PLA2G6 guards placental trophoblasts against ferroptotic injury [Applied Biological Sciences]
The recently identified ferroptotic cell death is characterized by excessive accumulation of hydroperoxy-arachidonoyl (C20:4)- or adrenoyl (C22:4)- phosphatidylethanolamine (Hp-PE). The selenium-dependent glutathione peroxidase 4 (GPX4) inhibits ferroptosis, converting unstable ferroptotic lipid hydroperoxides to nontoxic lipid alcohols in a tissue-specific manner. While placental oxidative stress and lipotoxicity are hallmarks of placental... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - November 3, 2020 Category: Science Authors: Ofer Beharier, Vladimir A. Tyurin, Julie P. Goff, Jennifer Guerrero-Santoro, Kazuhiro Kajiwara, Tianjiao Chu, Yulia Y. Tyurina, Claudette M. St Croix, Callen T. Wallace, Samuel Parry, W. Tony Parks, Valerian E. Kagan, Yoel Sadovsky Tags: Biological Sciences Source Type: research
Molecules, Vol. 25, Pages 5067: Extraction of Inulin from Andean Plants: An Approach to Non-Traditional Crops of Ecuador
Jaramillo
Inulin is a polysaccharide of fructose widely used in the food and pharmaceutical industry due to its physicochemical properties and technological applications. Inulin from jicama (Smallanthus sonchifolius) and cabuya (Agave americana) was obtained. The steps for inulin obtention were: raw material preparation, extraction and purification. The extraction conditions were determined using a random design with three levels of stirring speed (0, 130 and 300 rpm), and a 32 factorial experimental design with three levels of temperature (40, 60 and 80 °C) and solid:liquid ratio (1:2, 1:3 and 1:5 S:L). Th...
Source: Molecules - November 1, 2020 Category: Chemistry Authors: Freddy R. Escobar-Ledesma Vanessa E. S ánchez-Moreno Edwin Vera Valerian Ciobot ă Paul Vargas Jentzsch Lorena I. Jaramillo Tags: Article Source Type: research
Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis
Cell Death & Disease, Published online: 27 October 2020; doi:10.1038/s41419-020-03118-0Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis (Source: Cell death and disease)
Source: Cell death and disease - October 27, 2020 Category: Internal Medicine Authors: Bartosz Wiernicki Hanne Dubois Yulia Y. Tyurina Behrouz Hassannia H ülya Bayir Valerian E. Kagan Peter Vandenabeele Andy Wullaert Tom Vanden Berghe Source Type: research
[ASAP] Studies on the Impact of Malting and Mashing on the Free, Soluble Ester-Bound, and Insoluble Ester-Bound Forms of Desired and Undesired Phenolic Acids Aiming at Styrene Mitigation during Wheat Beer Brewing
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.0c04835 (Source: Journal of Agricultural and Food Chemistry)
Source: Journal of Agricultural and Food Chemistry - October 20, 2020 Category: Food Science Authors: Valerian Kalb, Torsten Seewald, Thomas Hofmann, and Michael Granvogl Source Type: research
Resolving the paradox of ferroptotic cell death: ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis
Publication date: Available online 16 October 2020Source: Redox BiologyAuthor(s): Tamil S. Anthonymuthu, Yulia Y. Tyurina, Wan-Yang Sun, Karolina Mikulska-Ruminska, Indira H. Shrivastava, Vladimir A. Tyurin, Fatma B. Cinemre, Haider H. Dar, Andrew P. VanDemark, Theodore R. Holman, Yoel Sadovsky, Brent R. Stockwell, Rong-Rong He, Ivet Bahar, Hülya Bayır, Valerian E. Kagan (Source: Redox Biology)
Source: Redox Biology - October 16, 2020 Category: Biology Source Type: research
Engineering functional group decorated ZIFs to high-performance Pd@ZIF-92 nanocatalysts for C(sp2)-C(sp2) couplings in aqueous medium
Publication date: Available online 8 October 2020Source: Journal of CatalysisAuthor(s): Li-Xin You, Bai-Bei Zhao, Shan-Xin Yao, Gang Xiong, Ileana Dragutan, Valerian Dragutan, Fu Ding, Ya-Guang Sun (Source: Journal of Catalysis)
Source: Journal of Catalysis - October 9, 2020 Category: Chemistry Source Type: research
A pervasive framework toward sustainability and smart-growth: Assessing multifaceted transportation performance measures for smart cities
Publication date: December 2020Source: Journal of Transport & Health, Volume 19Author(s): Ahmad Feizi, Shinhye Joo, Valerian Kwigizile, Jun-Seok Oh (Source: Journal of Transport and Health)
Source: Journal of Transport and Health - October 8, 2020 Category: Occupational Health Source Type: research
The Critical Role of Pulmonary Artery Wedge Pressure Saturation In The Standardization of Pulmonary Artery Wedge Pressure Measurement
Inadequate balloon occlusion while measuring pulmonary artery wedge pressure (PAWP) during right heart catheterization (RHC) may lead to inaccurate measures and clinically relevant misdiagnosis of disease. Following the 6th World Symposium on Pulmonary Hypertension (PH) recommendations, we instituted a standard of care clinical protocol at the Medical University of South Carolina that required obtaining a PAWP saturation (sat) to confirm complete occlusion whenever initially measured PAWP is>15 mmHg. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 30, 2020 Category: Cardiology Authors: Michael C. Viray, Eric L. Bonno, Nicholas Gabrielle, Jessica L. Atkins, Nicholas S. Amoroso, Valerian L.C. Fernandez, Anbukarasi Maran, Christopher D. Nielsen, Eric R. Powers, Daniel H. Steinberg, Thomas M. Todoran, Thomas G. Di Salvo, Gregory R. Jackson, Tags: 110 Source Type: research
Management of Nonoperative Diverticulitis : Is Surgical Admission Always Best?
CONCLUSION: Institutional policy mandating admissions for patients receiving nonoperative management of diverticulitis to surgical services does not reduce hospital LOS or cost. This argues that admission to medical services may be an acceptable practice. This raises the question, is acute diverticulitis always a surgical issue?
PMID: 32967441 [PubMed - as supplied by publisher] (Source: The American Surgeon)
Source: The American Surgeon - September 22, 2020 Category: Surgery Authors: Malizia RA, Martinolich JL, Ata A, Fitz NG, Williams KK, Valerian BT, Stain SC, Lee EC Tags: Am Surg Source Type: research
Lysocardiolipin acyltransferase regulates NSCLC cell proliferation and migration by modulating mitochondrial dynamics [Lipids]
In this study, in silico analysis of TCGA lung cancer data sets revealed a significant increase in LYCAT expression, which was later corroborated in human lung cancer tissues and immortalized lung cancer cell lines via indirect immunofluorescence and immunoblotting, respectively. Stable knockdown of LYCAT in NSCLC cell lines not only reduced CL and increased monolyso-CL levels but also reduced in vivo tumor growth, as determined by xenograft studies in athymic nude mice. Furthermore, blocking LYCAT activity using a LYCAT mimetic peptide attenuated cell migration, suggesting a novel role for LYCAT activity in promoting NSCL...
Source: Journal of Biological Chemistry - September 17, 2020 Category: Chemistry Authors: Long Shuang Huang, Sainath R. Kotha, Sreedevi Avasarala, Michelle VanScoyk, Robert A. Winn, Arjun Pennathur, Puttaraju S. Yashaswini, Mounica Bandela, Ravi Salgia, Yulia Y. Tyurina, Valerian E. Kagan, Xiangdong Zhu, Sekhar P. Reddy, Tara Sudhadevi, Prasan Tags: Molecular Bases of Disease Source Type: research
Chemical constituents isolated from Valeriana officinalis L
Publication date: December 2020Source: Biochemical Systematics and Ecology, Volume 93Author(s): Hao Fan, Yuze Li, Xiaofei Liang, Shuting Yan, Yuwen Cui, Huawei Zhang, Wenli Huang, Xinjie Yang, Xiaomei Song (Source: Biochemical Systematics and Ecology)
Source: Biochemical Systematics and Ecology - September 16, 2020 Category: Biochemistry Source Type: research
Molecules, Vol. 25, Pages 4212: Field-Scale Evaluation of Botanical Extracts Effect on the Yield, Chemical Composition and Antioxidant Activity of Celeriac (Apium graveolens L. Var. rapaceum)
szula Piszcz
The use of higher plants for the production of plant growth biostimulants is receiving increased attention among scientists, farmers, investors, consumers and regulators. The aim of the present study was to examine the possibility of converting plants commonly occurring in Europe (St. John’s wort, giant goldenrod, common dandelion, red clover, nettle, valerian) into valuable and easy to use bio-products. The biostimulating activity of botanical extracts and their effect on the chemical composition of celeriac were identified. Plant-based extracts, obtained by ultrasound-assisted extraction an...
Source: Molecules - September 13, 2020 Category: Chemistry Authors: Katarzyna Godlewska Pawe ł Pacyga Izabela Michalak Anita Biesiada Antoni Szumny Natalia Pachura Urszula Piszcz Tags: Article Source Type: research
[ASAP] Photoluminescence Response in Carbon Nanomaterials to Enzymatic Degradation
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01380 (Source: Analytical Chemistry)
Source: Analytical Chemistry - September 4, 2020 Category: Chemistry Authors: Xiaoyun He, David L. White, Alexandr A. Kapralov, Valerian E. Kagan, and Alexander Star Source Type: research
The role of electrophysiologic study in high ‐risk patients with new‐onset conduction disturbances following alcohol septal ablation for hypertrophic obstructive cardiomyopathy
Journal of Cardiovascular Electrophysiology, EarlyView. (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - July 17, 2020 Category: Cardiology Authors: Patrick Badertscher,
Thomas A. Turnage,
Valerian Fernandes,
Christopher Nielsen,
Michael R. Gold Tags: BRIEF COMMUNICATION Source Type: research
The Role of Electrophysiologic Study in High Risk Patients with New ‐onset Conduction Disturbances following Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy
This article is protected by copyright. All rights reserved. (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - July 12, 2020 Category: Cardiology Authors: Patrick Badertscher,
Thomas A. Turnage,
Valerian Fernandes,
Christopher Nielsen,
Michael R. Gold Tags: BRIEF COMMUNICATION Source Type: research
