID: 32271935 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 6, 2020 Category: General Medicine Authors: Peloso A, Moeckli B, Oldani G, Triponez F, Toso C Tags: Swiss Med Wkly Source Type: research

Coronary and structural heart interventions in Switzerland 2018.
Abstract Since the first coronary angioplasty by Andreas Grüntzig in Zurich in 1977, the number of cardiac interventional procedures has steadily increased. The aim of this report is to summarise the state of catheter-based cardiac interventions in adults in Switzerland in 2018. Since 1987, the Working Group Interventional Cardiology of the Swiss Society of Cardiology has collected annually aggregate data from all facilities with cardiac catheterisation laboratories in the country, currently 36 institutions in 17 cantons of Switzerland. Over past years, the numbers of coronary angiography procedures (CAs)...
Source: Swiss Medical Weekly - April 6, 2020 Category: General Medicine Authors: Nestelberger T, Twerenbold R, Cook S, Gaemperli O, Meier P, Mueller O, Nietlisbach F, Raeber L, Weilenmann D, Jeger R Tags: Swiss Med Wkly Source Type: research

COVID-19 and Iran: swimming with hands tied!
PMID: 32255497 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 6, 2020 Category: General Medicine Authors: Gharebaghi R, Heidary F Tags: Swiss Med Wkly Source Type: research

Prevalence and practice of opioid prescription at a Swiss emergency department: 2013-2017.
CONCLUSIONS: Opioid prescriptions in a Swiss ED decreased between 2013 and 2017. Although this might be a sign of awareness of the risks of opioid prescription, the conclusion is derived from a single centre study and the observed trend warrants confirmation by data from other sources. PMID: 32249923 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 6, 2020 Category: General Medicine Authors: Gaertner K, Wildbolz S, Speidel V, Exadaktylos AK, Hautz WE, Müller M Tags: Swiss Med Wkly Source Type: research

Code status discussions in medical inpatients: results of a survey of patients and physicians.
CONCLUSION: A majority of patients do not report having discussed code status during their hospital stay and physicians frequently omit such discussions, thereby potentially failing to attend to patients’ preferences for care. Physician training regarding code status discussions may improve the quality of informed decision-making and patient-centred care. PMID: 32239481 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - March 23, 2020 Category: General Medicine Authors: Becker C, Künzli N, Perrig S, Beck K, Vincent A, Widmer M, Thommen E, Schaefert R, Bassetti S, Hunziker S Tags: Swiss Med Wkly Source Type: research

Systematic review of pneumothoraces after endoscopic retrograde cholangiopancreatography.
CONCLUSIONS: A post-ERCP pneumothorax should be considered when subcutaneous emphysema, cardiovascular instability or respiratory distress occurs. Thoraco-abdominal computed tomography facilitates identification and therapy tailoring. Because of possible late or discrete onset, patients should be monitored carefully. PMID: 32242910 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - March 23, 2020 Category: General Medicine Authors: Lehmann V, Keller W, Egger B Tags: Swiss Med Wkly Source Type: research

Marfan syndrome and related connective tissue disorders in the current era in Switzerland in 103 patients: medical and surgical management and impact of genetic testing.
CONCLUSIONS: In this cohort a high percentage of patients fulfilling the revised Ghent criteria for MFS underwent genetic testing, often leading to or confirming the diagnosis of MFS. Other CTDs could be discriminated best by genetic testing. With respect to the diagnosis of MFS and related CTDs, the usefulness of the systemic score is limited, showing the importance of genetic testing, which enabled definitive diagnosis in 95% of tested patients. Patient education on medical treatment still has to be improved. (Trial registration no: KEK-ZH-Nr. 2013-0241). PMID: 32242911 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - March 23, 2020 Category: General Medicine Authors: Bombardieri E, Rohrbach M, Greutmann M, Matyas G, Weber R, Radulovic J, Fasnacht Boillat M, Linka A, De Pasquale G, Bonassin F, Attenhofer Jost CH Tags: Swiss Med Wkly Source Type: research

Good rules for ICU admission allow a fair allocation of resources, even in a pandemic.
PMID: 32208496 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - March 23, 2020 Category: General Medicine Authors: Suter P Tags: Swiss Med Wkly Source Type: research