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Chronic social isolation in adaptation of HPA axis to heterotypic stress.
CONCLUSION: Chronic IS augments the changes of IL-1β level induced by a longer crowding period than ACTH and CORT. Modulatory action of IL-1β and pituitary-adrenocortical hormones adaptation to chronic social stress is asynchronous. PMID: 29128802 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 9, 2017 Category: Drugs & Pharmacology Authors: Gądek-Michalska A, Bugajski A, Tadeusz J, Rachwalska P, Bugajski J Tags: Pharmacol Rep Source Type: research

Autophagy, mitophagy and apoptotic gene changes in the hippocampal CA1 area in a rat ischemic model of Alzheimer's disease.
CONCLUSION: It may be inferred that mitophagy process markedly accompanies apoptosis during delayed neuronal death in hippocampal CA1 area following brain ischemia. PMID: 29128811 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - July 14, 2017 Category: Drugs & Pharmacology Authors: Ułamek-Kozioł M, Kocki J, Bogucka-Kocka A, Januszewski S, Bogucki J, Czuczwar SJ, Pluta R Tags: Pharmacol Rep Source Type: research

Baicalin protects against gastroduodenal ulcers via the modulation of Nrf2 expression: Experimental, biochemical, and histological analyses.
Abstract BACKGROUND: The present study aimed to determine the mechanisms underlying the gastroprotective effects of baicalin using several animal models of chemically induced gastric ulcers. METHODS: The gastroprotective effects of baicalin against ulcers induced by water immersion stress, alcohol-induced ligation, and indomethacin-induced pylorus ligation were assessed in the present study. Additionally, macroscopic evaluations were performed at the completion of the study and Western blot analyses of Nrf2 were conducted to determine the possible mechanisms of action underlying the effects of baicalin. ...
Source: Pharmacological Reports - July 8, 2017 Category: Drugs & Pharmacology Authors: Zhang T, Yang D, Meng X Tags: Pharmacol Rep Source Type: research

Mechanistic evaluation of neuroprotective effect of estradiol on rotenone and 6-OHDA induced Parkinson's disease.
CONCLUSION: In view of the above results, it may be suggested that the estradiol may be as a useful therapeutic agent against rotenone-induced neurotoxicity such as Parkinson's disease. PMID: 29128798 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - July 8, 2017 Category: Drugs & Pharmacology Authors: Shen D, Tian X, Zhang B, Song R Tags: Pharmacol Rep Source Type: research

Chemosensitive effects of Astragaloside IV in osteosarcoma cells via induction of apoptosis and regulation of caspase-dependent Fas/FasL signaling.
CONCLUSION: It indicated that Astragaloside IV might be a promising therapeutic agent for osteosarcoma treatment. PMID: 29128795 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - July 5, 2017 Category: Drugs & Pharmacology Authors: Hu T, Fei Z, Wei N Tags: Pharmacol Rep Source Type: research

FTY720 inhibits the Nrf2/ARE pathway in human glioblastoma cell lines and sensitizes glioblastoma cells to temozolomide.
CONCLUSION: Our results indicated the potential application of FTY720 in treatment of glioblastoma and demonstrated that inhibition of Nrf2 can enhance the sensitivity of cancer cells to chemotherapeutic drugs. PMID: 29128799 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - July 4, 2017 Category: Drugs & Pharmacology Authors: Zhang L, Wang H Tags: Pharmacol Rep Source Type: research

Beneficial roles of honey polyphenols against some human degenerative diseases: A review.
Abstract Honey contains many active constituents and antioxidants such as polyphenols. Polyphenols are phytochemicals, a generic term for the several thousand plant-based molecules with antioxidant properties. Many in vitro studies in human cell cultures as well as many animal studies confirm the protective effect of polyphenols on a number of diseases such as cardiovascular diseases (CVD), diabetes, cancer, neurodegenerative diseases, pulmonary diseases, liver diseases and so on. Nevertheless, it is challenging to identify the specific biological mechanism underlying individual polyphenols and to determine how po...
Source: Pharmacological Reports - July 4, 2017 Category: Drugs & Pharmacology Authors: Hossen MS, Ali MY, Jahurul MHA, Abdel-Daim MM, Gan SH, Khalil MI Tags: Pharmacol Rep Source Type: research

ACPA and JWH-133 modulate the vascular tone of superior mesenteric arteries through cannabinoid receptors, BKCa channels, and nitric oxide dependent mechanisms.
CONCLUSIONS: CB1 and CB2 receptor activation in superior mesenteric artery causes vasorelaxation by mechanisms involving BKCa channels and NO release. PMID: 29128791 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - July 1, 2017 Category: Drugs & Pharmacology Authors: López-Dyck E, Andrade-Urzúa F, Elizalde A, Ferrer-Villada T, Dagnino-Acosta A, Huerta M, Osuna-Calleros Z, Rangel-Sandoval C, Sánchez-Pastor E Tags: Pharmacol Rep Source Type: research

Hexachlorobenzene as a persistent organic pollutant: Toxicity and molecular mechanism of action.
Abstract Hexachlorobenzene (HCB) is an organochlorine pesticide widely distributed in the environment. Chronic exposure of humans to HCB leads to a number of effects, such as triggering of porphyria, microsomal enzyme induction, thyroid dysfunctions, neurological symptoms, and immunological disorders. In animals, HCB induced hepatic porphyria, neurotoxic effects, and toxic effects on the thyroid function, reproductive system, and immune system. HCB as a dioxin-like compound and a weak ligand of the aryl hydrocarbon receptor (AhR) is a hormonal disruptor. HCB is also known to cause tumors of the liver, thyroid and ...
Source: Pharmacological Reports - July 1, 2017 Category: Drugs & Pharmacology Authors: Starek-Świechowicz B, Budziszewska B, Starek A Tags: Pharmacol Rep Source Type: research

Apigenin, a novel candidate involving herb-drug interaction (HDI), interacts with organic anion transporter 1 (OAT1).
CONCLUSION: Our results demonstrate that apigenin regulates OAT1, and can cause TDI or herb-drug interaction (HDI) when used in combination with acyclovir or adefovir. Therefore, apigenin could be used as a nephroprotective agent when used in combination with the substrates of OAT1. PMID: 29128807 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 27, 2017 Category: Drugs & Pharmacology Authors: Wu T, Li H, Chen J, Cao Y, Fu W, Zhou P, Pang J Tags: Pharmacol Rep Source Type: research

Attenuation of renal damage in type I diabetic rats by umbelliferone - a coumarin derivative.
CONCLUSION: Umbelliferone treatment can significantly reduce the diabetes induced renal damage and can improve the pathological conditions related to the diabetic nephropathy by down regulation of TGF-β. PMID: 29128808 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 27, 2017 Category: Drugs & Pharmacology Authors: Garud MS, Kulkarni YA Tags: Pharmacol Rep Source Type: research

Nanomechanical testing of drug activities at the cellular level: Case study for endothelium-targeted drugs.
CONCLUSIONS: The anti-inflammatory activity of the simvastatin is well illustrated by the endothelium cell elasticity changes returning from the characteristic inflammation time cycle "soft-stiff-soft" to control values. Furthermore, the elasticity results and F-actin labeling data indicated a preventive effect for 1- MP, whereas 1,4-DMP does not exhibit endothelium activity even at toxic concentrations. PMID: 29128796 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 24, 2017 Category: Drugs & Pharmacology Authors: Kolodziejczyk AM, Targosz-Korecka M, Szymonski M Tags: Pharmacol Rep Source Type: research

Emotional disorders induced by Hemopressin and RVD-hemopressin( α) administration in rats.
CONCLUSION: In conclusion, in the present study we demonstrated behavioral effects induced by peripheral hemopressin and RVD-hemopressin(α) injections, that could involve modulatory effects on monoaminergic signaling, in the prefrontal cortex. PMID: 29128806 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 23, 2017 Category: Drugs & Pharmacology Authors: Leone S, Recinella L, Chiavaroli A, Martinotti S, Ferrante C, Mollica A, Macedonio G, Stefanucci A, Dvorácskó S, Tömböly C, De Petrocellis L, Vacca M, Brunetti L, Orlando G Tags: Pharmacol Rep Source Type: research

Icariin induces apoptosis in acute promyelocytic leukemia by targeting PIM1.
CONCLUSIONS: Icariin potently inhibits the cell growth of APL in vitro through inducing caspase-dependent apoptosis. Hence, it can be considered as a promising candidate therapeutic agent for treating APL, although further studies including clinical trials are warranted. PMID: 29128809 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 15, 2017 Category: Drugs & Pharmacology Authors: Zhang H, Li P, Li J, Song T, Wang L, Li E, Wang J, Wang L, Wei N, Wang Z Tags: Pharmacol Rep Source Type: research

Effect of aromatase inhibitors on learning and memory and modulation of hippocampal dickkopf-1 and sclerostin in female mice.
CONCLUSION: The present study demonstrates that aromatase inhibitors have adverse impact on cognition. Furthermore, modulation of Wnt signaling following estrogen depletion possibly contributed to observed effects in case of anastrozole and letrozole. PMID: 29128813 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 13, 2017 Category: Drugs & Pharmacology Authors: Zameer S, Vohora D Tags: Pharmacol Rep Source Type: research

Effect of dietary copper nanoparticles versus one copper (II) salt: Analysis of vasoreactivity in a rat model.
CONCLUSIONS: Our results demonstrate for the first time that the observed effects of copper administration in the form of NPs are attributed mainly to the NPs rather than copper itself. Thus another mechanism not related with Cu,Zn-SOD and CAT seems to be involved. PMID: 29128810 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 12, 2017 Category: Drugs & Pharmacology Authors: Majewski M, Ognik K, Zdunczyk P, Juskiewicz J Tags: Pharmacol Rep Source Type: research

An ApoB100-mimetic vaccine prevents obesity and liver steatosis in ApoE-/- mice.
Abstract BACKGROUND: Recently, a peptide vaccine (B4T) was developed that prevents high fat diet (HFD)-induced obesity and liver steatosis in wild type mice and appears to target an epitope present in ApoB100 but not ApoB48. Here, we ask whether B4T remains effective in ApoE knockout (ApoE-ko) mice, which exhibit a greatly increased ApoB48/ApoB100 ratio and develop atherosclerosis under HFD. METHODS: HFD-fed male ApoE-ko mice were injected with B4T or vehicle 3 times between 5 and 15 weeks of age. Until 45 weeks of age, they were regularly weighed and antibody titers determined. In the end, adiposity and orga...
Source: Pharmacological Reports - June 4, 2017 Category: Drugs & Pharmacology Authors: Kong SK, Choe MK, Kim HJ, Kim YS, Binas B, Kim HJ Tags: Pharmacol Rep Source Type: research

Phytochemicals genistein and capsaicin modulate Kv2.1 channel gating.
CONCLUSION: This study effectively demonstrated the inhibitory effects of genistein and capsaicin on Kv2.1 channels. As Kv2.1 channels play a prominent role in glucose-stimulated insulin secretion, our findings contribute to our understanding of the putative mechanism by which these phytochemicals exert their reported hypoglycemic effects. PMID: 29128793 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 3, 2017 Category: Drugs & Pharmacology Authors: Aréchiga-Figueroa IA, Morán-Zendejas R, Delgado-Ramírez M, Rodríguez-Menchaca AA Tags: Pharmacol Rep Source Type: research

Pharmacological evidence for the involvement of adenosine triphosphate sensitive potassium channels in chloroquine-induced itch in mice.
CONCLUSIONS: We suggest that KATP channels are possibly involved in CQ-induced itch. While, further studies will be significant to better elucidate the association of metabolic state of cells and itch. PMID: 29128812 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 3, 2017 Category: Drugs & Pharmacology Authors: Ostadhadi S, Foroutan A, Haddadi NS, Norouzi-Javidan A, Momeny M, Zarrinrad G, Ghaffari SH, Dehpour AR Tags: Pharmacol Rep Source Type: research

Depressive-like neurochemical and behavioral markers of Parkinson's disease after 6-OHDA administered unilaterally to the rat medial forebrain bundle.
CONCLUSIONS: Administration of the highest dose of 6-OHDA without desipramine pretreatment evoked neurochemical and behavioral changes resembling the advanced PD with coexisting depression. PMID: 28843848 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 3, 2017 Category: Drugs & Pharmacology Authors: Kamińska K, Lenda T, Konieczny J, Czarnecka A, Lorenc-Koci E Tags: Pharmacol Rep Source Type: research

Environmental influences in the etiology of colorectal cancer: the premise of metabolomics.
Abstract PURPOSE OF REVIEW: In this review we discuss how environmental exposures predominate the etiology of colorectal cancer (CRC). With CRC being a personalized disease influenced by genes and environment, our goal was to explore the role metabolomics can play in identifying exposures, assessing the interplay between co-exposures, and the development of personalized therapeutic interventions. RECENT FINDINGS: Approximately 10 % of CRC cases can be explained by germ-line mutations, whereas the prevailing majority are caused by an initiating exposure event occurring decades prior to diagnosis. Recent resear...
Source: Pharmacological Reports - June 1, 2017 Category: Drugs & Pharmacology Authors: Rattray NJW, Charkoftaki G, Rattray Z, Hansen JE, Vasiliou V, Johnson CH Tags: Curr Pharmacol Rep Source Type: research

The mechanism of neuroprotective action of natural compounds.
Abstract Disturbance of cerebral redox homeostasis is the primary cause of human neurodegenerative disorders, such as Parkinson's disease or Alzheimer's disease. Well known experimental research demonstrates that oxidative stress is a main cause of cell death. A high concentration of reactive oxygen and nitrogen species leads to damage of a lot of proteins, lipids and also DNA. Synthetic compounds used for the treatment in the neurodegenerative diseases failed to meet the hopes they had raised and often exhibit a number of side effects. Therefore, in recent years interest in natural compounds derived from plants a...
Source: Pharmacological Reports - April 30, 2017 Category: Drugs & Pharmacology Authors: Wąsik A, Antkiewicz-Michaluk L Tags: Pharmacol Rep Source Type: research

Naringenin prevents ischemic stroke damage via anti-apoptotic and anti-oxidant effects.
This study aimed to investigate the anti-apoptotic and anti-oxidant effects of naringenin on ischemic stroke. In vitro, cortical neuron cells isolated from the brains of neonatal Sprague-Dawley rats were randomly divided into control, oxygen and glucose deprivation/reperfusion (OGD/Rep), NAR-L, NAR-M and NAR-H groups. MTT and RT-PCR were used for cell proliferation and apoptosis-related proteins analyses. The effects of NAR on the Nrf2 signaling pathway were investigated using transfection approaches. Differences in mitochondrial dysfunction were analyzed by flow cytometry. In vivo, middle cerebral artery occlusion (MCAO) ...
Source: Pharmacological Reports - April 28, 2017 Category: Drugs & Pharmacology Authors: Wang K, Chen Z, Huang J, Huang L, Luo N, Liang X, Liang M, Xie W Tags: Clin Exp Pharmacol Physiol Source Type: research

Corrigendum to "Epicutaneous immunization with protein antigen TNP-Ig alleviates TNBS-induced colitis in mice" [Pharmacol. Rep. 64 (2012) 1497-1504].
Corrigendum to "Epicutaneous immunization with protein antigen TNP-Ig alleviates TNBS-induced colitis in mice" [Pharmacol. Rep. 64 (2012) 1497-1504]. Pharmacol Rep. 2017 Apr 08;: Authors: Majewska-Szczepanik M, Góralska M, Marcińska K, Zemelka-Wiącek M, Strzępa A, Dorożyńska I, Szczepanik M PMID: 28400086 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 8, 2017 Category: Drugs & Pharmacology Authors: Majewska-Szczepanik M, Góralska M, Marcińska K, Zemelka-Wiącek M, Strzępa A, Dorożyńska I, Szczepanik M Tags: Pharmacol Rep Source Type: research

Acute behavioral effects of co-administration of mephedrone and MDMA in mice.
CONCLUSIONS: The effects of mephedrone and MDMA combination on mammalian organisms were attempted to be evaluated in our study and the results are described in the present report. These results may help explain the reasons for and consequences of a concomitant administration of psychoactive substances with regards to the central nervous system, while being possibly useful in the treatment of polydrug intoxication. PMID: 28073060 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Budzynska B, Michalak A, Frankowska M, Kaszubska K, Biała G Tags: Pharmacol Rep Source Type: research

The significance of microRNAs in the course of rDD.
CONCLUSIONS: 1. There is no significant difference in miRNAs expression between patients with recurrent depressive disorders and those in the first episode of depression. 2. The differences in terms of expression of the analysed variables between the subjects with symptoms of depression and healthy individuals were confirmed. PMID: 28073061 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Bobińska K, Szemraj J, Mossakowska-Wójcik J, Gałecki P, Talarowska M Tags: Pharmacol Rep Source Type: research

Application of the DREADD technique in biomedical brain research.
Abstract The DREADD (Designer Receptors Exclusively Activated by Designer Drugs) technique is a new chemogenetic approach allowing for selective and remote control of neural activity with a high degree of spatial resolution. Since its discovery in 2007 the DREADD technique was successfully employed into basic research, and together with the optogenetic method provided so far the best tool to influence the activity of the brain circuits and cell populations. The first aim of this review was to concisely describe the technique with regard to such issues like the history of its development, biochemistry as well as mo...
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Dobrzanski G, Kossut M Tags: Pharmacol Rep Source Type: research

Antinociceptive effect of co-administered NMDA and histamine H4 receptor antagonists in a rat model of acute pain.
CONCLUSIONS: The results show for the first time that the H4R and NMDA receptors play a significant role in antinociception in an acute non-inflammatory pain. Furthermore, the blockage of NMDA receptors at the peripheral and spinal, but not supraspinal sites produces a profound antinociceptive response upon simultaneous H4R antagonism. Thus, this study clearly demonstrates the relevance of NMDA and H4R receptors in the modulation of pain signals and that their role is not exclusively limited to their modulatory activity in inflammatory pain states. PMID: 28092808 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Wolińska R, Leśniak A, Żochowska M, Sacharczuk M, Kieć-Kononowicz K, Bujalska-Zadrożny M Tags: Pharmacol Rep Source Type: research

Liver alpha-amylase gene expression as an early obesity biomarker.
CONCLUSIONS: Elevated liver alpha-amylase levels may be indicative of initial stages of obesity and the use of acarbose could be considered as a treatment of obesity which could be potentially effective at multiple levels. PMID: 28095353 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Mojbafan M, Afsartala Z, Amoli MM, Mahmoudi M, Yaghmaei P, Larijani B, Ebrahim-Habibi A Tags: Pharmacol Rep Source Type: research

Genetic variants of dopamine D2 receptor impact heterodimerization with dopamine D1 receptor.
CONCLUSION: The data presented in this paper support the hypothesis on the role of calcium signaling regulated by the D1-D2 heteromer which may be of relevance for schizophrenia etiology. PMID: 28119185 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Błasiak E, Łukasiewicz S, Szafran-Pilch K, Dziedzicka-Wasylewska M Tags: Pharmacol Rep Source Type: research

The effect of α-synuclein on gliosis and IL-1α, TNFα, IFNγ, TGFβ expression in murine brain.
CONCLUSION: Our results suggest that both the microglia activation and supressing astrocytes play a crucial role in ASN-related dopaminergic neurotoxicity. PMID: 28126640 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Sznejder-Pachołek A, Joniec-Maciejak I, Wawer A, Ciesielska A, Mirowska-Guzel D Tags: Pharmacol Rep Source Type: research

The application of skin metabolomics in the context of transdermal drug delivery.
Abstract Metabolomics is a powerful emerging tool for the identification of biomarkers and the exploration of metabolic pathways in a high-throughput manner. As an administration site for percutaneous absorption, the skin has a variety of metabolic enzymes, except other than hepar. However, technologies to fully detect dermal metabolites remain lacking. Skin metabolomics studies have mainly focused on the regulation of dermal metabolites by drugs or on the metabolism of drugs themselves. Skin metabolomics techniques include collection and preparation of skin samples, data collection, data processing and analysis. ...
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Li J, Xu W, Liang Y, Wang H Tags: Pharmacol Rep Source Type: research

Effects of fenoterol on the skeletal system depend on the androgen level.
CONCLUSIONS: The results indicate the favorable action of fenoterol in conditions of testosterone deficiency, and its destructive influence upon the skeleton in the presence of androgens. The results confirm the key role of sympathetic nervous system in the regulation of bone remodeling. PMID: 28126642 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Śliwiński L, Cegieła U, Pytlik M, Folwarczna J, Janas A, Zbrojkiewicz M Tags: Pharmacol Rep Source Type: research

Protective effect of cardamonin against acetic acid-induced ulcerative colitis in rats.
Abstract BACKGROUND: Ulcerative colitis (UC) is an inflammatory bowel disease with significant morbidity. Cardamonin is a natural chalcone derivative with considerable anti-inflammatory activity. Herein, the potential protective effect of cardamonin against UC was tested in a rat model. METHODS: Rats were given 10 or 30mg/kg/day of cardamonin orally for 14days before induction of UC. On the 14th day of treatment, UC was induced by intrarectal instillation of 2ml 3% acetic acid. Twenty four h after acetic acid instillation, rats were sacrificed and colons were analyzed by macroscopic and histopathological exam...
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Ali AA, Abd Al Haleem EN, Khaleel SA, Sallam AS Tags: Pharmacol Rep Source Type: research

Antidepressant and anxiolytic-like activity of sodium selenite after acute treatment in mice.
CONCLUSIONS: These potential antidepressant- and anxiolytic-like effects of Se require more detailed experimental study using animal models to approach a clear conclusion regarding the potential mechanism of the observed effect. PMID: 28167456 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Kędzierska E, Dudka J, Poleszak E, Kotlińska JH Tags: Pharmacol Rep Source Type: research

A review on antioxidant potential of bioactive heterocycle benzofuran: Natural and synthetic derivatives.
Abstract The majority of heterocycle compounds and typically common heterocycle fragments present in most pharmaceuticals currently marketed, alongside with their intrinsic versatility and unique physicochemical properties, have poised them as true cornerstones of medicinal chemistry. In this context, oxygen heterocycles exhibit diverse biological and pharmacological activities due in part to the similarities with many natural and synthetic molecules with known biological activity. Among oxygen containing heterocycles, benzofuran (synthetic and natural isolated) and its derivatives have attracted medicinal chemist...
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Chand K, Rajeshwari, Hiremathad A, Singh M, Santos MA, Keri RS Tags: Pharmacol Rep Source Type: research

Attenuation of stress induced memory deficits by nonsteroidal anti-inflammatory drugs (NSAIDs) in rats: Role of antioxidant enzymes.
CONCLUSION: In conclusion this study suggests a therapeutic potential of indomethacin and diclofenac against repeated stress-induced memory deficits. PMID: 28178591 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Emad S, Qadeer S, Sadaf S, Batool Z, Haider S, Perveen T Tags: Pharmacol Rep Source Type: research

Sertraline and venlafaxine improves motor performance and neurobehavioral deficit in quinolinic acid induced Huntington's like symptoms in rats: Possible neurotransmitters modulation.
CONCLUSION: The present study suggests that modulation of monoamines level, normalization of GABA and glutamatergic signaling, anti-oxidant and anti-inflammatory properties could underlie the neuroprotective effect of sertraline and venlafaxine in QA induced Huntington's like symptoms. PMID: 28178592 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Gill JS, Jamwal S, Kumar P, Deshmukh R Tags: Pharmacol Rep Source Type: research

The role of histamine in the regulation of the viability, proliferation and transforming growth factor β1 secretion of rat wound fibroblasts.
CONCLUSION: The regulatory influence of histamine on wound fibroblast function (viability/metabolic activity or secretion of TGFβ1) is dependent on H1 receptor stimulation. Contrary to wound fibroblasts, these cells express a very low level of H1 receptors when isolated from intact dermis and histamine is unable to modify their metabolic activity. PMID: 28178593 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Wolak M, Bojanowska E, Staszewska T, Ciosek J, Juszczak M, Drobnik J Tags: Pharmacol Rep Source Type: research

Diabetic nephropathy: A potential savior with 'rotten-egg' smell.
Abstract Diabetic nephropathy (DN) is currently the leading cause of end-stage renal disease. Despite optimal management, DN is still a major contributor to morbidity and mortality of diabetic patients worldwide. The major pathological alterations in DN include excessive accumulation and deposition of extracellular matrix, leading to expansion of mesangial matrix, thickening of glomerular basement membrane and tubulointerstitial fibrosis. At the molecular level, accumulating evidence suggests that hyperglycemia or high glucose mediates renal injury in DN via multiple molecular mechanisms such as induction of oxida...
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Dugbartey GJ Tags: Pharmacol Rep Source Type: research

Population pharmacokinetic modelling of valproic acid and its selected metabolites in acute VPA poisoning.
CONCLUSIONS: None of the models perfectly described the experimental data. Important factors like the variable degree of protein binding by VPA could not be included in the models. The small number of subjects used in the study made the analysis of more covariates impossible. PMID: 28187395 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Jawień W, Wilimowska J, Kłys M, Piekoszewski W Tags: Pharmacol Rep Source Type: research

Methyl-orvinol-Dual activity opioid receptor ligand inhibits gastrointestinal transit and alleviates abdominal pain in the mouse models mimicking diarrhea-predominant irritable bowel syndrome.
CONCLUSION: Methyl-orvinol could become a promising drug candidate in chronic therapy of functional GI diseases such as IBS-D. PMID: 28187396 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Zielińska M, Jarmuż A, Wasilewski A, Cami-Kobeci G, Husbands S, Fichna J Tags: Pharmacol Rep Source Type: research

Telmisartan attenuates diabetes induced depression in rats.
Abstract BACKGROUND: Role of brain renin angiotensin system (RAS) is well understood and various clinical studies have proposed neuroprotective effects of ARB's. It is also assumed that diabetic depression is associated with activation of brain RAS, HPA axis dysregulation and brain inflammatory events. Therefore, the present study was designed to investigate the antidepressant effect of low dose telmisartan (TMS) in diabetes induced depression (DID) in rats. METHODS: Diabetes was induced by injecting streptozotocin. After 21days of treatment the rats were subjected to forced swim test (FST). The rats, with in...
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Aswar U, Chepurwar S, Shintre S, Aswar M Tags: Pharmacol Rep Source Type: research

Enhancement of oral bioavailability of rivastigmine with quercetin nanoparticles by inhibiting CYP3A4 and esterases.
Abstract BACKGROUND: Quercetin is a well-known flavonoid, has pharmacokinetic interaction with ester drugs due to its capability of esterase inhibition in the gut and liver. However, the interaction between quercetin nanoparticles (NQC) and rivastigmine has not been reported. Hence, the present study was performed to evaluate the effect of quercetin alone and its nanoparticles on the pharmacokinetics of rivastigmine in rats. METHODS: NQC prepared by antisolvent precipitation method. The influence of quercetin on the pharmacokinetics of rivastigmine was evaluated by following methods i.e. in vitro inhibitory e...
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Palle S, Neerati P Tags: Pharmacol Rep Source Type: research

Corrigendum to "Epicutaneous immunization with hapten-conjugated protein antigen alleviates contact sensitivity mediated by three different types of effector cells" [Pharmacol. Rep. 64 (2012) 919-926].
Corrigendum to "Epicutaneous immunization with hapten-conjugated protein antigen alleviates contact sensitivity mediated by three different types of effector cells" [Pharmacol. Rep. 64 (2012) 919-926]. Pharmacol Rep. 2017 Mar 16;: Authors: Majewska-Szczepanik M, Strzępa A, Drożyńska I, Motyl S, Banach T, Szczepanik M PMID: 28325474 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 16, 2017 Category: Drugs & Pharmacology Authors: Majewska-Szczepanik M, Strzępa A, Drożyńska I, Motyl S, Banach T, Szczepanik M Tags: Pharmacol Rep Source Type: research

Corrigendum to "The effect of combined treatment with risperidone and antidepressants on the MK-801-induced deficits in the social interaction test in rats" [Pharmacol. Rep. 67 (2015) 1183-1187].
Corrigendum to "The effect of combined treatment with risperidone and antidepressants on the MK-801-induced deficits in the social interaction test in rats" [Pharmacol. Rep. 67 (2015) 1183-1187]. Pharmacol Rep. 2017 Mar 15;: Authors: Kamińska K, Rogóż Z PMID: 28325475 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 15, 2017 Category: Drugs & Pharmacology Authors: Kamińska K, Rogóż Z Tags: Pharmacol Rep Source Type: research

Progress in Prediction and Interpretation of Clinically Relevant Metabolic Drug-Drug Interactions: a Minireview Illustrating Recent Developments and Current Opportunities.
Abstract PURPOSE OF REVIEW: This review gives a perspective on the current "state of the art" in metabolic drug-drug interaction (DDI) prediction. We highlight areas of successful prediction and illustrate progress in areas where limits in scientific knowledge or technologies prevent us from having full confidence. RECENT FINDINGS: Several examples of success are highlighted. Work done for bitopertin shows how in vitro and clinical data can be integrated to give a model-based understanding of pharmacokinetics and drug interactions. The use of interpolative predictions to derive explicit dosage recom...
Source: Pharmacological Reports - March 8, 2017 Category: Drugs & Pharmacology Authors: Fowler S, Morcos PN, Cleary Y, Martin-Facklam M, Parrott N, Gertz M, Yu L Tags: Curr Pharmacol Rep Source Type: research

Corrigendum to "Exenatide (a GLP-1 agonist) expresses anti-inflammatory properties in cultured human monocytes/macrophages in a protein kinase A and B/Akt manner" [Pharmacological Reports 68 (2016) 329-337].
Corrigendum to "Exenatide (a GLP-1 agonist) expresses anti-inflammatory properties in cultured human monocytes/macrophages in a protein kinase A and B/Akt manner" [Pharmacological Reports 68 (2016) 329-337]. Pharmacol Rep. 2017 Feb 05;: Authors: Bułdak Ł, Machnik G, Bułdak RJ, Łabuzek K, Bołdys A, Belowski D, Basiak M, Okopień B PMID: 28179083 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 4, 2017 Category: Drugs & Pharmacology Authors: Bułdak Ł, Machnik G, Bułdak RJ, Łabuzek K, Bołdys A, Belowski D, Basiak M, Okopień B Tags: Pharmacol Rep Source Type: research

Corrigendum to "Influence of caffeine on the protective activity of gabapentin and topiramate in a mouse model of generalized tonic-clonic seizures" [Pharmacol. Rep. 68 (2016) 680-685].
Corrigendum to "Influence of caffeine on the protective activity of gabapentin and topiramate in a mouse model of generalized tonic-clonic seizures" [Pharmacol. Rep. 68 (2016) 680-685]. Pharmacol Rep. 2017 Feb 05;: Authors: Jargiełło-Baszak M, Chrościńska-Krawczyk M, Andres-Mach M, Łuszczki JJ, Czuczwar SJ PMID: 28179084 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 4, 2017 Category: Drugs & Pharmacology Authors: Jargiełło-Baszak M, Chrościńska-Krawczyk M, Andres-Mach M, Łuszczki JJ, Czuczwar SJ Tags: Pharmacol Rep Source Type: research

Manganese neurotoxicity and protective effects of resveratrol and quercetin in preclinical research.
CONCLUSION: Repeated Mn administration induces toxic effects in several rat brain structures and treatment with R and QCT may be a potential therapeutic strategy to attenuate the metal neurotoxicity. PMID: 28183032 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 13, 2016 Category: Drugs & Pharmacology Authors: Gawlik M, Gawlik MB, Smaga I, Filip M Tags: Pharmacol Rep Source Type: research