Redox-activity and in vitro effects of regional atmospheric aerosol pollution: Seasonal differences and correlation between oxidative potential and in vitro toxicity of PM < sub > 1 < /sub >
Toxicol Appl Pharmacol. 2024 Mar 22:116913. doi: 10.1016/j.taap.2024.116913. Online ahead of print.ABSTRACTParticulate Matter (PM) is a complex and heterogeneous mixture of atmospheric particles recognized as a threat to human health. Oxidative Potential (OP) measurement is a promising and integrative method for estimating PM-induced health impacts since it is recognized as more closely associated with adverse health effects than ordinarily used PM mass concentrations. OP measurements could be introduced in the air quality monitoring, along with the parameters currently evaluated. PM deposition in the lungs induces oxidati...
Source: Toxicology and Applied Pharmacology - March 24, 2024 Category: Toxicology Authors: Gloria Melzi Lorenzo Massimi Maria Agostina Frezzini Martina Iulini Naima Tarallo Matteo Rinaldi Marco Paglione Emma Nozza Federica Crova Sara Valentini Gianluigi Valli Francesca Costabile Silvia Canepari Stefano Decesari Roberta Vecchi Marina Marinovich Source Type: research
Preparation, antibacterial activity, and structure-activity relationship of low molecular weight κ-carrageenan
Int J Biol Macromol. 2024 Mar 22:131021. doi: 10.1016/j.ijbiomac.2024.131021. Online ahead of print.ABSTRACTκ-Carrageenan (KC) is a polysaccharide widely used in food industry. It has been widely studied for its excellent physicochemical and beneficial properties. However, the high molecular weight and high viscosity of KC make it difficult to be absorbed and to exert its' biological activities, thus limit its extensive industrial application. In order to solve this problem, five low molecular weight κ-carrageenans (DCPs) were prepared by the degradation of KC using hydrogen peroxide (H2O2) and ascorbic acid (AH2). The c...
Source: International Journal of Biological Macromolecules - March 24, 2024 Category: Biochemistry Authors: Haibing Huang Qing Wang Zichen Ning Yake Ma Yayan Huang Yaqing Wu Yucheng Yang Meitian Xiao Jing Ye Source Type: research
Ascorbyl palmitate ameliorates inflammatory diseases by inhibition of NLRP3 inflammasome
Int Immunopharmacol. 2024 Mar 23;131:111915. doi: 10.1016/j.intimp.2024.111915. Online ahead of print.ABSTRACTThe aberrant activation of NLRP3 inflammasome contributes to pathogenesis of multiple inflammation-driven human diseases. However, the medications targeting NLRP3 inflammasome are not approved for clinic use to date. Here, we show that ascorbyl palmitate (AP), a lipophilic derivative of ascorbic acid (AA) and a safe food additive, is a potent inhibitor of NLRP3 inflammasome. Compared with AA, AP inhibited the activation of NLRP3 inflammasome with increased potency and specificity. Mechanistically, AP directly scave...
Source: International Immunopharmacology - March 24, 2024 Category: Allergy & Immunology Authors: Luchen Zhang Guoyang Li Bolong Lin Hongbin He Rongbin Zhou Wei Jiang Source Type: research
Redox-activity and in vitro effects of regional atmospheric aerosol pollution: Seasonal differences and correlation between oxidative potential and in vitro toxicity of PM < sub > 1 < /sub >
Toxicol Appl Pharmacol. 2024 Mar 24;485:116913. doi: 10.1016/j.taap.2024.116913. Online ahead of print.ABSTRACTParticulate Matter (PM) is a complex and heterogeneous mixture of atmospheric particles recognized as a threat to human health. Oxidative Potential (OP) measurement is a promising and integrative method for estimating PM-induced health impacts since it is recognized as more closely associated with adverse health effects than ordinarily used PM mass concentrations. OP measurements could be introduced in the air quality monitoring, along with the parameters currently evaluated. PM deposition in the lungs induces oxi...
Source: Toxicology and Applied Pharmacology - March 24, 2024 Category: Toxicology Authors: Gloria Melzi Lorenzo Massimi Maria Agostina Frezzini Martina Iulini Naima Tarallo Matteo Rinaldi Marco Paglione Emma Nozza Federica Crova Sara Valentini Gianluigi Valli Francesca Costabile Silvia Canepari Stefano Decesari Roberta Vecchi Marina Marinovich Source Type: research
Preparation, antibacterial activity, and structure-activity relationship of low molecular weight κ-carrageenan
Int J Biol Macromol. 2024 Mar 22:131021. doi: 10.1016/j.ijbiomac.2024.131021. Online ahead of print.ABSTRACTκ-Carrageenan (KC) is a polysaccharide widely used in food industry. It has been widely studied for its excellent physicochemical and beneficial properties. However, the high molecular weight and high viscosity of KC make it difficult to be absorbed and to exert its' biological activities, thus limit its extensive industrial application. In order to solve this problem, five low molecular weight κ-carrageenans (DCPs) were prepared by the degradation of KC using hydrogen peroxide (H2O2) and ascorbic acid (AH2). The c...
Source: International Journal of Biological Macromolecules - March 24, 2024 Category: Biochemistry Authors: Haibing Huang Qing Wang Zichen Ning Yake Ma Yayan Huang Yaqing Wu Yucheng Yang Meitian Xiao Jing Ye Source Type: research
Vitamin deficiencies in children: Lessons from clinical and neuroimaging findings
CONCLUSIONS: Acquired vitamin deficiencies may display reversible clinical symptoms mimicking inherited metabolic disorders. Some situations raise suspicion for diagnosis: concordant clinical presentation, suggestive neuroimaging findings, and/or biochemical evidence. Any acute neurological condition should be treated without waiting for definitive biochemical confirmation.PMID:38520815 | DOI:10.1016/j.ejpn.2024.02.013 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - March 23, 2024 Category: Neurology Authors: Gabrielle Dupuy Charles-Joris Roux R émi Barrois Apolline Imbard Cl ément Pontoizeau Marie Th érèse Dangles M élodie Aubart Jean-Baptiste Arnoux Diane Margoses Ana ïs Brassier Clothilde Marbach Claire-Marine B érat Eug énie Sarda Cyril Gitiaux Pas Source Type: research
Vitamin deficiencies in children: Lessons from clinical and neuroimaging findings
CONCLUSIONS: Acquired vitamin deficiencies may display reversible clinical symptoms mimicking inherited metabolic disorders. Some situations raise suspicion for diagnosis: concordant clinical presentation, suggestive neuroimaging findings, and/or biochemical evidence. Any acute neurological condition should be treated without waiting for definitive biochemical confirmation.PMID:38520815 | DOI:10.1016/j.ejpn.2024.02.013 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - March 23, 2024 Category: Neurology Authors: Gabrielle Dupuy Charles-Joris Roux R émi Barrois Apolline Imbard Cl ément Pontoizeau Marie Th érèse Dangles M élodie Aubart Jean-Baptiste Arnoux Diane Margoses Ana ïs Brassier Clothilde Marbach Claire-Marine B érat Eug énie Sarda Cyril Gitiaux Pas Source Type: research
Vitamin deficiencies in children: Lessons from clinical and neuroimaging findings
CONCLUSIONS: Acquired vitamin deficiencies may display reversible clinical symptoms mimicking inherited metabolic disorders. Some situations raise suspicion for diagnosis: concordant clinical presentation, suggestive neuroimaging findings, and/or biochemical evidence. Any acute neurological condition should be treated without waiting for definitive biochemical confirmation.PMID:38520815 | DOI:10.1016/j.ejpn.2024.02.013 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - March 23, 2024 Category: Neurology Authors: Gabrielle Dupuy Charles-Joris Roux R émi Barrois Apolline Imbard Cl ément Pontoizeau Marie Th érèse Dangles M élodie Aubart Jean-Baptiste Arnoux Diane Margoses Ana ïs Brassier Clothilde Marbach Claire-Marine B érat Eug énie Sarda Cyril Gitiaux Pas Source Type: research
