Diffuse large B-cell lymphoma chemotherapy reveals a combined immunodeficiency syndrome in cartilage hair hypoplasia.
We report a 27-year-old female who presented a picture of combined immunodeficiency after receiving an adriamycin-based chemotherapy regimen followed by autologous stem cell transplantation. Her medical history indicated neonatal dwarfism, recurrent ear, nose and throat and respiratory infections, and hypogammaglobulinaemia, which were suggestive of a primary minor B-cell immune deficiency. Taken together, the diagnosis of cartilage hair hypoplasia was suspected and confirmed by means of molecular biological analysis. Here, we discuss the causal relationship and molecular mechanisms existing between both primary immunodefi...
Source: Swiss Medical Weekly - October 11, 2018 Category: General Medicine Authors: Nguyen A, Martin Silva N, de Boysson H, Damaj G, Aouba A Tags: Swiss Med Wkly Source Type: research

Correction to: Jeger V, et al. Is there a role for procalcitonin in differentiating uncomplicated and complicated diverticulitis in order to reduce antibiotic therapy?
PMID: 30294770 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - September 24, 2018 Category: General Medicine Authors: Jeger V, Pop R, Forudastan F, Barras JP, Zuber M, Piso RJ Tags: Swiss Med Wkly Source Type: research

Effects of maternal caffeine consumption on the breastfed child: a systematic review.
CONCLUSION: Evidence for recommendations on caffeine intake for breastfeeding women is scant, of limited quality and inconclusive. Birth cohort studies investigating the potential positive and negative effects of various levels of maternal caffeine consumption on the breastfed child and breastfeeding mother could improve the knowledge base and allow evidence-based advice for breastfeeding mothers. Systematic review registration number: CRD42017078790. PMID: 30294771 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - September 24, 2018 Category: General Medicine Authors: McCreedy A, Bird S, Brown LJ, Shaw-Stewart J, Chen YF Tags: Swiss Med Wkly Source Type: research

Rethinking hospitalisations for substance use disorders.
PMID: 30294772 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - September 24, 2018 Category: General Medicine Authors: Zullino D Tags: Swiss Med Wkly Source Type: research

The immune influence of a parabiosis model on tumour-bearing mice.
Abstract AIM: The aim of this study was to analyse the immune influence of a parabiosis model on tumour-bearing mice. METHODS: Parabiosis was established between C57BL/6 wild-type mice expressing green fluorescent protein (GFP+) and C57BL/6 wild-type mice without green fluorescent protein (GFP) to ensure blood cross-circulation between animals, and then the expression of CD4+ T cells, CD8+ T cells and interleukins 2, 4 and 10, and interferon-gamma (INF-γ) in spleen cells of parabiosis model mice were examined with flow cytometry. At day 8 and day 14 after conjoined surgery, we were aiming to sample t...
Source: Swiss Medical Weekly - September 24, 2018 Category: General Medicine Authors: Feng N, Luo JM, Guo X Tags: Swiss Med Wkly Source Type: research

Health-seeking behaviour and treatment delay in patients with pulmonary tuberculosis in Switzerland: some slip through the net.
CONCLUSIONS: No predictor of patient delay was found among the variables collected. For one fourth of the patients, the health system delay was longer than 7 weeks. General practitioners are commonly approached first, and they have to consider TB, also for patients not considered at high-risk for TB. PMID: 30232794 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - August 27, 2018 Category: General Medicine Authors: Auer C, Kiefer S, Zuske M, Schindler C, Wyss K, Blum J, Bosch-Capblanch X, Widmer U, Sauthier S, Janssens JP, Bossard K, Chatonnet C, Mazza-Stalder J, Začek B, Zellweger JP, Altpeter E, Mäusezahl M Tags: Swiss Med Wkly Source Type: research

Coercion in substance use disorders: clinical course of compulsory admissions in a Swiss psychiatric hospital.
Abstract According to the Swiss legal system, involuntary admission is one of the farthest-reaching incursions into personal autonomy. The effect of compulsory admission in treatment of substance use disorders (SUDs) on variables such as length of stay or leaving treatment before recommended discharge remains elusive. In order to elucidate these effects, we retrospectively analysed the clinical course of treatment of 608 patients who were admitted between November 2016 and October 2017 to the Department of Addictive Disorders of the canton of Aargau. Involuntarily admitted patients showed lower health and social f...
Source: Swiss Medical Weekly - August 27, 2018 Category: General Medicine Authors: Habermeyer B, Wyder L, Roser P, Vogel M Tags: Swiss Med Wkly Source Type: research

Correction to: Baseline characteristics and patterns of care in testicular cancer patients: first data from the Swiss Austrian German Testicular Cancer Cohort Study (SAG TCCS).
s A, Jüni P, Gilessen S PMID: 30182362 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - August 27, 2018 Category: General Medicine Authors: Rothermundt C, Thurneisen C, Cathomas R, Müller B, Mingrone W, Hirschi-Blickenstorfer A, Wehrhahn T, Ruf C, Rothschild SI, Seifert B, Terbuch A, Grassmugg T, Woelky R, Fankhauser C, Kunit T, Fischer N, Fischer NF, Inauen R, Kamradt J, Ziegler K, Haynes A Tags: Swiss Med Wkly Source Type: research

Video analysis for the evaluation of vaginal births: a comment.
PMID: 30141516 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - August 13, 2018 Category: General Medicine Authors: Pecks U, Alkatout I Tags: Swiss Med Wkly Source Type: research

The Expanded Risk Score in Rheumatoid Arthritis (ERS-RA): performance of a disease-specific calculator in comparison with the traditional prediction scores in the assessment of the 10-year risk of cardiovascular disease in patients with rheumatoid arthrit.
CONCLUSIONS: Using a surrogate marker of subclinical atherosclerotic organ damage as indicator of CVD burden, the newly ERS-RA risk score that incorporates specific aspects of RA performs as well as ACC/AHA 2013, mSCORE, FRS BMI and QRISK3 estimators. PMID: 30141517 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - August 13, 2018 Category: General Medicine Authors: Salaffi F, Carotti M, Di Carlo M, Tardella M, Lato V, Becciolini A, Favalli EG, Giovagnoni A Tags: Swiss Med Wkly Source Type: research

The clinical benefit of imaging in the diagnosis and treatment of giant cell arteritis.
Abstract Historically, giant cell arteritis (GCA) was considered to be synonymous with temporal arteritis. However, the disease spectrum of GCA extends much further, and includes vasculitis of the aorta and its branches with or without involvement of the temporal arteries. Imaging is crucial for the diagnosis and follow-up of GCA patients. Large vessel GCA (LV-GCA) often presents as an inflammatory syndrome and is only detected by imaging modalities such as: colour duplex sonography (CDS), computed tomography (CT) / CT angiography (CTA), magnetic resonance imaging (MRI) or 18F-fluorodeoxyglucose positron emission ...
Source: Swiss Medical Weekly - August 13, 2018 Category: General Medicine Authors: Berger CT, Sommer G, Aschwanden M, Staub D, Rottenburger C, Daikeler T Tags: Swiss Med Wkly Source Type: research

Cardiac Resynchronisation Therapy (CRT) Survey II: CRT implantation in Europe and in Switzerland.
ing C Abstract AIM: Between October 2015 and December 2016, 11,088 patients from 42 countries having cardiac resynchronisation therapy (CRT) devices implanted were included in the CRT II Survey. We compared the characteristics of Swiss CRT recipients with the overall European population. METHODS: Demographic and procedural data from seven Swiss centres recruiting all consecutive patients undergoing either de-novo CRT implantation or an upgrade to a CRT system were collected and compared with the European population. RESULTS: A total of 320 Swiss patients (24.4% female, mean age 71.0 ± 10.2 years, ...
Source: Swiss Medical Weekly - August 13, 2018 Category: General Medicine Authors: Zeljkovic I, Burri H, Breitenstein A, Ammann P, Mueller A, Auricchio A, Delacrétaz E, Dickstein K, Linde C, Normand C, Sticherling C Tags: Swiss Med Wkly Source Type: research

Continuous deep sedation until death in patients admitted to palliative care specialists and internists: a focus group study on conceptual understanding and administration in German-speaking Switzerland.
CONCLUSION: We found substantial variation in terminology and definition, indication and medication used for continuous deep sedation until death. To provide optimal symptom management in terminally ill patients, early involvement of palliative care experts as well as financial and regulatory support should be provided to encourage multi-disciplinary collaboration and thus consensus for defining the distinct sedation practices. PMID: 30141521 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - August 13, 2018 Category: General Medicine Authors: Ziegler S, Schmid M, Bopp M, Bosshard G, Puhan MA Tags: Swiss Med Wkly Source Type: research

First report of sexually transmitted multi-drug resistant Shigella sonnei infections in Switzerland, investigated by whole genome sequencing.
This report underlines the importance of the implementation of new sequencing technologies in the investigation of epidemiological aspects of this STI circulating in the population of MSM. In such cases, therapy should always be guided by antimicrobial susceptibility testing owing to increasing resistances. Greater awareness of this emerging sexually transmitted infection is needed. PMID: 30141522 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - August 13, 2018 Category: General Medicine Authors: Hinic V, Seth-Smith H, Stöckle M, Goldenberger D, Egli A Tags: Swiss Med Wkly Source Type: research

Predictors for shorter and longer length of hospital stay outliers: a retrospective case-control study of 8247 patients at a university hospital trauma department.
The objective of this study was to identify independent diagnosis related group (DRG)-related risk factors for shorter and longer LOS outlier status. METHODS: A retrospective case-control study was conducted at a Swiss level 1 trauma centre between January 2012 and December 2014. The study included all patients with available information on LOS based on DRG. Many predictor variables were tested. The outcome variable was the DRG-based LOS. Logistic regression models were fitted for shorter and longer LOS outliers, with a significance level of
Source: Swiss Medical Weekly - August 13, 2018 Category: General Medicine Authors: Jentzsch T, Seifert B, Neuhaus V, Moos RM Tags: Swiss Med Wkly Source Type: research

Adenoma size and postoperative IGF-1 levels predict surgical outcomes in acromegaly patients: results of the Swiss Pituitary Registry (SwissPit).
CONCLUSION: This small, observational registry study showed a relevant success rate of initial pituitary surgery in patients with confirmed acromegaly. Initial tumour size and postoperative IGF-1 levels help to risk stratify patients regarding expected outcomes. In the case of disease persistence, a multimodal approach using drug and radiotherapy is mandatory. PMID: 30141524 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - August 13, 2018 Category: General Medicine Authors: Kempf J, Schmitz A, Meier A, Delfs N, Mueller B, Fandino J, Schuetz P, Berkmann S Tags: Swiss Med Wkly Source Type: research

A buyers' club to improve access to hepatitis C treatment for vulnerable populations.
This article discusses some of the key issues on this topic, such as reaching the populations most at risk from the hepatitis C virus (HCV) infection, and improving access to care and treatment for underserved, uninsured populations. We suggest a personal importation scheme for unapproved generics of DAA medications, and the use of a buyers' club as a strategy for improving universal access to hepatitis C medicines among vulnerable populations such as uninsured patients, in order to achieve the WHO goals with minimal disruption of the conventional, patent-based business model. PMID: 30141526 [PubMed - in process] (Sou...
Source: Swiss Medical Weekly - August 13, 2018 Category: General Medicine Authors: Vernaz N, Calmy A, Hurst S, Jackson Y, Negro F, Perrier A, Wolff H Tags: Swiss Med Wkly Source Type: research

In-vitro characterisation of a novel antimicrobial agent, TNP-2092, against Helicobacter pylori clinical isolates.
CONCLUSIONS: TNP-2092 is highly active against H. pylori and against strains resistant to clarithromycin or levofloxacin. Its antibacterial activity is both concentration- and time-dependent .The antibacterial activity of TNP-2092 appears to be pH-dependent and is more active under neutral pH. TNP-2092 represents a promising new therapy for the treatment of H. pylori infection in primary patients. PMID: 30044468 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - July 23, 2018 Category: General Medicine Authors: Wang B, Zhao Q, Yin W, Yuan Y, Wang X, Wang YH, Wang H, Ye W, Chen S, Guo HL, Xie Y Tags: Swiss Med Wkly Source Type: research

Is breastfeeding an equipoise option in effectively treated HIV-infected mothers in a high-income setting?
Abstract Combined antiretroviral treatment (cART) has reduced mother-to-child transmission (MTCT) of the human immunodeficiency virus (HIV) to virtually zero in industrialised countries, where strictly bottle feeding is recommended for HIV-infected mothers, and to as low as 0.7% after 12 months in low-resource settings, where breastfeeding is strongly encouraged. Given the theoretically very low risk of transmission by breastfeeding with cART, and the advantages and benefits of breastfeeding, also in industrialised countries, the strong recommendation to HIV-infected mothers to refrain from breastfeeding in this s...
Source: Swiss Medical Weekly - July 23, 2018 Category: General Medicine Authors: Kahlert C, Aebi-Popp K, Bernasconi E, Martinez de Tejada B, Nadal D, Paioni P, Rudin C, Staehelin C, Wagner N, Vernazza P Tags: Swiss Med Wkly Source Type: research

Diagnosis and treatment of follicular lymphoma: an update.
Abstract Over the last few years, there have been many changes in the management of patients with follicular lymphoma, resulting in improvements in progression-free survival and quality of life. In addition to established regimens such as radiotherapy and immunochemotherapy, new treatment options are on the horizon. Furthermore, even the use of established chemotherapy agents has evolved, with new combinations moving to the forefront of the current treatment strategy. Nevertheless, there remains an unmet need for patients who have early relapses, those who are not responsive to anti-CD20 treatment regimens and for...
Source: Swiss Medical Weekly - July 23, 2018 Category: General Medicine Authors: Bargetzi M, Baumann R, Cogliatti S, Dietrich PY, Duchosal M, Goede J, Hitz F, Konermann C, Lohri A, Mey U, Novak U, Papachristofilou A, Stenner F, Taverna C, Zander T, Renner C Tags: Swiss Med Wkly Source Type: research

Obesity-related respiratory failure: a new area for extracorporeal lung support?
PMID: 30044477 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - July 23, 2018 Category: General Medicine Authors: Giraud R, Bendjelid K, Banfi C Tags: Swiss Med Wkly Source Type: research

Baseline characteristics and patterns of care in testicular cancer patients: first data from the Swiss Austrian German Testicular Cancer Cohort Study (SAG TCCS).
CONCLUSION: It is important to enrol GCT patients in prospective studies in general, but also in follow-up studies to assess baseline characteristics, oncological outcome, and long-term toxicity and to validate the performance of follow-up schedules. This is the first time that the distribution of disease, detailed baseline characteristics and the respective treatment of men with GCT is collected in a prospective manner in German speaking countries (Switzerland, Austria and Germany) and therefore patterns of care have been evaluated. SAG TCCS results will inform on future modifications of surveillance schedules and follow-...
Source: Swiss Medical Weekly - July 23, 2018 Category: General Medicine Authors: Rothermundt C, Thurneysen C, Cathomas R, Müller B, Mingrone W, Hirschi-Blickenstorfer A, Wehrhahn T, Ruf C, Rothschild S, Seifert B, Terbuch A, Grassmugg T, Woelky R, Fankhauser C, Kunit T, Fischer NF, Inauen R, Kamradt J, Ziegler K, Haynes A, Jüni P, G Tags: Swiss Med Wkly Source Type: research

Adherence to guidelines when evaluating fitness-to-drive in the elderly: a practice review of Swiss physicians.
CONCLUSIONS: Many Swiss GPs seem not to systematically follow the current Swiss recommendations. Although several important procedures appear to routinely be part of older drivers' assessment, others are infrequently performed. Further research should identify how GPs select the recommended items to which they adhere and those they never apply, and how to facilitate the use of recommended procedures to help them decide if a person is fit, unfit or requiring further evaluation. PMID: 30044469 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - July 9, 2018 Category: General Medicine Authors: Sebo P, Haller DM, Favrat B, Huber P, Mueller Y, Vaucher P Tags: Swiss Med Wkly Source Type: research

Termination of pregnancy in a border region between Switzerland and Italy (2008-2015).
In this study, we aimed to illustrate trends in the VTPs in the Canton Ticino between 2008 and 2015 and demonstrate differences between the Swiss women resident in Switzerland (SSR), foreign women resident in Switzerland (FSR) and foreign women resident abroad (FAR), focusing in particular on the Italian women as during this period there were legal changes in Italy. The number of VTPs was constant on a national level (10,924 in 2008, 10,255 in 2015); in contrast, since 2012 the number has progressively decreased (41%) in Ticino, mainly because of the significant reduction in VTPs in women resident in Italy (decrease of 75....
Source: Swiss Medical Weekly - July 9, 2018 Category: General Medicine Authors: Reinholz D, Casati S, Beretta O, Merlani G Tags: Swiss Med Wkly Source Type: research

The inconsistent ethical oversight of healthcare quality data in Switzerland.
PMID: 30044471 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - July 9, 2018 Category: General Medicine Authors: McLennan S, Maritz R, Shaw D, Elger B Tags: Swiss Med Wkly Source Type: research

Video analysis for the evaluation of vaginal births: a prospective observational study.
CONCLUSIONS: Video analysis of obstetric procedures in the labour ward is an easily applicable and very useful tool for teaching and learning purposes. It contributes to showing and improving the quality of procedures and the interactions of the staff and can be used for staff evaluation. PMID: 30044472 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - July 9, 2018 Category: General Medicine Authors: Kimmich N, Zimmermann R, Kreft M Tags: Swiss Med Wkly Source Type: research

Venovenous extracorporeal membrane oxygenation to treat hypercapnia in a morbidly obese patient.
We report a case of a 33-year-old female patient who was in an extraordinarily bad medical state, with severe hypercapnia (pCO2 15.1 kPa), sepsis, acute anuric kidney failure and resulting acidosis (pH 6.96). Her body mass index was 84 kg/m2. Her chances of survival were considered very low after failed attempts at noninvasive ventilation. Based on prior research, we refrained from intubation and chose venovenous extracorporeal membrane oxygenation to treat the hypercapnia. In the entire medical literature, we are not aware of a similarly extraordinary case of obesity-related hypoventilation syndrome that could finally be ...
Source: Swiss Medical Weekly - July 9, 2018 Category: General Medicine Authors: Lederer H, Stalder M, Tisljar K, Lanzi F, Landmann E, Mosimann T, Zeeh F, Zuercher S, Mosimann V, Spiegel R, Sutter R, Hunziker P Tags: Swiss Med Wkly Source Type: research

Recommendations for genetic testing and counselling after sudden cardiac death: practical aspects for Swiss practice.
ath Abstract There is a need to standardise, within a coordinated Swiss framework, the practical aspects of genetic testing and genetic counselling on possibly inherited cardiovascular disorders in relatives of a sudden cardiac death (SCD) victim. Because of the major advances in genetic investigation techniques and recent publication of international guidelines in the field of cardiology, genetics and pathology, we consider it important to summarise the current evidence and propose an optimal approach to post-mortem genetic investigation for SCD victims and their families in Switzerland. In this article, we discu...
Source: Swiss Medical Weekly - July 9, 2018 Category: General Medicine Authors: Medeiros Domingo A, Bolliger S, Gräni C, Rieubland C, Hersch D, Asatryan B, Schyma C, Saguner A, Wyler D, Bhuiyan Z, Fellman F, Osculati AM, Ringger R, Fokstuen S, Sabatasso S, Wilhelm M, Michaud K, Swiss Working Group On Sudden Cardiac Death Tags: Swiss Med Wkly Source Type: research

Comparison of metabolic outcomes in patients undergoing laparoscopic roux-en-Y gastric bypass versus sleeve gastrectomy - a systematic review and meta-analysis of randomised controlled trials.
r M Abstract BACKGROUND AND OBJECTIVES: Bariatric surgery is the most effective treatment for morbid obesity and is known to have beneficial effects on glycaemic control in patients with type 2 diabetes mellitus (T2DM) and in diabetes prevention. The preferred type of surgery and mechanism of action is, however, unclear. We performed a systematic review and meta-analysis of randomised controlled trials (RCTs) comparing the effects of laparoscopic roux-en-Y gastric bypass (RYGB) with those of sleeve gastrectomy (SG) on metabolic outcome, with a special focus on glycaemic control. METHODS: A literature search o...
Source: Swiss Medical Weekly - July 9, 2018 Category: General Medicine Authors: Hayoz C, Hermann T, Raptis DA, Brönnimann A, Peterli R, Zuber M Tags: Swiss Med Wkly Source Type: research

Look before you SPRINT: look at the data and look at the consequences.
PMID: 29964291 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - June 25, 2018 Category: General Medicine Authors: Nordmann A, Fernandes M, Olde Rikkert MGM Tags: Swiss Med Wkly Source Type: research

Excipients: not so inert? When the excipient plays the role of an active substance, as exemplified by systemic lupus.
Abstract It is well recognised that the historical timeline required for developing a drug, beginning with target identification and validation, is long and often tedious. It requires a large set of competences in various areas of molecular and cellular biology, chemistry, pharmacology, imaging, and model animal experimentation. Once the active molecule appears to be ready for human testing in controlled clinical trials, then the question arises of how to formulate it to render it stable, adequately packaged, according to the chosen route of administration, and bioavailable to reach its target in the affected orga...
Source: Swiss Medical Weekly - June 25, 2018 Category: General Medicine Authors: Muller S Tags: Swiss Med Wkly Source Type: research

Clinical characteristics, audiological and neurodevelopmental outcomes of newborns with congenital cytomegalovirus infection.
CONCLUSIONS: All infants with subsequent SNHL or abnormal neurodevelopment were symptomatic at birth. Similar long-term neurodevelopmental and audiological outcomes were observed in infants born to mothers with a primary and nonprimary infection. PMID: 29894555 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - June 12, 2018 Category: General Medicine Authors: Kobas M, Bickle Graz M, Truttmann AC, Giannoni E, Meylan P, Asner SA Tags: Swiss Med Wkly Source Type: research

Adaptation of cost-effectiveness analyses to a single country: the case of bariatric surgery for obesity and overweight.
Abstract OBJECTIVES: The aims of this study were to (a) identify and assess the quality of reporting of published cost-effectiveness studies of bariatric surgery, (b) assess their transferability to Switzerland, and (c) adapt transferable cost-effectiveness results to Switzerland. METHODS: A systematic literature search was performed in Medline, Embase and other databases. Two reviewers independently undertook screening, extraction, assessment of reporting quality utilising the Consolidated Health Economic Evaluation Reporting Standards, transferability, adaptation of cost data and recalculation of cost-effec...
Source: Swiss Medical Weekly - June 12, 2018 Category: General Medicine Authors: Ademi Z, Tomonaga Y, van Stiphout J, Glinz D, Gloy V, Raatz H, Bucher HC, Schwenkglenks M Tags: Swiss Med Wkly Source Type: research

Accidental or intentional exposure to potentially toxic medications, natural toxins and chemicals during pregnancy: analysis of data from Tox Info Suisse.
CONCLUSIONS: Tox Info Suisse recorded an average of 137 cases of agent exposure during pregnancy per year, mostly due to accidents with household products. Suicidal intentions played a role in a considerable number of exposures. Measures are needed to prevent accidental exposure of pregnant women to toxic substances and to support them in this exceptional life period. PMID: 29767826 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - May 16, 2018 Category: General Medicine Authors: Vogel T, Lüde S, Baumgartner R, Rauber-Lüthy C, Simões-Wüst AP Tags: Swiss Med Wkly Source Type: research

Directing citizens to create advance directives.
This article describes the Swiss law on advance directives that was passed at the beginning of 2013 and led to more certainty about the legally binding character of such directives. However, for various reasons the drafting of advance directives is not yet widespread in Switzerland, and many resources might be put to better use if this became a common practice. A recent proposal by members of a political party to make the discussion, although not the actual drafting, of advance directives mandatory was rejected by the Swiss Federal Parliament, and the proposal was written off after having been pending for 2 years. We consi...
Source: Swiss Medical Weekly - May 16, 2018 Category: General Medicine Authors: Haesen S, Shaw D Tags: Swiss Med Wkly Source Type: research

A digitally facilitated citizen-science driven approach accelerates participant recruitment and increases study population diversity.
CONCLUSION: Academic and industry-driven medical research faces substantial challenges in terms of patient involvement, recruitment, relevance and generalisability. Digital studies and stakeholder engagement may have enormous potential for medical research. But many digital studies are based on limited participant information and/or informed consent and unclear data ownership, and are subject to selection bias, confounding and information bias. The Swiss MS Registry serves as an example of a digitally enhanced, citizen-science study that leverages the advantages of both traditional medical research, with its established re...
Source: Swiss Medical Weekly - May 16, 2018 Category: General Medicine Authors: Puhan MA, Steinemann N, Kamm CP, Müller S, Kuhle J, Kurmann R, Calabrese P, Kesselring J, von Wyl V, Swiss Multiple Sclerosis Registry Smsr Tags: Swiss Med Wkly Source Type: research

Immunotherapy in head and neck cancer - scientific rationale, current treatment options and future directions.
hild SI Abstract Head and neck squamous cell carcinoma (HNSCC) is a frequent tumour arising from multiple anatomical subsites in the head and neck region. The treatment for early-stage disease is generally single modality, either surgery or radiotherapy. The treatment for locally advanced tumours is multimodal. For recurrent/metastatic HNSCC palliative chemotherapy is standard of care. The prognosis is limited and novel treatment approaches are urgently needed. HNSCC evades immune responses through multiple resistance mechanisms. HNSCC is particularly characterised by an immunosuppressive environment which include...
Source: Swiss Medical Weekly - May 14, 2018 Category: General Medicine Authors: Rothschild U, Muller L, Lechner A, Schlösser HA, Beutner D, Läubli H, Zippelius A, Rothschild SI Tags: Swiss Med Wkly Source Type: research

External validation of the 80+ score and comparison with three clinical scores identifying patients at least 75 years old at risk of unplanned readmission within 30 days after discharge.
CONCLUSION: In our study, the 80+ score was externally validated and showed less favourable discrimination than the three other scores in this population. PMID: 29756634 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - May 14, 2018 Category: General Medicine Authors: Schwab C, Le Moigne A, Fernandez C, Durieux P, Sabatier B, Korb-Savoldelli V Tags: Swiss Med Wkly Source Type: research

Trends in the use of mammography for early breast cancer detection in Switzerland: Swiss Health Surveys 2007 and 2012.
n M Abstract AIMS: Breast cancer is the most common cancer in women worldwide. We assessed changes in the use of breast cancer screening 2007-2012 in Switzerland, and associations with socioeconomic and health-related determinants. METHODS: We used the nationwide and representative data from the Swiss Health Surveys 2007 and 2012. We analysed the self-reported use of mammography in the last 12 months (proportion of population) among women aged 40-79 years, and opportunistic (without clinical symptoms, initiated by the woman or a physician) and programmatic screening mammography (as part of a systematic screen...
Source: Swiss Medical Weekly - May 14, 2018 Category: General Medicine Authors: Fenner L, Kässner A, Berlin C, Egger M, Zwahlen M Tags: Swiss Med Wkly Source Type: research

The impact of clinical trial units on the value of clinical research in Switzerland.
s C Abstract A prominent 2014 series by The Lancet on "Increasing value, reducing waste in biomedical research" provided recommendations on how to optimise precious resources, including in clinical research. Despite being ideally placed to lead the movement in patient-oriented clinical research, academia struggles to take corresponding measures and find ways to evaluate their impact. A decade ago, Swiss stakeholders established constructive initiatives to improve the quality of clinical research, including a national Clinical Trial Unit (CTU) Network, predominantly rooted in university hospitals. At the ...
Source: Swiss Medical Weekly - April 26, 2018 Category: General Medicine Authors: von Niederhäusern B, Magnin A, Pauli-Magnus C Tags: Swiss Med Wkly Source Type: research

Occupational exposure to plant protection products and health effects in Switzerland: what do we know and what do we need to do?
CONCLUSIONS: Due to increasing evidence of an association between PPP exposure and health effects, increased collaboration between stakeholders is necessary to develop links between the data sources that already exist. Our study was the first to investigate the health effects linked to PPP exposure among the Swiss agricultural population. The recommendations presented in this paper would help promote a safer and healthier agricultural workforce in Switzerland, as well as the population at large. PMID: 29698541 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 26, 2018 Category: General Medicine Authors: Graczyk H, Hopf NB, Mediouni Z, Guseva-Canu I, Sanvido O, Schmid K, Berthet A Tags: Swiss Med Wkly Source Type: research

Point prevalence of healthcare-associated infections and antibiotic use in three large Swiss acute-care hospitals.
CONCLUSIONS: HAI prevalence and antimicrobial use in this survey were similar to findings of the past ECDC PPS. The ECDC methodology proved applicable to Swiss acute-care hospitals. PMID: 29698542 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 26, 2018 Category: General Medicine Authors: Metsini A, Vazquez M, Sommerstein R, Marschall J, Voide C, Troillet N, Gardiol C, Pittet D, Zingg W, The Swissnoso Network Tags: Swiss Med Wkly Source Type: research

Clinical course and prevalence of coercive measures: an observational study among involuntarily hospitalised psychiatric patients.
CONCLUSIONS: The prevalence of coercive measures is still high in involuntarily hospitalised patients. Seclusion was the most frequently used coercive measure, which may be based on cultural and clinical aspects and differs from findings in other countries where restraint is more frequently used. Some sociodemographic and clinical characteristics were associated with the use of coercion. This underlines the importance of developing treatment strategies for patients at risk to prevent situations in which the use of coercion is necessary. To enable comparison between different study sites, standardised protocols should be us...
Source: Swiss Medical Weekly - April 26, 2018 Category: General Medicine Authors: Hotzy F, Moetteli S, Theodoridou A, Schneeberger AR, Seifritz E, Hoff P, Jäger M Tags: Swiss Med Wkly Source Type: research

The Swiss Cystic Fibrosis Infant Lung Development (SCILD) cohort.
Abstract The Swiss Cystic Fibrosis Infant Lung Development (SCILD) cohort is a prospective birth cohort study investigating the initiating events of cystic fibrosis lung disease during infancy, and their influence on the trajectory of disease progression throughout early childhood. Infants with cystic fibrosis are recruited throughout Switzerland after diagnosis by new-born screening. It is the first European population-based prospective cohort study of infants with cystic fibrosis taking advantage of a nationwide new-born screening programme. The study was established in 2011 and recruitment is ongoing. The cohor...
Source: Swiss Medical Weekly - April 26, 2018 Category: General Medicine Authors: Korten I, Kieninger E, Yammine S, Regamey N, Nyilas S, Ramsey K, Casaulta C, Latzin P, For The Scild Study Group Tags: Swiss Med Wkly Source Type: research

The role of molecular imaging in assessing degenerative parkinsonism - an updated review.
Abstract Diagnosing degenerative forms of parkinsonism still relies on a thorough clinical assessment, which in Parkinson's disease involves the presence of an asymmetric bradykinesia with rest tremor and/or rigidity that respond substantially to levodopa. Conversely, atypical forms, including multiple system atrophy, progressive supranuclear palsy and corticobasal degeneration, exhibit additional features (cerebellar or pyramidal signs, early postural instability), a poor response to dopamine replacement therapy and a bad prognosis. Consensus diagnostic criteria have excellent specificity, but lack sensitivity, a...
Source: Swiss Medical Weekly - April 26, 2018 Category: General Medicine Authors: Nicastro N, Garibotto V, Burkhard PR Tags: Swiss Med Wkly Source Type: research

The epidemiology of hepatitis C in Switzerland: trends in notifications, 1988-2015.
l M Abstract With an estimated antibody prevalence of 0.7% in the low-risk population, hepatitis C virus (HCV) endemicity in Switzerland is low. We reviewed data from mandatory hepatitis C surveillance for 1988-2015 in order to describe the evolution of acute HCV infections and newly reported non-acute cases, and their epidemiological features. Crude and stratified annual incidence and notification rates and rate ratios were calculated using Poisson regression. Acute HCV incidence peaked in 2002 at 1.8 cases per 100,000 population, then declined sharply, levelling at around 0.7/100,000 from 2006. Notification rate...
Source: Swiss Medical Weekly - April 26, 2018 Category: General Medicine Authors: Richard JL, Schaetti C, Basler S, Mäusezahl M Tags: Swiss Med Wkly Source Type: research

First case of Candida auris in Switzerland: discussion about preventive strategies.
PMID: 29698547 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 26, 2018 Category: General Medicine Authors: Riat A, Neofytos D, Coste A, Harbarth S, Bizzini A, Grandbastien B, Pugin J, Lamoth F Tags: Swiss Med Wkly Source Type: research

The place of the Ozaki procedure in the treatment of aortic valve disease.
re R PMID: 29698548 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 26, 2018 Category: General Medicine Authors: Sologashvili T, Prêtre R Tags: Swiss Med Wkly Source Type: research

Impairment of chondrocyte proliferation after exposure of young murine cartilage to an aged systemic environment in a heterochronic parabiosis model.
Abstract AIM: The aim of this study was to investigate whether an aged systemic environment could impair young cartilage tissue in mice. METHODS: Mice differing in age were randomly divided into three groups. Group 1 was the experimental group (Y/O group) consisting of the heterochronic parabiosis model (2-month-old/12-month-old, young/old). Group 2 was the surgical control group (Y/Y group) with the isochronic parabiosis model (2-month-old/2-month-old, young/young). Group 3 consisted of the ageing control mice (2-month-old alone, Y group). Young knee cartilages collected from all three groups at 4 months aft...
Source: Swiss Medical Weekly - April 25, 2018 Category: General Medicine Authors: Li L, Wei X, Geng X, Duan Z, Wang X, Li P, Wang C, Wei L Tags: Swiss Med Wkly Source Type: research

Extended-criteria donors in lung transplantation in Switzerland: an evaluation of two adapted lung donor scores.
CONCLUSIONS: Both scoring systems are able to predict whether or not donor lungs are accepted by the two Swiss lung transplant centres. As an alternative to adapting an established scoring system, a national lung quality score could be derived de novo. This could be based on a logistic regression analysis including the most relevant donor characteristics. However, such a new score would need to be validated on an independent sample and ideally tested for its predictive value in terms of post-transplantation outcome. PMID: 29689119 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 24, 2018 Category: General Medicine Authors: Elmer A, Birrer M, Weiss J, Aubert JD, Benden C, Inci I, Krüger T, Soccal PM, Immer FF Tags: Swiss Med Wkly Source Type: research