Factors associated with late diagnosis of cervical cancer at two national referral hospitals, Kenya 2017: A case control study
CONCLUSION: Cost of seeking care and the quality of the diagnostic process were important factors in this study. Decentralization of care, innovative health financing solutions and clear diagnostic and referral algorithms for women presenting with gynecological symptoms could reduce late-stage diagnosis in Kenya.PMID:38500641 | PMC:PMC10945120 | DOI:10.1016/j.gore.2024.101355 (Source: Cancer Control)
Source: Cancer Control - March 19, 2024 Category: Cancer & Oncology Authors: Valerian Mwenda Martin Mwangi Gladwell Gathecha Joseph Kibachio Robert Too Zeinab Gura Marleen Temmerman Source Type: research
Molecular Targets of Valeric Acid: A Bioactive Natural Product for Endocrine, Metabolic, and Immunological Disorders
CONCLUSION: These findings highlight the role of valeric acid as a potential novel therapeutic agent for endocrine, metabolic and immunity-related health conditions, and it must be tested under clinical conditions to develop as a promising drug.PMID:38375842 | DOI:10.2174/0118715303262653231120043819 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 20, 2024 Category: Endocrinology Authors: Bindu Kumari Usha Kumari Dhananjay Kumar Singh Gulam Mohammad Husain Dinesh Kumar Patel Anshul Shakya Ravi Bhushan Singh Gyan Prakash Modi Gireesh Kumar Singh Source Type: research
Molecular Targets of Valeric Acid: A Bioactive Natural Product for Endocrine, Metabolic, and Immunological Disorders
CONCLUSION: These findings highlight the role of valeric acid as a potential novel therapeutic agent for endocrine, metabolic and immunity-related health conditions, and it must be tested under clinical conditions to develop as a promising drug.PMID:38375842 | DOI:10.2174/0118715303262653231120043819 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 20, 2024 Category: Drugs & Pharmacology Authors: Bindu Kumari Usha Kumari Dhananjay Kumar Singh Gulam Mohammad Husain Dinesh Kumar Patel Anshul Shakya Ravi Bhushan Singh Gyan Prakash Modi Gireesh Kumar Singh Source Type: research
Molecular Targets of Valeric Acid: A Bioactive Natural Product for Endocrine, Metabolic, and Immunological Disorders
CONCLUSION: These findings highlight the role of valeric acid as a potential novel therapeutic agent for endocrine, metabolic and immunity-related health conditions, and it must be tested under clinical conditions to develop as a promising drug.PMID:38375842 | DOI:10.2174/0118715303262653231120043819 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 20, 2024 Category: Endocrinology Authors: Bindu Kumari Usha Kumari Dhananjay Kumar Singh Gulam Mohammad Husain Dinesh Kumar Patel Anshul Shakya Ravi Bhushan Singh Gyan Prakash Modi Gireesh Kumar Singh Source Type: research
Molecular Targets of Valeric Acid: A Bioactive Natural Product for Endocrine, Metabolic, and Immunological Disorders
CONCLUSION: These findings highlight the role of valeric acid as a potential novel therapeutic agent for endocrine, metabolic and immunity-related health conditions, and it must be tested under clinical conditions to develop as a promising drug.PMID:38375842 | DOI:10.2174/0118715303262653231120043819 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 20, 2024 Category: Drugs & Pharmacology Authors: Bindu Kumari Usha Kumari Dhananjay Kumar Singh Gulam Mohammad Husain Dinesh Kumar Patel Anshul Shakya Ravi Bhushan Singh Gyan Prakash Modi Gireesh Kumar Singh Source Type: research
Comparison of microparticle transport and deposition in nasal cavity of three different age groups
This study aims to understand the particle deposition patterns in three age groups: neonate, infant, and adult.Materials and methods: The CT scans are built using MIMICS 21.0, followed by CATIA V6 to generate a patient-specific airway model. Fluid flow is simulated using ANSYS FLUENT 2021 R2. Spherical monodisperse microparticles ranging from 2 to 60 µm and a density of 1100 kg/m3 are simulated at steady-state and sedentary inspiration conditions.Results: The highest nasal valve depositions for the neonate are 25% for 20 µm, for infants, 10% for 50 µm, 15% for adults, and 15% for 15 µm. At mid nasal region, deposition ...
Source: Inhalation Toxicology - February 12, 2024 Category: Respiratory Medicine Authors: John Valerian Corda B Satish Shenoy Kamarul Arifin Ahmad Leslie Lewis Prakashini K Anoop Rao Mohammad Zuber Source Type: research
New Iridoids and Acyclic Monoterpenoids from the Roots and Rhizomes of Valeriana officinalis var. latifolia
Chem Biodivers. 2024 Feb 7:e202301949. doi: 10.1002/cbdv.202301949. Online ahead of print.ABSTRACTFive new iridoids, valeralides A-E (1-5), two new acyclic monoterpenoids, valeralides F (6) and G (7), together with two known iridoids (8 and 9), were isolated from the roots and rhizomes of Valeriana officinalis var. latifolia. Their structures were elucidated based on 1D and 2D NMR, as well as HR-ESI-MS spectroscopic data. The absolute configuration of compounds 1-4 were elucidated based on electronic circular dichroism (ECD) calculation. In addition, all the isolates were evaluated for their inhibition on nitric oxide prod...
Source: Chemistry and Biodiversity - February 7, 2024 Category: Biochemistry Authors: Jia-Jin Liu Li-Zhong Wang Yuan-Ting Duan Dan Liu Hong-Mei Li Rong-Tao Li Source Type: research
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression
Cell Metab. 2024 Jan 29:S1550-4131(24)00005-6. doi: 10.1016/j.cmet.2024.01.006. Online ahead of print.ABSTRACTAlthough the role of ferroptosis in killing tumor cells is well established, recent studies indicate that ferroptosis inducers also sabotage anti-tumor immunity by killing neutrophils and thus unexpectedly stimulate tumor growth, raising a serious issue about whether ferroptosis effectively suppresses tumor development in vivo. Through genome-wide CRISPR-Cas9 screenings, we discover a pleckstrin homology-like domain family A member 2 (PHLDA2)-mediated ferroptosis pathway that is neither ACSL4-dependent nor requires...
Source: Cell Metabolism - February 3, 2024 Category: Cytology Authors: Xin Yang Zhe Wang Svetlana N Samovich Alexander A Kapralov Andrew A Amoscato Vladimir A Tyurin Haider H Dar Zhiming Li Shoufu Duan Ning Kon Delin Chen Benjamin Tycko Zhiguo Zhang Xuejun Jiang H ülya Bayir Brent R Stockwell Valerian E Kagan Wei Gu Source Type: research
Sensors, Vol. 24, Pages 359: Microwave Receiving System Based on Cryogenic Sensors for the Optical Big Telescope Alt-Azimuth
This article presents the results of evaluating the possibility of conducting radio astronomy studies in the windows of atmospheric transparency ~100, ~230, and ~350 GHz using the optical Big Telescope Alt-Azimuthal (BTA) of the Special Astrophysical Observatory of the Russian Academy of Sciences (SAO RAS). A list of some promising astronomical tasks is proposed. The astroclimat conditions at the BTA site and possible optical, cryogenic, and mechanical interfaces for mounting a superconducting radio receiver at the focus of the optical telescope are considered. As a receiving system, arrays of detectors cooled to ~0.3 K ba...
Source: Sensors - January 7, 2024 Category: Biotechnology Authors: Yurii Balega Grigory Bubnov Artem Chekushkin Victor Dubrovich Valerian Edelman Aleksandra Gunbina Sergey Kapustin Tatyana Khabarova Dmitrii Kukushkin Igor Lapkin Maria Mansfeld Andrei Maruhno Vladimir Parshin Aleksey Raevskiy Vladislav Stolyarov Mikhail T Tags: Article Source Type: research
Molecules, Vol. 29, Pages 112: Chemical Diversity of Wild-Growing and Cultivated Common Valerian (Valeriana officinalis L. s.l.) Originating from Poland
na Bączek
Common valerian is a medicinal plant. The underground organs of this species are used as a mild sedative and sleeping aid. Poland is one of the largest producers of this raw material in Europe, with local cultivar ‘Lubelski’ as a primary cultivated form. Although valerian is the subject of more or less deliberate selection carried out by farmers, it is still genetically unstable. The aim of this study was to determine the diversity of the ‘Lubelski’ cultivar originating from four regions of Poland (forms: L1–L4) in relation to wild-growing...
Source: Molecules - December 23, 2023 Category: Chemistry Authors: Kavana Raj Zenon W ęglarz Jaros ław L. Przybył Olga Kosakowska Anna Pawe łczak Łukasz Gontar Marta Puchta-Jasi ńska Katarzyna B ączek Tags: Article Source Type: research
Immune modulation of innate and adaptive responses restores immune surveillance and establishes anti-tumor immunological memory
Cancer Immunol Res. 2023 Dec 11. doi: 10.1158/2326-6066.CIR-23-0127. Online ahead of print.ABSTRACTCurrent immunotherapies have proven effective in strengthening anti-tumor immune responses, but constant opposing signals from tumor cells and the surrounding microenvironment eventually lead to immune escape. We hypothesized that in situ release of antigens and regulation of both the innate and adaptive arms of the immune system would provide a robust and long-term anti-tumor effect by creating immunological memory against tumors. To achieve this, we developed CARG-2020, a genetically modified virus-like vesicle (VLV) that i...
Source: Cell Research - December 11, 2023 Category: Cytology Authors: Ayesha B Alvero Alexandra Fox Bhaskara Reddy Madina Marie M Krady Radhika Gogoi Hussein Chehade Valerian Nakaar Bijan Almassian Timur O Yarovinsky Thomas Rutherford Gil Mor Source Type: research
Immune modulation of innate and adaptive responses restores immune surveillance and establishes anti-tumor immunological memory
Cancer Immunol Res. 2023 Dec 11. doi: 10.1158/2326-6066.CIR-23-0127. Online ahead of print.ABSTRACTCurrent immunotherapies have proven effective in strengthening anti-tumor immune responses, but constant opposing signals from tumor cells and the surrounding microenvironment eventually lead to immune escape. We hypothesized that in situ release of antigens and regulation of both the innate and adaptive arms of the immune system would provide a robust and long-term anti-tumor effect by creating immunological memory against tumors. To achieve this, we developed CARG-2020, a genetically modified virus-like vesicle (VLV) that i...
Source: Cell Research - December 11, 2023 Category: Cytology Authors: Ayesha B Alvero Alexandra Fox Bhaskara Reddy Madina Marie M Krady Radhika Gogoi Hussein Chehade Valerian Nakaar Bijan Almassian Timur O Yarovinsky Thomas Rutherford Gil Mor Source Type: research
Should the vasoactive inotropic score be a determinant for early initiation of VA-ECMO in post-cardiotomy cardiogenic shock?
Objectives: We investigated the role of early veno-arterial extracorporeal membrane oxygenation (VA-ECMO) implantation in patients suffering from post-cardiotomy cardiogenic shock on mortality and morbidity, when integrating vasoactive-inotropic score (VIS) and type of catecholamine support.Design: A retrospective, multicenter, observational study with propensity weight matchingSetting: Four University-affiliated intensive care unitsParticipants: Patients suffering from post-cardiotomy cardiogenic shock in the operating roomInterventions: Early VA-ECMO supportMeasurements and Main Results: Of 2742 patients screened during ...
Source: Journal of Cardiothoracic and Vascular Anesthesia - November 30, 2023 Category: Anesthesiology Authors: Vincenza Caruso, Vivien Berthoud, Olivier Bouchot, Maxime Nguyen, Belaid Bouhemad, Pierre-Gr égoire Guinot, Audrey Martin, Bastien Durand, Valerian Duclos, Alexandra Spitz, Tiberiu Constandache, Sandrine Grosjean, Mohamed Radhouani, Jean-Baptiste Anciaux Tags: Original Article Source Type: research
Cancers, Vol. 15, Pages 5569: Quality of Life and Independent Factors Associated with Poor Digestive Function after Ivor Lewis Esophagectomy
. Gutschow
Transthoracic esophagectomy results in a radical change in foregut anatomy with multiple consequences for digestive physiology. The aim of this study was to identify factors associated with poor functional outcomes by assessing multiple dimensions of digestive performance and health-related quality of life (HRQL). Patients with cancer-free survival after Ivor Lewis esophagectomy were included. Four functional syndromes (dysphagia, gastroesophageal reflux disease (GERD), delayed gastric conduit emptying (DGCE), and dumping syndrome (DS)) and HRQL were assessed using specifically designed questionnaires. Patie...
Source: Cancers - November 24, 2023 Category: Cancer & Oncology Authors: Valerian Dirr Diana Vetter Thomas Sartoretti Marcel Andr é Schneider Francesca Da Canal Christian A. Gutschow Tags: Article Source Type: research
Use of a 5-Item Modified Frailty Index for Assessing Outcomes After Hartmann's Reversal: An ACS-NSQIP Study
DISCUSSION: An mFI-5 of ≥2 was associated with greater morbidity, mortality, and eLOS following Hartmann's reversal. However, there were no mortality or eLOS differences in patients with an mFI-5 of 1 and only a 14% increase in any morbidity, making these patients potentially good candidates for Hartmann's reversal. Furthermore, laparoscopic surgery was associated with a protective effect for overall morbidity and eLOS, potentially mitigating some of the risk associated with higher frailty scores.PMID:37978813 | DOI:10.1177/00031348231216483 (Source: The American Surgeon)
Source: The American Surgeon - November 18, 2023 Category: Surgery Authors: Kathryn E Ottaviano David C Palange Susanna S Hill Ashar Ata A David Chismark Jonathan J Canete Brian T Valerian Edward C Lee Source Type: research
