Are there lost opportunities in chronic kidney disease? A region-wide cohort study
Conclusions
While we noted underdiagnosis and undertreatment of CKD in this large contemporary population, we also identified a substantial realisable potential to improve CKD outcomes and reduce its burden by treating patients early with guideline-directed pharmacological therapy. (Source: BMJ Open)
Source: BMJ Open - April 19, 2024 Category: General Medicine Authors: Sundström, J., Norhammar, A., Karayiannides, S., Bodegard, J., Gustafsson, S., Cars, T., Eriksson Svensson, M., Ärnlöv, J. Tags: Open access, Epidemiology Source Type: research
GlycA Levels Independently Predict Coronary Artery Calcium Incidence and Progression in the ELSA-Brasil Cohort (Brazilian Longitudinal Study of Adult Health)
Am J Cardiol. 2024 Apr 16:S0002-9149(24)00265-0. doi: 10.1016/j.amjcard.2024.03.041. Online ahead of print.ABSTRACTAtherosclerosis is an inflammatory disease. Coronary artery calcium (CAC) is a marker of atherosclerotic disease events and mortality risk. Elevated GlycA, an emerging marker of inflammation, is associated with a higher risk for coronary artery disease (CAD). However, there is conflicting evidence on whether GlycA predicts subclinical CAD progression. We hypothesized that GlycA can predict subclinical CAC incidence/progression in healthy individuals. We included 2,690 ELSA-Brasil cohort participants without ca...
Source: Atherosclerosis - April 18, 2024 Category: Cardiology Authors: Ronaldo C Fabiano Filho Giuliano Generoso Rhanderson Cardoso Steven R Jones Raul D Santos Peter P Toth Isabela M Bensenor Paulo A Lotufo Marcio S Bittencourt Source Type: research
Pragmatic Trial of Messaging to Providers About Treatment of Hyperlipidemia (PROMPT-LIPID): A Randomized Clinical Trial
CONCLUSIONS: With a real-time, targeted, individualized EHR alert as compared with usual care, the proportion of patients with atherosclerotic cardiovascular disease with LLT intensification was numerically higher but not statistically significant. Among clinicians who did not dismiss the alert, there was a > 2-fold increase in LLT intensification. EHR alerts, coupled with strategies to reduce clinician dismissal, may help address persistent gaps in LDL-C management.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04394715, https://www.clinicaltrials.gov/ct2/show/study/NCT04394715.PMID:38634282 |...
Source: Atherosclerosis - April 18, 2024 Category: Cardiology Authors: Nimish N Shah Lama Ghazi Yu Yamamoto Sanchit Kumar Melissa Martin Michael Simonov Ralph J Riello Iii Kamil F Faridi Tariq Ahmad F Perry Wilson Nihar R Desai Source Type: research
Effectiveness of statins in people living with HIV: a systematic review and meta-analysis of randomized controlled trials
CONCLUSION: When considered collectively, statin therapy's advantages appear to exceed its occasional predictable side effects like liver or muscle toxicity.REGISTRATION: PROSPERO registration ID: CRD42023469521.PMID:38629133 | DOI:10.1080/17512433.2024.2344672 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - April 17, 2024 Category: Drugs & Pharmacology Authors: Sai Santhosha Mrudula Alla Dhruv J Shah Vysakh Ratheesh Deekshitha Alla Thanmayee Tummala Moksh S Khetan Ritika J Shah Ruth G Bayeh Mahek Fatima Sanah K Ahmed Mert Sab ıroğlu Source Type: research
Extract of Gualou-Xiebai Herb Pair Improves Lipid Metabolism Disorders by Enhancing the Reverse Cholesterol Transport in Atherosclerosis Mice
CONCLUSION: In summary, our results suggested that GXE improved lipid metabolism disorders by enhancing RCT, providing a scientific basis for the clinical use of GXE in AS treatment.PMID:38629368 | DOI:10.2174/0115672026308438240405055719 (Source: Cell Research)
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Yarong Liu Tian Wang Lidan Ding Zhenglong Li Yexiang Zhang Min Dai Hongfei Wu Source Type: research
Extract of Gualou-Xiebai Herb Pair Improves Lipid Metabolism Disorders by Enhancing the Reverse Cholesterol Transport in Atherosclerosis Mice
CONCLUSION: In summary, our results suggested that GXE improved lipid metabolism disorders by enhancing RCT, providing a scientific basis for the clinical use of GXE in AS treatment.PMID:38629368 | DOI:10.2174/0115672026308438240405055719 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Yarong Liu Tian Wang Lidan Ding Zhenglong Li Yexiang Zhang Min Dai Hongfei Wu Source Type: research
Effectiveness of statins in people living with HIV: a systematic review and meta-analysis of randomized controlled trials
CONCLUSION: When considered collectively, statin therapy's advantages appear to exceed its occasional predictable side effects like liver or muscle toxicity.REGISTRATION: PROSPERO registration ID: CRD42023469521.PMID:38629133 | DOI:10.1080/17512433.2024.2344672 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Sai Santhosha Mrudula Alla Dhruv J Shah Vysakh Ratheesh Deekshitha Alla Thanmayee Tummala Moksh S Khetan Ritika J Shah Ruth G Bayeh Mahek Fatima Sanah K Ahmed Mert Sab ıroğlu Source Type: research
Lipid-Lowering Meroterpenoids Penihemeroterpenoids A-F from < em > Penicillium herquei < /em > GZU-31-6 via Targeting the AMPK/ACC/SREBP-1c Signaling Pathway
Org Lett. 2024 Apr 17. doi: 10.1021/acs.orglett.4c00946. Online ahead of print.ABSTRACTPenihemeroterpenoids A-C, the first meroterpenoids with an unprecedented 6/5/6/5/5/6/5 heptacyclic ring system, together with precursors penihemeroterpenoids D-F, were co-isolated from the fungus Penicillium herquei GZU-31-6. Among them, penihemeroterpenoids C-F exhibited lipid-lowering effects comparable to those of the positive control simvastatin by the activation of the AMPK/ACC/SREBP-1c signaling pathway, downregulated the mRNA levels of lipid synthesis genes FAS and PNPLA3, and increased the level of mRNA expression of the lipid ex...
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Huimei Deng Jingxin He Binglin Chang Qingcui Li Yena Liu Zhongxiang Zhao Zhongqiu Liu Hui Cui Source Type: research
Effect of Statins on Serum Levels of TNF-alpha and Interleukin-6 in Patients with Kidney Disease: A Meta-analysis of Randomized Clinical Trials
CONCLUSION: Statins only marginally decreased the concentration of IL-6 in patients with kidney disease, but neither high-intensity nor moderate/low-intensity statin treatment could significantly influence the level of IL6. However, statins reduced serum levels of TNF-α in patients with kidney disease.PMID:38629355 | DOI:10.2174/0113816128299493240403084905 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 17, 2024 Category: Drugs & Pharmacology Authors: Bahman Razi Saeed Aslani Danyal Imani Sajad Salehiyeh Mahdieh Fasihi Željko Reiner Amirhossein Sahebkar Source Type: research
Pharmacokinetic interaction between regorafenib and atorvastatin in rats
CONCLUSIONS: This animal model study showed a significant pharmacokinetic interaction between regorafenib and atorvastatin. While this interaction may be clinically significant, this needs to be confirmed in clinical trials involving cancer patients.PMID:38632186 | DOI:10.1007/s43440-024-00570-z (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 17, 2024 Category: Drugs & Pharmacology Authors: Danuta Szkutnik-Fiedler Edyta Sza łek Filip Otto Andrzej Czyrski Marta Kara źniewicz-Łada Anna Wolc Edmund Grze śkowiak Konrad Lewandowski Agnieszka Karbownik Source Type: research
Effectiveness of statins in people living with HIV: a systematic review and meta-analysis of randomized controlled trials
CONCLUSION: When considered collectively, statin therapy's advantages appear to exceed its occasional predictable side effects like liver or muscle toxicity.REGISTRATION: PROSPERO registration ID: CRD42023469521.PMID:38629133 | DOI:10.1080/17512433.2024.2344672 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - April 17, 2024 Category: Drugs & Pharmacology Authors: Sai Santhosha Mrudula Alla Dhruv J Shah Vysakh Ratheesh Deekshitha Alla Thanmayee Tummala Moksh S Khetan Ritika J Shah Ruth G Bayeh Mahek Fatima Sanah K Ahmed Mert Sab ıroğlu Source Type: research
Extract of Gualou-Xiebai Herb Pair Improves Lipid Metabolism Disorders by Enhancing the Reverse Cholesterol Transport in Atherosclerosis Mice
CONCLUSION: In summary, our results suggested that GXE improved lipid metabolism disorders by enhancing RCT, providing a scientific basis for the clinical use of GXE in AS treatment.PMID:38629368 | DOI:10.2174/0115672026308438240405055719 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - April 17, 2024 Category: Neurology Authors: Yarong Liu Tian Wang Lidan Ding Zhenglong Li Yexiang Zhang Min Dai Hongfei Wu Source Type: research
Effectiveness of statins in people living with HIV: a systematic review and meta-analysis of randomized controlled trials
CONCLUSION: When considered collectively, statin therapy's advantages appear to exceed its occasional predictable side effects like liver or muscle toxicity.REGISTRATION: PROSPERO registration ID: CRD42023469521.PMID:38629133 | DOI:10.1080/17512433.2024.2344672 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - April 17, 2024 Category: Drugs & Pharmacology Authors: Sai Santhosha Mrudula Alla Dhruv J Shah Vysakh Ratheesh Deekshitha Alla Thanmayee Tummala Moksh S Khetan Ritika J Shah Ruth G Bayeh Mahek Fatima Sanah K Ahmed Mert Sab ıroğlu Source Type: research
The effect of statins on the risk of anti-tuberculosis drug-induced liver injury among patients with active tuberculosis: A cohort study
CONCLUSION: Statin treatment had a protective effect against the risk of anti-TB DILI with a positive dose-response relationship.PMID:38632021 | DOI:10.1016/j.jmii.2024.04.002 (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - April 17, 2024 Category: Microbiology Authors: Chun-Kai Huang Jei-Yie Huang Chin-Hao Chang Shang-Jie Tsai Chin-Chung Shu Hao-Chien Wang Kuo-Liong Chien Source Type: research
Extract of Gualou-Xiebai Herb Pair Improves Lipid Metabolism Disorders by Enhancing the Reverse Cholesterol Transport in Atherosclerosis Mice
CONCLUSION: In summary, our results suggested that GXE improved lipid metabolism disorders by enhancing RCT, providing a scientific basis for the clinical use of GXE in AS treatment.PMID:38629368 | DOI:10.2174/0115672026308438240405055719 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Yarong Liu Tian Wang Lidan Ding Zhenglong Li Yexiang Zhang Min Dai Hongfei Wu Source Type: research
