Look before you SPRINT: look at the data and look at the consequences.
PMID: 29964291 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - June 25, 2018 Category: General Medicine Authors: Nordmann A, Fernandes M, Olde Rikkert MGM Tags: Swiss Med Wkly Source Type: research

Excipients: not so inert? When the excipient plays the role of an active substance, as exemplified by systemic lupus.
Abstract It is well recognised that the historical timeline required for developing a drug, beginning with target identification and validation, is long and often tedious. It requires a large set of competences in various areas of molecular and cellular biology, chemistry, pharmacology, imaging, and model animal experimentation. Once the active molecule appears to be ready for human testing in controlled clinical trials, then the question arises of how to formulate it to render it stable, adequately packaged, according to the chosen route of administration, and bioavailable to reach its target in the affected orga...
Source: Swiss Medical Weekly - June 25, 2018 Category: General Medicine Authors: Muller S Tags: Swiss Med Wkly Source Type: research

Clinical characteristics, audiological and neurodevelopmental outcomes of newborns with congenital cytomegalovirus infection.
CONCLUSIONS: All infants with subsequent SNHL or abnormal neurodevelopment were symptomatic at birth. Similar long-term neurodevelopmental and audiological outcomes were observed in infants born to mothers with a primary and nonprimary infection. PMID: 29894555 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - June 12, 2018 Category: General Medicine Authors: Kobas M, Bickle Graz M, Truttmann AC, Giannoni E, Meylan P, Asner SA Tags: Swiss Med Wkly Source Type: research

Adaptation of cost-effectiveness analyses to a single country: the case of bariatric surgery for obesity and overweight.
Abstract OBJECTIVES: The aims of this study were to (a) identify and assess the quality of reporting of published cost-effectiveness studies of bariatric surgery, (b) assess their transferability to Switzerland, and (c) adapt transferable cost-effectiveness results to Switzerland. METHODS: A systematic literature search was performed in Medline, Embase and other databases. Two reviewers independently undertook screening, extraction, assessment of reporting quality utilising the Consolidated Health Economic Evaluation Reporting Standards, transferability, adaptation of cost data and recalculation of cost-effec...
Source: Swiss Medical Weekly - June 12, 2018 Category: General Medicine Authors: Ademi Z, Tomonaga Y, van Stiphout J, Glinz D, Gloy V, Raatz H, Bucher HC, Schwenkglenks M Tags: Swiss Med Wkly Source Type: research

Accidental or intentional exposure to potentially toxic medications, natural toxins and chemicals during pregnancy: analysis of data from Tox Info Suisse.
CONCLUSIONS: Tox Info Suisse recorded an average of 137 cases of agent exposure during pregnancy per year, mostly due to accidents with household products. Suicidal intentions played a role in a considerable number of exposures. Measures are needed to prevent accidental exposure of pregnant women to toxic substances and to support them in this exceptional life period. PMID: 29767826 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - May 16, 2018 Category: General Medicine Authors: Vogel T, Lüde S, Baumgartner R, Rauber-Lüthy C, Simões-Wüst AP Tags: Swiss Med Wkly Source Type: research

Directing citizens to create advance directives.
This article describes the Swiss law on advance directives that was passed at the beginning of 2013 and led to more certainty about the legally binding character of such directives. However, for various reasons the drafting of advance directives is not yet widespread in Switzerland, and many resources might be put to better use if this became a common practice. A recent proposal by members of a political party to make the discussion, although not the actual drafting, of advance directives mandatory was rejected by the Swiss Federal Parliament, and the proposal was written off after having been pending for 2 years. We consi...
Source: Swiss Medical Weekly - May 16, 2018 Category: General Medicine Authors: Haesen S, Shaw D Tags: Swiss Med Wkly Source Type: research

A digitally facilitated citizen-science driven approach accelerates participant recruitment and increases study population diversity.
CONCLUSION: Academic and industry-driven medical research faces substantial challenges in terms of patient involvement, recruitment, relevance and generalisability. Digital studies and stakeholder engagement may have enormous potential for medical research. But many digital studies are based on limited participant information and/or informed consent and unclear data ownership, and are subject to selection bias, confounding and information bias. The Swiss MS Registry serves as an example of a digitally enhanced, citizen-science study that leverages the advantages of both traditional medical research, with its established re...
Source: Swiss Medical Weekly - May 16, 2018 Category: General Medicine Authors: Puhan MA, Steinemann N, Kamm CP, Müller S, Kuhle J, Kurmann R, Calabrese P, Kesselring J, von Wyl V, Swiss Multiple Sclerosis Registry Smsr Tags: Swiss Med Wkly Source Type: research

Immunotherapy in head and neck cancer - scientific rationale, current treatment options and future directions.
hild SI Abstract Head and neck squamous cell carcinoma (HNSCC) is a frequent tumour arising from multiple anatomical subsites in the head and neck region. The treatment for early-stage disease is generally single modality, either surgery or radiotherapy. The treatment for locally advanced tumours is multimodal. For recurrent/metastatic HNSCC palliative chemotherapy is standard of care. The prognosis is limited and novel treatment approaches are urgently needed. HNSCC evades immune responses through multiple resistance mechanisms. HNSCC is particularly characterised by an immunosuppressive environment which include...
Source: Swiss Medical Weekly - May 14, 2018 Category: General Medicine Authors: Rothschild U, Muller L, Lechner A, Schlösser HA, Beutner D, Läubli H, Zippelius A, Rothschild SI Tags: Swiss Med Wkly Source Type: research

External validation of the 80+ score and comparison with three clinical scores identifying patients at least 75 years old at risk of unplanned readmission within 30 days after discharge.
CONCLUSION: In our study, the 80+ score was externally validated and showed less favourable discrimination than the three other scores in this population. PMID: 29756634 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - May 14, 2018 Category: General Medicine Authors: Schwab C, Le Moigne A, Fernandez C, Durieux P, Sabatier B, Korb-Savoldelli V Tags: Swiss Med Wkly Source Type: research

Trends in the use of mammography for early breast cancer detection in Switzerland: Swiss Health Surveys 2007 and 2012.
n M Abstract AIMS: Breast cancer is the most common cancer in women worldwide. We assessed changes in the use of breast cancer screening 2007-2012 in Switzerland, and associations with socioeconomic and health-related determinants. METHODS: We used the nationwide and representative data from the Swiss Health Surveys 2007 and 2012. We analysed the self-reported use of mammography in the last 12 months (proportion of population) among women aged 40-79 years, and opportunistic (without clinical symptoms, initiated by the woman or a physician) and programmatic screening mammography (as part of a systematic screen...
Source: Swiss Medical Weekly - May 14, 2018 Category: General Medicine Authors: Fenner L, Kässner A, Berlin C, Egger M, Zwahlen M Tags: Swiss Med Wkly Source Type: research

The impact of clinical trial units on the value of clinical research in Switzerland.
s C Abstract A prominent 2014 series by The Lancet on "Increasing value, reducing waste in biomedical research" provided recommendations on how to optimise precious resources, including in clinical research. Despite being ideally placed to lead the movement in patient-oriented clinical research, academia struggles to take corresponding measures and find ways to evaluate their impact. A decade ago, Swiss stakeholders established constructive initiatives to improve the quality of clinical research, including a national Clinical Trial Unit (CTU) Network, predominantly rooted in university hospitals. At the ...
Source: Swiss Medical Weekly - April 26, 2018 Category: General Medicine Authors: von Niederhäusern B, Magnin A, Pauli-Magnus C Tags: Swiss Med Wkly Source Type: research

Occupational exposure to plant protection products and health effects in Switzerland: what do we know and what do we need to do?
CONCLUSIONS: Due to increasing evidence of an association between PPP exposure and health effects, increased collaboration between stakeholders is necessary to develop links between the data sources that already exist. Our study was the first to investigate the health effects linked to PPP exposure among the Swiss agricultural population. The recommendations presented in this paper would help promote a safer and healthier agricultural workforce in Switzerland, as well as the population at large. PMID: 29698541 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 26, 2018 Category: General Medicine Authors: Graczyk H, Hopf NB, Mediouni Z, Guseva-Canu I, Sanvido O, Schmid K, Berthet A Tags: Swiss Med Wkly Source Type: research

Point prevalence of healthcare-associated infections and antibiotic use in three large Swiss acute-care hospitals.
CONCLUSIONS: HAI prevalence and antimicrobial use in this survey were similar to findings of the past ECDC PPS. The ECDC methodology proved applicable to Swiss acute-care hospitals. PMID: 29698542 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 26, 2018 Category: General Medicine Authors: Metsini A, Vazquez M, Sommerstein R, Marschall J, Voide C, Troillet N, Gardiol C, Pittet D, Zingg W, The Swissnoso Network Tags: Swiss Med Wkly Source Type: research

Clinical course and prevalence of coercive measures: an observational study among involuntarily hospitalised psychiatric patients.
CONCLUSIONS: The prevalence of coercive measures is still high in involuntarily hospitalised patients. Seclusion was the most frequently used coercive measure, which may be based on cultural and clinical aspects and differs from findings in other countries where restraint is more frequently used. Some sociodemographic and clinical characteristics were associated with the use of coercion. This underlines the importance of developing treatment strategies for patients at risk to prevent situations in which the use of coercion is necessary. To enable comparison between different study sites, standardised protocols should be us...
Source: Swiss Medical Weekly - April 26, 2018 Category: General Medicine Authors: Hotzy F, Moetteli S, Theodoridou A, Schneeberger AR, Seifritz E, Hoff P, Jäger M Tags: Swiss Med Wkly Source Type: research

The Swiss Cystic Fibrosis Infant Lung Development (SCILD) cohort.
Abstract The Swiss Cystic Fibrosis Infant Lung Development (SCILD) cohort is a prospective birth cohort study investigating the initiating events of cystic fibrosis lung disease during infancy, and their influence on the trajectory of disease progression throughout early childhood. Infants with cystic fibrosis are recruited throughout Switzerland after diagnosis by new-born screening. It is the first European population-based prospective cohort study of infants with cystic fibrosis taking advantage of a nationwide new-born screening programme. The study was established in 2011 and recruitment is ongoing. The cohor...
Source: Swiss Medical Weekly - April 26, 2018 Category: General Medicine Authors: Korten I, Kieninger E, Yammine S, Regamey N, Nyilas S, Ramsey K, Casaulta C, Latzin P, For The Scild Study Group Tags: Swiss Med Wkly Source Type: research

The role of molecular imaging in assessing degenerative parkinsonism - an updated review.
Abstract Diagnosing degenerative forms of parkinsonism still relies on a thorough clinical assessment, which in Parkinson's disease involves the presence of an asymmetric bradykinesia with rest tremor and/or rigidity that respond substantially to levodopa. Conversely, atypical forms, including multiple system atrophy, progressive supranuclear palsy and corticobasal degeneration, exhibit additional features (cerebellar or pyramidal signs, early postural instability), a poor response to dopamine replacement therapy and a bad prognosis. Consensus diagnostic criteria have excellent specificity, but lack sensitivity, a...
Source: Swiss Medical Weekly - April 26, 2018 Category: General Medicine Authors: Nicastro N, Garibotto V, Burkhard PR Tags: Swiss Med Wkly Source Type: research

The epidemiology of hepatitis C in Switzerland: trends in notifications, 1988-2015.
l M Abstract With an estimated antibody prevalence of 0.7% in the low-risk population, hepatitis C virus (HCV) endemicity in Switzerland is low. We reviewed data from mandatory hepatitis C surveillance for 1988-2015 in order to describe the evolution of acute HCV infections and newly reported non-acute cases, and their epidemiological features. Crude and stratified annual incidence and notification rates and rate ratios were calculated using Poisson regression. Acute HCV incidence peaked in 2002 at 1.8 cases per 100,000 population, then declined sharply, levelling at around 0.7/100,000 from 2006. Notification rate...
Source: Swiss Medical Weekly - April 26, 2018 Category: General Medicine Authors: Richard JL, Schaetti C, Basler S, Mäusezahl M Tags: Swiss Med Wkly Source Type: research

First case of Candida auris in Switzerland: discussion about preventive strategies.
PMID: 29698547 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 26, 2018 Category: General Medicine Authors: Riat A, Neofytos D, Coste A, Harbarth S, Bizzini A, Grandbastien B, Pugin J, Lamoth F Tags: Swiss Med Wkly Source Type: research

The place of the Ozaki procedure in the treatment of aortic valve disease.
re R PMID: 29698548 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 26, 2018 Category: General Medicine Authors: Sologashvili T, Prêtre R Tags: Swiss Med Wkly Source Type: research

Impairment of chondrocyte proliferation after exposure of young murine cartilage to an aged systemic environment in a heterochronic parabiosis model.
Abstract AIM: The aim of this study was to investigate whether an aged systemic environment could impair young cartilage tissue in mice. METHODS: Mice differing in age were randomly divided into three groups. Group 1 was the experimental group (Y/O group) consisting of the heterochronic parabiosis model (2-month-old/12-month-old, young/old). Group 2 was the surgical control group (Y/Y group) with the isochronic parabiosis model (2-month-old/2-month-old, young/young). Group 3 consisted of the ageing control mice (2-month-old alone, Y group). Young knee cartilages collected from all three groups at 4 months aft...
Source: Swiss Medical Weekly - April 25, 2018 Category: General Medicine Authors: Li L, Wei X, Geng X, Duan Z, Wang X, Li P, Wang C, Wei L Tags: Swiss Med Wkly Source Type: research

Extended-criteria donors in lung transplantation in Switzerland: an evaluation of two adapted lung donor scores.
CONCLUSIONS: Both scoring systems are able to predict whether or not donor lungs are accepted by the two Swiss lung transplant centres. As an alternative to adapting an established scoring system, a national lung quality score could be derived de novo. This could be based on a logistic regression analysis including the most relevant donor characteristics. However, such a new score would need to be validated on an independent sample and ideally tested for its predictive value in terms of post-transplantation outcome. PMID: 29689119 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 24, 2018 Category: General Medicine Authors: Elmer A, Birrer M, Weiss J, Aubert JD, Benden C, Inci I, Krüger T, Soccal PM, Immer FF Tags: Swiss Med Wkly Source Type: research

Patient experience in primary care: association with patient, physician and practice characteristics in a fee-for-service system.
CONCLUSIONS: In this study, we found that patient experience in family medicine in Switzerland was very good for all domains studied; access, family physician-patient communication and continuity-coordination of care. Most often, predictive factors of care experience relate to the patient's characteristics, such as age and health status. However, several practice characteristics such as size, composition and functioning (in particular, time spent with the patient) represent potential levers for improving patient-reported experience. The variations observed between the three linguistic areas in Switzerland are also interest...
Source: Swiss Medical Weekly - April 3, 2018 Category: General Medicine Authors: Cohidon C, Wild P, Senn N Tags: Swiss Med Wkly Source Type: research

Gamma knife radiosurgery for arteriovenous malformations: general principles and preliminary results in a Swiss cohort.
We report obliteration rates, radiation-induced complications and haemorrhages during follow-up course. RESULTS: The mean age was 46 years (range 13-79 years). The mean follow-up period was 36.4 months (median 38, range 12-75 months). Most common pretherapeutic clinical presentation was haemorrhage (50%). The most common Pollock-Flickinger score was between 1.01 and 1.5 (46%) and Spetzler-Martin grade III (46%). In 39 (60.1%) of cases, GKR was performed as upfront therapeutic option. The mean gross target volume (GTV) was 2.3 ml (median 1.2, range 0.03-11.3 ml). Mean marginal dose was 22.4 Gy (median 24, range 18-24 G...
Source: Swiss Medical Weekly - April 3, 2018 Category: General Medicine Authors: Raboud M, Tuleasca C, Maeder P, Schiappacasse L, Marguet M, Daniel RT, Levivier M Tags: Swiss Med Wkly Source Type: research

Reply to comment on: Sailer CO, et al. Primary polydipsia in the medical and psychiatric patient: characteristics, complications and therapy.
PMID: 29614200 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 3, 2018 Category: General Medicine Authors: Sailer CO, Winzeler B, Christ-Crain M Tags: Swiss Med Wkly Source Type: research

Comment on: Sailer C, et al. Primary polydipsia in the medical and psychiatric patient: characteristics, complications and therapy.
PMID: 29614201 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 3, 2018 Category: General Medicine Authors: Margetić B Tags: Swiss Med Wkly Source Type: research

New insights into the pathophysiology of inflammatory bowel disease: microbiota, epigenetics and common signalling pathways.
Abstract The exact pathophysiology of inflammatory bowel disease (IBD) is still unknown. However, over the years important insights allowed the development of novel therapeutic approaches that are at the threshold of introduction into clinical practice, or at least in clinical trials. After being first described by Burrill B. Crohn, Crohn's disease, one of the two major forms of IBD, was perceived as an infectious disease. When the concept of autoimmune diseases was formulated, Crohn's disease and ulcerative colitis were thought to be members of this disease group. T cells certainly contribute to the chronificatio...
Source: Swiss Medical Weekly - March 22, 2018 Category: General Medicine Authors: Rogler G, Luc B, Scharl M Tags: Swiss Med Wkly Source Type: research

Screening for delirium with the Intensive Care Delirium Screening Checklist (ICDSC): a re-evaluation of the threshold for delirium.
CONCLUSION: In clinical routine, decreasing the ICDSC threshold for delirium to ≥3 increased the accuracy in detecting delirium at the cost of over-identification and is therefore recommended as the optimal threshold. Increasing the cut-off score to ≥5 decreased the concurrent validity and sensitivity; in addition, the under-detection of delirium was substantial. PMID: 29537480 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - March 14, 2018 Category: General Medicine Authors: Boettger S, Garcia Nuñez D, Meyer R, Richter A, Rudiger A, Schubert M, Jenewein J Tags: Swiss Med Wkly Source Type: research

Technical comment on: Hagner M. Open access, data capitalism and academic publishing.
PMID: 29538794 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - March 14, 2018 Category: General Medicine Authors: Egger M, Kalt A Tags: Swiss Med Wkly Source Type: research

How I manage patients with anticoagulation-associated bleeding or urgent surgery.
We present an algorithm for anticoagulant-associated bleeding and urgent surgery, derived from available data and recommendations, and implemented at our institution. Decisions regarding reversal agents or postponing surgery are based on two questions: the occurrence of a life-threatening bleed or urgent indication for surgery, and the presence of a relevant drug level. Immediate application of reversal agents is suggested if the clinical situation is urgent and laboratory test results are delayed or unavailable. A relevant anticoagulant drug level is required in all other cases. We discuss appropriate laboratory assays fo...
Source: Swiss Medical Weekly - March 14, 2018 Category: General Medicine Authors: Sauter TC, Eberle B, Wuillemin WA, Thiele T, Angelillo-Scherrer A, Exadaktylos AK, Erdös G, Cuker A, Nagler M Tags: Swiss Med Wkly Source Type: research

Response to Matthias Egger and Angelika Kalt.
PMID: 29538796 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - March 14, 2018 Category: General Medicine Authors: Hagner M Tags: Swiss Med Wkly Source Type: research

Low 5-year cumulative incidence of post-transplant lymphoproliferative disorders after solid organ transplantation in Switzerland.
CONCLUSIONS: At 5 years, the cumulative incidence of PTLD, regardless of the organ transplanted, was only 0.96% in the STCS cohort, which is lower than that reported in the literature. PMID: 29518251 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - March 8, 2018 Category: General Medicine Authors: Steiner R, Kridel R, Giostra E, McKee T, Achermann R, Mueller N, Manuel O, Dickenmann M, Schuurmans MM, de Leval L, Fehr T, Tinguely M, Binet I, Cogliatti S, Haralamvieva E, Koller M, The Swiss Transplant Cohort Study Stcs, Dietrich PY Tags: Swiss Med Wkly Source Type: research

Haematopoietic cell transplantation in Switzerland, changes and results over 20 years: a report from the Swiss Blood Stem Cell Transplantation Working Group for Blood and Marrow Transplantation registry 1997-2016.
This study included all HCTs performed in Switzerland during the period of observation and the data are useful for quality assurance programmes, healthcare cost estimation and healthcare planning. Between 50 and 60% of patients were long-term survivors after both types of HCT, indicating growing populations of surviving patients requiring long-term care and observation. PMID: 29493715 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - March 1, 2018 Category: General Medicine Authors: Passweg JR, Baldomero H, Ansari M, Baerlocher GM, Bargetzi M, Chalandon Y, Duchosal MA, Gerull S, Güngör T, Halter JP, Heim D, Hess U, Leibundgut K, Masouridi-Levrat S, Müller A, Nair G, Pabst T, Renner C, Schmidt A, Stussi G, Nicoloso de Faveri G, Sch Tags: Swiss Med Wkly Source Type: research

Shared decision-making for prostate cancer screening and treatment: a systematic review of randomised controlled trials.
CONCLUSIONS: There is significant variation in the extent of SDM implementation among studies addressing SDM for prostate cancer screening and treatment. Further evaluation of these results on patient outcomes, a standardised SDM definition and guidance for an effective implementation in several clinical settings are needed. PMID: 29473938 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 23, 2018 Category: General Medicine Authors: Martínez-González NA, Plate A, Senn O, Markun S, Rosemann T, Neuner-Jehle S Tags: Swiss Med Wkly Source Type: research

Overuse of antimicrobial prophylaxis in low-risk patients undergoing transurethral resection of the prostate.
CONCLUSION: A low adherence to guidelines for low-risk patients undergoing TURP or PVP was reported. Given these preliminary data, there is an urgent need to monitor adherence to antimicrobial prophylaxis guidelines in urology to reduce antimicrobial resistance rates. PMID: 29473939 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 23, 2018 Category: General Medicine Authors: Bausch K, Roth JA, Seifert HH, Widmer AF Tags: Swiss Med Wkly Source Type: research

First experience in Switzerland in Phe508del homozygous cystic fibrosis patients with end-stage pulmonary disease enrolled in a lumacaftor-ivacaftor therapy trial - preliminary results.
n C Abstract AIMS OF THE STUDY: Cystic fibrosis is the most common genetic disorder in Caucasians. The combination of the cystic fibrosis transmembrane conductance regulator (CFTR) corrector lumacaftor / potentiator ivacaftor (LUM/IVA) has been shown to increase forced expiratory volume in 1 second (FEV1) moderately, but predominantly reduce acute exacerbation rate (AER) in Phe508del homozygous cystic fibrosis patients; however, patients with FEV1
Source: Swiss Medical Weekly - February 16, 2018 Category: General Medicine Authors: Murer C, Huber LC, Kurowski T, Hirt A, Robinson CA, Bürgi U, Benden C Tags: Swiss Med Wkly Source Type: research

Open Access, data capitalism and academic publishing.
Abstract Open Access (OA) is widely considered a breakthrough in the history of academic publishing, rendering the knowledge produced by the worldwide scientific community accessible to all. In numerous countries, national governments, funding institutions and research organisations have undertaken enormous efforts to establish OA as the new publishing standard. The benefits and new perspectives, however, cause various challenges. This essay addresses several issues, including that OA is deeply embedded in the logic and practices of data capitalism. Given that OA has proven an attractive business model for commerc...
Source: Swiss Medical Weekly - February 16, 2018 Category: General Medicine Authors: Hagner M Tags: Swiss Med Wkly Source Type: research

Aortic valve replacement using autologous pericardium: single centre experience with the Ozaki technique.
CONCLUSION: This aortic valve replacement technique has become available only recently. In our experience, it can be mastered after a relatively short training period, and has become part of our routine clinical toolbox. The use of autologous pericardium in combination with excellent haemodynamics may have the potential to overcome the structural disadvantages of biological aortic valves, to be beneficial in infective endocarditis, and to represent an alternative for patients with small annuli. PMID: 29442340 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 14, 2018 Category: General Medicine Authors: Reuthebuch O, Koechlin L, Schurr U, Grapow M, Fassl J, Eckstein FS Tags: Swiss Med Wkly Source Type: research

The influence of hospitalisation on the initiation, continuation and discontinuation of benzodiazepines and Z-drugs - an observational study.
CONCLUSIONS: The hospital effect on initiating and increasing hypnotic or sedative drug use seems to be only moderate and temporary. A change in favour of short-acting substances is even welcome. In less than 1% of patients, the hospital initiated the continuous use of benzodiazepines and Z-drugs, which may put pressure on primary care physicians. However, the widespread use of these drugs in hospitals does not seem to be continued on a large scale in primary care. PMID: 29442341 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 14, 2018 Category: General Medicine Authors: Grimmsmann T, Harden M, Fiß T, Himmel W Tags: Swiss Med Wkly Source Type: research

A ten-year follow-up study of treatment outcome of craniopharyngiomas.
Abstract PURPOSE: Craniopharyngioma-related hypothalamic obesity is a devastating complication with limited data on whether long-term follow-up should focus on problems other than endocrine deficiencies and weight gain. The primary endpoint was the assessment of predictors of hypothalamic obesity development; the secondary endpoint was the assessment of functional outcome (endocrine deficiencies, visual acuity) at long-term follow-up. METHODS: This retrospective case-note study examined craniopharyngioma patients with at least 2 years of follow-up. Clinical, radiological and biochemical characteristics were a...
Source: Swiss Medical Weekly - February 14, 2018 Category: General Medicine Authors: Andereggen L, Hess B, Andres R, El-Koussy M, Mariani L, Raabe A, Seiler RW, Christ E Tags: Swiss Med Wkly Source Type: research

Diet, medication use and drug intake during pregnancy: data from the Swiss Health Surveys 2007 and 2012.
PMID: 29442343 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 14, 2018 Category: General Medicine Authors: Koutelidakis A Tags: Swiss Med Wkly Source Type: research

Comparison of ESSDAI and ClinESSDAI in potential optimisation of trial outcomes in primary Sj ögren's syndrome: examination of data from the UK Primary Sjögren's Syndrome Registry.
Comparison of ESSDAI and ClinESSDAI in potential optimisation of trial outcomes in primary Sjögren's syndrome: examination of data from the UK Primary Sjögren's Syndrome Registry. Swiss Med Wkly. 2018 Feb 14;148:w14588 Authors: Dumusc A, Ng WF, James K, Griffiths B, Price E, Pease C, Emery P, Lanyon P, Jones A, Bombardieri M, Sutcliffe N, Pitzalis C, Gupta M, McLaren J, Cooper A, Giles I, Isenberg D, Saravanan V, Coady D, Dasgupta B, McHugh N, Young-Min S, Moots R, Gendi N, Akil M, Barone F, Fisher B, Rauz S, Richards A, Bowman S Abstract OBJECTIVES: To assess the use of the Clinical EULAR S...
Source: Swiss Medical Weekly - February 14, 2018 Category: General Medicine Authors: Dumusc A, Ng WF, James K, Griffiths B, Price E, Pease C, Emery P, Lanyon P, Jones A, Bombardieri M, Sutcliffe N, Pitzalis C, Gupta M, McLaren J, Cooper A, Giles I, Isenberg D, Saravanan V, Coady D, Dasgupta B, McHugh N, Young-Min S, Moots R, Gendi N, Akil Tags: Swiss Med Wkly Source Type: research

Craniopharyngioma - a chronic disease.
r H PMID: 29442345 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 14, 2018 Category: General Medicine Authors: Müller H Tags: Swiss Med Wkly Source Type: research

Idiopathic pulmonary fibrosis in a Swiss interstitial lung disease reference centre.
CONCLUSION: Registries for rare diseases such as IPF are a valuable resource for studying the course of the disease under current compliance with diagnostic and treatment guidelines and to appreciate local epidemiological particularities. PMID: 29376545 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - January 29, 2018 Category: General Medicine Authors: Guler S, Zumstein P, Berezowska S, Pöllinger A, Geiser T, Funke-Chambour M Tags: Swiss Med Wkly Source Type: research

Hospital discharge of patients with ongoing care needs: a cross-sectional study using data from a city hospital under SwissDRG.
CONCLUSION: The study identified important concerns related to receiving ATC after a hospital stay, that is, more problems/conflicts occur with patients discharged to ATC and that the introduction of ATC might particularly disadvantage female patients, who are less likely to receive rehabilitation care. PMID: 29376546 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - January 29, 2018 Category: General Medicine Authors: Koné I, Zimmermann B, Wangmo T, Richner S, Weber M, Elger B Tags: Swiss Med Wkly Source Type: research

Digital health: meeting the ethical and policy challenges.
Abstract Digital health encompasses a wide range of novel digital technologies related to health and medicine. Such technologies rely on recent advances in the collection and analysis of ever increasing amounts of data from both patients and healthy citizens. Along with new opportunities, however, come new ethical and policy challenges. These range from the need to adapt current evidence-based standards, to issues of privacy, oversight, accountability and public trust as well as national and international data governance and management. This review illustrates key issues and challenges facing the rapidly unfolding...
Source: Swiss Medical Weekly - January 29, 2018 Category: General Medicine Authors: Vayena E, Haeusermann T, Adjekum A, Blasimme A Tags: Swiss Med Wkly Source Type: research

Vitamin D levels in Swiss breast cancer survivors.
n B Abstract BACKGROUND: Cholecalciferol (vitamin D3) is widely supplemented in breast cancer survivors because of the role of vitamin D in multiple health outcomes. METHODS: We conducted an observational study in 332 women in Eastern Switzerland with early, i.e., nonmetastatic breast cancer. Tumour-, patient-related and sociodemographic variables were recorded. Cholecalciferol intake and serum 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2D) levels were measured at the first visit (baseline) and during a follow-up visit in a median of 210 days (range 87-857) after the first visit. Patie...
Source: Swiss Medical Weekly - January 29, 2018 Category: General Medicine Authors: Baumann M, Dani SU, Dietrich D, Hochstrasser A, Klingbiel D, Mark MT, Riesen WF, Ruhstaller T, Templeton AJ, Thürlimann B Tags: Swiss Med Wkly Source Type: research

Technical comment on: G üller et al. Lower hospital volume is associated with higher mortality after oesophageal, gastric, pancreatic and rectal cancer resection.
Technical comment on: Güller et al. Lower hospital volume is associated with higher mortality after oesophageal, gastric, pancreatic and rectal cancer resection. Swiss Med Wkly. 2018 Jan 29;148:w14582 Authors: Romanens M PMID: 29376549 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - January 29, 2018 Category: General Medicine Authors: Romanens M Tags: Swiss Med Wkly Source Type: research

Preventing HIV transmission through blockade of CCR5: rationale, progress and perspectives.
Abstract Of the two million people estimated to be newly infected with human immunodeficiency virus (HIV) every year, 95% live in poorer regions of the world where effective HIV treatment is not universally available. Strategies to reduce the spread of HIV infection, which predominantly occurs via sexual contact, are urgently required. In the absence of an effective vaccine, a number of approaches to prevent HIV infection have been developed. These include using potent anti-HIV drugs prophylactically, either through systemic administration or topical application to the mucosal tissues that HIV initially encounters...
Source: Swiss Medical Weekly - January 29, 2018 Category: General Medicine Authors: Hartley O, Martins E, Scurci I Tags: Swiss Med Wkly Source Type: research

Availability and accessibility of perinatal data for the Robson classification of caesarean sections in Switzerland.
PMID: 29376551 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - January 29, 2018 Category: General Medicine Authors: Grylka-Baeschlin S, Hess TH, Erdin R, Prentl E, Pehlke-Milde J Tags: Swiss Med Wkly Source Type: research

Impact of a fracture liaison service on patient management after an osteoporotic fracture: the CHUV FLS.
In this study we compared the management between the FLS team and the GP in terms of diagnosis of osteoporosis, treatment, refracture rates and mortality after FLS recording. Results are compared with the management of osteoporosis before the creation of the FLS, as reported in the survey study Osteocare. A total of 606 patients were included (80% women); 55% chose management by the FLS and 45% their GP. The mean age was 78.5, and hip was the main fracture site (44%). The percentage of patients having dual X-ray absorptiometry to diagnose osteoporosis was significantly higher in the FLS group than the GP group (72 vs 26.5%, p
Source: Swiss Medical Weekly - January 29, 2018 Category: General Medicine Authors: Aubry-Rozier B, Stoll D, Gonzalez Rodriguez E, Hans D, Prudent V, Seuret A, Farron A, Lamy O Tags: Swiss Med Wkly Source Type: research