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Depressive-like neurochemical and behavioral markers of Parkinson's disease after 6-OHDA administered unilaterally to the rat medial forebrain bundle.
CONCLUSIONS: Administration of the highest dose of 6-OHDA without desipramine pretreatment evoked neurochemical and behavioral changes resembling the advanced PD with coexisting depression. PMID: 28843848 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 3, 2017 Category: Drugs & Pharmacology Authors: Kamińska K, Lenda T, Konieczny J, Czarnecka A, Lorenc-Koci E Tags: Pharmacol Rep Source Type: research

Environmental influences in the etiology of colorectal cancer: the premise of metabolomics.
Abstract PURPOSE OF REVIEW: In this review we discuss how environmental exposures predominate the etiology of colorectal cancer (CRC). With CRC being a personalized disease influenced by genes and environment, our goal was to explore the role metabolomics can play in identifying exposures, assessing the interplay between co-exposures, and the development of personalized therapeutic interventions. RECENT FINDINGS: Approximately 10 % of CRC cases can be explained by germ-line mutations, whereas the prevailing majority are caused by an initiating exposure event occurring decades prior to diagnosis. Recent resear...
Source: Pharmacological Reports - June 1, 2017 Category: Drugs & Pharmacology Authors: Rattray NJW, Charkoftaki G, Rattray Z, Hansen JE, Vasiliou V, Johnson CH Tags: Curr Pharmacol Rep Source Type: research

The mechanism of neuroprotective action of natural compounds.
Abstract Disturbance of cerebral redox homeostasis is the primary cause of human neurodegenerative disorders, such as Parkinson's disease or Alzheimer's disease. Well known experimental research demonstrates that oxidative stress is a main cause of cell death. A high concentration of reactive oxygen and nitrogen species leads to damage of a lot of proteins, lipids and also DNA. Synthetic compounds used for the treatment in the neurodegenerative diseases failed to meet the hopes they had raised and often exhibit a number of side effects. Therefore, in recent years interest in natural compounds derived from plants a...
Source: Pharmacological Reports - April 30, 2017 Category: Drugs & Pharmacology Authors: Wąsik A, Antkiewicz-Michaluk L Tags: Pharmacol Rep Source Type: research

Naringenin prevents ischemic stroke damage via anti-apoptotic and anti-oxidant effects.
This study aimed to investigate the anti-apoptotic and anti-oxidant effects of naringenin on ischemic stroke. In vitro, cortical neuron cells isolated from the brains of neonatal Sprague-Dawley rats were randomly divided into control, oxygen and glucose deprivation/reperfusion (OGD/Rep), NAR-L, NAR-M and NAR-H groups. MTT and RT-PCR were used for cell proliferation and apoptosis-related proteins analyses. The effects of NAR on the Nrf2 signaling pathway were investigated using transfection approaches. Differences in mitochondrial dysfunction were analyzed by flow cytometry. In vivo, middle cerebral artery occlusion (MCAO) ...
Source: Pharmacological Reports - April 28, 2017 Category: Drugs & Pharmacology Authors: Wang K, Chen Z, Huang J, Huang L, Luo N, Liang X, Liang M, Xie W Tags: Clin Exp Pharmacol Physiol Source Type: research

Corrigendum to "Epicutaneous immunization with protein antigen TNP-Ig alleviates TNBS-induced colitis in mice" [Pharmacol. Rep. 64 (2012) 1497-1504].
Corrigendum to "Epicutaneous immunization with protein antigen TNP-Ig alleviates TNBS-induced colitis in mice" [Pharmacol. Rep. 64 (2012) 1497-1504]. Pharmacol Rep. 2017 Apr 08;: Authors: Majewska-Szczepanik M, Góralska M, Marcińska K, Zemelka-Wiącek M, Strzępa A, Dorożyńska I, Szczepanik M PMID: 28400086 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 8, 2017 Category: Drugs & Pharmacology Authors: Majewska-Szczepanik M, Góralska M, Marcińska K, Zemelka-Wiącek M, Strzępa A, Dorożyńska I, Szczepanik M Tags: Pharmacol Rep Source Type: research

Acute behavioral effects of co-administration of mephedrone and MDMA in mice.
CONCLUSIONS: The effects of mephedrone and MDMA combination on mammalian organisms were attempted to be evaluated in our study and the results are described in the present report. These results may help explain the reasons for and consequences of a concomitant administration of psychoactive substances with regards to the central nervous system, while being possibly useful in the treatment of polydrug intoxication. PMID: 28073060 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Budzynska B, Michalak A, Frankowska M, Kaszubska K, Biała G Tags: Pharmacol Rep Source Type: research

The significance of microRNAs in the course of rDD.
CONCLUSIONS: 1. There is no significant difference in miRNAs expression between patients with recurrent depressive disorders and those in the first episode of depression. 2. The differences in terms of expression of the analysed variables between the subjects with symptoms of depression and healthy individuals were confirmed. PMID: 28073061 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Bobińska K, Szemraj J, Mossakowska-Wójcik J, Gałecki P, Talarowska M Tags: Pharmacol Rep Source Type: research

Application of the DREADD technique in biomedical brain research.
Abstract The DREADD (Designer Receptors Exclusively Activated by Designer Drugs) technique is a new chemogenetic approach allowing for selective and remote control of neural activity with a high degree of spatial resolution. Since its discovery in 2007 the DREADD technique was successfully employed into basic research, and together with the optogenetic method provided so far the best tool to influence the activity of the brain circuits and cell populations. The first aim of this review was to concisely describe the technique with regard to such issues like the history of its development, biochemistry as well as mo...
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Dobrzanski G, Kossut M Tags: Pharmacol Rep Source Type: research

Antinociceptive effect of co-administered NMDA and histamine H4 receptor antagonists in a rat model of acute pain.
CONCLUSIONS: The results show for the first time that the H4R and NMDA receptors play a significant role in antinociception in an acute non-inflammatory pain. Furthermore, the blockage of NMDA receptors at the peripheral and spinal, but not supraspinal sites produces a profound antinociceptive response upon simultaneous H4R antagonism. Thus, this study clearly demonstrates the relevance of NMDA and H4R receptors in the modulation of pain signals and that their role is not exclusively limited to their modulatory activity in inflammatory pain states. PMID: 28092808 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Wolińska R, Leśniak A, Żochowska M, Sacharczuk M, Kieć-Kononowicz K, Bujalska-Zadrożny M Tags: Pharmacol Rep Source Type: research

Liver alpha-amylase gene expression as an early obesity biomarker.
CONCLUSIONS: Elevated liver alpha-amylase levels may be indicative of initial stages of obesity and the use of acarbose could be considered as a treatment of obesity which could be potentially effective at multiple levels. PMID: 28095353 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Mojbafan M, Afsartala Z, Amoli MM, Mahmoudi M, Yaghmaei P, Larijani B, Ebrahim-Habibi A Tags: Pharmacol Rep Source Type: research

Genetic variants of dopamine D2 receptor impact heterodimerization with dopamine D1 receptor.
CONCLUSION: The data presented in this paper support the hypothesis on the role of calcium signaling regulated by the D1-D2 heteromer which may be of relevance for schizophrenia etiology. PMID: 28119185 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Błasiak E, Łukasiewicz S, Szafran-Pilch K, Dziedzicka-Wasylewska M Tags: Pharmacol Rep Source Type: research

The effect of α-synuclein on gliosis and IL-1α, TNFα, IFNγ, TGFβ expression in murine brain.
CONCLUSION: Our results suggest that both the microglia activation and supressing astrocytes play a crucial role in ASN-related dopaminergic neurotoxicity. PMID: 28126640 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Sznejder-Pachołek A, Joniec-Maciejak I, Wawer A, Ciesielska A, Mirowska-Guzel D Tags: Pharmacol Rep Source Type: research

The application of skin metabolomics in the context of transdermal drug delivery.
Abstract Metabolomics is a powerful emerging tool for the identification of biomarkers and the exploration of metabolic pathways in a high-throughput manner. As an administration site for percutaneous absorption, the skin has a variety of metabolic enzymes, except other than hepar. However, technologies to fully detect dermal metabolites remain lacking. Skin metabolomics studies have mainly focused on the regulation of dermal metabolites by drugs or on the metabolism of drugs themselves. Skin metabolomics techniques include collection and preparation of skin samples, data collection, data processing and analysis. ...
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Li J, Xu W, Liang Y, Wang H Tags: Pharmacol Rep Source Type: research

Effects of fenoterol on the skeletal system depend on the androgen level.
CONCLUSIONS: The results indicate the favorable action of fenoterol in conditions of testosterone deficiency, and its destructive influence upon the skeleton in the presence of androgens. The results confirm the key role of sympathetic nervous system in the regulation of bone remodeling. PMID: 28126642 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Śliwiński L, Cegieła U, Pytlik M, Folwarczna J, Janas A, Zbrojkiewicz M Tags: Pharmacol Rep Source Type: research

Protective effect of cardamonin against acetic acid-induced ulcerative colitis in rats.
Abstract BACKGROUND: Ulcerative colitis (UC) is an inflammatory bowel disease with significant morbidity. Cardamonin is a natural chalcone derivative with considerable anti-inflammatory activity. Herein, the potential protective effect of cardamonin against UC was tested in a rat model. METHODS: Rats were given 10 or 30mg/kg/day of cardamonin orally for 14days before induction of UC. On the 14th day of treatment, UC was induced by intrarectal instillation of 2ml 3% acetic acid. Twenty four h after acetic acid instillation, rats were sacrificed and colons were analyzed by macroscopic and histopathological exam...
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Ali AA, Abd Al Haleem EN, Khaleel SA, Sallam AS Tags: Pharmacol Rep Source Type: research

Antidepressant and anxiolytic-like activity of sodium selenite after acute treatment in mice.
CONCLUSIONS: These potential antidepressant- and anxiolytic-like effects of Se require more detailed experimental study using animal models to approach a clear conclusion regarding the potential mechanism of the observed effect. PMID: 28167456 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Kędzierska E, Dudka J, Poleszak E, Kotlińska JH Tags: Pharmacol Rep Source Type: research

A review on antioxidant potential of bioactive heterocycle benzofuran: Natural and synthetic derivatives.
Abstract The majority of heterocycle compounds and typically common heterocycle fragments present in most pharmaceuticals currently marketed, alongside with their intrinsic versatility and unique physicochemical properties, have poised them as true cornerstones of medicinal chemistry. In this context, oxygen heterocycles exhibit diverse biological and pharmacological activities due in part to the similarities with many natural and synthetic molecules with known biological activity. Among oxygen containing heterocycles, benzofuran (synthetic and natural isolated) and its derivatives have attracted medicinal chemist...
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Chand K, Rajeshwari, Hiremathad A, Singh M, Santos MA, Keri RS Tags: Pharmacol Rep Source Type: research

Attenuation of stress induced memory deficits by nonsteroidal anti-inflammatory drugs (NSAIDs) in rats: Role of antioxidant enzymes.
CONCLUSION: In conclusion this study suggests a therapeutic potential of indomethacin and diclofenac against repeated stress-induced memory deficits. PMID: 28178591 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Emad S, Qadeer S, Sadaf S, Batool Z, Haider S, Perveen T Tags: Pharmacol Rep Source Type: research

Sertraline and venlafaxine improves motor performance and neurobehavioral deficit in quinolinic acid induced Huntington's like symptoms in rats: Possible neurotransmitters modulation.
CONCLUSION: The present study suggests that modulation of monoamines level, normalization of GABA and glutamatergic signaling, anti-oxidant and anti-inflammatory properties could underlie the neuroprotective effect of sertraline and venlafaxine in QA induced Huntington's like symptoms. PMID: 28178592 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Gill JS, Jamwal S, Kumar P, Deshmukh R Tags: Pharmacol Rep Source Type: research

The role of histamine in the regulation of the viability, proliferation and transforming growth factor β1 secretion of rat wound fibroblasts.
CONCLUSION: The regulatory influence of histamine on wound fibroblast function (viability/metabolic activity or secretion of TGFβ1) is dependent on H1 receptor stimulation. Contrary to wound fibroblasts, these cells express a very low level of H1 receptors when isolated from intact dermis and histamine is unable to modify their metabolic activity. PMID: 28178593 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Wolak M, Bojanowska E, Staszewska T, Ciosek J, Juszczak M, Drobnik J Tags: Pharmacol Rep Source Type: research

Diabetic nephropathy: A potential savior with 'rotten-egg' smell.
Abstract Diabetic nephropathy (DN) is currently the leading cause of end-stage renal disease. Despite optimal management, DN is still a major contributor to morbidity and mortality of diabetic patients worldwide. The major pathological alterations in DN include excessive accumulation and deposition of extracellular matrix, leading to expansion of mesangial matrix, thickening of glomerular basement membrane and tubulointerstitial fibrosis. At the molecular level, accumulating evidence suggests that hyperglycemia or high glucose mediates renal injury in DN via multiple molecular mechanisms such as induction of oxida...
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Dugbartey GJ Tags: Pharmacol Rep Source Type: research

Population pharmacokinetic modelling of valproic acid and its selected metabolites in acute VPA poisoning.
CONCLUSIONS: None of the models perfectly described the experimental data. Important factors like the variable degree of protein binding by VPA could not be included in the models. The small number of subjects used in the study made the analysis of more covariates impossible. PMID: 28187395 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Jawień W, Wilimowska J, Kłys M, Piekoszewski W Tags: Pharmacol Rep Source Type: research

Methyl-orvinol-Dual activity opioid receptor ligand inhibits gastrointestinal transit and alleviates abdominal pain in the mouse models mimicking diarrhea-predominant irritable bowel syndrome.
CONCLUSION: Methyl-orvinol could become a promising drug candidate in chronic therapy of functional GI diseases such as IBS-D. PMID: 28187396 [PubMed - indexed for MEDLINE] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Zielińska M, Jarmuż A, Wasilewski A, Cami-Kobeci G, Husbands S, Fichna J Tags: Pharmacol Rep Source Type: research

Telmisartan attenuates diabetes induced depression in rats.
Abstract BACKGROUND: Role of brain renin angiotensin system (RAS) is well understood and various clinical studies have proposed neuroprotective effects of ARB's. It is also assumed that diabetic depression is associated with activation of brain RAS, HPA axis dysregulation and brain inflammatory events. Therefore, the present study was designed to investigate the antidepressant effect of low dose telmisartan (TMS) in diabetes induced depression (DID) in rats. METHODS: Diabetes was induced by injecting streptozotocin. After 21days of treatment the rats were subjected to forced swim test (FST). The rats, with in...
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Aswar U, Chepurwar S, Shintre S, Aswar M Tags: Pharmacol Rep Source Type: research

Enhancement of oral bioavailability of rivastigmine with quercetin nanoparticles by inhibiting CYP3A4 and esterases.
Abstract BACKGROUND: Quercetin is a well-known flavonoid, has pharmacokinetic interaction with ester drugs due to its capability of esterase inhibition in the gut and liver. However, the interaction between quercetin nanoparticles (NQC) and rivastigmine has not been reported. Hence, the present study was performed to evaluate the effect of quercetin alone and its nanoparticles on the pharmacokinetics of rivastigmine in rats. METHODS: NQC prepared by antisolvent precipitation method. The influence of quercetin on the pharmacokinetics of rivastigmine was evaluated by following methods i.e. in vitro inhibitory e...
Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Palle S, Neerati P Tags: Pharmacol Rep Source Type: research

Corrigendum to "Epicutaneous immunization with hapten-conjugated protein antigen alleviates contact sensitivity mediated by three different types of effector cells" [Pharmacol. Rep. 64 (2012) 919-926].
Corrigendum to "Epicutaneous immunization with hapten-conjugated protein antigen alleviates contact sensitivity mediated by three different types of effector cells" [Pharmacol. Rep. 64 (2012) 919-926]. Pharmacol Rep. 2017 Mar 16;: Authors: Majewska-Szczepanik M, Strzępa A, Drożyńska I, Motyl S, Banach T, Szczepanik M PMID: 28325474 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 16, 2017 Category: Drugs & Pharmacology Authors: Majewska-Szczepanik M, Strzępa A, Drożyńska I, Motyl S, Banach T, Szczepanik M Tags: Pharmacol Rep Source Type: research

Corrigendum to "The effect of combined treatment with risperidone and antidepressants on the MK-801-induced deficits in the social interaction test in rats" [Pharmacol. Rep. 67 (2015) 1183-1187].
Corrigendum to "The effect of combined treatment with risperidone and antidepressants on the MK-801-induced deficits in the social interaction test in rats" [Pharmacol. Rep. 67 (2015) 1183-1187]. Pharmacol Rep. 2017 Mar 15;: Authors: Kamińska K, Rogóż Z PMID: 28325475 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 15, 2017 Category: Drugs & Pharmacology Authors: Kamińska K, Rogóż Z Tags: Pharmacol Rep Source Type: research

Progress in Prediction and Interpretation of Clinically Relevant Metabolic Drug-Drug Interactions: a Minireview Illustrating Recent Developments and Current Opportunities.
Abstract PURPOSE OF REVIEW: This review gives a perspective on the current "state of the art" in metabolic drug-drug interaction (DDI) prediction. We highlight areas of successful prediction and illustrate progress in areas where limits in scientific knowledge or technologies prevent us from having full confidence. RECENT FINDINGS: Several examples of success are highlighted. Work done for bitopertin shows how in vitro and clinical data can be integrated to give a model-based understanding of pharmacokinetics and drug interactions. The use of interpolative predictions to derive explicit dosage recom...
Source: Pharmacological Reports - March 8, 2017 Category: Drugs & Pharmacology Authors: Fowler S, Morcos PN, Cleary Y, Martin-Facklam M, Parrott N, Gertz M, Yu L Tags: Curr Pharmacol Rep Source Type: research

Corrigendum to "Exenatide (a GLP-1 agonist) expresses anti-inflammatory properties in cultured human monocytes/macrophages in a protein kinase A and B/Akt manner" [Pharmacological Reports 68 (2016) 329-337].
Corrigendum to "Exenatide (a GLP-1 agonist) expresses anti-inflammatory properties in cultured human monocytes/macrophages in a protein kinase A and B/Akt manner" [Pharmacological Reports 68 (2016) 329-337]. Pharmacol Rep. 2017 Feb 05;: Authors: Bułdak Ł, Machnik G, Bułdak RJ, Łabuzek K, Bołdys A, Belowski D, Basiak M, Okopień B PMID: 28179083 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 4, 2017 Category: Drugs & Pharmacology Authors: Bułdak Ł, Machnik G, Bułdak RJ, Łabuzek K, Bołdys A, Belowski D, Basiak M, Okopień B Tags: Pharmacol Rep Source Type: research

Corrigendum to "Influence of caffeine on the protective activity of gabapentin and topiramate in a mouse model of generalized tonic-clonic seizures" [Pharmacol. Rep. 68 (2016) 680-685].
Corrigendum to "Influence of caffeine on the protective activity of gabapentin and topiramate in a mouse model of generalized tonic-clonic seizures" [Pharmacol. Rep. 68 (2016) 680-685]. Pharmacol Rep. 2017 Feb 05;: Authors: Jargiełło-Baszak M, Chrościńska-Krawczyk M, Andres-Mach M, Łuszczki JJ, Czuczwar SJ PMID: 28179084 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 4, 2017 Category: Drugs & Pharmacology Authors: Jargiełło-Baszak M, Chrościńska-Krawczyk M, Andres-Mach M, Łuszczki JJ, Czuczwar SJ Tags: Pharmacol Rep Source Type: research

Manganese neurotoxicity and protective effects of resveratrol and quercetin in preclinical research.
CONCLUSION: Repeated Mn administration induces toxic effects in several rat brain structures and treatment with R and QCT may be a potential therapeutic strategy to attenuate the metal neurotoxicity. PMID: 28183032 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 13, 2016 Category: Drugs & Pharmacology Authors: Gawlik M, Gawlik MB, Smaga I, Filip M Tags: Pharmacol Rep Source Type: research

The pharmacokinetics of oral ketoprofen in patients after gastric resection.
CONCLUSIONS: Lower concentrations of ketoprofen in patients after gastrectomy suggest that it might be necessary to apply higher dose of the analgesic. PMID: 28178590 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - December 8, 2016 Category: Drugs & Pharmacology Authors: Porażka J, Karbownik A, Murawa D, Spychała A, Firlej M, Grabowski T, Murawa P, Grześkowiak E, Szałek E Tags: Pharmacol Rep Source Type: research

The Role of Interaction Model in Simulation of Drug Interactions and QT Prolongation.
Abstract Computational modelling is a cornerstone of Comprehensive In Vitro Proarrhythmia Assay and is re-increasingly being used in drug development. Electrophysiological effects of drug-drug interactions can be predicted in silico, e.g. with the use of in vitro cardiac ion channel data, PK profiles and human ventricular cardiomyocyte models. There are, however, several approaches with different assumptions used to assess the combined effect of multiple drugs, and there is no agreed standard interaction model. The aim of this study was to assess whether the choice of the drug-drug interaction (DDI) model (Bliss i...
Source: Pharmacological Reports - December 6, 2016 Category: Drugs & Pharmacology Authors: Wiśniowska B, Polak S Tags: Curr Pharmacol Rep Source Type: research

Toyocamycin induces apoptosis via the crosstalk between reactive oxygen species and p38/ERK MAPKs signaling pathway in human prostate cancer PC-3 cells.
CONCLUSION: ROS-mediated activation of p38/ERK partially contributes to Toyocamycin-induced apoptosis, and p38/ERK MAPKs regulate the ROS production in PC-3 cells. PMID: 27912102 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 23, 2016 Category: Drugs & Pharmacology Authors: Park SG, Kim SH, Kim KY, Yu SN, Choi HD, Kim YW, Nam HW, Seo YK, Ahn SC Tags: Pharmacol Rep Source Type: research

Dietary phytochemicals for possible preventive and therapeutic option of uterine fibroids: Signaling pathways as target.
Abstract A growing interest has emerged on dietary phytochemicals to control diverse pathological conditions. Unfortunately, dietary phytochemical research in uterine fibroids is still under construction. Uterine fibroids/leiomyomas are benign tumors developing from the myometrium of the uterus in premenopausal women. They may occur in more than 70% of women, and approximately 25% of women show clinically significant symptoms. These include heavy and prolonged menstrual bleeding, pelvic pressure (urinary frequency, incontinence, and difficulty with urination), pelvic pain, pelvic mass, infertility, and reproductiv...
Source: Pharmacological Reports - October 19, 2016 Category: Drugs & Pharmacology Authors: Islam MS, Segars JH, Castellucci M, Ciarmela P Tags: Pharmacol Rep Source Type: research

Bioinformatic Analysis of DNA Methylation in Neural Progenitor Cell Models of Alcohol Abuse.
Abstract Several recent publications sought to investigate the effects of ethanol treatment on models of central nervous system development, specifically through changes in DNA methylation. Regulation of DNA methylation causes a long-lasting, epigenetic change in the capacity of the genome to respond to developmental or metabolic stimuli. Changes in technologies for quantifying DNA methylation have increased the ability to identify and interpret potential effects of ethanol. Here, we review these recent studies in order to evaluate the detection technologies and bioinformatic analyses. Our evaluation finds that wh...
Source: Pharmacological Reports - September 30, 2016 Category: Drugs & Pharmacology Authors: Oni EN, Hart RP Tags: Curr Pharmacol Rep Source Type: research

Epilepsy coexisting with depression.
Abstract Depression episodes in epilepsy is the most common commorbidity, affecting between 11% and 62% of patients with epilepsy. Although researchers have documented a strong association between epilepsy and psychiatric comorbidities, the nature of this relationship is poorly understood. The manifestation of depression in epilepsy is a complex issue having many interacting neurobiological and psychosocial determinants, including clinical features of epilepsy (seizure frequency, type, foci, or lateralization of foci) and neurochemical or iatrogenic mechanisms. Other risk factors are a family history of psychiatri...
Source: Pharmacological Reports - September 19, 2016 Category: Drugs & Pharmacology Authors: Błaszczyk B, Czuczwar SJ Tags: Pharmacol Rep Source Type: research

Cerebellar level of neurotransmitters in rats exposed to paracetamol during development.
CONCLUSION: The effect of paracetamol on monoaminergic neurotransmission in the cerebellum is reflected by changes in the level of catabolic end-products of serotonin (5-HIAA) and noradrenaline (MHPG) degradation. Further work is required to define the mechanism of action and impact of prenatal and postnatal exposure to paracetamol in the cerebellum and other structures of the central nervous system (CNS). PMID: 27611980 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 5, 2016 Category: Drugs & Pharmacology Authors: Blecharz-Klin K, Joniec-Maciejak I, Jawna-Zboińska K, Pyrzanowska J, Piechal A, Wawer A, Widy-Tyszkiewicz E Tags: Pharmacol Rep Source Type: research

Bone mineral density is reduced by telmisartan in male spontaneously hypertensive rats.
CONCLUSION: Results showed that telmisartan negatively affected bones suggesting that caution should be taken in possible therapeutic applications for protecting bone health in hypertensive conditions. More studies are necessary to clarify the mechanisms through which telmisartan favors bone loss in this model. PMID: 27607362 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 4, 2016 Category: Drugs & Pharmacology Authors: Birocale AM, Medeiros AR, Ruffoni LD, Takayama L, de Oliveira JM, Nonaka KO, Pereira RM, Bissoli NS Tags: Pharmacol Rep Source Type: research

N-3 long chain polyunsaturated fatty acids increase the expression of PPAR γ-target genes and resistance of isolated heart and cultured cardiomyocytes to ischemic injury.
CONCLUSIONS: n-3 PUFAs application has cardioprotective effects and increases mRNA level of FATP, IL-1ra, GJP43, and BCL2 genes in culture of neonatal cardiomyocytes and in adult hearts. PMID: 27588389 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 29, 2016 Category: Drugs & Pharmacology Authors: Shysh AM, Nagibin VS, Kaplinskii SP, Dosenko VE Tags: Pharmacol Rep Source Type: research

Effects of long-term administration of pantoprazole on bone mineral density in young male rats.
ąg A Abstract INTRODUCTION: Epidemiological studies suggest that long-term administration of proton pump inhibitors (PPIs) may decrease bone mineral density (BMD) and increase the risk of osteoporotic fractures. The aim of the study was to assess the influence of pantoprazole on bone metabolism in growing rats. METHODS: The experiment was carried out on twenty-four young male Wistar rats divided into two groups receiving either pantoprazole at the dose of 3mg/kg or vehicle for 12 weeks. Femoral bone mineral density (BMD) and bone histomorphometry were assessed. Serum total calcium, inorganic phosphate and ma...
Source: Pharmacological Reports - August 19, 2016 Category: Drugs & Pharmacology Authors: Matuszewska A, Nowak B, Rzeszutko M, Zduniak K, Szandruk M, Jędrzejuk D, Landwójtowicz M, Bolanowski M, Pieśniewska M, Kwiatkowska J, Szeląg A Tags: Pharmacol Rep Source Type: research

Resveratrol intake enhances indoleamine-2,3-dioxygenase activity in humans.
Abstract BACKGROUND: Resveratrol is a polyphenol compound found in various nutrients that was shown to have immunomodulatory, anti-cancerogenic, and cardioprotective effects. The regulation of indoleamine-2,3-dioxygenase (IDO), the rate-limiting enzyme in inflammatory tryptophan metabolism, has been proposed to be involved in resveratrol's biological effects. These observations, however, rely on in vitro findings and animal studies. Therefore, we assessed the impact of resveratrol on tryptophan metabolism after oral intake in humans. METHODS: Healthy volunteers were orally administrated 5g resveratrol (n=8) o...
Source: Pharmacological Reports - August 19, 2016 Category: Drugs & Pharmacology Authors: Gualdoni GA, Fuchs D, Zlabinger GJ, Gostner JM Tags: Pharmacol Rep Source Type: research

Intravenous lidocaine infusions in a multidirectional model of treatment of neuropathic pain patients.
CONCLUSIONS: The best therapeutic effects of lidocaine infusion was observed in pain symptoms characterized by the highest intensity of baseline pain. Intravenous lidocaine administered at the dose of 5mg/kg of body weight over 30min is effective, safe and caused no significant adverse effects. PMID: 27552062 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 19, 2016 Category: Drugs & Pharmacology Authors: Przeklasa-Muszyńska A, Kocot-Kępska M, Dobrogowski J, Wiatr M, Mika J Tags: Pharmacol Rep Source Type: research

Combining hypobaric hypoxia or hyperbaric oxygen postconditioning with memantine reduces neuroprotection in 7-day-old rat hypoxia-ischemia.
CONCLUSIONS: Our results show that, combining HBO or HH postconditioning with memantine produce no additive increase in the neuroprotective effect. On the contrary, combining the treatments resulted in lower neuroprotection in comparison to the effects of memantine, HBO or HH alone. PMID: 27552063 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 19, 2016 Category: Drugs & Pharmacology Authors: Gamdzyk M, Ziembowicz A, Bratek E, Salinska E Tags: Pharmacol Rep Source Type: research

N-pentyl-nitrofurantoin induces apoptosis in HL-60 leukemia cell line by upregulating BAX and downregulating BCL-xL gene expression.
CONCLUSION: The results indicate that NFP induces apoptosis in HL-60 cells by upregulating BAX and downregulating BCL-xL. PMID: 27505854 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 5, 2016 Category: Drugs & Pharmacology Authors: Andrade JK, Souza MI, Gomes Filho MA, Silva DM, Barros AL, Rodrigues MD, Silva PB, Nascimento SC, Aguiar JS, Brondani DJ, Militão GC, Silva TG Tags: Pharmacol Rep Source Type: research

Puerarin inhibits the inflammatory response in atherosclerosis via modulation of the NF- κB pathway in a rabbit model.
CONCLUSIONS: This study indicates that the effect of puerarin on the suppression of atherosclerosis was connected with an inhibited inflammatory response and reduced NF-κB activation. PMID: 27505855 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 5, 2016 Category: Drugs & Pharmacology Authors: Ji L, Du Q, Li Y, Hu W Tags: Pharmacol Rep Source Type: research

Peripheral mRNA expression of pluripotency markers in bipolar disorder and the effect of long-term lithium treatment.
CONCLUSIONS: The overexpression of the pluripotency master transcriptional factors in patients with a long duration of BD not treated with lithium, may contribute to the pathogenesis of the illness and make them potential biological markers of BD. Long-term lithium treatment may attenuate these excessive regenerative processes, especially in relation to the transcription factors Oct-4 and Sox2. PMID: 27472467 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - July 25, 2016 Category: Drugs & Pharmacology Authors: Ferensztajn-Rochowiak E, Tarnowski M, Samochowiec J, Michalak M, Ratajczak MZ, Rybakowski JK Tags: Pharmacol Rep Source Type: research

Top-down, Bottom-up and Middle-out Strategies for Drug Cardiac Safety Assessment via Modeling and Simulations.
Abstract Cardiac safety is an issue causing early terminations at various stages of drug development. Efforts are put into the elimination of false negatives as well as false positives resulting from the current testing paradigm. In silico approaches offer mathematical system and data description from the ion current, through cardiomyocytes level, up to incorporation of inter-individual variability at the population level. The article aims to review three main modelling and simulation approaches, i.e. "top-down" which refers to models built on the observed data, "bottom-up", which stands for a ...
Source: Pharmacological Reports - July 20, 2016 Category: Drugs & Pharmacology Authors: Tylutki Z, Polak S, Wiśniowska B Tags: Curr Pharmacol Rep Source Type: research

Transplant drugs affect the expression of phase II and antioxidant enzymes in human carcinoma cells HepG2 but not in primary cultures of human hepatocytes: In vitro comparative study.
CONCLUSION: We showed that the tested transplant drugs have no effect on the expression of selected phase II and antioxidant enzymes in human hepatocytes. Nevertheless, the experiments carried out in two common and frequently used in vitro cellular models, we emphasize that finding based solely on carcinoma cells must be taken with caution when transposing to in vivo situations. PMID: 27428762 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - July 14, 2016 Category: Drugs & Pharmacology Authors: Vrzal R, Illes P, Dvorak Z Tags: Pharmacol Rep Source Type: research

Coenzyme Q10 - A new player in the treatment of heart failure?
Abstract Coenzyme Q10 is the only endogenously synthesized lipid with a redox function which exhibits broad tissue and intracellular distribution in mammals. Beneficial effects of CoenzymeQ10 supplementation were observed in several age-related diseases including heart failure. CoQ10 (coenzyme Q10) level is significantly decreased in patients with this disease, which correlates with severity of clinical symptoms. Supplementation with various pharmaceutical formulations of CoQ10 improves impaired cardiac function and clinical course of heart failure. Current data from clinical trials indicate that CoQ10 can signifi...
Source: Pharmacological Reports - July 14, 2016 Category: Drugs & Pharmacology Authors: Jankowski J, Korzeniowska K, Cieślewicz A, Jabłecka A Tags: Pharmacol Rep Source Type: research