Use of a 5-Item Modified Frailty Index for Assessing Outcomes After Hartmann's Reversal: An ACS-NSQIP Study
DISCUSSION: An mFI-5 of ≥2 was associated with greater morbidity, mortality, and eLOS following Hartmann's reversal. However, there were no mortality or eLOS differences in patients with an mFI-5 of 1 and only a 14% increase in any morbidity, making these patients potentially good candidates for Hartmann's reversal. Furthermore, laparoscopic surgery was associated with a protective effect for overall morbidity and eLOS, potentially mitigating some of the risk associated with higher frailty scores.PMID:37978813 | DOI:10.1177/00031348231216483 (Source: The American Surgeon)
Source: The American Surgeon - November 18, 2023 Category: Surgery Authors: Kathryn E Ottaviano David C Palange Susanna S Hill Ashar Ata A David Chismark Jonathan J Canete Brian T Valerian Edward C Lee Source Type: research
Pharmaceutical agents as potential drivers in the development of Early-Onset Colorectal Cancer: A Case-Control Study
CONCLUSIONS: Our analysis suggests that the development of EOCRC may be correlated with prior use of specific medications. Additional analyses should be employed to validate the results. The mechanism of action inducing EOCRC by candidate pharmaceutical agents will then need to be determined.PMID:37933755 | DOI:10.2196/50110 (Source: Cancer Control)
Source: Cancer Control - November 7, 2023 Category: Cancer & Oncology Authors: Irit Ben-Aharon Ran Rotem Cheli Metzger Gilad Twig Andrea Cercek Elizabeth Half Tal Ghosen Gabriel Chodik David Kelsen Source Type: research
Plants and mental disorders: the case of Catalan linguistic area
Discussion: The number of use reports analysed to treat mental disorders in CLA is 2,544 spread over 183 taxa belonging to 64 families, being the most cited the Malvaceae (29.36% of use reports), Lamiaceae (16.71%), Caprifoliaceae (7.94%), Rutaceae (7.47%) and Papaveraceae (6.01%). The most used taxa to treat or alleviate the mental disorders have been Tilia platyphyllos Scop. (24.53%), Valeriana officinalis L. (7.47%), Salvia officinalis L. (5.07%), Sambucus nigra L. (4.28%), and Ruta chalepensis L. (3.89%). The flowers or inflorescences (47.68%), followed by aerial part (23.49%), have been the most used plant parts, and ...
Source: Frontiers in Pharmacology - October 31, 2023 Category: Drugs & Pharmacology Source Type: research
Valerenic acid reduces anxiety-like behavior in young adult, female (C57BL/6J) mice
Behav Brain Res. 2023 Oct 16:114717. doi: 10.1016/j.bbr.2023.114717. Online ahead of print.ABSTRACTExtracts from the plant Valeriana officinalis are marketed as an herbal remedy to treat anxiety and insomnia. Valerenic acid (VA) is a major chemical component of Valeriana extracts. To date, there is relatively little information about how VA affects behavior. The purpose of these experiments was to (1) test whether administration of VA induces measurable changes in anxiety-like, depression-like, or locomotor behaviors; (2) determine whether the effects of VA on behavior are dose-dependent; and (3) compare the effects of VA ...
Source: Brain Research - October 18, 2023 Category: Neurology Authors: Natalie E Pinder Isaac Y Ligocki Brent M Horton John E Hoover Source Type: research
Valerenic acid reduces anxiety-like behavior in young adult, female (C57BL/6J) mice
Behav Brain Res. 2023 Oct 16:114717. doi: 10.1016/j.bbr.2023.114717. Online ahead of print.ABSTRACTExtracts from the plant Valeriana officinalis are marketed as an herbal remedy to treat anxiety and insomnia. Valerenic acid (VA) is a major chemical component of Valeriana extracts. To date, there is relatively little information about how VA affects behavior. The purpose of these experiments was to (1) test whether administration of VA induces measurable changes in anxiety-like, depression-like, or locomotor behaviors; (2) determine whether the effects of VA on behavior are dose-dependent; and (3) compare the effects of VA ...
Source: Behavioural Brain Research - October 18, 2023 Category: Neurology Authors: Natalie E Pinder Isaac Y Ligocki Brent M Horton John E Hoover Source Type: research
Vitamin E/Coenzyme Q-Dependent “Free Radical Reductases”: Redox Regulators in Ferroptosis
Antioxidants&Redox Signaling, Ahead of Print. (Source: Antioxidants and Redox Signaling)
Source: Antioxidants and Redox Signaling - October 16, 2023 Category: Research Authors: Valerian E. Kagan Adam C. Straub Yulia Y. Tyurina Alexandr A. Kapralov Robert Hall Sally E. Wenzel Rama K. Mallampalli H ülya Bayir Source Type: research
Vitamin C is Mandatory for the TCA Cycle Production of Anti-Inflammatory Itaconate
Am J Respir Crit Care Med. 2023 Oct 2. doi: 10.1164/rccm.202304-0636LE. Online ahead of print.NO ABSTRACTPMID:37782815 | DOI:10.1164/rccm.202304-0636LE (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 2, 2023 Category: Respiratory Medicine Authors: Elif Soysal Elizabeth Castellano Aybike Korkmaz Steven J Mullett Nahmah Kim-Campbell Michael Epperly Stacy Wendell Valerian E Kagan H ülya Bayır Redox Health Study Group Source Type: research
Vitamin C is Mandatory for the TCA Cycle Production of Anti-Inflammatory Itaconate
Am J Respir Crit Care Med. 2023 Oct 2. doi: 10.1164/rccm.202304-0636LE. Online ahead of print.NO ABSTRACTPMID:37782815 | DOI:10.1164/rccm.202304-0636LE (Source: Respiratory Care)
Source: Respiratory Care - October 2, 2023 Category: Respiratory Medicine Authors: Elif Soysal Elizabeth Castellano Aybike Korkmaz Steven J Mullett Nahmah Kim-Campbell Michael Epperly Stacy Wendell Valerian E Kagan H ülya Bayır Redox Health Study Group Source Type: research
Vitamin C is Mandatory for the TCA Cycle Production of Anti-Inflammatory Itaconate
Am J Respir Crit Care Med. 2023 Oct 2. doi: 10.1164/rccm.202304-0636LE. Online ahead of print.NO ABSTRACTPMID:37782815 | DOI:10.1164/rccm.202304-0636LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - October 2, 2023 Category: Intensive Care Authors: Elif Soysal Elizabeth Castellano Aybike Korkmaz Steven J Mullett Nahmah Kim-Campbell Michael Epperly Stacy Wendell Valerian E Kagan H ülya Bayır Redox Health Study Group Source Type: research
Vitamin C is Mandatory for the TCA Cycle Production of Anti-Inflammatory Itaconate
Am J Respir Crit Care Med. 2023 Oct 2. doi: 10.1164/rccm.202304-0636LE. Online ahead of print.NO ABSTRACTPMID:37782815 | DOI:10.1164/rccm.202304-0636LE (Source: Respiratory Care)
Source: Respiratory Care - October 2, 2023 Category: Respiratory Medicine Authors: Elif Soysal Elizabeth Castellano Aybike Korkmaz Steven J Mullett Nahmah Kim-Campbell Michael Epperly Stacy Wendell Valerian E Kagan H ülya Bayır Redox Health Study Group Source Type: research
Vitamin C is Mandatory for the TCA Cycle Production of Anti-Inflammatory Itaconate
Am J Respir Crit Care Med. 2023 Oct 2. doi: 10.1164/rccm.202304-0636LE. Online ahead of print.NO ABSTRACTPMID:37782815 | DOI:10.1164/rccm.202304-0636LE (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 2, 2023 Category: Respiratory Medicine Authors: Elif Soysal Elizabeth Castellano Aybike Korkmaz Steven J Mullett Nahmah Kim-Campbell Michael Epperly Stacy Wendell Valerian E Kagan H ülya Bayır Redox Health Study Group Source Type: research
Sub-100?fs all-fiber polarization maintaining widely tunable laser at 2? µ m
An all-fiber polarization maintaining (PM) laser tunable over 170?nm via Raman soliton self-frequency shift (SSFS) delivering sub-100?fs ... (Source: Optics Letters)
Source: Optics Letters - October 2, 2023 Category: Physics Authors: Adrian Grande Dia Darwich Valerian Freysz Johan Boullet Eric Cormier Source Type: research
Decentralizing cancer care in sub-Saharan Africa through an integrated regional cancer centre model: The case of Kenya
This study aimed to analyze the status of the utilization of services at regional cancer centers. We analyzed data from the district health information system, focusing on patient demographics, visit type, cancer stage, and the type of treatment provided. For comparison, a trend analysis of new cancer cases recorded at the main national referral hospital between 2011-2021 was also conducted. We conducted a descriptive analysis of the variables of interest; the median was used to summarize continuous variables and percentages were used for categorical variables. A total of 29,321 patients visited the regional centers in 202...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Mary F Nyangasi Angela A McLigeyo David Kariuki Siwillis Mithe Albert Orwa Valerian Mwenda Source Type: research
Membrane regulation of 15LOX-1/PEBP1 complex prompts the generation of ferroptotic signals, oxygenated PEs
Free Radic Biol Med. 2023 Sep 5:S0891-5849(23)00613-5. doi: 10.1016/j.freeradbiomed.2023.09.001. Online ahead of print.ABSTRACTFerroptosis is a regulated form of cell death, the mechanism of which is still to be understood. 15-lipoxygenase (15LOX) complex with phosphatidylethanolamine (PE)-binding protein 1 (PEBP1) catalyzes the generation of pro-ferroptotic cell death signals, hydroperoxy-polyunsaturated PE. We focused on gaining new insights into the molecular basis of these pro-ferroptotic interactions using computational modeling and liquid chromatography-mass spectrometry experiments. Simulations of 15LOX-1/PEBP1 comp...
Source: Free Radical Biology and Medicine - September 7, 2023 Category: Biology Authors: Thiliban Manivarma Aleksandr A Kapralov Svetlana N Samovich Yulia Y Tyurina Vladimir A Tyurin Andy P VanDemark Wieslaw Nowak H ülya Bayır Ivet Bahar Valerian E Kagan Karolina Mikulska-Ruminska Source Type: research
Membrane regulation of 15LOX-1/PEBP1 complex prompts the generation of ferroptotic signals, oxygenated PEs
Free Radic Biol Med. 2023 Sep 5:S0891-5849(23)00613-5. doi: 10.1016/j.freeradbiomed.2023.09.001. Online ahead of print.ABSTRACTFerroptosis is a regulated form of cell death, the mechanism of which is still to be understood. 15-lipoxygenase (15LOX) complex with phosphatidylethanolamine (PE)-binding protein 1 (PEBP1) catalyzes the generation of pro-ferroptotic cell death signals, hydroperoxy-polyunsaturated PE. We focused on gaining new insights into the molecular basis of these pro-ferroptotic interactions using computational modeling and liquid chromatography-mass spectrometry experiments. Simulations of 15LOX-1/PEBP1 comp...
Source: Free Radical Biology and Medicine - September 7, 2023 Category: Biology Authors: Thiliban Manivarma Aleksandr A Kapralov Svetlana N Samovich Yulia Y Tyurina Vladimir A Tyurin Andy P VanDemark Wieslaw Nowak H ülya Bayır Ivet Bahar Valerian E Kagan Karolina Mikulska-Ruminska Source Type: research
