An Inclisiran First Strategy vs Usual Care in Patients with Atherosclerosis
CONCLUSIONS: An "inclisiran first" implementation strategy led to greater LDL-C lowering compared with usual care without discouraging statin use or raising new safety concerns.PMID:38593947 | DOI:10.1016/j.jacc.2024.03.382 (Source: Atherosclerosis)
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Michael J Koren Fatima Rodriguez Cara East Peter P Toth Veena Watwe Cheryl A Abbas Samiha Sarwat Kelly Kleeman Biswajit Kumar Yousuf Ali Naseem Jaffrani Source Type: research
Atorvastatin causes developmental and behavioral toxicity in yellowstripe goby (Mugilogobius chulae) embryos/larvae via disrupting lipid metabolism and autophagy processes
Aquat Toxicol. 2024 Apr 6;271:106909. doi: 10.1016/j.aquatox.2024.106909. Online ahead of print.ABSTRACTAtorvastatin (ATV) is one of the most commonly prescribed lipid-lowering drugs detected frequently in the environment due to its high use and low degradation rate. However, the toxic effects of residual ATV in the aquatic environment on non-target organisms and its toxic mechanisms are still largely unknown. In the present study, embryos of a native estuarine benthic fish, Mugilogobius chulae, were employed to investigate the developmental and behavioral toxic effects of ATV including environmentally relevant concentrati...
Source: Aquatic Toxicology - April 9, 2024 Category: Toxicology Authors: Yufei Zhao Yimeng Wang Jinzhi Ren Weibo Gong Xiangping Nie Ying Peng Jianjun Li Chunni Duan Source Type: research
Assessing the structural stability and drug encapsulation efficiency of poly(ethylene glycol)-poly(L-lactic acid) nanoparticles loaded with atorvastatin calcium: Based on dissipative particle dynamics
This study aims to investigate the structural stability of drug-loading micelles formed by two diblock/triblock polymers with various block sequences through coarse-grained dissipative particle dynamics (DPD) simulations. From the perspectives of the binding strength of poly(L-lactic acid) (PLLA) and polyethylene glycol (PEG) in nanoparticles, hydrophilic bead surface coverage, and the morphological alteration of nanoparticles induced by shear force, the ratio of hydrophilic/hydrophobic sequence length has been observed to affect the stability of nanoparticles. We have found that for diblock polymers, PEG3kda-PLLA2kda has ...
Source: International Journal of Biological Macromolecules - April 9, 2024 Category: Biochemistry Authors: Yun Hao Feng Wei Xin Guo Zhuo Lin Li Liu Fu Hu Yue Liu Li Yue Jing Jianhao Wang Mohammad-Ali Shahbazi Bo Zhi Chen Xin Dong Guo Source Type: research
Alirocumab and cardiovascular outcomes according to sex and lipoprotein(a) after acute coronary syndrome: ODYSSEY OUTCOMES
Women are often underrepresented in clinical trials, leading to uncertainty in subgroup analyses by sex and lower quality data to guide evidence-based therapy.1,2 While many individual trials are inconclusive, patient-level meta-analyses show that women with established cardiovascular disease benefit from statin therapy to the same degree as men.3 However, sex-specific data for non-statin lipid-lowering therapies are sparse.2 A recent statement by the European Society of Atherosclerosis highlighted differences in lipoprotein concentrations through the life course in women versus men, as well as sex differences in the relat...
Source: Journal of Clinical Lipidology - April 9, 2024 Category: Lipidology Authors: Vera A. Bittner, Gregory G. Schwartz, Deepak L. Bhatt, Terrance Chua, H. Asita De Silva, Rafael Diaz, Shaun G. Goodman, Robert A. Harrington, J. Wouter Jukema, Jennifer McGinniss, Robert Pordy, Genevieve Garon, Michel Scemama, Harvey D. White, Ph. Gabriel Tags: Original Research Source Type: research
Immune-Mediated Necrotizing Myopathies: Current Landscape
This article provides a succinct overview of IMNM, including clinical features, diagnostic strategies, and treatment approaches.Recent FindingsRecent insights highlight the different clinical presentations and therapeutic options of IMNM stratified by autoantibody positivity and type. Additionally, recent findings call into question the reported link between statin use and IMNM.SummaryThis review synthesizes current knowledge on IMNM, emphasizing its distinct clinical features and challenging management. The evolving understanding of IMNM underscores the need for a comprehensive diagnostic approach that utilizes a growing ...
Source: Current Neurology and Neuroscience Reports - April 9, 2024 Category: Neuroscience Source Type: research
A Computational Study of Green Tea Extracts and their Derivatives as Potential Inhibitors for Squalene Monooxygenase
CONCLUSION: The results obtained from this study suggest that green tea polyphenols have the potential for inhibition of squalene monooxygenase, except for theasinensin A.PMID:38584555 | DOI:10.2174/0115734064280290240211170037 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - April 8, 2024 Category: Chemistry Authors: Kabelo Phuti Mokgopa Kevin A Lobb Tendamudzimu Tshiwawa Source Type: research
Overcoming statin resistance in prostate cancer cells by targeting the 3-hydroxy-3-methylglutaryl-CoA-reductase
Biochem Biophys Res Commun. 2024 Mar 28;710:149841. doi: 10.1016/j.bbrc.2024.149841. Online ahead of print.ABSTRACTProstate cancer is the most prevalent malignancy in men. While diagnostic and therapeutic interventions have substantially improved in recent years, disease relapse, treatment resistance, and metastasis remain significant contributors to prostate cancer-related mortality. Therefore, novel therapeutic approaches are needed. Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate pathway which plays an essential role in cholesterol homeostasis. N...
Source: Biochemical and Biophysical Research communications - April 8, 2024 Category: Biochemistry Authors: Andy G öbel Sophie P ählig Anja Motz Dorit Breining Sofia Traikov Lorenz C Hofbauer Tilman D Rachner Source Type: research
A Computational Study of Green Tea Extracts and their Derivatives as Potential Inhibitors for Squalene Monooxygenase
CONCLUSION: The results obtained from this study suggest that green tea polyphenols have the potential for inhibition of squalene monooxygenase, except for theasinensin A.PMID:38584555 | DOI:10.2174/0115734064280290240211170037 (Source: Molecular Medicine)
Source: Molecular Medicine - April 8, 2024 Category: Molecular Biology Authors: Kabelo Phuti Mokgopa Kevin A Lobb Tendamudzimu Tshiwawa Source Type: research
Overcoming statin resistance in prostate cancer cells by targeting the 3-hydroxy-3-methylglutaryl-CoA-reductase
Biochem Biophys Res Commun. 2024 Mar 28;710:149841. doi: 10.1016/j.bbrc.2024.149841. Online ahead of print.ABSTRACTProstate cancer is the most prevalent malignancy in men. While diagnostic and therapeutic interventions have substantially improved in recent years, disease relapse, treatment resistance, and metastasis remain significant contributors to prostate cancer-related mortality. Therefore, novel therapeutic approaches are needed. Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate pathway which plays an essential role in cholesterol homeostasis. N...
Source: Cell Research - April 8, 2024 Category: Cytology Authors: Andy G öbel Sophie P ählig Anja Motz Dorit Breining Sofia Traikov Lorenz C Hofbauer Tilman D Rachner Source Type: research
New approaches to triglyceride reduction: Is there any hope left?
Am J Prev Cardiol. 2024 Mar 22;18:100648. doi: 10.1016/j.ajpc.2024.100648. eCollection 2024 Jun.ABSTRACTTriglycerides play a crucial role in the efficient storage of energy in the body. Mild and moderate hypertriglyceridemia (HTG) is a heterogeneous disorder with significant association with atherosclerotic cardiovascular disease (ASCVD), including myocardial infarction, ischemic stroke, and peripheral artery disease and represents an important component of the residual ASCVD risk in statin treated patients despite optimal low-density lipoprotein cholesterol reduction. Individuals with severe HTG (>1,000 mg/dL) rarely d...
Source: Atherosclerosis - April 8, 2024 Category: Cardiology Authors: Annalisa Filtz Siddhant Parihar Garred S Greenberg Christine M Park Andrea Scotti Daniel Lorenzatti Juan J Badimon Daniel E Soffer Peter P Toth Carl J Lavie Vera Bittner Salim S Virani Leandro Slipczuk Source Type: research
The association between trajectory of serum cholesterol, statin dosage, and the risk of recurrent biliary stone diseases
CONCLUSION: This study supports the potential benefits of statin use and the role of cholecystectomy in reducing the risk of recurrent biliary stone diseases.PMID:38589275 | DOI:10.1016/j.jfma.2024.04.003 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - April 8, 2024 Category: General Medicine Authors: Fai-Meng Sou Chien-Ning Hsu Yi-Chun Chiu Cheng-Kun Wu Lung-Sheng Lu Chung-Mou Kuo Shao-Ming Chiu Seng-Kee Chuah Yao-Hsu Yang Chih-Ming Liang Source Type: research
A Computational Study of Green Tea Extracts and their Derivatives as Potential Inhibitors for Squalene Monooxygenase
CONCLUSION: The results obtained from this study suggest that green tea polyphenols have the potential for inhibition of squalene monooxygenase, except for theasinensin A.PMID:38584555 | DOI:10.2174/0115734064280290240211170037 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - April 8, 2024 Category: Chemistry Authors: Kabelo Phuti Mokgopa Kevin A Lobb Tendamudzimu Tshiwawa Source Type: research
Overcoming statin resistance in prostate cancer cells by targeting the 3-hydroxy-3-methylglutaryl-CoA-reductase
Biochem Biophys Res Commun. 2024 Mar 28;710:149841. doi: 10.1016/j.bbrc.2024.149841. Online ahead of print.ABSTRACTProstate cancer is the most prevalent malignancy in men. While diagnostic and therapeutic interventions have substantially improved in recent years, disease relapse, treatment resistance, and metastasis remain significant contributors to prostate cancer-related mortality. Therefore, novel therapeutic approaches are needed. Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate pathway which plays an essential role in cholesterol homeostasis. N...
Source: Biochemical and Biophysical Research communications - April 8, 2024 Category: Biochemistry Authors: Andy G öbel Sophie P ählig Anja Motz Dorit Breining Sofia Traikov Lorenz C Hofbauer Tilman D Rachner Source Type: research
A Computational Study of Green Tea Extracts and their Derivatives as Potential Inhibitors for Squalene Monooxygenase
CONCLUSION: The results obtained from this study suggest that green tea polyphenols have the potential for inhibition of squalene monooxygenase, except for theasinensin A.PMID:38584555 | DOI:10.2174/0115734064280290240211170037 (Source: Molecular Medicine)
Source: Molecular Medicine - April 8, 2024 Category: Molecular Biology Authors: Kabelo Phuti Mokgopa Kevin A Lobb Tendamudzimu Tshiwawa Source Type: research
The association between trajectory of serum cholesterol, statin dosage, and the risk of recurrent biliary stone diseases
CONCLUSION: This study supports the potential benefits of statin use and the role of cholecystectomy in reducing the risk of recurrent biliary stone diseases.PMID:38589275 | DOI:10.1016/j.jfma.2024.04.003 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - April 8, 2024 Category: General Medicine Authors: Fai-Meng Sou Chien-Ning Hsu Yi-Chun Chiu Cheng-Kun Wu Lung-Sheng Lu Chung-Mou Kuo Shao-Ming Chiu Seng-Kee Chuah Yao-Hsu Yang Chih-Ming Liang Source Type: research
