Valproate in pregnancy: comment from the SAPP
Swiss Med Wkly. 2021 Feb 19;151:w20476. doi: 10.4414/smw.2021.20476. eCollection 2021 Feb 15.NO ABSTRACTPMID:33641107 | DOI:10.4414/smw.2021.20476 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 28, 2021 Category: General Medicine Authors: Ursula von Mandach Irene H ösli None Swiss Academy For Perinatal Pharmacology Sapp Source Type: research

The SilenT AtRial FIBrillation (STAR-FIB) study programme - design and rationale
CONCLUSIONS: The STAR-FIB study programme will estimate the age- and sex-specific prevalence of silent atrial fibrillation in a hospitalised patient population, and develop and validate a clinical prediction model to identify patients at risk of silent atrial fibrillation.PMID:33641108 | DOI:10.4414/smw.2021.20421 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 28, 2021 Category: General Medicine Authors: Nikolas Nozica Anna Lam Eleni Goulouti Elena Elchinova Alessandro Spirito Mattia Branca Helge Servatius Fabian Noti Jens Seiler Samuel H Baldinger Andreas Haeberlin Stefano F de Marchi Babken Asatryan Nicolas Rodondi Jacques Donz é Drahomir Aujesky Hilde Source Type: research

Medical student selection: the quest for the Grail
Swiss Med Wkly. 2021 Feb 27;151:w20467. doi: 10.4414/smw.2021.20467. eCollection 2021 Feb 15.NO ABSTRACTPMID:33641109 | DOI:10.4414/smw.2021.20467 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 28, 2021 Category: General Medicine Authors: Mathieu Nendaz Source Type: research

Harnessing unique experiences to build competence: Medical student engagement in frontline care during the COVID-19 pandemic
Swiss Med Wkly. 2021 Feb 20;151:w20480. doi: 10.4414/smw.2021.20480. eCollection 2021 Feb 15.NO ABSTRACTPMID:33641110 | DOI:10.4414/smw.2021.20480 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 28, 2021 Category: General Medicine Authors: Jennifer Margaretha Klasen Roland Bingisser Andrea Meienberg Bryce Bogie Source Type: research

Valproate in pregnancy: authors' reply
Swiss Med Wkly. 2021 Feb 19;151:w20481. doi: 10.4414/smw.2021.20481. eCollection 2021 Feb 15.NO ABSTRACTPMID:33641111 | DOI:10.4414/smw.2021.20481 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 28, 2021 Category: General Medicine Authors: Julia Spoendlin Eva Blozik Sereina Graber Marlene Rauch Carole Marxer Stephan Ruegg Christoph Meier Ursula Winterfeld Alice Panchaud Source Type: research

Valproate in pregnancy: comment from the SAPP
Swiss Med Wkly. 2021 Feb 19;151:w20476. doi: 10.4414/smw.2021.20476. eCollection 2021 Feb 15.NO ABSTRACTPMID:33641107 | DOI:10.4414/smw.2021.20476 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 28, 2021 Category: General Medicine Authors: Ursula von Mandach Irene H ösli None Swiss Academy For Perinatal Pharmacology Sapp Source Type: research

The SilenT AtRial FIBrillation (STAR-FIB) study programme - design and rationale
CONCLUSIONS: The STAR-FIB study programme will estimate the age- and sex-specific prevalence of silent atrial fibrillation in a hospitalised patient population, and develop and validate a clinical prediction model to identify patients at risk of silent atrial fibrillation.PMID:33641108 | DOI:10.4414/smw.2021.20421 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 28, 2021 Category: General Medicine Authors: Nikolas Nozica Anna Lam Eleni Goulouti Elena Elchinova Alessandro Spirito Mattia Branca Helge Servatius Fabian Noti Jens Seiler Samuel H Baldinger Andreas Haeberlin Stefano F de Marchi Babken Asatryan Nicolas Rodondi Jacques Donz é Drahomir Aujesky Hilde Source Type: research

Medical student selection: the quest for the Grail
Swiss Med Wkly. 2021 Feb 27;151:w20467. doi: 10.4414/smw.2021.20467. eCollection 2021 Feb 15.NO ABSTRACTPMID:33641109 | DOI:10.4414/smw.2021.20467 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 28, 2021 Category: General Medicine Authors: Mathieu Nendaz Source Type: research

Harnessing unique experiences to build competence: Medical student engagement in frontline care during the COVID-19 pandemic
Swiss Med Wkly. 2021 Feb 20;151:w20480. doi: 10.4414/smw.2021.20480. eCollection 2021 Feb 15.NO ABSTRACTPMID:33641110 | DOI:10.4414/smw.2021.20480 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 28, 2021 Category: General Medicine Authors: Jennifer Margaretha Klasen Roland Bingisser Andrea Meienberg Bryce Bogie Source Type: research

Valproate in pregnancy: authors' reply
Swiss Med Wkly. 2021 Feb 19;151:w20481. doi: 10.4414/smw.2021.20481. eCollection 2021 Feb 15.NO ABSTRACTPMID:33641111 | DOI:10.4414/smw.2021.20481 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 28, 2021 Category: General Medicine Authors: Julia Spoendlin Eva Blozik Sereina Graber Marlene Rauch Carole Marxer Stephan Ruegg Christoph Meier Ursula Winterfeld Alice Panchaud Source Type: research

Cohort profile: SARS-CoV-2/COVID-19 hospitalised patients in Switzerland
CONCLUSION: The surveillance system has been successfully initiated and provides a robust set of data for Switzerland by including about 80% (compared with official statistics) of SARS-CoV-2/COVID-19 hospitalised patients, with similar age and comorbidity distributions. It adds detailed information on the epidemiology, risk factors and clinical course of these cases and, therefore, is a valuable addition to the existing mandatory reporting.PMID:33638351 | DOI:10.4414/smw.2021.20475 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 27, 2021 Category: General Medicine Authors: Amaury Thiabaud Anne Iten Carlo Balmelli Laurence Senn Nicolas Troillet Andreas Widmer Domenica Flury Peter W Schreiber Miriam V ázquez Lauro Damonti Michael Buettcher Danielle Vuichard-Gysin Christoph Kuhm Alexia Cusini Thomas Riedel Yvonne Nussbaumer-O Source Type: research

Use of psychotropic substances among elite athletes - a narrative review
CONCLUSION: Knowledge on the underlying causes and patterns of substance use, as well as the prevalence of substance use disorders in professional sports, is still limited. High prevalence of various substances (i.e., nicotine, prescription opioids) may indicate potentially harmful patterns of use, requiring further research. Specific preventive and therapeutic concepts for the treatment of substance use disorders in elite athletes should be developed.PMID:33638352 | DOI:10.4414/smw.2021.20412 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 27, 2021 Category: General Medicine Authors: Jan Exner Raoul Bitar Xaver Berg Eva-Maria Pichler Marcus Herdener Erich Seifritz Malte Christian Claussen Source Type: research

Adherence to, and patient convenience of, prolonged-release tacrolimus in stable kidney and liver transplant recipients after conversion from immediate-release tacrolimus in routine clinical practice in Switzerland
CONCLUSION: Overall, 1-year non-adherence rates were similar following conversion from immediate-release to prolonged-release tacrolimus; however, prolonged-release tacrolimus intake was more convenient. No new safety signals were detected.PMID:33638353 | DOI:10.4414/smw.2021.20453 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 27, 2021 Category: General Medicine Authors: Marco Bonani Alexandre Balaphas Giulia Bedino L éo Bühler Philipp Dutkowski Kathrin Fausch Silvia Gluderer Nicole Graf Patricia Hirt-Minkowski Beat M üllhaupt Carlo Sch önholzer Martin Mp Schulz Reto Venzin Rudolf P W üthrich Source Type: research

Outcome of open inguinal hernia repair using sutureless self-gripping mesh - a retrospective single cohort study
CONCLUSIONS: This study shows that open inguinal hernia repair using a self-gripping mesh is feasible, with a short operation time and low hernia recurrence rates in a peripheral teaching hospital. However, significant differences in neurological disturbances dependent on the surgeons experience were identified. Especially younger patients should be operated on by an experienced surgeon to reduce neurological disturbances and neuralgia.PMID:33638354 | DOI:10.4414/smw.2021.20455 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 27, 2021 Category: General Medicine Authors: Flurin Schnyder Daniela Cabalzar-Wondberg Dimitri Aristotle Raptis Lukas Eisner Markus Zuber Benjamin Weixler Source Type: research

Cohort profile: SARS-CoV-2/COVID-19 hospitalised patients in Switzerland
CONCLUSION: The surveillance system has been successfully initiated and provides a robust set of data for Switzerland by including about 80% (compared with official statistics) of SARS-CoV-2/COVID-19 hospitalised patients, with similar age and comorbidity distributions. It adds detailed information on the epidemiology, risk factors and clinical course of these cases and, therefore, is a valuable addition to the existing mandatory reporting.PMID:33638351 | DOI:10.4414/smw.2021.20475 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 27, 2021 Category: General Medicine Authors: Amaury Thiabaud Anne Iten Carlo Balmelli Laurence Senn Nicolas Troillet Andreas Widmer Domenica Flury Peter W Schreiber Miriam V ázquez Lauro Damonti Michael Buettcher Danielle Vuichard-Gysin Christoph Kuhm Alexia Cusini Thomas Riedel Yvonne Nussbaumer-O Source Type: research

Use of psychotropic substances among elite athletes - a narrative review
CONCLUSION: Knowledge on the underlying causes and patterns of substance use, as well as the prevalence of substance use disorders in professional sports, is still limited. High prevalence of various substances (i.e., nicotine, prescription opioids) may indicate potentially harmful patterns of use, requiring further research. Specific preventive and therapeutic concepts for the treatment of substance use disorders in elite athletes should be developed.PMID:33638352 | DOI:10.4414/smw.2021.20412 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 27, 2021 Category: General Medicine Authors: Jan Exner Raoul Bitar Xaver Berg Eva-Maria Pichler Marcus Herdener Erich Seifritz Malte Christian Claussen Source Type: research

Adherence to, and patient convenience of, prolonged-release tacrolimus in stable kidney and liver transplant recipients after conversion from immediate-release tacrolimus in routine clinical practice in Switzerland
CONCLUSION: Overall, 1-year non-adherence rates were similar following conversion from immediate-release to prolonged-release tacrolimus; however, prolonged-release tacrolimus intake was more convenient. No new safety signals were detected.PMID:33638353 | DOI:10.4414/smw.2021.20453 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 27, 2021 Category: General Medicine Authors: Marco Bonani Alexandre Balaphas Giulia Bedino L éo Bühler Philipp Dutkowski Kathrin Fausch Silvia Gluderer Nicole Graf Patricia Hirt-Minkowski Beat M üllhaupt Carlo Sch önholzer Martin Mp Schulz Reto Venzin Rudolf P W üthrich Source Type: research

Outcome of open inguinal hernia repair using sutureless self-gripping mesh - a retrospective single cohort study
CONCLUSIONS: This study shows that open inguinal hernia repair using a self-gripping mesh is feasible, with a short operation time and low hernia recurrence rates in a peripheral teaching hospital. However, significant differences in neurological disturbances dependent on the surgeons experience were identified. Especially younger patients should be operated on by an experienced surgeon to reduce neurological disturbances and neuralgia.PMID:33638354 | DOI:10.4414/smw.2021.20455 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 27, 2021 Category: General Medicine Authors: Flurin Schnyder Daniela Cabalzar-Wondberg Dimitri Aristotle Raptis Lukas Eisner Markus Zuber Benjamin Weixler Source Type: research

Iatrogenic events contributing to paediatric intensive care unit admission
CONCLUSION: In our setting, the number of PICU admissions associated with iatrogenic events is significant and comparable to adult data on admission to ICU caused by iatrogenic events. The categories with most potential for improvement are nosocomial infections and the wrong management decisions / delayed diagnoses. Focused measures on these iatrogenic events may have a major impact on patient outcome, availability of PICU resources and healthcare costs.PMID:33635535 | DOI:10.4414/smw.2021.20414 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 26, 2021 Category: General Medicine Authors: Romana Salvini Bernhard Frey Source Type: research

Enhanced-view totally extraperitoneal approach in emergency ventral incision hernia repair: a case report
We report the case of a 57 years old white male, with history of multiple abdominal interventions by laparotomy, admitted in the emergency department with vomiting and periumbilical pain progressing since 3 days. On clinical examination, we find a strangulated incisional para-umbilical hernia with local cellulitis and tenderness in the right flank. Abdominal CT scan confirm the diagnostic and some signs of thickening of intestinal wall and multiples ventral hernias. The patient was admitted and operated the same day by the eTEP technique without necessity of intestinal resection. The patient was discharged at postoperative...
Source: Swiss Medical Weekly - February 26, 2021 Category: General Medicine Authors: Sameer Nazeeruddin Fabio Butti Gilles Herren Source Type: research

Iatrogenic events contributing to paediatric intensive care unit admission
CONCLUSION: In our setting, the number of PICU admissions associated with iatrogenic events is significant and comparable to adult data on admission to ICU caused by iatrogenic events. The categories with most potential for improvement are nosocomial infections and the wrong management decisions / delayed diagnoses. Focused measures on these iatrogenic events may have a major impact on patient outcome, availability of PICU resources and healthcare costs.PMID:33635535 | DOI:10.4414/smw.2021.20414 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 26, 2021 Category: General Medicine Authors: Romana Salvini Bernhard Frey Source Type: research

Enhanced-view totally extraperitoneal approach in emergency ventral incision hernia repair: a case report
We report the case of a 57 years old white male, with history of multiple abdominal interventions by laparotomy, admitted in the emergency department with vomiting and periumbilical pain progressing since 3 days. On clinical examination, we find a strangulated incisional para-umbilical hernia with local cellulitis and tenderness in the right flank. Abdominal CT scan confirm the diagnostic and some signs of thickening of intestinal wall and multiples ventral hernias. The patient was admitted and operated the same day by the eTEP technique without necessity of intestinal resection. The patient was discharged at postoperative...
Source: Swiss Medical Weekly - February 26, 2021 Category: General Medicine Authors: Sameer Nazeeruddin Fabio Butti Gilles Herren Source Type: research

Multimodal treatment strategies for colorectal liver metastases
Swiss Med Wkly. 2021 Feb 15;151:w20390. doi: 10.4414/smw.2021.20390. eCollection 2021 Feb 15.ABSTRACTColorectal cancer is the third most common cancer worldwide. Half of CRC patients develop liver metastases during the course of the disease, with a 5-year survival rate close to zero in the absence of therapy. Surgical resection remains the only possible curative option, and current guidelines recommend adjuvant chemotherapy, resulting in a 5-year survival rate exceeding 50%. Neoadjuvant systemic therapy is not indicated in cases with simple resection but should be offered to all patients with extensive bilobar disease. Per...
Source: Swiss Medical Weekly - February 25, 2021 Category: General Medicine Authors: Dominique L Birrer Christoph Tschuor Caecilia Reiner Ralph Fritsch Thomas Pfammatter Helena Garcia Sch üler Matea Pavic Michelle De Oliveira Henrik Petrowsky Philipp Dutkowski Christian Oberkofler Pierre-Alain Clavien Source Type: research

COVID-19 Inmate Risk Appraisal (CIRA): development and validation of a screening tool to assess COVID-19 vulnerability in prisons
CONCLUSIONS: The CIRA scores have a high discriminative ability and will be important in custodial settings to support decisions and prioritise actions using a standardised valid assessment method. However, as knowledge on risk factors for COVID-19 mortality is still limited, the CIRA may be considered preliminary. Underlying data will be updated regularly on the website (http://www.prison-research.com), where the CIRA algorithm is freely available.PMID:33580705 | DOI:10.4414/smw.2021.20471 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 13, 2021 Category: General Medicine Authors: Leonel Cunha Gon çalves St éphanie Baggio Michael Weber Laurent G étaz Hans Wolff Jay Singh Andreas Naegeli Astrid Rossegger J érôme Endrass Source Type: research

Impact of cardiopulmonary resuscitation on organ donation in Switzerland
CONCLUSION: Our study reveals that a substantial proprotion of deceased organ donors in Switzerland underwent CPR in context of their hospitalisation. CPR donors are different from non-CPR donors with respect to age, cause of death and donation type. However, when carefully selected according to their haemodynamic condition, CPR donors are comparable to non-CPR donors in terms of donor and organ utilisation, as well as the average organ yield. Thus, all patients who are resuscitated from cardiac arrest but who subsequently progress to death should be evaluated for organ donation. How CPR donors compare with non-CPR donors ...
Source: Swiss Medical Weekly - February 13, 2021 Category: General Medicine Authors: Mirjam Gottschalk Andreas Elmer Christian Benden Franziska Beyeler Franz Immer Source Type: research

Beware the inhaled steroids or corticophobia?
Swiss Med Wkly. 2021 Feb 6;151:w20450. doi: 10.4414/smw.2021.20450. eCollection 2021 Feb 1.ABSTRACTInhaled corticosteroids have been the cornerstone of atopic, allergic asthma management for more than half a century. They have side effects (as does every medication), but they have transformed the control of asthma and saved many lives since their introduction. The current review revisits local and systemic side effects of inhaled corticosteroids and explores the prevalence and nature of parental fears (“corticophobia”) in different parts of the world. The empathetic physician treating asthma should bear...
Source: Swiss Medical Weekly - February 13, 2021 Category: General Medicine Authors: Dimos K Gidaris Stella Stabouli Andrew Bush Source Type: research

COVID-19 Inmate Risk Appraisal (CIRA): development and validation of a screening tool to assess COVID-19 vulnerability in prisons
CONCLUSIONS: The CIRA scores have a high discriminative ability and will be important in custodial settings to support decisions and prioritise actions using a standardised valid assessment method. However, as knowledge on risk factors for COVID-19 mortality is still limited, the CIRA may be considered preliminary. Underlying data will be updated regularly on the website (http://www.prison-research.com), where the CIRA algorithm is freely available.PMID:33580705 | DOI:10.4414/smw.2021.20471 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 13, 2021 Category: General Medicine Authors: Leonel Cunha Gon çalves St éphanie Baggio Michael Weber Laurent G étaz Hans Wolff Jay Singh Andreas Naegeli Astrid Rossegger J érôme Endrass Source Type: research

Impact of cardiopulmonary resuscitation on organ donation in Switzerland
CONCLUSION: Our study reveals that a substantial proprotion of deceased organ donors in Switzerland underwent CPR in context of their hospitalisation. CPR donors are different from non-CPR donors with respect to age, cause of death and donation type. However, when carefully selected according to their haemodynamic condition, CPR donors are comparable to non-CPR donors in terms of donor and organ utilisation, as well as the average organ yield. Thus, all patients who are resuscitated from cardiac arrest but who subsequently progress to death should be evaluated for organ donation. How CPR donors compare with non-CPR donors ...
Source: Swiss Medical Weekly - February 13, 2021 Category: General Medicine Authors: Mirjam Gottschalk Andreas Elmer Christian Benden Franziska Beyeler Franz Immer Source Type: research

Beware the inhaled steroids or corticophobia?
Swiss Med Wkly. 2021 Feb 6;151:w20450. doi: 10.4414/smw.2021.20450. eCollection 2021 Feb 1.ABSTRACTInhaled corticosteroids have been the cornerstone of atopic, allergic asthma management for more than half a century. They have side effects (as does every medication), but they have transformed the control of asthma and saved many lives since their introduction. The current review revisits local and systemic side effects of inhaled corticosteroids and explores the prevalence and nature of parental fears (“corticophobia”) in different parts of the world. The empathetic physician treating asthma should bear...
Source: Swiss Medical Weekly - February 13, 2021 Category: General Medicine Authors: Dimos K Gidaris Stella Stabouli Andrew Bush Source Type: research

COVID-19 Inmate Risk Appraisal (CIRA): development and validation of a screening tool to assess COVID-19 vulnerability in prisons
CONCLUSIONS: The CIRA scores have a high discriminative ability and will be important in custodial settings to support decisions and prioritise actions using a standardised valid assessment method. However, as knowledge on risk factors for COVID-19 mortality is still limited, the CIRA may be considered preliminary. Underlying data will be updated regularly on the website (http://www.prison-research.com), where the CIRA algorithm is freely available.PMID:33580705 | DOI:10.4414/smw.2021.20471 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 13, 2021 Category: General Medicine Authors: Leonel Cunha Gon çalves St éphanie Baggio Michael Weber Laurent G étaz Hans Wolff Jay Singh Andreas Naegeli Astrid Rossegger J érôme Endrass Source Type: research

Impact of cardiopulmonary resuscitation on organ donation in Switzerland
CONCLUSION: Our study reveals that a substantial proprotion of deceased organ donors in Switzerland underwent CPR in context of their hospitalisation. CPR donors are different from non-CPR donors with respect to age, cause of death and donation type. However, when carefully selected according to their haemodynamic condition, CPR donors are comparable to non-CPR donors in terms of donor and organ utilisation, as well as the average organ yield. Thus, all patients who are resuscitated from cardiac arrest but who subsequently progress to death should be evaluated for organ donation. How CPR donors compare with non-CPR donors ...
Source: Swiss Medical Weekly - February 13, 2021 Category: General Medicine Authors: Mirjam Gottschalk Andreas Elmer Christian Benden Franziska Beyeler Franz Immer Source Type: research

Beware the inhaled steroids or corticophobia?
Swiss Med Wkly. 2021 Feb 6;151:w20450. doi: 10.4414/smw.2021.20450. eCollection 2021 Feb 1.ABSTRACTInhaled corticosteroids have been the cornerstone of atopic, allergic asthma management for more than half a century. They have side effects (as does every medication), but they have transformed the control of asthma and saved many lives since their introduction. The current review revisits local and systemic side effects of inhaled corticosteroids and explores the prevalence and nature of parental fears (“corticophobia”) in different parts of the world. The empathetic physician treating asthma should bear...
Source: Swiss Medical Weekly - February 13, 2021 Category: General Medicine Authors: Dimos K Gidaris Stella Stabouli Andrew Bush Source Type: research

Lymphovascular invasion is an independent prognostic factor for survival in pathologically proven N2 non-small cell lung cancer
CONCLUSION: Lymphovascular invasion was identified as the only independent prognostic factor for 5-year overall survival and recurrence-free survival in our pathologically proven N2 NSCLC cohort when controlled for adjuvant therapy. This study extends the current evidence of an adverse prognostic effect of lymphovascular invasion on a stage III population, confirms the adverse prognostic effect of lymphovascular invasion detected by immunohistochemistry, and thereby reveals another subgroup within the pN2 population with worse prognosis regarding 5-year overall survival and recurrence-free survival. &nbsp.PMID:33577703...
Source: Swiss Medical Weekly - February 12, 2021 Category: General Medicine Authors: Laura Chiara Guglielmetti Didier Schneiter Sven Hillinger Isabelle Opitz Claudio Caviezel Walter Weder Ilhan Inci Source Type: research

Gestational trophoblastic disease in Switzerland: retrospective study of the impact of a regional reference centre
CONCLUSIONS: This study reflects the activity of the Swiss trophoblastic disease centre from the French-speaking part of Switzerland created in 2009, and its role as local and national reference centre, in terms of global health, for women with gestational trophoblastic disease.PMID:33578430 | DOI:10.4414/smw.2021.20406 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 12, 2021 Category: General Medicine Authors: Aurore Fehlmann Khadidja Benkortbi Ginette Rosseel Ulrike Meyer-Hamme Jean-Christophe Tille Fr édérique Sloan-Bena Ariane Paoloni-Giacobino Anne-Laure Rougemont Alexandre Bodmer Diomidis Botsikas Patrice Mathevet Patrick Petignat Manuela Undurraga Malin Source Type: research

Association of in-hospital multimorbidity with healthcare outcomes in Swiss medical inpatients
CONCLUSIONS: Multimorbidity is highly prevalent in medical inpatients and has a relevant association with poor healthcare outcomes. Further investigation is needed to specify risk factors as well as to optimise the management of multimorbid patients to improve outcomes.PMID:33578431 | DOI:10.4414/smw.2021.20405 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 12, 2021 Category: General Medicine Authors: Magdalena M üller Monika Huembein Ciril Baechli Ulrich Wagner Philipp Schuetz Beat Mueller Alexander Kutz Source Type: research

Swiss family physicians and home visits: a 10-year retrospective analysis and typology based on billing data
CONCLUSIONS: Family physician home visits are mainly routine visits without additional investigation. Thus, we wonder if a part of this activity could be delegated to other healthcare professionals.PMID:33578432 | DOI:10.4414/smw.2021.20396 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 12, 2021 Category: General Medicine Authors: Joachim Lutula Patrick Taff é Stephane David Nicolas Senn Yolanda Mueller Source Type: research

Lymphovascular invasion is an independent prognostic factor for survival in pathologically proven N2 non-small cell lung cancer.
CONCLUSION: Lymphovascular invasion was identified as the only independent prognostic factor for 5-year overall survival and recurrence-free survival in our pathologically proven N2 NSCLC cohort when controlled for adjuvant therapy. This study extends the current evidence of an adverse prognostic effect of lymphovascular invasion on a stage III population, confirms the adverse prognostic effect of lymphovascular invasion detected by immunohistochemistry, and thereby reveals another subgroup within the pN2 population with worse prognosis regarding 5-year overall survival and recurrence-free survival. &nbsp. PMID: 3...
Source: Swiss Medical Weekly - February 1, 2021 Category: General Medicine Authors: Guglielmetti LC, Schneiter D, Hillinger S, Opitz I, Caviezel C, Weder W, Inci I Tags: Swiss Med Wkly Source Type: research

Gestational trophoblastic disease in Switzerland: retrospective study of the impact of a regional reference centre.
CONCLUSIONS: This study reflects the activity of the Swiss trophoblastic disease centre from the French-speaking part of Switzerland created in 2009, and its role as local and national reference centre, in terms of global health, for women with gestational trophoblastic disease. PMID: 33578430 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 1, 2021 Category: General Medicine Authors: Fehlmann A, Benkortbi K, Rosseel G, Meyer-Hamme U, Tille JC, Sloan-Bena F, Paoloni-Giacobino A, Rougemont AL, Bodmer A, Botsikas D, Mathevet P, Petignat P, Undurraga Malinverno M Tags: Swiss Med Wkly Source Type: research

Association of in-hospital multimorbidity with healthcare outcomes in Swiss medical inpatients.
CONCLUSIONS: Multimorbidity is highly prevalent in medical inpatients and has a relevant association with poor healthcare outcomes. Further investigation is needed to specify risk factors as well as to optimise the management of multimorbid patients to improve outcomes. PMID: 33578431 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 1, 2021 Category: General Medicine Authors: Müller M, Huembein M, Baechli C, Wagner U, Schuetz P, Mueller B, Kutz A Tags: Swiss Med Wkly Source Type: research

Swiss family physicians and home visits: a 10-year retrospective analysis and typology based on billing data.
CONCLUSIONS: Family physician home visits are mainly routine visits without additional investigation. Thus, we wonder if a part of this activity could be delegated to other healthcare professionals. PMID: 33578432 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 1, 2021 Category: General Medicine Authors: Lutula J, Taffé P, David S, Senn N, Mueller Y Tags: Swiss Med Wkly Source Type: research

Retrospective analysis of adverse drug reactions leading to short-term emergency hospital readmission.
CONCLUSION: ADR-related readmissions constituted a considerable part of short-term emergency readmissions. Despite being a relevant cause for rehospitalisation, only a minority of the ADRs were reported to the regulatory authorities. Strategies to prevent ADR-related readmissions and to improve reporting rates are needed. PMID: 33516159 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - January 18, 2021 Category: General Medicine Authors: Banholzer S, Dunkelmann L, Haschke M, Derungs A, Exadaktylos A, Krähenbühl S, Liakoni E Tags: Swiss Med Wkly Source Type: research

Laparoscopic liver resection: a single-centre experience.
CONCLUSION: This study showed that in our centre laparoscopic liver surgery is a safe and effective treatment option for both benign and malignant liver lesions. PMID: 33516160 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - January 18, 2021 Category: General Medicine Authors: Ghielmetti M, Ramser M, Oertli D Tags: Swiss Med Wkly Source Type: research

Real-world effectiveness and safety of glecaprevir/pibrentasvir therapy in patients with chronic hepatitis C virus infection in Switzerland.
CONCLUSION: These real-world effectiveness and safety data of GLE/PIB in patients from Switzerland were consistent with those seen in the multinational registration trials. (Trial registration number: Clinicaltrials.gov: NCT03303599.). PMID: 33516161 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - January 18, 2021 Category: General Medicine Authors: Müllhaupt B, Semela D, Ruckstuhl L, Magenta L, Clerc O, Torgler R, Negro F, Semmo N Tags: Swiss Med Wkly Source Type: research

Distribution of low quality filtering facepiece respirators during the COVID-19 pandemic: an independent analysis of the situation in Switzerland.
CONCLUSION: The demand for FFP respirators exceeded the supply capacity from established suppliers of the Swiss market. New production and import channels emerged, as did the number of poor-quality FFP respirators. FFP respirators remaining in stocks should be checked for conformity before being used, or eliminated and replaced if quality does not meet standards. PMID: 33516162 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - January 18, 2021 Category: General Medicine Authors: Delaloye JR, Vernez D, Suarez G, de Courten D, Zingg W, Perret V, Metzger CMJA, Richner G Tags: Swiss Med Wkly Source Type: research

Autophagy and coronavirus infection - a Trojan horse or Achilles heel?
PMID: 33516163 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - January 18, 2021 Category: General Medicine Authors: Seiler K, Tschan MPP Tags: Swiss Med Wkly Source Type: research

Risk factors for peritonsillar abscess in streptococcus A-negative tonsillitis: a case control study.
CONCLUSION: The Centor criteria, as well as C-reactive protein and white blood cell count, have a low discriminatory performance, and the FeverPAIN score is not useful in identifying patients at risk for peritonsillar abscess in group A haemolytic streptococcus-negative tonsillitis. To guide a rational antibiotic prescription, new decision tools need to be developed. These might include items such as difficulty swallowing, dyspnoea, tonsillar swelling and unilaterality. PMID: 33516164 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - January 18, 2021 Category: General Medicine Authors: Helfenberger L, Fischer R, Giezendanner S, Zeller A Tags: Swiss Med Wkly Source Type: research

Research projects in human genetics in Switzerland: analysis of research protocols submitted to cantonal ethics committees in 2018.
CONCLUSIONS: This study overviewed the key dimensions of regulatory and ethical assessments pertaining to genetic investigations that are performed on human beings as part of research projects in Switzerland. The data’s potential impact to shape the Federal Act on Human Genetic Testing and the Human Research Act in the future is also discussed. A direct transfer of standards for quality, consultation and communication of genetic testing within clinical genetic routines to genetic testing of human beings in the research context is neither required nor appropriate. It would bear a high risk of excluding patients an...
Source: Swiss Medical Weekly - January 18, 2021 Category: General Medicine Authors: Driessen S, Gervasoni P Tags: Swiss Med Wkly Source Type: research

Haemophagocytic lymphohistiocytosis and liver failure-induced massive hyperferritinaemia in a male COVID-19 patient.
Abstract The authors present the case of a 58-year-old man with the unique combination of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and, later on, haemophagocytic lymphohistiocytosis admitted to the intensive care unit. During his ICU stay the patient developed a variety of complications including acute respiratory distress syndrome, pulmonary embolism, right heart failure and suspected HLH leading to multiorgan failure and death. Despite the proven diagnosis of haemophagocytic lymphohistiocytosis, the excessively high ferritin levels of the patient did not seem fully explained by this...
Source: Swiss Medical Weekly - January 18, 2021 Category: General Medicine Authors: Zellweger NM, Huber J, Tsakiris DA, Tzankov A, Gebhard CE, Siegemund M Tags: Swiss Med Wkly Source Type: research

Reply to comment on: Haubitz et al. Outcome of Clostridioides difficile infections treated in a Swiss tertiary care hospital: an observational study.
PMID: 33508138 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - January 1, 2021 Category: General Medicine Authors: Haubitz S, Fux CA Tags: Swiss Med Wkly Source Type: research

Comment on: Haubitz et al. Outcome of Clostridioides difficile infections treated in a Swiss tertiary care hospital: an observational study.
PMID: 33508139 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - January 1, 2021 Category: General Medicine Authors: Zha M, Ren X, Lu J, Luo J Tags: Swiss Med Wkly Source Type: research