Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney

Nature Reviews Nephrology, Published online: 15 March 2023; doi:10.1038/s41581-023-00689-xFerroptosis is an iron-dependent mechanism of regulated necrosis that is driven by the robust oxidation of polyunsaturated fatty acid-containing phospholipids. This Review describes the fundamental mechanisms of ferroptosis, the potential contribution of ferroptosis to kidney disease and therapeutic strategies for targeting ferroptosis.
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Source Type: research