Design and evaluation of a multi-epitope assembly peptide vaccine against Acinetobacter baumannii infection in mice.
CONCLUSIONS: This is the first report of the design and study of a rMEP vaccine against A. baumannii. The results indicate that the rMEP is a promising vaccine candidate for the control of infections caused by A. baumannii. PMID: 31203576 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - June 3, 2019 Category: General Medicine Authors: Ren S, Guan L, Dong Y, Wang C, Feng L, Xie Y Tags: Swiss Med Wkly Source Type: research

Swiss paediatrician survey on complementary medicine.
CONCLUSIONS: In a representative sample of paediatricians in Switzerland, their personal attitude towards CM is positive, emphasised by great interest in CM training, a willingness to contribute to CM research and a high rate of paediatricians who use CM for themselves and their families. In contrast, the percentage of paediatricians offering CM is currently rather low despite strong demand for CM for children. This study provides key pointers for the future development of complementary and integrative medicine for children in Switzerland. PMID: 31203577 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - June 3, 2019 Category: General Medicine Authors: Huber BM, von Schoen-Angerer T, Hasselmann O, Wildhaber J, Wolf U Tags: Swiss Med Wkly Source Type: research

Measles in Switzerland - progress made, but communication challenges lie ahead.
PMID: 31185126 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - June 3, 2019 Category: General Medicine Authors: Tarr PE, Deml MJ, Huber BM Tags: Swiss Med Wkly Source Type: research

Measles outbreaks: plea for a regular check of the vaccination booklet.
PMID: 31185127 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - June 3, 2019 Category: General Medicine Authors: Koch D Tags: Swiss Med Wkly Source Type: research

Approaching measles elimination in Switzerland: changing epidemiology 2007-2018.
t N Abstract Switzerland is aiming to eliminate measles, in line with the objectives of the World Health Organization (WHO). Physicians, laboratories and public health authorities have made great efforts to reach this goal. A continually increasing measles vaccination coverage and other preventive measures have made an impact: no major measles outbreak has been recorded since 2011. In order to evaluate progress towards elimination, measles epidemiology of a previous epidemic period (2007–2011) was compared with the current post-epidemic period (2012–July 2018) by analysis of data from the manda...
Source: Swiss Medical Weekly - June 3, 2019 Category: General Medicine Authors: Richard JL, Mäusezahl M, Basler S, Eckert N Tags: Swiss Med Wkly Source Type: research

Safety and efficacy of outpatient endovenous laser ablation in patients 75 years and older: a propensity score-matched analysis.
CONCLUSION: EVLA performed as an outpatient procedure seems to be effective and safe in the elderly population as compared to the younger age group. PMID: 31154658 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - May 20, 2019 Category: General Medicine Authors: Keo HH, Spinedi L, Staub D, Diehm N, Holtz D, Broz P, Uthoff H Tags: Swiss Med Wkly Source Type: research

Use of day and night urinary iodine excretion to estimate the prevalence of inadequate iodine intakes via the estimated average requirement cut-point method.
The objectives were to determine urinary iodine concentration (UIC) in day and night samples collected over a 24-hour period and evaluate the usual dietary iodine intake distribution from this collection. We propose a method by which the prevalence of inadequacy can be calculated from a single 24-hour collection, reducing the burden on participants and the study costs. The samples from 1128 participants were collected between 2009 and 2013 within the framework of the Swiss Kidney Project on Genes observational cohort study; 1024 samples were suitable for statistical evaluation of iodine analysis. Participants were over 18,...
Source: Swiss Medical Weekly - May 20, 2019 Category: General Medicine Authors: Stalder E, Haldimann M, Blanc A, Dudler V, Ponte B, Pruijm M, Ackermann D, Bochud M Tags: Swiss Med Wkly Source Type: research

Designing artificial senses: steps from physiology to clinical implementation.
and N Abstract Our senses are the main information channels through which we perceive and interact with the world. Consequently, the physical and social functioning of patients suffering from severe sensory disabilities is limited on several levels. This has motivated the development of a novel therapeutic alternative: “artificial senses”, more commonly known as sensory neuroprostheses. In order to restore lost function, sensory neuroprostheses attempt to take advantage of the information transfer pathway common to all senses: (i) transduction of the physical stimulus by sensory receptors, (ii)...
Source: Swiss Medical Weekly - May 20, 2019 Category: General Medicine Authors: Pérez Fornos A, Van de Berg R, Sommerhalder J, Guinand N Tags: Swiss Med Wkly Source Type: research

Neurodevelopmental outcome at early school age in a Swiss national cohort of very preterm children.
CONCLUSION: This is the first study to report neurodevelopmental outcomes at early school age in a Swiss cohort. The majority had favourable outcomes, but 21% of children demonstrated cognitive impairment, which was most pronounced in short-term memory. Our findings were similar to those of international cohorts and indicate that preterm children born before 300/7 gestational weeks, especially those living in unfavourable social environments, are at an increased risk of cognitive impairment and need close monitoring beyond early school age. Trial registration no: KEK-ZH-Nr.2014-0552 &nbsp. PMID: 31154661 [PubMed -...
Source: Swiss Medical Weekly - May 20, 2019 Category: General Medicine Authors: Pittet-Metrailler MP, Mürner-Lavanchy I, Adams M, Graz MB, Pfister RE, Natalucci G, Grunt S, Tolsa CB, Swiss National Network And Follow-Up Group Tags: Swiss Med Wkly Source Type: research

Extracellular matrix: a new player in memory maintenance and psychiatric disorders.
Abstract How the brain performs higher cognitive functions such as learning and memory is traditionally studied by investigating how neurons work. However, over the past two decades, evidence has accumulated which suggests that components of the extracellular matrix contribute to the storing of information through learning processes. Thus, matrix regulation – either changes in the protein composition of the perineural network surrounding neurons or cleavage of this network by specific metalloproteases – could be relevant to the many psychiatric disorders that are shaped by previous experiences,...
Source: Swiss Medical Weekly - May 20, 2019 Category: General Medicine Authors: Bach D, Brown SA, Kleim B, Tyagarajan S Tags: Swiss Med Wkly Source Type: research

Solid cancer development in solid organ transplant recipients within the Swiss Transplant Cohort Study.
udy Abstract In solid organ transplant recipients (sOTRs), 5 years after transplantation cancer is a relevant cause of death. We aimed to report cancer incidence in the Swiss Transplant Cohort Study (STCS) between 2008 and 2014 and conducted a prospective cohort study of kidney, heart, lung, pancreas and liver transplant recipients enrolled into the STCS by retrospective analysis of collected data. The STCS provided data on 2758 solid organ transplants. In total, 134 cases of cancer were observed (30 liver, 21 prostate, 18 lung, 13 kidney, 52 other cancers). Standardised incidence ratios (SIRs) were highest for li...
Source: Swiss Medical Weekly - May 6, 2019 Category: General Medicine Authors: Lengwiler E, Stampf S, Zippelius A, Salati E, Zaman K, Schäfer N, Schardt J, Siano M, Hofbauer G, The Swiss Transplant Cohort Study Tags: Swiss Med Wkly Source Type: research

Cell therapies for skin regeneration: an overview of 40 years of experience in burn units.
Abstract The earliest attempts at cell therapy can be attributed to Charles-Edward Brown-Séquard (1817–1894), who sought to treat senescence and aging by injecting animal gonad shreds into his contemporaries, a practice that was widespread in late 19th century. Since then, advances in science have enabled the development of biological substitutes to restore the function of various tissues. Skin was one of the first tissues to be regenerated. For severe burns, patient survival depends on the restoration of skin function as a barrier against pathogens and control of body temperature and fluid loss. ...
Source: Swiss Medical Weekly - May 6, 2019 Category: General Medicine Authors: Abdel-Sayed P, Michetti M, Scaletta C, Flahaut M, Hirt-Burri N, de Buys Roessingh A, Raffoul W, Applegate LA Tags: Swiss Med Wkly Source Type: research

Use of cardiac magnetic resonance imaging and single photon emission computed tomography for the diagnosis of stable coronary artery disease in Switzerland.
CONCLUSION: The use of SPECT versus CMR in Switzerland for the diagnosis of stable CAD is heterogeneous, but reflects the guidelines, which do not distinguish between the two diagnostic techniques. Expert opinions underlined that discussion should not be so much about the choice of the diagnostic modality but about how a clinical question in a patient can best be answered. PMID: 31104309 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - May 6, 2019 Category: General Medicine Authors: du Fay de Lavallaz J, Zellweger MJ, Felder S Tags: Swiss Med Wkly Source Type: research

Adjuvant trastuzumab chemotherapy in early breast cancer: meta-analysis of randomised trials and cost-effectiveness analysis.
CONCLUSION: Trastuzumab for HER2-positive early breast cancer had a high ICER. It is unclear why the Pharmaceutical Benefits Scheme listing does not use restrictions to improve the cost-effectiveness of the drug. PMID: 31104310 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - May 6, 2019 Category: General Medicine Authors: Doan TN, Barendregt J Tags: Swiss Med Wkly Source Type: research

Controlled attenuation parameter for the assessment of liver steatosis in comparison with liver histology: a single-centre real life experience.
CONCLUSIONS: CAP values are strongly associated with the degree of steatosis irrespective of the underlying liver disease. Integrating CAP measurements in the standard work-up may identify patients with NAFLD. &nbsp. PMID: 31026041 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 22, 2019 Category: General Medicine Authors: Baumeler S, Jochum W, Neuweiler J, Bergamin I, Semela D Tags: Swiss Med Wkly Source Type: research

Impact of co-amoxicillin-resistant Escherichia coli and Pseudomonas aeruginosa on the rate of infectious complications in paediatric complicated appendicitis.
CONCLUSION: Results of the multivariable analysis of this small, retrospective study revealed a statistically significant increase in the risk of postoperative complications in the presence of co-amoxicillin-resistant E. coli. The choice of antibiotic should be adapted accordingly. More data are needed to justify the systematic coverage of P. aeruginosa in children with complicated appendicitis. &nbsp. PMID: 31026042 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 22, 2019 Category: General Medicine Authors: Andrey V, Crisinel PA, Prod'hom G, Croxatto A, Joseph JM Tags: Swiss Med Wkly Source Type: research

Associations of regrets and coping strategies with job satisfaction and turnover intention: international prospective cohort study of novice healthcare professionals.
CONCLUSIONS: Our results revealed that care-related regrets and maladaptive coping strategies are associated with job dissatisfaction and the intention to quit patient care. Helping healthcare professionals to cope with these emotional experiences seems essential to prevent early job quitting. &nbsp. PMID: 31026043 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 22, 2019 Category: General Medicine Authors: Cheval B, Cullati S, Mongin D, Schmidt RE, Lauper K, Pihl-Thingvad J, Chopard P, Courvoisier DS Tags: Swiss Med Wkly Source Type: research

Is it the moon? Effects of the lunar cycle on psychiatric admissions, discharges and length of stay.
CONCLUSIONS: Despite the widespread belief that the moon impacts peoples’ mental health and subsequently psychiatric treatment, this study provides no evidence that our celestial neighbour influences our mental well-being. PMID: 31012946 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 22, 2019 Category: General Medicine Authors: Gupta R, Nolan DR, Bux DA, Schneeberger AR Tags: Swiss Med Wkly Source Type: research

Nevirapine in HIV maintenance therapy - can "old drugs" survive in current HIV management?
CONCLUSIONS: In this study, two thirds of the patients continued nevirapine with favourable long-term tolerability and efficacy. Thus, this low-cost “old drug” may still represent a valid treatment switch option for maintenance therapy in selected patients with a fully suppressed viral load. However, further evaluation is needed. &nbsp. PMID: 31017649 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 22, 2019 Category: General Medicine Authors: Notter J, Bregenzer A, Vernazza P, Kahlert CR Tags: Swiss Med Wkly Source Type: research

Association between income and control of cardiovascular risk factors after acute coronary syndromes: an observational study.
CONCLUSION: A high household income was associated with a higher rate of smoking cessation and better control of blood pressure one year after ACS, independently of education, living status and working status. PMID: 30994923 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 8, 2019 Category: General Medicine Authors: Jaquet E, Gencer B, Auer R, Moschetti K, Muller O, Matter CM, Lüscher TF, Mach F, Rodondi N, Bodenmann P, Nanchen D Tags: Swiss Med Wkly Source Type: research

Characteristics of children and adolescents at the Switzerland-wide first ambulatory interdisciplinary pain clinic at the University Children's Hospital Basel - a retrospective study.
CONCLUSIONS: The average of more than 2 years of pain before referral to the clinic seems to be a long time. Assuming that specialised support is mandatory for young patients with complex pain syndromes, the referral time should be reduced. Furthermore, patients with headache were underrepresented in Basel compared with other centres. Interestingly, in our study, patients’ parents suffered more often from psychiatric diseases than the mean Swiss population. PMID: 30994924 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 8, 2019 Category: General Medicine Authors: Schneider T, Pfister D, Wörner A, Ruppen W Tags: Swiss Med Wkly Source Type: research

Establishing a non-intubated thoracoscopic surgery programme for bilateral uniportal sympathectomy.
CONCLUSION: Thoracoscopic sympathectomy is a suitable procedure with which to establish a NiVATS programme. Patients are usually young and of healthy weight, facilitating the learning curve for the local anaesthesia techniques and the surgery. Compared to VATS, sympathectomy is more likely to be performed as an outpatient procedure and has a lower cost, while safety and efficacy are maintained. PMID: 30994925 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 8, 2019 Category: General Medicine Authors: Caviezel C, Schuepbach R, Grande B, Opitz I, Zalunardo M, Weder W, Hillinger S Tags: Swiss Med Wkly Source Type: research

A curious association of chronic homeopathic arsenic ingestion with nonspecific symptoms in a Swiss teenager.
Abstract Arsenic is a toxicant that has no dose threshold below which exposures are not harmful. Here I report a curious association of chronic homeopathic arsenic ingestion with nonspecific symptoms in a Swiss teenager. For about 4 years she had taken globules of a freely purchasable homeopathic remedy containing inorganic arsenic (iAs), infinitesimally diluted to D6 (average arsenic content per single globule: 0.85 ± 0.08 ng). In the previous 7 months she had taken 20 to 50 globules daily (average 30 ng arsenic daily). She complained of nausea, stomach and abdominal cramps, diarrhoea and flatulence, h...
Source: Swiss Medical Weekly - April 8, 2019 Category: General Medicine Authors: Dani SU Tags: Swiss Med Wkly Source Type: research

Outcome of inter-hospital transfer of patients on extracorporeal membrane oxygenation in Switzerland.
CONCLUSIONS: The first results of our ECMO transportation programme show its feasibility, safety and efficacy without on-site implant or on-transport complications or mortality. The favourable early survival may justify the large effort with respect to logistics, costs and manpower. With rising awareness, referring centres may increasingly consider this lifesaving option at an early stage, which may further improve outcomes. PMID: 30995683 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 8, 2019 Category: General Medicine Authors: Wilhelm MJ, Inderbitzin DT, Reser D, Halbe M, Van Tillburg K, Albrecht R, Müller SM, Wenger U, Maggiorini M, Rudiger A, Bettex D, Schüpbach R, Weber A, Benussi S, Von Segesser LK, Flammer AJ, Maisano F, Ruschitzka F Tags: Swiss Med Wkly Source Type: research

Negligible impact of highly patient-specific decision support for potassium-increasing drug-drug interactions - a cluster-randomised controlled trial.
CONCLUSIONS: A highly patient-specific CDS feature combination had a negligible impact on the management of potentially serious potassium-increasing DDIs and was unable to improve safety among hospitalised patients. PMID: 30957213 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 8, 2019 Category: General Medicine Authors: Beeler PE, Eschmann E, Schneemann M, Blaser J Tags: Swiss Med Wkly Source Type: research

Tissue engineering for paediatric patients.
Abstract The effects of oncological treatment, congenital anomalies, traumatic injuries and post-infection damage critically require sufficient amounts of tissue for structural and functional surgical reconstructions. The patient’s own body is typically the gold standard source of transplant material, but in children autologous tissue is available only in small quantities and with severe morbidity at donor sites. Engineering of tissue grafts starting from a small amount of autologous material, combined with suitable surgical manipulation of the recipient site, is expected to enhance child and adolescent ...
Source: Swiss Medical Weekly - March 25, 2019 Category: General Medicine Authors: Mumme M, Wixmerten A, Miot S, Barbero A, Kaempfen A, Saxer F, Gehmert S, Krieg A, Schaefer DJ, Jakob M, Martin I Tags: Swiss Med Wkly Source Type: research

Reflecting upon the humanitarian use of unmanned aerial vehicles (drones).
In conclusion, it is questionable whether the benefits of using drones outnumber the moral obstacles they raise, and whether they will eventually be considered an inseparable part of humanitarian aid as well as a cutting-edge technological toy. PMID: 30950503 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - March 25, 2019 Category: General Medicine Authors: Tatsidou E, Tsiamis C, Karamagioli E, Boudouris G, Pikoulis A, Kakalou E, Pikoulis E Tags: Swiss Med Wkly Source Type: research

Management of brainstem haemorrhages.
Abstract Among spontaneous intracranial haemorrhages, primary non-traumatic brainstem haemorrhages are associated with the highest mortality rate. Patients classically present with rapid neurological deterioration. Previous studies have found that the severity of initial neurological symptoms and hydrocephalus are predictors of poor outcomes. In addition, radiological parameters aim to classify brainstem haematomas according to volume, extension and impact on prognosis. However, previous studies have failed to agree on a differentiated radiological classification for outcome and functional recovery. Electrophysiol...
Source: Swiss Medical Weekly - March 25, 2019 Category: General Medicine Authors: Wang SS, Yang Y, Velz J, Keller E, Luft AR, Regli L, Neidert MC, Bozinov O Tags: Swiss Med Wkly Source Type: research

Erratum to: Clinical characteristics, audiological and neurodevelopmental outcomes of newborns with congenital cytomegalovirus infection.
PMID: 30942894 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - March 25, 2019 Category: General Medicine Authors: Kobas M, Bickle Graz M, Truttmann AC, Giannoni E, Meylan P, Asner SA Tags: Swiss Med Wkly Source Type: research

Erratum to: Molecular imaging for neuroendeocrine tumours.
PMID: 30943307 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - March 25, 2019 Category: General Medicine Authors: Kwadwo A, Guillaume N, Wild D, Christ E Tags: Swiss Med Wkly Source Type: research

Updated recommendations for diagnosis and treatment of plasma cell myeloma in Switzerland.
Abstract This update on plasma cell myeloma has been elaborated by a Swiss expert panel as a result of the plethora of new data on the treatment of plasma cell myeloma reported recently. It adds new insights to the more extensive review that was published 3 years ago and may help clinicians on decision making for their patients. The new recommendations for distinguishing plasma cell myeloma from smouldering myeloma are briefly presented, including a section on contemporary imaging studies with this respect. Former panel recommendations that remain unchanged by new results will not be discussed in detail as the maj...
Source: Swiss Medical Weekly - March 25, 2019 Category: General Medicine Authors: Samaras P, Bargetzi M, Betticher DC, Driessen C, Duchosal MA, Heim D, Ketterer N, Lerch E, Matthes T, Mey U, Pabst T, Schmidt A, Taverna C, Zander T, Renner C Tags: Swiss Med Wkly Source Type: research

High-throughput sequencing in clinical oncology: from past to present.
Abstract The war on cancer remains a major challenge as one of the hurdles for additional progress is the complexity of the mechanisms underlying the disease. Cutting-edge technologies and computing tools have led to whole genome sequencing as well as an integrated and inclusive omic approach of cancers with accurate molecular tumors' signatures through impressive progress in the field of Next Generation Sequencing (NGS). Genomic data may foster strategies for new drug development in addition to a better understanding of cancer genesis, opening a new era in oncology clinical practice. This review discusses the dev...
Source: Swiss Medical Weekly - March 25, 2019 Category: General Medicine Authors: Mery B, Vallard A, Rowinski E, Magne N Tags: Swiss Med Wkly Source Type: research

Screening strategy for Chagas disease in a non-endemic country (Switzerland): a prospective evaluation.
The objective was to assess the feasibility and acceptability of a screening strategy in one Swiss canton. From February 2011 to September 2012, people attending six healthcare centres of different types were offered a rapid diagnostic test if they or their mother were of Latin American origin (or, at the blood donation centre, if they had travelled for ≥1 year in Latin America). In addition, testing was offered during events where Latin Americans gathered. In total, 1,010 people were tested, mainly originating from Brazil (24%), Ecuador (13%) and Chile (10%). 54% were born in Latin America, 15% had a Latin American...
Source: Swiss Medical Weekly - March 25, 2019 Category: General Medicine Authors: Da Costa-Demaurex C, Cárdenas MT, Aparicio H, Bodenmann P, Genton B, D'Acremont V Tags: Swiss Med Wkly Source Type: research

The rate of mother-to-child transmission of antiretroviral drug-resistant HIV strains is low in the Swiss Mother and Child HIV Cohort Study.
CONCLUSIONS: HIV-tDRM were low in this Swiss MoCHIV cohort, making them a minor yet preventable complication of prenatal HIV care, whereas HIV-sDRM are a significant challenge in paediatric HIV care. PMID: 30946481 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - March 25, 2019 Category: General Medicine Authors: Compagno F, Naegele K, Kahlert CR, Hösli I, Aebi-Popp K, Martinez de Tejada B, Paioni P, Yerly S, Böni J, Battegay M, Rudin C, Hirsch HH, Swiss Hiv Cohort Study Tags: Swiss Med Wkly Source Type: research

Setting as informed consent in psychotherapy.
PMID: 30903798 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - March 11, 2019 Category: General Medicine Authors: Novosel D Tags: Swiss Med Wkly Source Type: research

Informed consent for psychotherapy includes much more than the setting.
PMID: 30903799 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - March 11, 2019 Category: General Medicine Authors: Trachsel M, Biller-Andorno N Tags: Swiss Med Wkly Source Type: research

Controlling HCV in Switzerland: running against the clock.
PMID: 30905058 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - March 11, 2019 Category: General Medicine Authors: Cerny A, Blindenbacher R, Moriggia A Tags: Swiss Med Wkly Source Type: research

A prospective observational study of the main features of nocturnal leg cramps in primary care.
CONCLUSIONS: Although nocturnal leg cramps are common among older patients in primary care, the disease burden of nocturnal leg cramps only appears to be severe in a minority of patients. PMID: 30905059 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - March 11, 2019 Category: General Medicine Authors: Sebo P, Haller D, Cerutti B, Maisonneuve H Tags: Swiss Med Wkly Source Type: research

Teamwork and clinician burnout in Swiss intensive care: the predictive role of workload, and demographic and unit characteristics.
CONCLUSION: We identified several demographic and unit-based factors in Swiss ICUs that were associated with lower perceptions of the quality of teamwork and higher self-reported burnout. Discrepant experiences regarding the quality of teamwork based on professional role, professional status and experience might affect team effectiveness. Furthermore, this study showed the importance of workload management, as objectively measured workload was associated with higher self-reported burnout. Results suggested that certain clinician groups (e.g., working predominantly night shifts) were at higher risk for burnout, thus highlig...
Source: Swiss Medical Weekly - March 11, 2019 Category: General Medicine Authors: Welp A, Rothen HU, Massarotto P, Manser T Tags: Swiss Med Wkly Source Type: research

Home visits made by general practitioners in the canton of Vaud between 2006 and 2015.
CONCLUSIONS: Although most physicians in the canton of Vaud continue to visit patients at home, the overall number of home visits is declining. Most home visits consist of routine visits to elderly patients. Physicians’ gender, age and specialty are associated with the number of home visits. In the rapidly evolving context of an ageing population and the development of home care, physicians’ role in home care provision should be revised, taking into account patient expectations and current health system constraints. PMID: 30905061 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - March 11, 2019 Category: General Medicine Authors: Mueller Y, David S, Cohidon C, Locatelli I, Senn N Tags: Swiss Med Wkly Source Type: research

Uncertain progress in Swiss perioperative mortality 1998-2014 for 22 operation groups.
CONCLUSIONS: In Switzerland, in-hospital POMR trends from 1998–2014 were unchanged or even increasing for the majority of IORs (73% of included operations). Our analysis used age-standardisation but cannot account for changes in coding practices and organisation of healthcare delivery. POMR trends should be systematically monitored at the national level and used to guide priorities in national quality improvement strategies. PMID: 30905062 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - March 11, 2019 Category: General Medicine Authors: Wacker J, Zwahlen M Tags: Swiss Med Wkly Source Type: research

Cost-effectiveness analysis of strategies to manage the disease burden of hepatitis C virus in Switzerland.
CONCLUSIONS: Increasing the number of patients treated and treating all fibrosis stages is cost-effective compared to the historical base case and could achieve break-even by 2031 at a price of 27,900 CHF. PMID: 30905063 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - March 11, 2019 Category: General Medicine Authors: Blach S, Schaetti C, Bruggmann P, Negro F, Razavi H Tags: Swiss Med Wkly Source Type: research

Chronic heart failure: advances in pharmacological treatment and future perspectives.
Abstract Besides noticeable progress in device therapy during the past decade, more recent advances in the management of chronic heart failure have led to exciting new pharmacological options. Among these, the combined angiotensin II receptor/neprilysin inhibitor (ARNI) valsartan/sacubitril has already proven highly effective in heart failure with reduced ejection fraction (HFrEF), and convincing data are available regarding the cardioprotective effects of sodium-glucose-co-transporter 2 (SGLT2) inhibitors. These two treatments have earned a class I and a class II recommendation, respectively, in the European Soci...
Source: Swiss Medical Weekly - March 11, 2019 Category: General Medicine Authors: Kuster GM, Pfister O Tags: Swiss Med Wkly Source Type: research

Clinical outcomes in patients with systemic lupus erythematosus treated with belimumab in clinical practice settings: a retrospective analysis of results from the OBSErve study in Switzerland.
CONCLUSIONS: This study provides real-world insight into belimumab use in clinical practice in Switzerland. In line with findings from other countries, Swiss patients with SLE who received belimumab demonstrated clinical and serological improvements in SLE and a reduction in corticosteroid use after six months of treatment. PMID: 30852830 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 25, 2019 Category: General Medicine Authors: von Kempis J, Duetsch S, Reuschling N, Villiger R, Villiger PM, Vallelian F, Schaer DJ, Mueller RB Tags: Swiss Med Wkly Source Type: research

Molecular imaging for neuroendocrine tumours.
Abstract Molecular imaging has found numerous applications in oncology as many tumours express or activate tumour specific target molecules or pathways. This relatively new imaging technique results in a better localisation of tumours and improved tumour staging, especially in the setting of hybrid imaging that is in combination with morphological imaging such as computed tomography. In well differentiated neuroendocrine tumours, somatostatin receptor imaging, as one of the first examples of receptor targeted imaging in humans, plays an important role in the diagnostic work-up of these patients. In poorly differen...
Source: Swiss Medical Weekly - February 25, 2019 Category: General Medicine Authors: Antwi K, Nicolas G, Wild D, Christ E Tags: Swiss Med Wkly Source Type: research

Treatment of chronic non-infectious uveitis and scleritis.
Abstract Ocular inflammations such as uveitis and scleritis can lead to significant visual impairment if not treated properly. To limit potentially sight-threatening complications, good control of the inflammation in the acute phase is necessary. Corticosteroids have been the mainstay of ocular therapies for many years, but high doses of corticosteroids, which are required to maintain quiescence in severe uveitis, can be associated with many systemic and ocular complications. In order to limit steroid side-effects, classic immunosuppressant and immunobiologic agents have been widely used as steroid-sparing agents....
Source: Swiss Medical Weekly - February 25, 2019 Category: General Medicine Authors: Rossi DC, Ribi C, Guex-Crosier Y Tags: Swiss Med Wkly Source Type: research

Reply to Roswitha Koch et al.
PMID: 30852833 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 25, 2019 Category: General Medicine Authors: Chmiel C, Giewer I, Frei A, Rosemann T Tags: Swiss Med Wkly Source Type: research

Cardiovascular disease after childhood acute lymphoblastic leukaemia: a cohort study.
CONCLUSIONS: Despite attempts to reduce cardiotoxicity in childhood cancer treatment, CVD risks in ALL survivors treated more recently do not seem to have declined. PMID: 30852834 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 25, 2019 Category: General Medicine Authors: Hau EM, Caccia JN, Kasteler R, Spycher B, Suter T, Ammann RA, von der Weid NX, Kuehni CE Tags: Swiss Med Wkly Source Type: research

Ketamine procedural analgosedation before and after introducing nitrous oxide 70% in a paediatric emergency department.
CONCLUSIONS: The use of ketamine PAS shifted to N2O PAS, especially in children older than three years and for the reduction of displaced upper extremity fractures. PMID: 30852835 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - February 25, 2019 Category: General Medicine Authors: Seiler M, Staubli G Tags: Swiss Med Wkly Source Type: research

Interventional treatment of mitral valve regurgitation: an alternative to surgery?
Abstract Mitral regurgitation is a highly prevalent condition among elderly patients, affecting almost 10% of the general population aged 75 and older. Left untreated, severe mitral regurgitation results in high mortality and frequent hospitalisation for treatment of heart failure. Surgical treatment remains the first-line therapy for symptomatic, severe mitral regurgitation , especially for patients presenting with a primary aetiology. However, a high proportion of patients with mitral regurgitation are turned down for open-heart surgery, mainly due to advanced age, diminished left ventricular function and comorb...
Source: Swiss Medical Weekly - February 25, 2019 Category: General Medicine Authors: Praz F, Brugger N, Kassar M, Hunziker L, Moschovitis A, Stortecky S, Reineke D, Pilgrim T, Windecker S Tags: Swiss Med Wkly Source Type: research