Effects of curcumin on neurological diseases: focus on astrocytes.
Abstract Astrocytes are the most abundant glial cells in the central nervous system, and are important players in both brain injury and neurodegenerative disease. Curcumin (1,7-bis[4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione), the major active component of turmeric, belongs to the curcuminoid family that was originally isolated from the plant Curcuma longa. Several studies suggest that curcumin may have a beneficial impact on the brain pathology and aging. These effects are due to curcumin's antioxidant, free-radical scavenging, and anti-inflammatory activity. In light of this, our current review aims to d...
Source: Pharmacological Reports - May 27, 2020 Category: Drugs & Pharmacology Authors: Eghbaliferiz S, Farhadi F, Barreto GE, Majeed M, Sahebkar A Tags: Pharmacol Rep Source Type: research

The effect of forskolin on membrane clock and calcium clock in the hypoxic/reoxygenation of sinoatrial node cells and its mechanism.
In this study, we investigated the effect of forskolin (FSK, a selective adenylate cyclase agonist) on the automatic diastolic depolarization of sinus node cells (SNC) with hypoxia/reoxygenation (H/R) injury. METHODS: The SNC of the newborn rat was randomly assigned into the control group, the H/R (H/R injury) group, or the H/R + FSK (H/R injury + FSK treatment) group. Patch-clamp was performed to record the action potential and electrophysiological changes. The cellular distribution of intracellular calcium concentration was analyzed by fluorescence staining. RESULTS: Compared with th...
Source: Pharmacological Reports - May 25, 2020 Category: Drugs & Pharmacology Authors: Zhang JC, Xie XT, Chen Q, Zou T, Wu HL, Zhu C, Dong Y, Ye L, Li Y, Zhu PL Tags: Pharmacol Rep Source Type: research

Correction to: Efficacy and safety of inhalation budesonide in the treatment of pediatric asthma in the emergency department: a systematic review and meta-analysis.
Abstract The original version of this article, published on 29 March 2020 unfortunately contains a mistake. PMID: 32430869 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 19, 2020 Category: Drugs & Pharmacology Authors: Viswanatha GL, Shylaja H, Nandakumar K, Venkataranganna MV, Prasad NBL Tags: Pharmacol Rep Source Type: research

Utilization of Physiologically Based Pharmacokinetic Modeling in Clinical Pharmacology and Therapeutics: an Overview.
Abstract The purpose of this review was to assess the advancement of applications for physiologically based pharmacokinetic (PBPK) modeling in various therapeutic areas. We conducted a PubMed search, and 166 articles published between 2012 and 2018 on FDA-approved drug products were selected for further review. Qualifying publications were summarized according to therapeutic area, medication(s) studied, pharmacokinetic model type utilized, simulator program used, and the applications of that modeling. The results showed a 13-fold increase in the number of papers published from 2012 to 2018, with the largest propor...
Source: Pharmacological Reports - May 12, 2020 Category: Drugs & Pharmacology Authors: Perry C, Davis G, Conner TM, Zhang T Tags: Curr Pharmacol Rep Source Type: research

Analgesic effects of the CTK 01512-2 toxin in different models of orofacial pain in rats.
CONCLUSIONS: The roles of TRPA1 in pain transduction and the performance of CTK 01512-2 in the inhibition of the N-type VGCCs were reinforced. This dual activity may represent an advantage in clinical treatments. PMID: 32399819 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 12, 2020 Category: Drugs & Pharmacology Authors: Caminski ES, de Freitas LM, Dallegrave E, Junior CADS, Gomez MV, Pereira EMR, Antunes FTT, de Souza AH Tags: Pharmacol Rep Source Type: research

Chemotherapy-induced peripheral neuropathy: part 1-current state of knowledge and perspectives for pharmacotherapy.
CONCLUSIONS: The prevalence of CIPN, potential causes, risk factors, symptoms and molecular mechanisms underlying this pharmacoresistant condition are discussed. PMID: 32394362 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 11, 2020 Category: Drugs & Pharmacology Authors: Sałat K Tags: Pharmacol Rep Source Type: research

An Update on Current Therapeutic Drugs Treating COVID-19.
Abstract The current pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has presented unprecedented challenges to the healthcare systems in almost every country around the world. Currently, there are no proven effective vaccines or therapeutic agents against the virus. Current clinical management includes infection prevention and control measures and supportive care including supplemental oxygen and mechanical ventilatory support. Evolving research and clinical data regarding the virologic SARS-CoV-2 suggest a potential list of repurposed drugs wi...
Source: Pharmacological Reports - May 11, 2020 Category: Drugs & Pharmacology Authors: Wu R, Wang L, Kuo HD, Shannar A, Peter R, Chou PJ, Li S, Hudlikar R, Liu X, Liu Z, Poiani GJ, Amorosa L, Brunetti L, Kong AN Tags: Curr Pharmacol Rep Source Type: research

Hot Topic Commentary on COVID-19.
Abstract The recent pandemic outbreak of COVID-19 (severe acute respiratory syndrome coronavirus 2; SARS-CoV-2) worldwide caught the health care systems in every country around the world by storm and without a proper defense mechanism to cope and control such a pandemic. In this special Theme issue, we would like to discuss the latest treatment modalities available around the world in tackling this dreadful disease. PMID: 32395419 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 11, 2020 Category: Drugs & Pharmacology Authors: Kong AN, Lau ATY, Brunetti L Tags: Curr Pharmacol Rep Source Type: research

Clinical significance of fluid biomarkers in Alzheimer's Disease.
Abstract The number of patients with Alzheimer's Disease (AD) and other types of dementia disorders has drastically increased over the last decades. AD is a complex progressive neurodegenerative disease affecting about 14 million patients in Europe and the United States. The hallmarks of this disease are neurotic plaques consist of the Amyloid-β peptide (Aβ) and neurofibrillary tangles (NFTs) formed of hyperphosphorylated Tau protein (pTau). Currently, four CSF biomarkers: Amyloid beta 42 (Aβ42), Aβ42/40 ratio, Tau protein, and Tau phosphorylated at threonine 181 (pTau181) have been indicated a...
Source: Pharmacological Reports - May 8, 2020 Category: Drugs & Pharmacology Authors: Lewczuk P, Łukaszewicz-Zając M, Mroczko P, Kornhuber J Tags: Pharmacol Rep Source Type: research

Chemotherapy-induced peripheral neuropathy-part 2: focus on the prevention of oxaliplatin-induced neurotoxicity.
CONCLUSION: Emerging novel chemical structures-potential future preventative pharmacotherapies for CIPN caused by oxaliplatin are reported. PMID: 32347537 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 28, 2020 Category: Drugs & Pharmacology Authors: Sałat K Tags: Pharmacol Rep Source Type: research

Reduction of the serotonin 5-HT1B and 5-HT2A receptor-mediated contraction of human pulmonary artery by the combined 5-HT1B receptor antagonist and serotonin transporter inhibitor LY393558.
CONCLUSIONS: LY393558 reduces the 5-HT-induced contraction antagonizing 5-HT1B and 5-HT2A receptors probably due to synergic interaction between SERT inhibition and 5-HT1B receptor antagonism. Thus, it might represent a valuable future option in the pulmonary arterial hypertension therapy. PMID: 32333296 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 24, 2020 Category: Drugs & Pharmacology Authors: Baranowska-Kuczko M, Kozłowska H, Schlicker E, Göthert M, MacLean MR, Kozłowski M, Kloza M, Sadowska O, Malinowska B Tags: Pharmacol Rep Source Type: research

Efficacy of single and repeated administration of ketamine in unipolar and bipolar depression: a meta-analysis of randomized clinical trials.
Abstract BACKGROUND: Due to unmet clinical needs for efficient drugs with a rapid onset of antidepressant effects, we aimed to evaluate the efficacy of single-dose ketamine in different subgroups of patients with major depression and establish whether repeated ketamine administration could be a viable strategy to maintain treatment gains. METHODS: Electronic databases (Medline via PubMed, Embase, Cochrane Library, Trip Database) were systematically searched until February 22, 2019, for published peer-reviewed randomized controlled trials (RCTs) concerning a single and repeated administration of ketamine in pa...
Source: Pharmacological Reports - April 16, 2020 Category: Drugs & Pharmacology Authors: Kryst J, Kawalec P, Mitoraj AM, Pilc A, Lasoń W, Brzostek T Tags: Pharmacol Rep Source Type: research

Population pharmacokinetics of standard-dose meropenem in critically ill patients on continuous renal replacement therapy: a prospective observational trial.
CONCLUSIONS: The population PK model was successfully developed to describe the time course of meropenem concentrations. The hypoalbuminemia was found to be associated with higher PTA in the CRRT patients after multiple short-term infusions. PMID: 32301057 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 16, 2020 Category: Drugs & Pharmacology Authors: Onichimowski D, Będźkowska A, Ziółkowski H, Jaroszewski J, Borys M, Czuczwar M, Wiczling P Tags: Pharmacol Rep Source Type: research

Lidocaine as an element of multimodal analgesic therapy in major spine surgical procedures in children: a prospective, randomized, double-blind study.
CONCLUSIONS: Perioperative lidocaine administration, as a part of the applied analgesic therapy regimen, may decrease postoperative opioid demand and accelerates convalescence of children undergoing major surgery. PMID: 32297162 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 15, 2020 Category: Drugs & Pharmacology Authors: Batko I, Kościelniak-Merak B, Tomasik PJ, Kobylarz K, Wordliczek J Tags: Pharmacol Rep Source Type: research

The atypical neuroleptics iloperidone and lurasidone inhibit human cytochrome P450 enzymes in vitro. Evaluation of potential metabolic interactions.
CONCLUSION: The examined neuroleptics showed inhibitory effects on different CYP enzymes. The obtained results indicate that metabolic/pharmacokinetic interactions with iloperidone (involving mainly CYP3A4 and CYP2D6) and possibly with lurasidone (involving CYP1A2, CYP2C9 or CYP2C19) may occur during combined therapy. PMID: 32279279 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 11, 2020 Category: Drugs & Pharmacology Authors: Danek PJ, Wójcikowski J, Daniel WA Tags: Pharmacol Rep Source Type: research

Chronic activation of GPR40 does not negatively impact upon BRIN-BD11 pancreatic β-cell physiology and function.
CONCLUSIONS: Chronic activation of GPR40 using GW9508 does not negatively impact upon BRIN-BD11 pancreatic β-cells physiology and function. The GPR40 antagonist GW1100 does not protect against the deleterious effects of chronic palmitate exposure. We conclude that GPR40 is probably not involved in mediating the toxicity associated with chronic palmitate exposure. PMID: 32274767 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 9, 2020 Category: Drugs & Pharmacology Authors: Vilas-Boas EA, Karabacz N, Marsiglio-Librais GN, Valle MMR, Nalbach L, Ampofo E, Morgan B, Carpinelli AR, Roma LP Tags: Pharmacol Rep Source Type: research

Ortho-vanillin nanoparticle-doped glucan microspheres  exacerbate the anti-arthritic effects of methotrexate in adjuvant-induced arthritis in rats.
Ortho-vanillin nanoparticle-doped glucan microspheres exacerbate the anti-arthritic effects of methotrexate in adjuvant-induced arthritis in rats. Pharmacol Rep. 2020 Apr 09;: Authors: Nasr S, Varshosaz J, Hajhashemi V Abstract BACKGROUND: Methotrexate (MTX) commonly used in rheumatoid arthritis (RA) has severe adverse effects. Ortho-vanillin, an inhibitor of Toll-like receptors (TLR), can prevent inflammation. Glucan is a cereal fiber recognized by dectin-1 or β-glucan receptors of phagocytic macrophages. The purpose of the current project was to study the effect of co-a...
Source: Pharmacological Reports - April 9, 2020 Category: Drugs & Pharmacology Authors: Nasr S, Varshosaz J, Hajhashemi V Tags: Pharmacol Rep Source Type: research

Anxiolytic-like effects of mirogabalin, a novel ligand for α2δ ligand of voltage-gated calcium channels, in rats repeatedly injected with acidic saline intramuscularly, as an experimental model of fibromyalgia.
CONCLUSIONS: Sluka model rats exhibited anxiety-like behaviours in the open field test and the elevated plus maze test, but mirogabalin alleviated these behaviours. Mirogabalin might thus have the potential to relieve anxiety in fibromyalgia patients. PMID: 32270470 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 8, 2020 Category: Drugs & Pharmacology Authors: Murasawa H, Kobayashi H, Yasuda SI, Saeki K, Domon Y, Arakawa N, Kubota K, Kitano Y Tags: Pharmacol Rep Source Type: research

Neuroprotective effects of mirtazapine and imipramine and their effect in pro- and anti-apoptotic gene expression in human neuroblastoma cells.
CONCLUSIONS: The obtained data indicate that mirtazapine and imipramine have neuroprotective effects against H2O2-induced cell death. Although both antidepressants reduced Bax and p53 mRNA expression, only the protection mediated by imipramine might be due to its ability to enhance Bcl-2/Bax ratio. PMID: 32240535 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 2, 2020 Category: Drugs & Pharmacology Authors: Lieberknecht V, Engel D, Rodrigues ALS, Gabilan NH Tags: Pharmacol Rep Source Type: research

Efficacy and safety of inhalation budesonide in the treatment of pediatric asthma in the emergency department: a systematic review and meta-analysis.
This study was aimed to evaluate the beneficial role of inhalation budesonide(BUD) in improving the pulmonary functions, and reducing the hospital admission rate, worsening of asthma and commonly encountered adverse events in pediatric asthma. METHODS: The electronic search was performed using PubMed, Scopus, CENTRAL (Cochrane Central Register of Controlled Trials) and Google scholar databases to identify the randomized control trials(RCTs). RESULTS: 21 RCTs involving 12,787 subjects were included. The meta-analysis revealed that the BUD has reduced the hospitalization rate (Mantel-Haenszel (M-H), random effects ...
Source: Pharmacological Reports - March 29, 2020 Category: Drugs & Pharmacology Authors: Viswanatha GL, Shylaja H, Nandakumar K, Venkataranganna MV, Prasad NBL Tags: Pharmacol Rep Source Type: research

Blockade of the colony-stimulating factor-1 receptor reverses bone loss in osteoporosis mouse models.
CONCLUSION: Our results demonstrate that blockade of CSF-1R signaling reverses bone loss in two different mouse models of osteoporosis. PMID: 32222915 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 28, 2020 Category: Drugs & Pharmacology Authors: Martínez-Martínez A, Muñoz-Islas E, Ramírez-Rosas MB, Acosta-González RI, Torres-Rodríguez HF, Jiménez-Andrade JM Tags: Pharmacol Rep Source Type: research

Influence of the endocannabinoid system on the antidepressant activity of bupropion and moclobemide in the behavioural tests in mice.
CONCLUSION: The outcomes of the present study revealed that particularly activation or inhibition of the CB1 receptor function may augment the antidepressant activity of bupropion, whereas only inhibition of the CB1 receptor function manages to increase activity of moclobemide. Most probably, an interplay between CB receptor ligands and bupropion or moclobemide takes place at the cellular level. PMID: 32221841 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 27, 2020 Category: Drugs & Pharmacology Authors: Poleszak E, Wośko S, Sławińska K, Wyska E, Szopa A, Świąder K, Wróbel A, Szponar J, Doboszewska U, Wlaź P, Wlaź A, Serefko A Tags: Pharmacol Rep Source Type: research

In vitro inhibition of human cytochrome P450 enzymes by the novel atypical antipsychotic drug asenapine: a prediction of possible drug-drug interactions.
CONCLUSION: The potent inhibition of CYP1A2 and CYP2D6 by asenapine, demonstrated in vitro, will most probably be observed also in vivo, since the calculated Ki values are close to the presumed concentration range for asenapine in the liver in vivo. Therefore, pharmacokinetic interactions involving asenapine and CYP2D6 or CYP1A2 substrates are likely to occur during their co-administration to patients. PMID: 32219694 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 26, 2020 Category: Drugs & Pharmacology Authors: Wójcikowski J, Danek PJ, Basińska-Ziobroń A, Pukło R, Daniel WA Tags: Pharmacol Rep Source Type: research

Potential antipsychotic action of the selective agonist of adenosine A1 receptors, 5'-Cl-5'-deoxy-ENBA, in amphetamine and MK-801 rat models.
CONCLUSION: The present study suggests that stimulation of adenosine A1 receptors may produce antipsychotic effects. PMID: 32219695 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 26, 2020 Category: Drugs & Pharmacology Authors: Ossowska K, Kosmowska B, Wardas J Tags: Pharmacol Rep Source Type: research

Changes in PCSK9 and LDL cholesterol concentrations by everolimus treatment and their effects on polymorphisms in PCSK9 and mTORC1.
CONCLUSIONS: Administration of everolimus significantly elevated plasma PCSK9 concentrations, potentially causing everolimus-induced hyperlipidemia. PMID: 32215854 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 25, 2020 Category: Drugs & Pharmacology Authors: Sato S, Akamine Y, Kagaya H, Saito M, Inoue T, Numakura K, Habuchi T, Satoh S, Miura M Tags: Pharmacol Rep Source Type: research

Aloe emodin inhibits telomerase activity in breast cancer cells: transcriptional and enzymological mechanism.
CONCLUSIONS: AE was a competitive inhibitor of telomerase and a G-quadruplex structure stabilizer. AE decreased the transcription of hTERT gene in the three breast cancer cell lines via up-regulation E2F1 and down-regulation c-myc expressions. The suppressed transcription was also related to the demethylation of the gene promoter. PMID: 32207090 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 23, 2020 Category: Drugs & Pharmacology Authors: Wang S, Yan WW, He M, Wei D, Long ZJ, Tao YM Tags: Pharmacol Rep Source Type: research

Desformylflustrabromine, a positive allosteric modulator of α4β2-containing nicotinic acetylcholine receptors, enhances cognition in rats.
CONCLUSIONS: These findings indicate that dFBr presents procognitive activity, supporting the strategy based on α4β2-nAChR potentiation as a plausible therapy for cognitive impairment. PMID: 32207091 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 23, 2020 Category: Drugs & Pharmacology Authors: Nikiforuk A, Litwa E, Krawczyk M, Popik P, Arias H Tags: Pharmacol Rep Source Type: research

Metformin protects rotenone-induced dopaminergic neurodegeneration by reducing lipid peroxidation.
CONCLUSIONS: Results showed that metformin treatment attenuated dopaminergic neuron loss in SN induced by rotenone by decreasing lipid peroxidation. PMID: 32207092 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 23, 2020 Category: Drugs & Pharmacology Authors: Ozbey G, Nemutlu-Samur D, Parlak H, Yildirim S, Aslan M, Tanriover G, Agar A Tags: Pharmacol Rep Source Type: research

Discovery of dual cation- π inhibitors of acetylcholinesterase: design, synthesis and biological evaluation.
CONCLUSIONS: Compounds possessing methylidenecyclohexanone scaffolds, with characteristic dual-binding and involving strong cation-π interactions, serves as new leads for AChE and opens a new direction for drug discovery efforts. PMID: 32200493 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 21, 2020 Category: Drugs & Pharmacology Authors: Damuka N, Kammari K, Potshangbam AM, Rathore RS, Kondapi AK, Vindal V Tags: Pharmacol Rep Source Type: research

Effects of carbamazepine, eslicarbazepine, valproic acid and levetiracetam on bone microarchitecture in rats.
CONCLUSIONS: Our findings suggest that VPA affects the microarchitectural properties of the bone. The AEDs CBZ, ESL and LEV appear to have less adverse effects on bone biology and may be a better choice when treating patients with respect to bone health. PMID: 32193854 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 19, 2020 Category: Drugs & Pharmacology Authors: Diemar SS, Sejling AS, Eiken P, Ellegaard M, Ding M, Andersen NB, Jørgensen NR Tags: Pharmacol Rep Source Type: research

Anti-oxidant and anti-inflammatory effects of auraptene on phytohemagglutinin (PHA)-induced inflammation in human lymphocytes.
Abstract BACKGROUND: Inflammation is characterized as a defensive response of our body against endogenous or exogenous stimuli. Chronic inflammation and oxidative stress play an important role in the pathogenesis of various disorders such as asthma, cancers, and multiple sclerosis. Recently, diverse pharmacological activities of auraptene, a natural prenyloxycoumarin, were reported. In the present study, we aimed to evaluate the anti-oxidative and anti-inflammatory effects of auraptene on human isolated lymphocytes. METHOD: The effects of auraptene (10, 30 and 90 μM) and dexamethasone (0.1 mM) we...
Source: Pharmacological Reports - March 12, 2020 Category: Drugs & Pharmacology Authors: Askari VR, Rahimi VB, Zargarani R, Ghodsi R, Boskabady M, Boskabady MH Tags: Pharmacol Rep Source Type: research

Antidepressant-like effects of kynurenic acid in a modified forced swim test.
CONCLUSIONS: The results demonstrated, for the first time, the presence of antidepressant-like effects of KYNA in a modified mouse FST. Furthermore, modified combination FST showed that the antidepressant-like actions of KYNA strongly interacted with 5-hydroxytryptamine type 2 SER-ergic receptors, weakly interacted with D2, D3, D4 DA-ergic receptors, and interacted moderately with GABAA receptors. PMID: 32162182 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 12, 2020 Category: Drugs & Pharmacology Authors: Tanaka M, Bohár Z, Martos D, Telegdy G, Vécsei L Tags: Pharmacol Rep Source Type: research

CoQ10 exerts hepatoprotective effect in fructose-induced fatty liver model in rats.
CONCLUSION: This study suggests CoQ10 supplement as a possible prophylaxis or treatment candidate for fructose-induced liver injury. PMID: 32157594 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 10, 2020 Category: Drugs & Pharmacology Authors: Elshazly SM, Alsemeh AE, Ahmad EAA, Rezq S Tags: Pharmacol Rep Source Type: research

The role of childhood adversities, FKBP5, BDNF, NRN1, and generalized self-efficacy in suicide attempts in alcohol-dependent patients.
CONCLUSIONS: Generalized self-efficacy should be considered as a target for psychotherapeutic interventions aimed at reducing the risk of suicide attempts in AD patients who were exposed to childhood victimization. The negative results concerning the hypothesized role of the three analysed SNPs should be carefully interpreted due to the relatively small study sample, but represent a theoretical foundation for further research studies with larger study samples. PMID: 32157595 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 10, 2020 Category: Drugs & Pharmacology Authors: Berent D, Szymańska B, Kulczycka-Wojdala D, Macander M, Pawłowska Z, Wojnar M Tags: Pharmacol Rep Source Type: research

Natural products as promising targets in glioblastoma multiforme: a focus on NF- κB signaling pathway.
CONCLUSION: In the current review, we elaborate on the role of NF-κB as a promising target in GBM and discuss some natural products affecting the NF-κB signaling pathway. PMID: 32152926 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 9, 2020 Category: Drugs & Pharmacology Authors: Soukhtanloo M, Mohtashami E, Maghrouni A, Mollazadeh H, Mousavi SH, Roshan MK, Tabatabaeizadeh SA, Hosseini A, Vahedi MM, Jalili-Nik M, Afshari AR Tags: Pharmacol Rep Source Type: research

Ameliorative effects of a phosphodiesterase 10A inhibitor, MR1916 on L-DOPA-induced dyskinesia in parkinsonian rats.
CONCLUSIONS: These results indicate that MR1916 specifically reduces L-DOPA-induced dyskinesia without affecting the antiparkinsonian effect of L-DOPA in parkinsonian rats. PMID: 32144743 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 6, 2020 Category: Drugs & Pharmacology Authors: Arakawa K, Yuge N, Maehara S Tags: Pharmacol Rep Source Type: research

Atorvastatin alleviates left ventricular remodeling in isoproterenol-induced chronic heart failure in rats by regulating the RhoA/Rho kinase signaling pathway.
This study aimed to investigate the effects of atorvastatin on left ventricular remodeling (LVR) and cardiac function in rats with isoproterenol-induced CHF and the possible mechanism. METHODS: An isoproterenol-induced CHF model was established in rata, which were subsequently treated with atorvastatin. Echocardiography, hemodynamic, and left ventricular mass indexes were assessed. The mRNA expression of RhoA, Rho kinase, and endothelial nitric oxide synthase (eNOS) was determined by RT-qPCR. The protein expression of myosin-binding subunit (MBS), MBS-P, eNOS, phosphorylated-eNOS, RhoA, and Rho kinase was measured by ...
Source: Pharmacological Reports - March 6, 2020 Category: Drugs & Pharmacology Authors: Sun D, Zhang F, Ma T, Zhang Y, Liang Z Tags: Pharmacol Rep Source Type: research

Synthesis, molecular modelling and biological activity of some pyridazinone derivatives as selective human monoamine oxidase-B inhibitors.
CONCLUSION: It was concluded that 4b is possibly recommended as a promising nominee for the design and development of new pyridazinones which can be used in the treatment of neurological diseases. PMID: 32144745 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 6, 2020 Category: Drugs & Pharmacology Authors: Özdemir Z, Alagöz MA, Uslu H, Karakurt A, Erikci A, Ucar G, Uysal M Tags: Pharmacol Rep Source Type: research

Curcumin augments therapeutic efficacy of TRAIL-based immunotoxins in leukemia.
Abstract BACKGROUND: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo2L) has been perceived as a promising anti-cancer agent because of its unique ability to kill cancer cells while sparing normal cells. However, translation of TRAIL to clinical studies was less successful as a large number of cancer cells acquire resistance to TRAIL-based monotherapies. An ideal strategy to overcome TRAIL resistance is to combine it with potential sensitizing agents. OBJECTIVE: To investigate the TRAIL-sensitizing effect of curcumin in leukemia. METHODS: The mechanism underlying TRAIL sensitization by ...
Source: Pharmacological Reports - March 5, 2020 Category: Drugs & Pharmacology Authors: Surapally S, Jayaprakasam M, Verma RS Tags: Pharmacol Rep Source Type: research

The dual reno- and neuro-protective effects of dimethyl fumarate against uremic encephalopathy in a renal ischemia/reperfusion model.
CONCLUSION: The current study advocates the novel DMF dual protection potential against renal I/R insult and its remote brain injury to compensate uremic encephalopathy and acute kidney injury as well. PMID: 32141026 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 5, 2020 Category: Drugs & Pharmacology Authors: Ragab D, Abdallah DM, El-Abhar HS Tags: Pharmacol Rep Source Type: research

New benzimidazole-aldehyde hybrids as neuroprotectors with hypochlorite and superoxide radical-scavenging activity.
CONCLUSIONS: Our studies suggest that the benzimidazole-aldehyde hybrids act as direct ROS scavengers and membranes' stabilizers against free radicals. Thus, they play a role in the antioxidative defense system and have a promising potential as therapeutic neuroprotective agents for the treatment of neurodegenerative disorders. PMID: 32125683 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 3, 2020 Category: Drugs & Pharmacology Authors: Anastassova N, Yancheva D, Hristova-Avakumova N, Hadjimitova V, Traykov T, Aluani D, Tzankova V, Kondeva-Burdina M Tags: Pharmacol Rep Source Type: research

Cyclic derivatives of morphiceptin possess anti-transit effect in the gastrointestinal tract and alleviate abdominal pain in mice.
CONCLUSIONS: Compound 1 is equally effective as P-317 in the mouse GI tract. The peptide bond reduction decreased the activity of compound 2. Fluorination appears to be an efficient way to increase the effects of morphiceptin analogs in the GI tract. PMID: 32125684 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 3, 2020 Category: Drugs & Pharmacology Authors: Szymaszkiewicz A, Włodarczyk J, Mazur M, Olczak J, Fichna J, Zielińska M Tags: Pharmacol Rep Source Type: research

Correction to: Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration.
ar SJ Abstract The article Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration. PMID: 32125685 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 3, 2020 Category: Drugs & Pharmacology Authors: Świąder MJ, Świąder K, Zakrocka I, Krzyżanowski M, Wróbel A, Łuszczki JJ, Czuczwar SJ Tags: Pharmacol Rep Source Type: research

Renal protective effect of nebivolol in rat models of acute renal injury: role of sodium glucose co-transporter 2.
CONCLUSION: Nebivolol has a direct renoprotective effect, at least in part, by down-regulating SGLT2 possibly via modulating HIF1α, ERK activity and PGE2 production. PMID: 32128711 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 3, 2020 Category: Drugs & Pharmacology Authors: Nasr AM, Rezq S, Shaheen A, Elshazly SM Tags: Pharmacol Rep Source Type: research

The radio-protective effect of rosmarinic acid against mobile phone and Wi-Fi radiation-induced oxidative stress in the brains of rats.
CONCLUSION: It can be concluded that RA can be considered a useful candidate for protecting brain tissues against RF radiation-induced oxidative stress at 915 and 2450 MHz frequencies through ameliorative effects on the antioxidant enzyme activities and oxidative stress indices. PMID: 32128712 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 3, 2020 Category: Drugs & Pharmacology Authors: Asl JF, Goudarzi M, Shoghi H Tags: Pharmacol Rep Source Type: research

Assessment of vitamin D and inflammatory markers profile in cardiac tissue on Parkinson disease animal model.
CONCLUSION: Our findings suggest a link between cardiac tissue changes and cardiac functional changes early after the central dopaminergic damage induced by 6-OHDA. Knowledge of the cardiac abnormalities in the 6-OHDA model is critical in identifying future therapeutic targets and disease-modifying approaches for PD non-motor features. PMID: 32124387 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 2, 2020 Category: Drugs & Pharmacology Authors: Nejm MB, Guimarães-Marques MJ, Oliveira LF, Damasceno L, Andersen ML, Tufik S, Fonseca F, Olszewer E, Leça R, de Almeida ACG, Scorza FA, Scorza CA Tags: Pharmacol Rep Source Type: research

Acute cocaine treatment enhances the antagonistic allosteric adenosine A2A-dopamine D2 receptor-receptor interactions in rat dorsal striatum without increasing significantly extracellular dopamine levels.
CONCLUSIONS: The molecular mechanism involved in the acute cocaine-induced increase in the antagonistic allosteric A2AR-D2R receptor-receptor interactions may be an increased formation of higher-order complexes A2AR-D2R-sigma1R in which cocaine by binding to the sigma1R protomer also allosterically enhances the inhibitory A2AR-D2R interaction in this receptor complex. PMID: 32124388 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 2, 2020 Category: Drugs & Pharmacology Authors: Romero-Fernandez W, Zhou Z, Beggiato S, Wydra K, Filip M, Tanganelli S, Borroto-Escuela DO, Ferraro L, Fuxe K Tags: Pharmacol Rep Source Type: research

mRNA level of ROCK1, RHOA, and LIMK2 as genes associated with apoptosis in evaluation of effectiveness of adalimumab treatment.
CONCLUSION: Adalimumab influences the expression of genes related to apoptosis and the values of dermatological indicators of patients. Changes in the expression level of genes associated with apoptosis suggest that ROCK1, RhoA, and LIMK2 may be genes that can potentially be indicators of treatment effectiveness and lack of response to biological treatment. PMID: 32124389 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 2, 2020 Category: Drugs & Pharmacology Authors: Krawczyk A, Strzałka-Mrozik B, Grabarek B, Wcisło-Dziadecka D, Kimsa-Dudek M, Kruszniewska-Rajs C, Gola J Tags: Pharmacol Rep Source Type: research

Adverse effects of interactions between antipsychotics and medications used in the treatment of cardiovascular disorders.
CONCLUSIONS: Due to a high risk of interactions and related adverse effects, particular attention should be paid while using cardiovascular medications with antipsychotics. Clinical decisions should be preceded by a detailed analysis of safety, risk-benefit ratio to search for, as safe as possible, drug combinations. PMID: 32124390 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 2, 2020 Category: Drugs & Pharmacology Authors: Siwek M, Woroń J, Gorostowicz A, Wordliczek J Tags: Pharmacol Rep Source Type: research

Differential effects of performance-enhancing drugs 'Methamphetamine' and 'hCG' on ex-vivo cultured primary blood mononuclear cells of male athletes.
CONCLUSION: This study demonstrated the differential effects of Meth and hCG on immune cells of athlete's blood. Meth acted as an inflammation and T cell dysfunction inducing agent, while hCG acted as an anti-inflammatory immunosuppressive molecule. PMID: 32124391 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 2, 2020 Category: Drugs & Pharmacology Authors: Pramanik A, Das S, Khanna GL Tags: Pharmacol Rep Source Type: research