Integrative medicine, naturopathic and complementary medicine in the treatment of fibromyalgia syndrome : An overview against the background of clinical experiences from routine treatment
Schmerz. 2023 May 22. doi: 10.1007/s00482-023-00716-7. Online ahead of print.ABSTRACTFibromyalgia syndrome is classified as a functional somatic syndrome. There are typical but not clearly defined symptom clusters, such as chronic widespread pain, non-restorative sleep, and a tendency to physical and/or mental exhaustion. The core principle of treatment in the S3 guidelines is a multimodal treatment, especially for severe forms of the disease. Complementary, naturopathic and integrative forms of treatment have an established place in the guidelines. Strong treatment recommendations with a high consensus exist for endurance...
Source: Schmerz - May 22, 2023 Category: Anesthesiology Authors: Andrea Langhorst Jost Langhorst Source Type: research
Integrative medicine, naturopathic and complementary medicine in the treatment of fibromyalgia syndrome : An overview against the background of clinical experiences from routine treatment
Schmerz. 2023 May 22. doi: 10.1007/s00482-023-00716-7. Online ahead of print.ABSTRACTFibromyalgia syndrome is classified as a functional somatic syndrome. There are typical but not clearly defined symptom clusters, such as chronic widespread pain, non-restorative sleep, and a tendency to physical and/or mental exhaustion. The core principle of treatment in the S3 guidelines is a multimodal treatment, especially for severe forms of the disease. Complementary, naturopathic and integrative forms of treatment have an established place in the guidelines. Strong treatment recommendations with a high consensus exist for endurance...
Source: Schmerz - May 22, 2023 Category: Anesthesiology Authors: Andrea Langhorst Jost Langhorst Source Type: research
Secondary structure of the human mitochondrial genome affects formation of deletions
Aging in postmitotic tissues is associated with clonal expansion of somatic mitochondrial deletions, the origin of which is not well understood. Such deletions are often flanked by direct nucleotide repeats, b... (Source: BMC Biology)
Source: BMC Biology - May 8, 2023 Category: Biology Authors: Victor Shamanskiy, Alina A. Mikhailova, Evgenii O. Tretiakov, Kristina Ushakova, Alina G. Mikhailova, Sergei Oreshkov, Dmitry A. Knorre, Natalia Ree, Jonathan B. Overdevest, Samuel W. Lukowski, Irina Gostimskaya, Valerian Yurov, Chia-Wei Liou, Tsu-Kung Li Tags: Research article Source Type: research
[ASAP] Visualizing Cardiolipin In Situ with HKCL-1M, a Highly Selective and Sensitive Fluorescent Probe
Journal of the American Chemical SocietyDOI: 10.1021/jacs.3c00243 (Source: Journal of the American Chemical Society)
Source: Journal of the American Chemical Society - April 27, 2023 Category: Chemistry Authors: Wei Wang, Nai-Kei Wong, Siu-Lun Bok, You Xu, Yang Guo, Lu Xu, Meiling Zuo, Claudette M. St. Croix, Gaowei Mao, Alexandr Kapralov, Hu ̈lya Bayir▼⧫, Valerian E. Kagan, and Dan Yang Source Type: research
Intestinal permeability and gut microbiota interactions of pharmacologically active compounds in valerian and St. John's wort
Biomed Pharmacother. 2023 Apr 5;162:114652. doi: 10.1016/j.biopha.2023.114652. Online ahead of print.ABSTRACTPhytomedicines such as valerian and St. John's wort are widely used for the treatment of sleeping disorders, anxiety and mild depression. They are perceived as safe alternatives to synthetic drugs, but limited information is available on the intestinal absorption and interaction with human intestinal microbiota of pharmacologically relevant constituents valerenic acid in valerian, and hyperforin and hypericin in St. John's wort. The intestinal permeability of these compounds and the antidepressant and anxiolytic dru...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 7, 2023 Category: Drugs & Pharmacology Authors: Antoine Chauveau Andrea Treyer Annelies Geirnaert Lea Bircher Angela Babst Vanessa Fabienne Abegg Ana Paula Sim ões-Wüst Christophe Lacroix Olivier Potterat Matthias Hamburger Source Type: research
Intestinal permeability and gut microbiota interactions of pharmacologically active compounds in valerian and St. John's wort
Biomed Pharmacother. 2023 Apr 5;162:114652. doi: 10.1016/j.biopha.2023.114652. Online ahead of print.ABSTRACTPhytomedicines such as valerian and St. John's wort are widely used for the treatment of sleeping disorders, anxiety and mild depression. They are perceived as safe alternatives to synthetic drugs, but limited information is available on the intestinal absorption and interaction with human intestinal microbiota of pharmacologically relevant constituents valerenic acid in valerian, and hyperforin and hypericin in St. John's wort. The intestinal permeability of these compounds and the antidepressant and anxiolytic dru...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 7, 2023 Category: Drugs & Pharmacology Authors: Antoine Chauveau Andrea Treyer Annelies Geirnaert Lea Bircher Angela Babst Vanessa Fabienne Abegg Ana Paula Sim ões-Wüst Christophe Lacroix Olivier Potterat Matthias Hamburger Source Type: research
Transplacental passage of hyperforin, hypericin, and valerenic acid
Safe medications for mild mental diseases in pregnancy are needed. Phytomedicines from St. John’s wort and valerian are valid candidates, but safety data in pregnancy are lacking. The transplacental transport of hyperforin and hypericin (from St. John’s wort), and valerenic acid (from valerian) was evaluated using the ex vivo cotyledon perfusion model (4 h perfusions, term placentae) and, in part, the in vitro Transwell assay with BeWo b30 cells. Antipyrine was used for comparison in both models. U(H)PLC-MS/MS bioanalytical methods were developed to quantify the compounds. Perfusion data obtained with term placentae s...
Source: Frontiers in Pharmacology - March 31, 2023 Category: Drugs & Pharmacology Source Type: research
Melanoma-associated repair-like Schwann cells suppress anti-tumor T-cells via 12/15-LOX/COX2-associated eicosanoid production
Volume 12, Issue 1, December 2023 . (Source: OncoImmunology)
Source: OncoImmunology - March 25, 2023 Category: Cancer & Oncology Authors: Oleg Kruglov Kavita Vats Vishal Soman Vladimir A. Tyurin Yulia Y. Tyurina Jiefei Wang Li ’an Williams Jiying Zhang Cara Donahue Carey Erik Jaklitsch Uma R. Chandran H ülya Bayir Valerian E. Kagan Yuri L. Bunimovich Source Type: research
Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney
Nature Reviews Nephrology, Published online: 15 March 2023; doi:10.1038/s41581-023-00689-xFerroptosis is an iron-dependent mechanism of regulated necrosis that is driven by the robust oxidation of polyunsaturated fatty acid-containing phospholipids. This Review describes the fundamental mechanisms of ferroptosis, the potential contribution of ferroptosis to kidney disease and therapeutic strategies for targeting ferroptosis. (Source: Nature Reviews Nephrology)
Source: Nature Reviews Nephrology - March 15, 2023 Category: Urology & Nephrology Authors: H ülya Bayır Scott J. Dixon Yulia Y. Tyurina John A. Kellum Valerian E. Kagan Source Type: research
Redox phospholipidomics discovers pro-ferroptotic death signals in A375 melanoma cells in vitro and in vivo
Redox Biol. 2023 Feb 28;61:102650. doi: 10.1016/j.redox.2023.102650. Online ahead of print.ABSTRACTGrowing cancer cells effectively evade most programs of regulated cell death, particularly apoptosis. This necessitates a search for alternative therapeutic modalities to cause cancer cell's demise, among them - ferroptosis. One of the obstacles to using pro-ferroptotic agents to treat cancer is the lack of adequate biomarkers of ferroptosis. Ferroptosis is accompanied by peroxidation of polyunsaturated species of phosphatidylethanolamine (PE) to hydroperoxy- (-OOH) derivatives, which act as death signals. We demonstrate that...
Source: Cancer Control - March 4, 2023 Category: Cancer & Oncology Authors: Yulia Y Tyurina Alexandr A Kapralov Vladimir A Tyurin Galina Shurin Andrew A Amoscato Dhivyaa Rajasundaram Hua Tian Yuri L Bunimovich Yulia Nefedova William G Herrick Ralph E Parchment James H Doroshow Hulya Bayir Apurva K Srivastava Valerian E Kagan Source Type: research
Piloting a hospital-based road traffic injury surveillance system in Nairobi County, Kenya, 2018 –2019
Road traffic injuries (RTIs) cause an estimated 1.35 million deaths globally every year, and they are the leading cause of death among people aged 5 –29 years.[1] Approximately 93% of fatal RTIs occur in low- and middle-income countries (LMICs). More than half of RTI deaths are among vulnerable road users such as pedestrians, cyclists, and motorcyclists,[1] who have the highest risk of injury or death since they have minimal external protectio n to absorb crash forces and reduce crash impact.[2] In addition, approximately 50 million people suffer nonfatal RTIs every year, many of which can result in long-term disability....
Source: Injury - February 26, 2023 Category: Orthopaedics Authors: Valerian Mwenda, Merissa A. Yellman, Elvis Oyugi, Philip Mwachaka, Gladwell Gathecha, Zeinab Gura Source Type: research
[ASAP] Impact of Topological Parameters on Melt Rheological Properties and Foamability of PS POM-POMs
MacromoleculesDOI: 10.1021/acs.macromol.2c02051 (Source: Macromolecules)
Source: Macromolecules - February 23, 2023 Category: Chemistry Authors: Marie-Christin Ro ̈pert, Valerian Hirschberg, Max G. Schußmann, and Manfred Wilhelm Source Type: research
Balanced Nonopioid General Anesthesia With Lidocaine Is Associated With Lower Postoperative Complications Compared With Balanced Opioid General Anesthesia With Sufentanil for Cardiac Surgery With Cardiopulmonary Bypass: A Propensity Matched Cohort Study
CONCLUSIONS: A balanced nonopioid general anesthesia protocol with lidocaine was associated with lower odds of postoperative complication composite outcome based on respiratory failure and confusion.PMID:36763521 | DOI:10.1213/ANE.0000000000006383 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - February 10, 2023 Category: Anesthesiology Authors: Pierre-Gr égoire Guinot Stefan Andrei Bastien Durand Audrey Martin Valerian Duclos Alexandra Spitz Vivien Berthoud Tiberiu Constandache Sandrine Grosjean Mohamed Radhouani Jean-Baptiste Anciaux Maxime Nguyen Belaid Bouhemad Source Type: research
Balanced Nonopioid General Anesthesia With Lidocaine Is Associated With Lower Postoperative Complications Compared With Balanced Opioid General Anesthesia With Sufentanil for Cardiac Surgery With Cardiopulmonary Bypass: A Propensity Matched Cohort Study
CONCLUSIONS: A balanced nonopioid general anesthesia protocol with lidocaine was associated with lower odds of postoperative complication composite outcome based on respiratory failure and confusion.PMID:36763521 | DOI:10.1213/ANE.0000000000006383 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - February 10, 2023 Category: Anesthesiology Authors: Pierre-Gr égoire Guinot Stefan Andrei Bastien Durand Audrey Martin Valerian Duclos Alexandra Spitz Vivien Berthoud Tiberiu Constandache Sandrine Grosjean Mohamed Radhouani Jean-Baptiste Anciaux Maxime Nguyen Belaid Bouhemad Source Type: research
Balanced Nonopioid General Anesthesia With Lidocaine Is Associated With Lower Postoperative Complications Compared With Balanced Opioid General Anesthesia With Sufentanil for Cardiac Surgery With Cardiopulmonary Bypass: A Propensity Matched Cohort Study
CONCLUSIONS: A balanced nonopioid general anesthesia protocol with lidocaine was associated with lower odds of postoperative complication composite outcome based on respiratory failure and confusion.PMID:36763521 | DOI:10.1213/ANE.0000000000006383 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - February 10, 2023 Category: Anesthesiology Authors: Pierre-Gr égoire Guinot Stefan Andrei Bastien Durand Audrey Martin Valerian Duclos Alexandra Spitz Vivien Berthoud Tiberiu Constandache Sandrine Grosjean Mohamed Radhouani Jean-Baptiste Anciaux Maxime Nguyen Belaid Bouhemad Source Type: research
