Rifampicin and Letermovir as potential repurposed drug candidate for COVID-19 treatment: insights from an in-silico study
CONCLUSION: This study provides an insight into the drug repurposing approach in which several FDA approved drugs were examined to inhibit COVID-19 infection by targeting the main protease of SARS-COV-2 and the cytokine storm.PMID:33970450 | PMC:PMC8107206 | DOI:10.1007/s43440-021-00228-0 (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 10, 2021 Category: Drugs & Pharmacology Authors: Yamini Pathak Amaresh Mishra Gourav Choudhir Anuj Kumar Vishwas Tripathi Source Type: research

Rifampicin and Letermovir as potential repurposed drug candidate for COVID-19 treatment: insights from an in-silico study
CONCLUSION: This study provides an insight into the drug repurposing approach in which several FDA approved drugs were examined to inhibit COVID-19 infection by targeting the main protease of SARS-COV-2 and the cytokine storm.PMID:33970450 | PMC:PMC8107206 | DOI:10.1007/s43440-021-00228-0 (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 10, 2021 Category: Drugs & Pharmacology Authors: Yamini Pathak Amaresh Mishra Gourav Choudhir Anuj Kumar Vishwas Tripathi Source Type: research

Rifampicin and Letermovir as potential repurposed drug candidate for COVID-19 treatment: insights from an in-silico study
CONCLUSION: This study provides an insight into the drug repurposing approach in which several FDA approved drugs were examined to inhibit COVID-19 infection by targeting the main protease of SARS-COV-2 and the cytokine storm.PMID:33970450 | DOI:10.1007/s43440-021-00228-0 (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 10, 2021 Category: Drugs & Pharmacology Authors: Yamini Pathak Amaresh Mishra Gourav Choudhir Anuj Kumar Vishwas Tripathi Source Type: research

The role of endocannabinoids in consolidation, retrieval, reconsolidation, and extinction of fear memory
Pharmacol Rep. 2021 May 6. doi: 10.1007/s43440-021-00246-y. Online ahead of print.ABSTRACTEndocannabinoids are involved in various physiological functions, including synaptic plasticity and memory, and some psychiatric disorders, such as posttraumatic stress disorder (PTSD), through the activation of cannabinoid (CB) receptors. Patients with PTSD often show excessive fear memory and impairment of fear extinction (FE). It has been reported that the stability of acquired fear memory is altered through multiple memory stages, such as consolidation and reconsolidation. FE also affects the stability of fear memory. Each stage o...
Source: Pharmacological Reports - May 6, 2021 Category: Drugs & Pharmacology Authors: Ikumi Mizuno Shingo Matsuda Source Type: research

Correction to: Functional approaches to the study of G-protein-coupled receptors in postmortem brain tissue: [ < sup > 35 < /sup > S]GTP γS binding assays combined with immunoprecipitation
Pharmacol Rep. 2021 May 6. doi: 10.1007/s43440-021-00268-6. Online ahead of print.NO ABSTRACTPMID:33956329 | DOI:10.1007/s43440-021-00268-6 (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 6, 2021 Category: Drugs & Pharmacology Authors: Rebeca Diez-Alarcia Yuji Odagaki Patricia Miranda-Azpiazu Ane M Gabilondo J Javier Meana Itziar Muneta-Arrate Source Type: research

The role of endocannabinoids in consolidation, retrieval, reconsolidation, and extinction of fear memory
Pharmacol Rep. 2021 May 6. doi: 10.1007/s43440-021-00246-y. Online ahead of print.ABSTRACTEndocannabinoids are involved in various physiological functions, including synaptic plasticity and memory, and some psychiatric disorders, such as posttraumatic stress disorder (PTSD), through the activation of cannabinoid (CB) receptors. Patients with PTSD often show excessive fear memory and impairment of fear extinction (FE). It has been reported that the stability of acquired fear memory is altered through multiple memory stages, such as consolidation and reconsolidation. FE also affects the stability of fear memory. Each stage o...
Source: Pharmacological Reports - May 6, 2021 Category: Drugs & Pharmacology Authors: Ikumi Mizuno Shingo Matsuda Source Type: research

Correction to: Functional approaches to the study of G-protein-coupled receptors in postmortem brain tissue: [ < sup > 35 < /sup > S]GTP γS binding assays combined with immunoprecipitation
Pharmacol Rep. 2021 May 6. doi: 10.1007/s43440-021-00268-6. Online ahead of print.NO ABSTRACTPMID:33956329 | DOI:10.1007/s43440-021-00268-6 (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 6, 2021 Category: Drugs & Pharmacology Authors: Rebeca Diez-Alarcia Yuji Odagaki Patricia Miranda-Azpiazu Ane M Gabilondo J Javier Meana Itziar Muneta-Arrate Source Type: research

The role of endocannabinoids in consolidation, retrieval, reconsolidation, and extinction of fear memory
Pharmacol Rep. 2021 May 6. doi: 10.1007/s43440-021-00246-y. Online ahead of print.ABSTRACTEndocannabinoids are involved in various physiological functions, including synaptic plasticity and memory, and some psychiatric disorders, such as posttraumatic stress disorder (PTSD), through the activation of cannabinoid (CB) receptors. Patients with PTSD often show excessive fear memory and impairment of fear extinction (FE). It has been reported that the stability of acquired fear memory is altered through multiple memory stages, such as consolidation and reconsolidation. FE also affects the stability of fear memory. Each stage o...
Source: Pharmacological Reports - May 6, 2021 Category: Drugs & Pharmacology Authors: Ikumi Mizuno Shingo Matsuda Source Type: research

Correction to: Functional approaches to the study of G-protein-coupled receptors in postmortem brain tissue: [ < sup > 35 < /sup > S]GTP γS binding assays combined with immunoprecipitation
Pharmacol Rep. 2021 May 6. doi: 10.1007/s43440-021-00268-6. Online ahead of print.NO ABSTRACTPMID:33956329 | DOI:10.1007/s43440-021-00268-6 (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 6, 2021 Category: Drugs & Pharmacology Authors: Rebeca Diez-Alarcia Yuji Odagaki Patricia Miranda-Azpiazu Ane M Gabilondo J Javier Meana Itziar Muneta-Arrate Source Type: research

The role of endocannabinoids in consolidation, retrieval, reconsolidation, and extinction of fear memory
Pharmacol Rep. 2021 May 6. doi: 10.1007/s43440-021-00246-y. Online ahead of print.ABSTRACTEndocannabinoids are involved in various physiological functions, including synaptic plasticity and memory, and some psychiatric disorders, such as posttraumatic stress disorder (PTSD), through the activation of cannabinoid (CB) receptors. Patients with PTSD often show excessive fear memory and impairment of fear extinction (FE). It has been reported that the stability of acquired fear memory is altered through multiple memory stages, such as consolidation and reconsolidation. FE also affects the stability of fear memory. Each stage o...
Source: Pharmacological Reports - May 6, 2021 Category: Drugs & Pharmacology Authors: Ikumi Mizuno Shingo Matsuda Source Type: research

Correction to: Functional approaches to the study of G-protein-coupled receptors in postmortem brain tissue: [ < sup > 35 < /sup > S]GTP γS binding assays combined with immunoprecipitation
Pharmacol Rep. 2021 May 6. doi: 10.1007/s43440-021-00268-6. Online ahead of print.NO ABSTRACTPMID:33956329 | DOI:10.1007/s43440-021-00268-6 (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 6, 2021 Category: Drugs & Pharmacology Authors: Rebeca Diez-Alarcia Yuji Odagaki Patricia Miranda-Azpiazu Ane M Gabilondo J Javier Meana Itziar Muneta-Arrate Source Type: research

Modulatory effect of olanzapine on SMIM20/phoenixin, NPQ/spexin and NUCB2/nesfatin-1 gene expressions in the rat brainstem
CONCLUSIONS: Olanzapine can affect novel peptidergic signaling in the rat brainstem. This may cautiously suggest the presence of an alternative mode of its action.PMID:33928538 | DOI:10.1007/s43440-021-00267-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 30, 2021 Category: Drugs & Pharmacology Authors: Artur Pa łasz Piotr Żarczyński Katarzyna Bogus Kinga Mordecka-Chamera Alessandra Della Vecchia Jakub Ska łbania John J Worthington Marek Krzystanek Ma łgorzata Żarczyńska Source Type: research

Modulatory effect of olanzapine on SMIM20/phoenixin, NPQ/spexin and NUCB2/nesfatin-1 gene expressions in the rat brainstem
CONCLUSIONS: Olanzapine can affect novel peptidergic signaling in the rat brainstem. This may cautiously suggest the presence of an alternative mode of its action.PMID:33928538 | DOI:10.1007/s43440-021-00267-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 30, 2021 Category: Drugs & Pharmacology Authors: Artur Pa łasz Piotr Żarczyński Katarzyna Bogus Kinga Mordecka-Chamera Alessandra Della Vecchia Jakub Ska łbania John J Worthington Marek Krzystanek Ma łgorzata Żarczyńska Source Type: research

Modulatory effect of olanzapine on SMIM20/phoenixin, NPQ/spexin and NUCB2/nesfatin-1 gene expressions in the rat brainstem
CONCLUSIONS: Olanzapine can affect novel peptidergic signaling in the rat brainstem. This may cautiously suggest the presence of an alternative mode of its action.PMID:33928538 | DOI:10.1007/s43440-021-00267-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 30, 2021 Category: Drugs & Pharmacology Authors: Artur Pa łasz Piotr Żarczyński Katarzyna Bogus Kinga Mordecka-Chamera Alessandra Della Vecchia Jakub Ska łbania John J Worthington Marek Krzystanek Ma łgorzata Żarczyńska Source Type: research

Modulatory effect of olanzapine on SMIM20/phoenixin, NPQ/spexin and NUCB2/nesfatin-1 gene expressions in the rat brainstem
CONCLUSIONS: Olanzapine can affect novel peptidergic signaling in the rat brainstem. This may cautiously suggest the presence of an alternative mode of its action.PMID:33928538 | DOI:10.1007/s43440-021-00267-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 30, 2021 Category: Drugs & Pharmacology Authors: Artur Pa łasz Piotr Żarczyński Katarzyna Bogus Kinga Mordecka-Chamera Alessandra Della Vecchia Jakub Ska łbania John J Worthington Marek Krzystanek Ma łgorzata Żarczyńska Source Type: research

Modulatory effect of olanzapine on SMIM20/phoenixin, NPQ/spexin and NUCB2/nesfatin-1 gene expressions in the rat brainstem
CONCLUSIONS: Olanzapine can affect novel peptidergic signaling in the rat brainstem. This may cautiously suggest the presence of an alternative mode of its action.PMID:33928538 | DOI:10.1007/s43440-021-00267-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 30, 2021 Category: Drugs & Pharmacology Authors: Artur Pa łasz Piotr Żarczyński Katarzyna Bogus Kinga Mordecka-Chamera Alessandra Della Vecchia Jakub Ska łbania John J Worthington Marek Krzystanek Ma łgorzata Żarczyńska Source Type: research

Indomethacin: Can It Counteract Bradykinin Effects in COVID-19 Patients?
Curr Pharmacol Rep. 2021 Apr 22:1-5. doi: 10.1007/s40495-021-00257-6. Online ahead of print.ABSTRACTCOVID-19 represents the biggest health challenge. Although the mortality rate of COVID-19 is low, the high numbers of infected people and those with post-COVID-19 symptoms represent a real problem for the health system. A high number of patients with COVID-19 or people recovered from COVID-19 suffer from a dry cough and/or myalgia. Interestingly, an imbalance in bradykinin was observed in COVID-19 patients, which might be due to the accumulation of bradykinin as a result of a reduction in the degradation of bradykinin. This ...
Source: Pharmacological Reports - April 28, 2021 Category: Drugs & Pharmacology Authors: Myasar Alkotaji Radhwan N Al-Zidan Source Type: research

Indomethacin: Can It Counteract Bradykinin Effects in COVID-19 Patients?
Curr Pharmacol Rep. 2021 Apr 22:1-5. doi: 10.1007/s40495-021-00257-6. Online ahead of print.ABSTRACTCOVID-19 represents the biggest health challenge. Although the mortality rate of COVID-19 is low, the high numbers of infected people and those with post-COVID-19 symptoms represent a real problem for the health system. A high number of patients with COVID-19 or people recovered from COVID-19 suffer from a dry cough and/or myalgia. Interestingly, an imbalance in bradykinin was observed in COVID-19 patients, which might be due to the accumulation of bradykinin as a result of a reduction in the degradation of bradykinin. This ...
Source: Pharmacological Reports - April 28, 2021 Category: Drugs & Pharmacology Authors: Myasar Alkotaji Radhwan N Al-Zidan Source Type: research

Indomethacin: Can It Counteract Bradykinin Effects in COVID-19 Patients?
Curr Pharmacol Rep. 2021 Apr 22:1-5. doi: 10.1007/s40495-021-00257-6. Online ahead of print.ABSTRACTCOVID-19 represents the biggest health challenge. Although the mortality rate of COVID-19 is low, the high numbers of infected people and those with post-COVID-19 symptoms represent a real problem for the health system. A high number of patients with COVID-19 or people recovered from COVID-19 suffer from a dry cough and/or myalgia. Interestingly, an imbalance in bradykinin was observed in COVID-19 patients, which might be due to the accumulation of bradykinin as a result of a reduction in the degradation of bradykinin. This ...
Source: Pharmacological Reports - April 28, 2021 Category: Drugs & Pharmacology Authors: Myasar Alkotaji Radhwan N Al-Zidan Source Type: research

Targeting HIF-1 α by newly synthesized Indolephenoxyacetamide (IPA) analogs to induce anti-angiogenesis-mediated solid tumor suppression
CONCLUSION: The IPA (8k) is a potent anti-proliferative molecule with anti-angiogenic activity and specifically targets HIF1α, thereby modulates its downstream regulatory genes both in vitro and in vivo. The study provides scope for new target-specific drug development against HIF-1α for the treatment of solid tumors.PMID:33904146 | DOI:10.1007/s43440-021-00266-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 27, 2021 Category: Drugs & Pharmacology Authors: Fares Hezam Al-Ostoot Ankith Sherapura Vigneshwaran V Giridhara Basappa Vivek H K Prabhakar B T Shaukath Ara Khanum Source Type: research

Targeting HIF-1 α by newly synthesized Indolephenoxyacetamide (IPA) analogs to induce anti-angiogenesis-mediated solid tumor suppression
CONCLUSION: The IPA (8k) is a potent anti-proliferative molecule with anti-angiogenic activity and specifically targets HIF1α, thereby modulates its downstream regulatory genes both in vitro and in vivo. The study provides scope for new target-specific drug development against HIF-1α for the treatment of solid tumors.PMID:33904146 | DOI:10.1007/s43440-021-00266-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 27, 2021 Category: Drugs & Pharmacology Authors: Fares Hezam Al-Ostoot Ankith Sherapura Vigneshwaran V Giridhara Basappa Vivek H K Prabhakar B T Shaukath Ara Khanum Source Type: research

Current status of hepatitis delta
Curr Opin Pharmacol. 2021 Apr 22;58:62-67. doi: 10.1016/j.coph.2021.03.008. Online ahead of print.ABSTRACTHepatitis D virus (HDV) infection in patients chronically infected with hepatitis B virus (HBV) causes the most severe form of chronic viral hepatitis and continues to represent a major health problem. The latest data show that the global prevalence is much higher than previously considered. Therefore, screening with the detection of anti-HDV antibodies is mandatory for all chronic HBV patients. In spite of the severity of liver disease, the only recommended treatment today is pegylated interferon-alpha, which has limi...
Source: Pharmacological Reports - April 25, 2021 Category: Drugs & Pharmacology Authors: Margarita Papatheodoridi George V Papatheodoridis Source Type: research

Current status of hepatitis delta
Curr Opin Pharmacol. 2021 Apr 22;58:62-67. doi: 10.1016/j.coph.2021.03.008. Online ahead of print.ABSTRACTHepatitis D virus (HDV) infection in patients chronically infected with hepatitis B virus (HBV) causes the most severe form of chronic viral hepatitis and continues to represent a major health problem. The latest data show that the global prevalence is much higher than previously considered. Therefore, screening with the detection of anti-HDV antibodies is mandatory for all chronic HBV patients. In spite of the severity of liver disease, the only recommended treatment today is pegylated interferon-alpha, which has limi...
Source: Pharmacological Reports - April 25, 2021 Category: Drugs & Pharmacology Authors: Margarita Papatheodoridi George V Papatheodoridis Source Type: research

Role of pirfenidone in TGF- β pathways and other inflammatory pathways in acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection: a theoretical perspective
CONCLUSION: The drug as a theoretical perspective may be an effective and safe choice for suppressing the inflammatory response during COVID-19. The recommendation would be a combination of pirfenidone and N-acetylcysteine to achieve maximum benefit during SARS-CoV-2 treatment.PMID:33880743 | PMC:PMC8057922 | DOI:10.1007/s43440-021-00255-x (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 21, 2021 Category: Drugs & Pharmacology Authors: Seyed Hootan Hamidi Sandhya Kadamboor Veethil Seyedeh Harir Hamidi Source Type: research

Role of pirfenidone in TGF- β pathways and other inflammatory pathways in acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection: a theoretical perspective
CONCLUSION: The drug as a theoretical perspective may be an effective and safe choice for suppressing the inflammatory response during COVID-19. The recommendation would be a combination of pirfenidone and N-acetylcysteine to achieve maximum benefit during SARS-CoV-2 treatment.PMID:33880743 | PMC:PMC8057922 | DOI:10.1007/s43440-021-00255-x (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 21, 2021 Category: Drugs & Pharmacology Authors: Seyed Hootan Hamidi Sandhya Kadamboor Veethil Seyedeh Harir Hamidi Source Type: research

Role of pirfenidone in TGF- β pathways and other inflammatory pathways in acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection: a theoretical perspective
CONCLUSION: The drug as a theoretical perspective may be an effective and safe choice for suppressing the inflammatory response during COVID-19. The recommendation would be a combination of pirfenidone and N-acetylcysteine to achieve maximum benefit during SARS-CoV-2 treatment.PMID:33880743 | PMC:PMC8057922 | DOI:10.1007/s43440-021-00255-x (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 21, 2021 Category: Drugs & Pharmacology Authors: Seyed Hootan Hamidi Sandhya Kadamboor Veethil Seyedeh Harir Hamidi Source Type: research

Role of pirfenidone in TGF- β pathways and other inflammatory pathways in acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection: a theoretical perspective
CONCLUSION: The drug as a theoretical perspective may be an effective and safe choice for suppressing the inflammatory response during COVID-19. The recommendation would be a combination of pirfenidone and N-acetylcysteine to achieve maximum benefit during SARS-CoV-2 treatment.PMID:33880743 | DOI:10.1007/s43440-021-00255-x (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 21, 2021 Category: Drugs & Pharmacology Authors: Seyed Hootan Hamidi Sandhya Kadamboor Veethil Seyedeh Harir Hamidi Source Type: research

Functional approaches to the study of G-protein-coupled receptors in postmortem brain tissue: [ < sup > 35 < /sup > S]GTP γS binding assays combined with immunoprecipitation
In conclusion, [35S]GTPγS binding combined with antibody-mediated immunodetection represents an useful method to separately evaluate the functional activity of drugs acting on GPCRs over each Gα-protein subtype.PMID:33876404 | DOI:10.1007/s43440-021-00253-z (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 20, 2021 Category: Drugs & Pharmacology Authors: Rebeca Diez-Alarcia Yuji Odagaki Patricia Miranda-Azpiazu Ane M Gabilondo J Javier Meana Itziar Muneta-Arrate Source Type: research

Optimization binding studies of opioid receptors, saturation and competition, using [ < sup > 3 < /sup > H]-DAMGO
CONCLUSION: Applying the centrifugation method instead of the filtration to separate free from bound radioligand produced repeatable and reliable results. The optimum conditions for radioligand binding were used in competition studies which resulted in the expected outcomes.PMID:33871815 | DOI:10.1007/s43440-021-00265-9 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 19, 2021 Category: Drugs & Pharmacology Authors: Mona Khoramjouy Fatemeh Ahmadi Mehrdad Faizi Soraya Shahhosseini Source Type: research

Optimization binding studies of opioid receptors, saturation and competition, using [ < sup > 3 < /sup > H]-DAMGO
CONCLUSION: Applying the centrifugation method instead of the filtration to separate free from bound radioligand produced repeatable and reliable results. The optimum conditions for radioligand binding were used in competition studies which resulted in the expected outcomes.PMID:33871815 | DOI:10.1007/s43440-021-00265-9 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 19, 2021 Category: Drugs & Pharmacology Authors: Mona Khoramjouy Fatemeh Ahmadi Mehrdad Faizi Soraya Shahhosseini Source Type: research

The selective cytotoxicity of silver thiosulfate, a silver complex, on MCF-7 breast cancer cells through ROS-induced cell death
CONCLUSION: The results obtained here are the first evidence to show that STS exhibited an anticancer activity through ROS-induced mechanisms, and that its cytotoxicity is highly selective to cancer cells. The results of the present study warrant further investigation on the detailed mechanism of STS actions, as well as its in vivo effectiveness and safety for clinical application.PMID:33864630 | DOI:10.1007/s43440-021-00260-0 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 17, 2021 Category: Drugs & Pharmacology Authors: Akira Ota Masataka Tajima Kazunori Mori Erika Sugiyama Vilasinee Hirunpanich Sato Hitoshi Sato Source Type: research

The selective cytotoxicity of silver thiosulfate, a silver complex, on MCF-7 breast cancer cells through ROS-induced cell death
CONCLUSION: The results obtained here are the first evidence to show that STS exhibited an anticancer activity through ROS-induced mechanisms, and that its cytotoxicity is highly selective to cancer cells. The results of the present study warrant further investigation on the detailed mechanism of STS actions, as well as its in vivo effectiveness and safety for clinical application.PMID:33864630 | DOI:10.1007/s43440-021-00260-0 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 17, 2021 Category: Drugs & Pharmacology Authors: Akira Ota Masataka Tajima Kazunori Mori Erika Sugiyama Vilasinee Hirunpanich Sato Hitoshi Sato Source Type: research

The selective cytotoxicity of silver thiosulfate, a silver complex, on MCF-7 breast cancer cells through ROS-induced cell death
CONCLUSION: The results obtained here are the first evidence to show that STS exhibited an anticancer activity through ROS-induced mechanisms, and that its cytotoxicity is highly selective to cancer cells. The results of the present study warrant further investigation on the detailed mechanism of STS actions, as well as its in vivo effectiveness and safety for clinical application.PMID:33864630 | DOI:10.1007/s43440-021-00260-0 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 17, 2021 Category: Drugs & Pharmacology Authors: Akira Ota Masataka Tajima Kazunori Mori Erika Sugiyama Vilasinee Hirunpanich Sato Hitoshi Sato Source Type: research

Roflumilast and tadalafil improve learning and memory deficits in intracerebroventricular A β1-42 rat model of Alzheimer's disease through modulations of hippocampal cAMP/cGMP/BDNF signaling pathway
CONCLUSION: The outcomes of the current study indicate that RFM and TDF lead to memory enhancement through upregulation of cAMP/cGMP/BDNF pathway, thus they may have a therapeutic potential in cognitive deficits associated with AD.PMID:33860460 | DOI:10.1007/s43440-021-00264-w (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 16, 2021 Category: Drugs & Pharmacology Authors: Noorul Hasan Saima Zameer Abul Kalam Najmi Suhel Parvez Mohammad Shahar Yar Mohd Akhtar Source Type: research

Mechanistic interplay of various mediators involved in mediating the neuroprotective effect of daphnetin
Pharmacol Rep. 2021 Apr 16. doi: 10.1007/s43440-021-00261-z. Online ahead of print.ABSTRACTDaphnetin is a 7, 8 dihydroxy coumarin isolated from different medicinal plants of the Thymelaeaceae family and exhibits copious pharmacological activities including neuroprotection, anti-cancer, anti-malarial, anti-inflammatory, anti-parasitic and anti-arthritic activity. It has been proved to be an effective neuroprotective agent in several preclinical animal studies and cell line examinations. It is found to interact with different cellular mediators and signaling pathways to confer protection against neurodegeneration. The reacti...
Source: Pharmacological Reports - April 16, 2021 Category: Drugs & Pharmacology Authors: Lovedeep Singh Amrit Pal Singh Rajbir Bhatti Source Type: research

Characterization of a mouse neuropathic pain model caused by the highly active antiviral therapy (HAART) Stavudine
CONCLUSION: Stavudine produced neuropathic pain as a function of dose and time in mice. Opioid analgesics appear to be effective in alleviating neuropathic pain in a D4T-induced mouse model.PMID:33860918 | DOI:10.1007/s43440-021-00262-y (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 16, 2021 Category: Drugs & Pharmacology Authors: Jenny L Wilkerson Jasmine S Felix Joshua A Bilbrey Christopher R McCurdy Lance R McMahon Source Type: research

Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone
CONCLUSION: Collectively, these results may suggest that long-term treatment with chlorpromazine may decrease neurogenic stem/progenitor cell formation in the rat SVZ and may affect rostral migratory stream formation.PMID:33843023 | DOI:10.1007/s43440-021-00259-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 12, 2021 Category: Drugs & Pharmacology Authors: Jakub Ska łbania Artur Pa łasz Iwona B łaszczyk Aleksandra Suszka- Świtek Marek Krzystanek Karina Paola Tulcanaz John J Worthington Kinga Mordecka-Chamera Source Type: research

Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone
CONCLUSION: Collectively, these results may suggest that long-term treatment with chlorpromazine may decrease neurogenic stem/progenitor cell formation in the rat SVZ and may affect rostral migratory stream formation.PMID:33843023 | DOI:10.1007/s43440-021-00259-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 12, 2021 Category: Drugs & Pharmacology Authors: Jakub Ska łbania Artur Pa łasz Iwona B łaszczyk Aleksandra Suszka- Świtek Marek Krzystanek Karina Paola Tulcanaz John J Worthington Kinga Mordecka-Chamera Source Type: research

Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone
CONCLUSION: Collectively, these results may suggest that long-term treatment with chlorpromazine may decrease neurogenic stem/progenitor cell formation in the rat SVZ and may affect rostral migratory stream formation.PMID:33843023 | DOI:10.1007/s43440-021-00259-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 12, 2021 Category: Drugs & Pharmacology Authors: Jakub Ska łbania Artur Pa łasz Iwona B łaszczyk Aleksandra Suszka- Świtek Marek Krzystanek Karina Paola Tulcanaz John J Worthington Kinga Mordecka-Chamera Source Type: research

Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone
CONCLUSION: Collectively, these results may suggest that long-term treatment with chlorpromazine may decrease neurogenic stem/progenitor cell formation in the rat SVZ and may affect rostral migratory stream formation.PMID:33843023 | DOI:10.1007/s43440-021-00259-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 12, 2021 Category: Drugs & Pharmacology Authors: Jakub Ska łbania Artur Pa łasz Iwona B łaszczyk Aleksandra Suszka- Świtek Marek Krzystanek Karina Paola Tulcanaz John J Worthington Kinga Mordecka-Chamera Source Type: research

Proton pump inhibitor on susceptibility to COVID-19 and its severity: a systematic review and meta-analysis
CONCLUSION: This meta-analysis showed a potential association between PPI use and composite poor outcome, but not susceptibility.PROSPERO ID: CRD42020224286.PMID:33840053 | DOI:10.1007/s43440-021-00263-x (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 11, 2021 Category: Drugs & Pharmacology Authors: Raymond Pranata Ian Huang Sherly Lawrensia Joshua Henrina Michael Anthonius Lim Antonia Anna Lukito Raden Ayu Tuty Kuswardhani I Dewa Nyoman Wibawa Source Type: research

An insight on promising strategies hoping to cure HIV-1 infection by targeting Rev protein-short review
Pharmacol Rep. 2021 Apr 11. doi: 10.1007/s43440-021-00257-9. Online ahead of print.ABSTRACTHuman immunodeficiency virus-1 (HIV-1) infection remains to be one of the major threats throughout the world. Many researchers are working in this area to find a cure for HIV-1. The group of the FDA approved drugs which are currently used against HIV-1 in the clinical practice include nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), integrase inhibitors (InIs), and protease inhibitors (PIs). Fixed dose combinations (FDCs) of these drugs are available and are used as per th...
Source: Pharmacological Reports - April 11, 2021 Category: Drugs & Pharmacology Authors: Sahana Pai Jayesh Mudgal B Venkatesh Kamath K Sreedhara Ranganath Pai Source Type: research

5-HT < sub > 2A < /sub > receptor- and M < sub > 1 < /sub > muscarinic acetylcholine receptor-mediated activation of G α < sub > q/11 < /sub > in postmortem dorsolateral prefrontal cortex of opiate addicts
CONCLUSION: Our data demonstrate that the signaling pathways mediated by Gαq/11 proteins coupled with 5-HT2A receptors and M1 mAChRs in prefrontal cortex are functionally altered in opiate addicts in comparison with control subjects. These alterations may underpin some aspects of addictive behavior to opiate as well as neuropsychological consequences or comorbid mental disorders associated with opioid use.PMID:33835465 | DOI:10.1007/s43440-021-00248-w (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 9, 2021 Category: Drugs & Pharmacology Authors: Yuji Odagaki Masakazu Kinoshita J Javier Meana Luis F Callado Jes ús A García-Sevilla Source Type: research

The pivotal role of pituitary adenylate cyclase-activating polypeptide for lactate production and secretion in astrocytes during fear memory
CONCLUSIONS: PACAP may enhance lactate production and secretion in astrocytes during the acquisition and recall of fear memories.PMID:33835466 | DOI:10.1007/s43440-021-00222-6 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 9, 2021 Category: Drugs & Pharmacology Authors: Yuki Kambe Yu Yamauchi Trung Thanh Nguyen Thu Thi Nguyen Yukio Ago Norihito Shintani Hitoshi Hashimoto Shimako Yoshitake Takashi Yoshitake Jan Kehr Namiko Kawamura Goro Katsuura Takashi Kurihara Atsuro Miyata Source Type: research

Influence of G protein-biased agonists of μ-opioid receptor on addiction-related behaviors
Pharmacol Rep. 2021 Apr 9. doi: 10.1007/s43440-021-00251-1. Online ahead of print.ABSTRACTOpioid analgesics remain a gold standard for the treatment of moderate to severe pain. However, their clinical utility is seriously limited by a range of adverse effects. Among them, their high-addictive potential appears as very important, especially in the context of the opioid epidemic. Therefore, the development of safer opioid analgesics with low abuse potential appears as a challenging problem for opioid research. Among the last few decades, different approaches to the discovery of novel opioid drugs have been assessed. One of t...
Source: Pharmacological Reports - April 9, 2021 Category: Drugs & Pharmacology Authors: Lucja Kudla Ryszard Przewlocki Source Type: research

5-HT < sub > 2A < /sub > receptor- and M < sub > 1 < /sub > muscarinic acetylcholine receptor-mediated activation of G α < sub > q/11 < /sub > in postmortem dorsolateral prefrontal cortex of opiate addicts
CONCLUSION: Our data demonstrate that the signaling pathways mediated by Gαq/11 proteins coupled with 5-HT2A receptors and M1 mAChRs in prefrontal cortex are functionally altered in opiate addicts in comparison with control subjects. These alterations may underpin some aspects of addictive behavior to opiate as well as neuropsychological consequences or comorbid mental disorders associated with opioid use.PMID:33835465 | DOI:10.1007/s43440-021-00248-w (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 9, 2021 Category: Drugs & Pharmacology Authors: Yuji Odagaki Masakazu Kinoshita J Javier Meana Luis F Callado Jes ús A García-Sevilla Source Type: research

The pivotal role of pituitary adenylate cyclase-activating polypeptide for lactate production and secretion in astrocytes during fear memory
CONCLUSIONS: PACAP may enhance lactate production and secretion in astrocytes during the acquisition and recall of fear memories.PMID:33835466 | DOI:10.1007/s43440-021-00222-6 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 9, 2021 Category: Drugs & Pharmacology Authors: Yuki Kambe Yu Yamauchi Trung Thanh Nguyen Thu Thi Nguyen Yukio Ago Norihito Shintani Hitoshi Hashimoto Shimako Yoshitake Takashi Yoshitake Jan Kehr Namiko Kawamura Goro Katsuura Takashi Kurihara Atsuro Miyata Source Type: research

Influence of G protein-biased agonists of μ-opioid receptor on addiction-related behaviors
Pharmacol Rep. 2021 Apr 9. doi: 10.1007/s43440-021-00251-1. Online ahead of print.ABSTRACTOpioid analgesics remain a gold standard for the treatment of moderate to severe pain. However, their clinical utility is seriously limited by a range of adverse effects. Among them, their high-addictive potential appears as very important, especially in the context of the opioid epidemic. Therefore, the development of safer opioid analgesics with low abuse potential appears as a challenging problem for opioid research. Among the last few decades, different approaches to the discovery of novel opioid drugs have been assessed. One of t...
Source: Pharmacological Reports - April 9, 2021 Category: Drugs & Pharmacology Authors: Lucja Kudla Ryszard Przewlocki Source Type: research

5-HT < sub > 2A < /sub > receptor- and M < sub > 1 < /sub > muscarinic acetylcholine receptor-mediated activation of G α < sub > q/11 < /sub > in postmortem dorsolateral prefrontal cortex of opiate addicts
CONCLUSION: Our data demonstrate that the signaling pathways mediated by Gαq/11 proteins coupled with 5-HT2A receptors and M1 mAChRs in prefrontal cortex are functionally altered in opiate addicts in comparison with control subjects. These alterations may underpin some aspects of addictive behavior to opiate as well as neuropsychological consequences or comorbid mental disorders associated with opioid use.PMID:33835465 | DOI:10.1007/s43440-021-00248-w (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 9, 2021 Category: Drugs & Pharmacology Authors: Yuji Odagaki Masakazu Kinoshita J Javier Meana Luis F Callado Jes ús A García-Sevilla Source Type: research

The pivotal role of pituitary adenylate cyclase-activating polypeptide for lactate production and secretion in astrocytes during fear memory
CONCLUSIONS: PACAP may enhance lactate production and secretion in astrocytes during the acquisition and recall of fear memories.PMID:33835466 | DOI:10.1007/s43440-021-00222-6 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 9, 2021 Category: Drugs & Pharmacology Authors: Yuki Kambe Yu Yamauchi Trung Thanh Nguyen Thu Thi Nguyen Yukio Ago Norihito Shintani Hitoshi Hashimoto Shimako Yoshitake Takashi Yoshitake Jan Kehr Namiko Kawamura Goro Katsuura Takashi Kurihara Atsuro Miyata Source Type: research