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Assessing the plight of young unaccompanied refugees.
PMID: 29185239 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 29, 2017 Category: General Medicine Authors: Blaser J, Ambresin AE, Monnat M, Faucherre F, Sanchis J, Rojas-Urrego A, Hunziker B, Gehri M, Bodenmann P Tags: Swiss Med Wkly Source Type: research

Insufficient recruitment and premature discontinuation of clinical trials in Switzerland: qualitative study with trialists and other stakeholders.
CONCLUSIONS: Recruitment of participants into clinical trials in Switzerland is challenging because of various, often interlinked factors related to the Swiss health system, available funding, investigators, and patients. Common goals and concerted efforts by involved stakeholders appear necessary to achieve improvement. PMID: 29185240 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 29, 2017 Category: General Medicine Authors: Briel M, Elger B, von Elm E, Satalkar P Tags: Swiss Med Wkly Source Type: research

Quality indicators of colorectal cancer care in southern Switzerland: results from a population-based study.
CONCLUSIONS: Our study showed the feasibility of assessing QoCC using Cancer Registry population-based data. Results according to the clinical domain of pathology, surgery, oncology and radio-oncology in southern Switzerland are generally positive and encouraging, sometimes more favourable in comparison with other international studies, except the very low proportion of patients with a diagnosis based on opportunistic screening (8.6%). Considering the lack in the literature of population-based studies, further national and international reports are urgently needed for comparative analysis as well as standardisation of QI d...
Source: Swiss Medical Weekly - November 29, 2017 Category: General Medicine Authors: Spitale A, Ortelli L, Mazzucchelli L, Bordoni A Tags: Swiss Med Wkly Source Type: research

Costs and benefits of diagnostic testing: four ways to improve patient care by purposive use of in vitro diagnostics.
HH Abstract Scientific advances and innovative targeted drugs, especially biologics, have revolutionised the treatment of many diseases. In oncology in particular, previously acute or lethal conditions have come to be considered chronic as new treatments have led to longer life expectancies and a lower rate of years lived with disability. These advances, however, come with rising costs in a resource-constrained environment. To achieve cost containment, reimbursement for in-vitro diagnostics (IVDs) is increasingly coming under pressure because they are perceived as a cost factor rather than as a tool to reduce exp...
Source: Swiss Medical Weekly - November 29, 2017 Category: General Medicine Authors: Binder C, Schmid M, Dieterle T, Schäfer HH Tags: Swiss Med Wkly Source Type: research

Risk of adverse outcome in patients referred by emergency medical services in Switzerland.
Abstract AIMS OF THE STUDY: Comparison of outcomes between different emergency medical services (EMS) is difficult and lacking in Switzerland. Therefore, knowledge about the inherent risks of EMS-referred patients is important. Targeted interventions may benefit these patients by optimising resource allocation. We therefore aimed to study outcomes in EMS-referred patients presenting to a Swiss emergency department (ED). METHODS: Prospective observational study in all patients presenting to the ED of Basel University Hospital. Mode of referral was recorded (EMS or other). Univariate and multivariate linear, Po...
Source: Swiss Medical Weekly - November 29, 2017 Category: General Medicine Authors: Bosia T, Malinovska A, Weigel K, Schmid F, Nickel CH, Bingisser R Tags: Swiss Med Wkly Source Type: research

Monobodies as possible next-generation protein therapeutics - a perspective.
Abstract Over the past two decades, hundreds of new somatic mutations have been identified in tumours, and a few dozen novel cancer therapeutics that selectively target these mutated oncoproteins have entered clinical practice. This development has resulted in clinical breakthroughs for a few tumour types, but more commonly patients' overall survival has not improved because of the development of drug resistance. Furthermore, only a very limited number of oncoproteins, largely protein kinases, are successfully targeted, whereas most non-kinase oncoproteins inside cancer cells remain untargeted. Engineered small pr...
Source: Swiss Medical Weekly - November 29, 2017 Category: General Medicine Authors: Hantschel O Tags: Swiss Med Wkly Source Type: research

HPV-negative CIN3 and cervical cancer in Switzerland: any evidence of impact on screening policies?
PMID: 29185245 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 29, 2017 Category: General Medicine Authors: Vassilakos P, Tran PL, Sahli R, Low N, Petignat P Tags: Swiss Med Wkly Source Type: research

Is there a role for procalcitonin in differentiating uncomplicated and complicated diverticulitis in order to reduce antibiotic therapy? A prospective diagnostic cohort study.
Abstract AIMS OF THE STUDY: While studies show that antibiotic treatment for uncomplicated diverticulitis seems to have no benefit, most experts advocate antimicrobial therapy for complicated diverticulitis. However, even for uncomplicated diverticulitis, most clinicians are very reluctant to withhold antibiotics. Biomarkers could help to guide antibiotic therapy as this approach has been shown to be effective for acute respiratory infections. In this diagnostic cohort study we evaluated whether procalcitonin could be a biomarker to distinguish complicated from uncomplicated cases of diverticulitis. METHODS: ...
Source: Swiss Medical Weekly - November 29, 2017 Category: General Medicine Authors: Jeger V, Pop R, Forudastan F, Barras JP, Zuber M, Piso RJ Tags: Swiss Med Wkly Source Type: research

Technical comment on: Gawinecka et al. Acute aortic dissection: pathogenesis, risk factors and diagnosis.
PMID: 29185247 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 29, 2017 Category: General Medicine Authors: Qanadli SD Tags: Swiss Med Wkly Source Type: research

Reply to technical comment on: Biskup E, et al. Oncological patients in the intensive care unit: prognosis, decision-making, therapies and end-of-life care.
PMID: 29185248 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 29, 2017 Category: General Medicine Authors: Biskup E, Cai F, Vetter M, Marsch S Tags: Swiss Med Wkly Source Type: research

Temporal trends of postpartum haemorrhage in Switzerland: a 22-year retrospective population-based cohort study.
Abstract AIM: Postpartum haemorrhage (PPH) is one of the leading causes of maternal morbidity and mortality. Studies have reported an increase in incidence of postpartum haemorrhage in recent years. Our goal was to investigate changes in the incidence of postpartum haemorrhage (PPH) and its risk factors in Switzerland from 1993 to 2014. METHODS: This population-based retrospective cohort study used data from the national Swiss Hospital in-patient database for obstetric and gynaecological hospital admissions - "Arbeitsgemeinschaft Schweizer Frauenkliniken" (ASF Statistik). All patients with deliverie...
Source: Swiss Medical Weekly - November 29, 2017 Category: General Medicine Authors: Kaelin Agten A, Passweg D, von Orelli S, Ringel N, Tschudi R, Tutschek B Tags: Swiss Med Wkly Source Type: research

Management of hepatitis C in decentralised versus centralised drug substitution programmes and minimally invasive point-of-care tests to close gaps in the HCV cascade.
CA Abstract BACKGROUND: In Switzerland, intravenous drug use accounts for the majority of hepatitis C virus (HCV) infections. Early HCV treatment prevents further transmissions and reduces morbidity and mortality due to decompensated liver cirrhosis and hepatocellular carcinoma. Nevertheless, patients in drug substitution programmes are often insufficiently screened and treated. AIM: The aim was to compare the current state of HCV management in centralised and decentralised drug substitution programmes of the canton Aargau. Objectives were human immunodeficiency virus (HIV) and HCV prevalence, compliance wit...
Source: Swiss Medical Weekly - November 29, 2017 Category: General Medicine Authors: Bregenzer A, Conen A, Knuchel J, Friedl A, Eigenmann F, Näf M, Ackle P, Roth M, Fux CA Tags: Swiss Med Wkly Source Type: research

Ultrasound indications for maternal STORCH testing in pregnancy.
CONCLUSION: Ultrasonographic findings associated with fetal infection are neither sensitive nor specific. Testing for STORCH infections should take into account exposure history, clinical signs and symptoms, obstetric history, and fetal ultrasound findings, but with special attention paid to cytomegalovirus and parvovirus B19. PMID: 29185251 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 29, 2017 Category: General Medicine Authors: Voekt CA, Rinderknecht T, Hirsch HH, Blaich A, Hösli IM Tags: Swiss Med Wkly Source Type: research

Multidrug resistant (or antimicrobial-resistant) pathogens - alternatives to new antibiotics?
Abstract For the last few decades, multidrug resistance has become an increasing concern for both Gram-positive and Gram-negative bacteria. The number of new molecules has dramatically decreased and antibiotic resistance is now a priority in the international community. Facing this new threat, a large number of new as well as "old" solutions are now being discussed in the medical community to propose an alternative to antibiotic treatments. A first option is to potentiate the effect of existing molecules through combinations to circumvent the individual molecule resistance. The second option is to neutra...
Source: Swiss Medical Weekly - November 29, 2017 Category: General Medicine Authors: Brunel AS, Guery B Tags: Swiss Med Wkly Source Type: research

Cost-effectiveness of sacubitril/valsartan in chronic heart-failure patients with reduced ejection fraction.
CONCLUSION: The treatment of HFrEF patients with sacubitril/valsartan versus enalapril is cost effective, if a willingness-to-pay threshold of CHF 50 000 per QALY gained ratio is assumed. PMID: 29185253 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 29, 2017 Category: General Medicine Authors: Ademi Z, Pfeil AM, Hancock E, Trueman D, Haroun RH, Deschaseaux C, Schwenkglenks M Tags: Swiss Med Wkly Source Type: research

Technical comment on: Biskup E, et al. Oncological patients in the intensive care unit: prognosis, decision-making, therapies and end-of-life care.
va SA PMID: 29185254 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 29, 2017 Category: General Medicine Authors: Ñamendys-Silva SA Tags: Swiss Med Wkly Source Type: research

Informal caregiving, work-privacy conflict and burnout among health professionals in Switzerland - a cross-sectional study.
CONCLUSION: Additional and large-scale studies focusing on the combination of formal and informal caregiving roles are needed to better understand its effect on burnout among healthcare professionals and to evaluate the role of work-privacy conflict. PMID: 29185255 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 29, 2017 Category: General Medicine Authors: Häusler N, Bopp M, Hämmig O Tags: Swiss Med Wkly Source Type: research

Reply to technical comment on: Gawinecka et al. Acute aortic dissection: pathogenesis, risk factors, diagnosis.
n A PMID: 29185256 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 29, 2017 Category: General Medicine Authors: Schönrath F, Gawinecka J, von Eckardstein A Tags: Swiss Med Wkly Source Type: research

Challenges in interprofessionalism in Swiss health care: the practice of successful interprofessional collaboration as experienced by professionals.
Abstract The topic of interprofessional collaboration (IPC) between healthcare professionals has been widely discussed in recent years. Whereas the growing calls for more and better IPC can scarcely be ignored and a broad range of definitions and normative concepts have been proposed, it remains unclear what IPC actually means for practising professionals. This exploratory survey investigated the various ways in which successful IPC is understood in practice. As a main finding of the study, we were able to identify three distinct modes of collaboration between different professions in health care. Moreover, we pro...
Source: Swiss Medical Weekly - November 9, 2017 Category: General Medicine Authors: Schmitz C, Atzeni G, Berchtold P Tags: Swiss Med Wkly Source Type: research

Innovative transition interventions to better align healthcare needs in hospitalised medical patients.
Abstract Understanding how best to manage the complex healthcare needs of hospitalised, mostly multimorbid medical patients is an international priority. Healthcare should be effective, safe and provide high quality at a reasonable cost. However, basic logistic and organisational issues of medical ward-based care have received less attention than the medical treatment of specific pathologies. Consequently, we still use old-fashioned care and transition procedures for medical inpatients. This contrasts with dynamic developments in other, non-healthcare industries, where process optimisation is a major part of innov...
Source: Swiss Medical Weekly - November 9, 2017 Category: General Medicine Authors: Kutz A, Ebrahimi F, Struja T, Greenwald J, Schuetz P, Mueller B Tags: Swiss Med Wkly Source Type: research

Four-year long-term follow-up of diabetes patients after implementation of the Chronic Care Model in primary care: a cross-sectional study.
Abstract AIMS: Implementing the Chronic Care Model (CCM) via involvement of specially trained practice nurses improves cardiovascular risk profiles and perception of care among type 2 diabetes patients in small primary care practices (PCPs) in the short term. Little is known about the long-term effects of this intervention. METHODS: Cross-sectional survey among the participants of the cluster randomised controlled CARAT trial (30 PCPs, 303 diabetes patients), 3 years after its completion. OUTCOMES: Proportion of patients still treated according to the CCM, possible reasons for discontinuation, glycosylat...
Source: Swiss Medical Weekly - November 9, 2017 Category: General Medicine Authors: Chmiel C, Giewer I, Frei A, Rosemann T Tags: Swiss Med Wkly Source Type: research

Hepatitis C virus dynamics among intravenous drug users suggest that an annual treatment uptake above 10% would eliminate the disease by 2030.
CONCLUSIONS: Timely treatment of hepatitis C virus among people who inject drugs is necessary to reduce the prevalence and prevent new infections in Switzerland. PMID: 29120012 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 9, 2017 Category: General Medicine Authors: Bruggmann P, Blach S, Deltenre P, Fehr J, Kouyos R, Lavanchy D, Müllhaupt B, Rauch A, Razavi H, Schmid P, Semela D, Stoeckle M, Negro F Tags: Swiss Med Wkly Source Type: research

Primary polydipsia in the medical and psychiatric patient: characteristics, complications and therapy.
Abstract Primary polydipsia (PP) has been defined as excessive intake of fluids. However, the pathogenesis of PP remains unexplored. Different theories include a dysfunction in the thirst mechanism, involvement of the hippocampus, stress-reducing behaviour and lesion occurrences in specific areas of the brain. Most studies have been performed in the psychiatric setting, indicating that PP coincides with schizophrenia, anxiety disorder and depression. However, an increasing number of case reports emphasise the incidence of PP in non-psychiatric patients. As often recommended by healthcare professions and in life-st...
Source: Swiss Medical Weekly - November 9, 2017 Category: General Medicine Authors: Sailer C, Winzeler B, Christ-Crain M Tags: Swiss Med Wkly Source Type: research

Strong, generous support for medical research emerges from a large cohort of Swiss patients.
PMID: 29120014 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 9, 2017 Category: General Medicine Authors: Aguzzi A Tags: Swiss Med Wkly Source Type: research

Ascending aortic remodelling in Fabry disease after long-term enzyme replacement therapy.
CONCLUSION: Our data suggest that the remodelling of the ascending aorta is more pronounced in male patients with Fabry disease under long-term enzyme replacement therapy compared with the progression observed in a large population study. PMID: 29120015 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 9, 2017 Category: General Medicine Authors: Monney P, Qanadli SD, Hajdu S, Tran C, Schwitter J, Dormond O, Barbey F Tags: Swiss Med Wkly Source Type: research

The subcutaneous implantable cardioverter defibrillator in daily clinical practice.
CONCLUSION: This first large Swiss experience demonstrates results consistent with available international data. The S-ICD may hence represent an attractive alternative to conventional transvenous ICDs for a variety of patients. PMID: 29120016 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 9, 2017 Category: General Medicine Authors: Özkartal T, Breitenstein A, Saguner AM, Inderbitzin DT, Wilhelm M, Benussi S, Maisano F, Lüscher TF, Ruschitzka F, Steffel J Tags: Swiss Med Wkly Source Type: research

Review of maternal immunisation during pregnancy: focus on pertussis and influenza.
This article aims to review the recommendations for maternal influenza and pertussis immunisation, and their physiological rationale, safety and benefit. PMID: 29120017 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 9, 2017 Category: General Medicine Authors: Blanchard-Rohner G, Eberhardt C Tags: Swiss Med Wkly Source Type: research

RNA metabolism in Staphylococcus aureus virulence.
Abstract The opportunistic pathogen Staphylococcus aureus encounters a variety of host defence systems depending on its localisation during colonisation in the nares, systemic infections within the body, or persistent infections within cells or embedded in biofilms. To respond rapidly to these different environments, this bacterium has evolved, in its longstanding interaction with animal and human hosts, a variety of mechanisms to fine-tune its gene expression. RNA metabolism, including transcription, processing, translation into proteins and RNA decay, is a central player in this response and might in the future ...
Source: Swiss Medical Weekly - November 9, 2017 Category: General Medicine Authors: Linder P, Armitano J Tags: Swiss Med Wkly Source Type: research

Cellular protection mechanisms that minimise accumulation of mutations in intestinal tissue.
Abstract The epithelial lining of the intestine is constantly exposed to a hostile environment containing a mixture of gastric acids, consumed harmful substances and microbes. It is widely accepted that the intestine has multiple mechanisms to protect itself against tissue damage. Here, we review three cellular protection mechanisms that protect intestinal tissue against accumulation of somatic mutations: the conveyer belt-like structure, stem cell competition and crypt fusion. We highlight the events that can perturb these cellular protection mechanisms, and their impact on accumulation of new (oncogenic) mutatio...
Source: Swiss Medical Weekly - November 9, 2017 Category: General Medicine Authors: van Rheenen J, Bruens L Tags: Swiss Med Wkly Source Type: research

Identification of a MAFB mutation in a patient with multicentric carpotarsal osteolysis.
Abstract Multicentric carpotarsal osteolysis (MCTO) is an autosomal dominant disease of the skeleton characterised by progressive destruction of carpal and tarsal bones. Recently, it has been demonstrated that this disease is caused by heterozygous mutations in the gene for the transcriptional repressor MAFB. We analysed genomic DNA and RNA from leucocytes of a female patient diagnosed with MCTO. We identified the mutation c.161C>T in the genomic sequence and in the expressed messenger RNA for MAFB. This is the second report of the c.161C>T mutation in a MCTO patient. Since the parents do not possess this mu...
Source: Swiss Medical Weekly - November 9, 2017 Category: General Medicine Authors: Zhuang L, Adler S, Aeberli D, Villiger PM, Trueb B Tags: Swiss Med Wkly Source Type: research

Swiss Adult Congenital HEart disease Registry (SACHER) - rationale, design and first results.
CONCLUSION: SACHER collects multicentre data on adults with CHD. Its structure enables prospective data analysis to assess detailed, lesion-specific outcomes with the aim to finally improve long-term outcomes. PMID: 29120021 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 9, 2017 Category: General Medicine Authors: Tobler D, Schwerzmann M, Bouchardy J, Engel R, Stambach D, Attenhofer Jost C, Wustmann K, Schwitz F, Rutz T, Gabriel H, Kuen HP, Auf der Maur C, Oxenius A, Seeliger T, Santos Lopes B, Bonassin F, Greutmann M, On Behalf Of Sacher Tags: Swiss Med Wkly Source Type: research

Does interprofessionality work in Swiss ICUs and should it be encouraged?
This article reviews several aspects of this concept, from definition and basic principles to the potential benefit for the patients and caregivers, and it discusses the difficulties in implementing interprofessional teamwork in the daily practice of an intensive care unit (ICU). Although collaborative and interprofessional teamwork seems a logical approach in the care of critically ill patients, little published evidence shows that it really improves the level of care, meaning that this may be harder to implement than to promote. Eventually, some clues to achieve a successful realisation of interprofessional collaboration...
Source: Swiss Medical Weekly - November 9, 2017 Category: General Medicine Authors: Fumeaux T, Wehrli M Tags: Swiss Med Wkly Source Type: research

Role of liver magnetic resonance imaging in hyperferritinaemia and the diagnosis of iron overload.
;e JP Abstract Hyperferritinaemia is a frequent clinical problem. Elevated serum ferritin levels can be detected in different genetic and acquired diseases and can occur with or without anaemia. It is therefore important to determine whether hyperferritinaemia is due to iron overload or due to a secondary cause. The main causes of iron overload are intestinal iron hyperabsorption disorders and transfusion-dependent disorders. Iron homeostasis and iron overload are quantified by different diagnostic approaches. The evaluation of serum ferritin and transferrin saturation is the first diagnostic step to identify the ...
Source: Swiss Medical Weekly - November 9, 2017 Category: General Medicine Authors: Ruefer A, Bapst C, Benz R, Bremerich J, Cantoni N, Infanti L, Samii K, Schmid M, Vallée JP Tags: Swiss Med Wkly Source Type: research

Swiss Medical Weekly congratulates Jaco van Rheenen, recipient of the Dr Josef Steiner Cancer Research Foundation Award for 2017.
PMID: 29120024 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 9, 2017 Category: General Medicine Authors: Hanahan D Tags: Swiss Med Wkly Source Type: research

Prevention and therapy of JC polyomavirus-mediated progressive multifocal leukoencephalopathy - a realistic possibility?
Abstract Progressive multifocal leukoencephalopathy (PML) is a serious opportunistic infection of the brain caused by the JC polyomavirus (JCPyV). PML occurs when immune control of persistent infection with JCPyV fails, the virus mutates and changes its cellular tropism, enters the brain and infects astrocytes, oligodendrocytes and, in particular cases, also neurones. Currently, there is no therapy for this often fatal disease. A number of approaches have failed, and only the restoration of protective immunity, if possible, can lead to clearance of the virus once PML has occurred. During the last two decades, inve...
Source: Swiss Medical Weekly - November 9, 2017 Category: General Medicine Authors: Jelcic I, Combaluzier B, Jelcic I, Sospedra M, Grimm J, Martin R Tags: Swiss Med Wkly Source Type: research

Risk factors for hypocalcaemia after completion hemithyroidectomy in thyroid cancer.
;ller W Abstract BACKGROUND: Hypocalcaemia (HC) is the most common complication after thyroid surgery in differentiated thyroid cancer and leads to a prolongation of the hospital stay. While risk factors for HC after total thyroidectomy (TE) are well investigated, only few studies have been published about HC risk factors after completion of thyroidectomy. Our aim was to identify potential risk factors for HC after completion of TE and to compare these incidences with figures from primary total TE. MATERIALS AND METHODS: A retrospective cohort study was undertaken including patients undergoing completion of T...
Source: Swiss Medical Weekly - November 9, 2017 Category: General Medicine Authors: Aqtashi B, Ahmad N, Frotzler A, Bähler S, Linder T, Müller W Tags: Swiss Med Wkly Source Type: research

Humanised mouse models for haematopoiesis and infectious diseases.
s A Abstract "Humanised" mouse models have emerged over past years as powerful tools for investigating human haematopoiesis and immunity. They allowed the identification of key factors for the maintenance and function of normal and leukaemic human haematopoietic stem cells. These findings have been widely used to dissect the pathogenesis of multiple myeloid and lymphoid neoplasms, such as acute myeloid leukaemia and acute lymphoblastic leukaemia. Furthermore, these models can serve as a stepping-stone to clinical trials by testing novel drugs that target leukaemic stem cells. The investigation of human i...
Source: Swiss Medical Weekly - November 9, 2017 Category: General Medicine Authors: Lysenko V, McHugh D, Behrmann L, Rochat MA, Wilk CM, Kovtonyuk L, Bourquin JP, Münz C, Manz MG, Speck R, Theocharides A Tags: Swiss Med Wkly Source Type: research

Precision medicine for monogenic diabetes: from a survey to the development of a next-generation diagnostic panel.
Abstract Monogenic diabetes (MD) accounts for 1-2% of all diabetes cases. Because of its wide phenotypic spectrum, MD is often misdiagnosed as type 1 or type 2 diabetes. While clinical and biochemical parameters can suggest MD, a definitive diagnosis requires genetic analysis. We conducted a survey among clinicians specialising in diabetes to document the cases with MD. Of 74 clinically suspected MD patients, 46% had undergone genetic analysis, which was mostly conducted using Sanger's classical sequencing method. The most common recorded mutations were located in the GCK gene, followed by the mitochondrial genome...
Source: Swiss Medical Weekly - November 9, 2017 Category: General Medicine Authors: Kherra S, Blouin JL, Santoni F, Schwitzgebel V Tags: Swiss Med Wkly Source Type: research

Safety and effectiveness of labour induction after caesarean section using balloon catheter or oxytocin.
CONCLUSIONS: Our study indicates that induction of labour with balloon catheter or oxytocin seems to be safe in women with previous CS. Labour induction using a balloon catheter in women with previous CS and unfavourable cervix has a disappointingly low success rate. We identified factors influencing vaginal delivery success rates. Women with previous CS and indications for labour induction should be informed about vaginal birth success rates and the alternative of elective repeat CS needs to be discussed. PMID: 29120029 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 9, 2017 Category: General Medicine Authors: Radan AP, Amylidi-Mohr S, Mosimann B, Simillion C, Raio L, Mueller M, Surbek D Tags: Swiss Med Wkly Source Type: research

Risk behaviours among native and immigrant youths in Switzerland: a cross-sectional study.
CONCLUSIONS: Our findings expose a lower engagement in risk behaviours among migrants. The migrant status in these two groups is clearly buffered if other control variables are considered. Thus, we can affirm that in the present study, migrants are not a high-risk population or not more at risk than the native group. Mixed origin youths showed higher risk behaviours than natives and migrants. Special attention should be given to this specific group, as they may be more vulnerable during adolescence. PMID: 29120030 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 9, 2017 Category: General Medicine Authors: Campisi L, Berchtold A, Barrense-Dias Y, Akre C, Gehri M, Suris JC Tags: Swiss Med Wkly Source Type: research

Evaluation of existing and desired antimicrobial stewardship activities and strategies in Swiss hospitals.
Abstract Antimicrobial stewardship (AMS) is an important component in the fight against antimicrobial resistance. Currently, few hospitals have an ongoing institutional AMS programme. Swissnoso - the national centre for infection prevention - has launched a national Swiss AMS initiative supported by the office of public health. To guide AMS priorities and resources, current AMS activities in Switzerland were assessed. We distributed an internet-based questionnaire directed mainly to board-certified infectious diseases specialists and, if not available, senior internal medicine staff. Responses were received from 6...
Source: Swiss Medical Weekly - October 24, 2017 Category: General Medicine Authors: Osthoff M, Belicki J, Widmer AF, For Swissnoso Tags: Swiss Med Wkly Source Type: research

On the relationship between proteinuria and plasma phosphate.
Abstract Albuminuria is strongly associated with renal and cardiovascular outcomes independently of renal function level. However, the pathophysiology of these associations is debated. In chronic kidney disease (CKD), phosphate retention participates in cardiovascular events and increased cardiovascular mortality. We hypothesised that albuminuria may modulate tubular phosphate handling by the kidney. To verify this hypothesis, we first studied the association between phosphataemia and albuminuria in children with nephrotic syndrome and in adults with CKD. In both cases, higher albuminuria was associated with highe...
Source: Swiss Medical Weekly - October 24, 2017 Category: General Medicine Authors: de Seigneux S, Wilhelm-Bals A, Courbebaisse M Tags: Swiss Med Wkly Source Type: research

Evaluation of the National Skin Cancer Campaign: a Swiss experience of Euromelanoma.
CONCLUSIONS: Our study provides an up-to-date evaluation of the Swiss Euromelanoma campaign 2016. The results are mostly in line with data from other European studies. Considering the morbidity, mortality and financial and social impact of skin cancer, the capacity to raise awareness of risk factors, skin cancer prevention methods and educating high-risk and at-risk individuals, we may assume that a National Screening Day has a crucial impact on the public health system. PMID: 29063525 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - October 24, 2017 Category: General Medicine Authors: Lieberherr S, Seyed Jafari SM, Cazzaniga S, Bianchi E, Schlagenhauff B, Tscharner G, Hafner J, Mainetti C, Lapointe AK, Hunger RE Tags: Swiss Med Wkly Source Type: research

Malaria cases in Switzerland from 2005 to 2015 and recent rise of imported Plasmodium vivax malaria.
Abstract Reporting cases of malaria to the Federal Office of Public Health has been mandatory in Switzerland since 1974. We analysed notifications of imported confirmed malaria cases between 2005 and 2015 in Switzerland or Liechtenstein. Data for previously visited countries, nationality and reason for travelling were analysed. In contrast with the impressive drop of malaria cases reported worldwide since 2000, we found that the number of malaria cases imported yearly in Switzerland doubled in 2014 and 2015 compared to the average for the preceding decade. Since 2014, Plasmodium vivax infection represented 36% of ...
Source: Swiss Medical Weekly - October 24, 2017 Category: General Medicine Authors: Eperon G, Durieux-Paillard S, Mauris A, Chappuis F, Gysin N Tags: Swiss Med Wkly Source Type: research

High participation rate among 25 721 patients with broad age range in a hospital-based research project involving whole-genome sequencing - the Lausanne Institutional Biobank.
Abstract AIMS: We aimed to evaluate the interest of adult inpatients and selected outpatients in engaging in a large, real-life, hospital-based, genomic medicine research project and in receiving clinically actionable incidental findings. METHODS: Within the framework of the cross-sectional Institutional Biobank of Lausanne, Switzerland, a total of 25721 patients of the CHUV University Hospital were systematically invited to grant researchers access to their biomedical data and to donate blood for future analyses, including whole-genome sequencing. Multivariable logistic regression analysis was used to identi...
Source: Swiss Medical Weekly - October 24, 2017 Category: General Medicine Authors: Bochud M, Currat C, Chapatte L, Roth C, Mooser V Tags: Swiss Med Wkly Source Type: research

Quality of vitamin K antagonist oral anticoagulation in 322 patients with atrial fibrillation - real-life data from a survey in Eastern Switzerland.
CONCLUSIONS: The quality of VKA anticoagulation in Switzerland is highly variable. Importantly, only 60% of patients achieve a TTR ≥65%, which is currently considered to be the minimal acceptable TTR required for VKA therapy. There are few clinical predictors of a good VKA anticoagulation quality. These data may represent a novel basis for decision making regarding the choice of anticoagulation for atrial fibrillation in Switzerland. PMID: 29039622 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - October 17, 2017 Category: General Medicine Authors: Maeder MT, König T, Bogdanovic S, Schneider I, Eugster W, Ammann P, König M, Beer J, Rickli H Tags: Swiss Med Wkly Source Type: research

The challenge of Takotsubo syndrome: heterogeneity of clinical features.
Abstract Takotsubo syndrome (TTS) was first described in 1991 as a rare, spontaneous and completely reversible left ventricular regional systolic dysfunction. Today the incidence of TTS is estimated at 2% in patients with an initial diagnosis of acute coronary syndrome (ACS). Notably, the incidence can be as high as 5.9 to 7.5% in female patients. TTS occurs predominantly in postmenopausal women, but both sexes may be affected, at any age. Acute chest pain or dyspnoea is a characteristic symptom of TTS, but initial presentation can also include more severe disease manifestation such as acute heart failure with pul...
Source: Swiss Medical Weekly - October 17, 2017 Category: General Medicine Authors: Schlossbauer SA, Ghadri JR, Scherff F, Templin C Tags: Swiss Med Wkly Source Type: research

Factors associated with cessation of smoking among Swiss adults between 1991 and 2011: results from the SAPALDIA cohort.
ndler C Abstract INTRODUCTION: Smoking is still the most preventable cause of disease and premature death in Switzerland, as elsewhere. We aimed to assess the main determinants of smoking cessation in the population-based cohort of SAPALDIA (Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults). METHODS: The SAPALDIA study was initiated in 1991 with 9651 participants aged 18 to 60 years from eight areas (S1). Follow-up assessments were conducted in 2002 (S2; 8047 participants) and 2010/11 (S3; 6088 participants). At each survey, detailed information on health and potential health-related ...
Source: Swiss Medical Weekly - October 17, 2017 Category: General Medicine Authors: Ayala-Bernal D, Probst-Hensch N, Rochat T, Bettschart R, Brändli O, Bridevaux PO, Burdet L, Frey M, Gerbase M, Pons M, Rothe T, Stolz D, Tschopp JM, Turk A, Künzli N, Schindler C Tags: Swiss Med Wkly Source Type: research

Genetic determinants of the epigenome in development and cancer.
Abstract Although we have detailed maps of epigenetic marks on DNA and chromatin for many cell types and disease states, the origin and significance of these patterns is incompletely understood. Deregulation of the epigenome is a frequent accompaniment to cancer, and it is therefore important that we learn how it contributes to tumour formation. Here it is proposed that the roles of DNA sequence signals as determinants of the epigenome have been underappreciated. Taking as a paradigm the part played by the dinucleotide CpG in regulating gene expression via its effects on the epigenome, it is suggested that factors...
Source: Swiss Medical Weekly - October 17, 2017 Category: General Medicine Authors: Bird A Tags: Swiss Med Wkly Source Type: research

An appreciation of Sir Adrian Peter Bird: winner of the Charles Rodolphe Brupbacher Prize for Cancer Research 2017.
PMID: 29039626 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - October 17, 2017 Category: General Medicine Authors: Jiricny J Tags: Swiss Med Wkly Source Type: research