A re-consideration of neural/receptor mechanisms in chemotherapy-induced nausea and vomiting: current scenario and future perspective
Pharmacol Rep. 2023 Aug 16. doi: 10.1007/s43440-023-00514-z. Online ahead of print.ABSTRACTThe neural mechanisms and the receptors behind the course of chemotherapy-induced nausea and vomiting (CINV) are well described and considered mechanistically multifactorial, whereas the neurobiology of nausea is not completely understood yet. Some of the anti-neoplastic medications like cisplatin result in biphasic vomiting response. The acute phase of vomiting is triggered mainly via the release of serotonin from the enterochromaffin (EC) cells in the gastrointestinal tract (GIT) and results in stimulation of dorsal vagal complex (...
Source: Pharmacological Reports - August 16, 2023 Category: Drugs & Pharmacology Authors: Ihsan Ullah Muhammad Ayaz Source Type: research
Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study
Pharmacol Rep. 2023 Aug 16. doi: 10.1007/s43440-023-00517-w. Online ahead of print.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently regarded as the twenty-first century's plague accounting for coronavirus disease 2019 (COVID-19). Besides its reported symptoms affecting the respiratory tract, it was found to alter several metabolic pathways inside the body. Nanoparticles proved to combat viral infections including COVID-19 to demonstrate great success in developing vaccines based on mRNA technology. However, various types of nanoparticles can affect the host metabolome. Considering the i...
Source: Pharmacological Reports - August 16, 2023 Category: Drugs & Pharmacology Authors: Marwa O El-Derany Diana M F Hanna John Youshia Enas Elmowafy Mohamed A Farag Samar S Azab Source Type: research
A re-consideration of neural/receptor mechanisms in chemotherapy-induced nausea and vomiting: current scenario and future perspective
Pharmacol Rep. 2023 Aug 16. doi: 10.1007/s43440-023-00514-z. Online ahead of print.ABSTRACTThe neural mechanisms and the receptors behind the course of chemotherapy-induced nausea and vomiting (CINV) are well described and considered mechanistically multifactorial, whereas the neurobiology of nausea is not completely understood yet. Some of the anti-neoplastic medications like cisplatin result in biphasic vomiting response. The acute phase of vomiting is triggered mainly via the release of serotonin from the enterochromaffin (EC) cells in the gastrointestinal tract (GIT) and results in stimulation of dorsal vagal complex (...
Source: Pharmacological Reports - August 16, 2023 Category: Drugs & Pharmacology Authors: Ihsan Ullah Muhammad Ayaz Source Type: research
Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study
Pharmacol Rep. 2023 Aug 16. doi: 10.1007/s43440-023-00517-w. Online ahead of print.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently regarded as the twenty-first century's plague accounting for coronavirus disease 2019 (COVID-19). Besides its reported symptoms affecting the respiratory tract, it was found to alter several metabolic pathways inside the body. Nanoparticles proved to combat viral infections including COVID-19 to demonstrate great success in developing vaccines based on mRNA technology. However, various types of nanoparticles can affect the host metabolome. Considering the i...
Source: Pharmacological Reports - August 16, 2023 Category: Drugs & Pharmacology Authors: Marwa O El-Derany Diana M F Hanna John Youshia Enas Elmowafy Mohamed A Farag Samar S Azab Source Type: research
A re-consideration of neural/receptor mechanisms in chemotherapy-induced nausea and vomiting: current scenario and future perspective
Pharmacol Rep. 2023 Aug 16. doi: 10.1007/s43440-023-00514-z. Online ahead of print.ABSTRACTThe neural mechanisms and the receptors behind the course of chemotherapy-induced nausea and vomiting (CINV) are well described and considered mechanistically multifactorial, whereas the neurobiology of nausea is not completely understood yet. Some of the anti-neoplastic medications like cisplatin result in biphasic vomiting response. The acute phase of vomiting is triggered mainly via the release of serotonin from the enterochromaffin (EC) cells in the gastrointestinal tract (GIT) and results in stimulation of dorsal vagal complex (...
Source: Pharmacological Reports - August 16, 2023 Category: Drugs & Pharmacology Authors: Ihsan Ullah Muhammad Ayaz Source Type: research
Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study
Pharmacol Rep. 2023 Aug 16. doi: 10.1007/s43440-023-00517-w. Online ahead of print.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently regarded as the twenty-first century's plague accounting for coronavirus disease 2019 (COVID-19). Besides its reported symptoms affecting the respiratory tract, it was found to alter several metabolic pathways inside the body. Nanoparticles proved to combat viral infections including COVID-19 to demonstrate great success in developing vaccines based on mRNA technology. However, various types of nanoparticles can affect the host metabolome. Considering the i...
Source: Pharmacological Reports - August 16, 2023 Category: Drugs & Pharmacology Authors: Marwa O El-Derany Diana M F Hanna John Youshia Enas Elmowafy Mohamed A Farag Samar S Azab Source Type: research
A re-consideration of neural/receptor mechanisms in chemotherapy-induced nausea and vomiting: current scenario and future perspective
Pharmacol Rep. 2023 Aug 16. doi: 10.1007/s43440-023-00514-z. Online ahead of print.ABSTRACTThe neural mechanisms and the receptors behind the course of chemotherapy-induced nausea and vomiting (CINV) are well described and considered mechanistically multifactorial, whereas the neurobiology of nausea is not completely understood yet. Some of the anti-neoplastic medications like cisplatin result in biphasic vomiting response. The acute phase of vomiting is triggered mainly via the release of serotonin from the enterochromaffin (EC) cells in the gastrointestinal tract (GIT) and results in stimulation of dorsal vagal complex (...
Source: Pharmacological Reports - August 16, 2023 Category: Drugs & Pharmacology Authors: Ihsan Ullah Muhammad Ayaz Source Type: research
Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study
Pharmacol Rep. 2023 Aug 16. doi: 10.1007/s43440-023-00517-w. Online ahead of print.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently regarded as the twenty-first century's plague accounting for coronavirus disease 2019 (COVID-19). Besides its reported symptoms affecting the respiratory tract, it was found to alter several metabolic pathways inside the body. Nanoparticles proved to combat viral infections including COVID-19 to demonstrate great success in developing vaccines based on mRNA technology. However, various types of nanoparticles can affect the host metabolome. Considering the i...
Source: Pharmacological Reports - August 16, 2023 Category: Drugs & Pharmacology Authors: Marwa O El-Derany Diana M F Hanna John Youshia Enas Elmowafy Mohamed A Farag Samar S Azab Source Type: research
Novel object recognition test as an alternative approach to assessing the pharmacological profile of sigma-1 receptor ligands
CONCLUSIONS: The nonlinear dose-response effect of PRE-084 in this assay does not justify its use for routine assessment of the functional activity of σ1R ligands.PMID:37572216 | DOI:10.1007/s43440-023-00516-x (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 12, 2023 Category: Drugs & Pharmacology Authors: Katarzyna Szczepa ńska Andrzej J Bojarski Piotr Popik Natalia Malikowska-Racia Source Type: research
Novel object recognition test as an alternative approach to assessing the pharmacological profile of sigma-1 receptor ligands
CONCLUSIONS: The nonlinear dose-response effect of PRE-084 in this assay does not justify its use for routine assessment of the functional activity of σ1R ligands.PMID:37572216 | DOI:10.1007/s43440-023-00516-x (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 12, 2023 Category: Drugs & Pharmacology Authors: Katarzyna Szczepa ńska Andrzej J Bojarski Piotr Popik Natalia Malikowska-Racia Source Type: research
Novel object recognition test as an alternative approach to assessing the pharmacological profile of sigma-1 receptor ligands
CONCLUSIONS: The nonlinear dose-response effect of PRE-084 in this assay does not justify its use for routine assessment of the functional activity of σ1R ligands.PMID:37572216 | DOI:10.1007/s43440-023-00516-x (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 12, 2023 Category: Drugs & Pharmacology Authors: Katarzyna Szczepa ńska Andrzej J Bojarski Piotr Popik Natalia Malikowska-Racia Source Type: research
Changes in expression of mesothelial BBS genes in 2D and 3D after lithium chloride and ammonium sulphate induction of primary cilium disturbance: a pilot study
CONCLUSIONS: These data indicate distinct BBSome molecular profiles in human benign and MPM cells cultured in 2D and 3D dimensions and support the notion that PC genes should be investigated as potential MPM therapeutic targets.PMID:37542187 | DOI:10.1007/s43440-023-00513-0 (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 4, 2023 Category: Drugs & Pharmacology Authors: Erasmia Rouka Rajesh M Jagirdar Ioannis Sarrigeorgiou Eleanna Pitaraki Sotirios I Sinis Charalambos Varsamas Eleftherios D Papazoglou Ourania S Kotsiou Peggy Lymberi Anastasios Giannou Chrissi Hatzoglou Konstantinos I Gourgoulianis Sotirios G Zarogiannis Source Type: research
Changes in expression of mesothelial BBS genes in 2D and 3D after lithium chloride and ammonium sulphate induction of primary cilium disturbance: a pilot study
CONCLUSIONS: These data indicate distinct BBSome molecular profiles in human benign and MPM cells cultured in 2D and 3D dimensions and support the notion that PC genes should be investigated as potential MPM therapeutic targets.PMID:37542187 | DOI:10.1007/s43440-023-00513-0 (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 4, 2023 Category: Drugs & Pharmacology Authors: Erasmia Rouka Rajesh M Jagirdar Ioannis Sarrigeorgiou Eleanna Pitaraki Sotirios I Sinis Charalambos Varsamas Eleftherios D Papazoglou Ourania S Kotsiou Peggy Lymberi Anastasios Giannou Chrissi Hatzoglou Konstantinos I Gourgoulianis Sotirios G Zarogiannis Source Type: research
Changes in expression of mesothelial BBS genes in 2D and 3D after lithium chloride and ammonium sulphate induction of primary cilium disturbance: a pilot study
CONCLUSIONS: These data indicate distinct BBSome molecular profiles in human benign and MPM cells cultured in 2D and 3D dimensions and support the notion that PC genes should be investigated as potential MPM therapeutic targets.PMID:37542187 | DOI:10.1007/s43440-023-00513-0 (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 4, 2023 Category: Drugs & Pharmacology Authors: Erasmia Rouka Rajesh M Jagirdar Ioannis Sarrigeorgiou Eleanna Pitaraki Sotirios I Sinis Charalambos Varsamas Eleftherios D Papazoglou Ourania S Kotsiou Peggy Lymberi Anastasios Giannou Chrissi Hatzoglou Konstantinos I Gourgoulianis Sotirios G Zarogiannis Source Type: research
Changes in expression of mesothelial BBS genes in 2D and 3D after lithium chloride and ammonium sulphate induction of primary cilium disturbance: a pilot study
CONCLUSIONS: These data indicate distinct BBSome molecular profiles in human benign and MPM cells cultured in 2D and 3D dimensions and support the notion that PC genes should be investigated as potential MPM therapeutic targets.PMID:37542187 | DOI:10.1007/s43440-023-00513-0 (Source: Pharmacological Reports)
Source: Pharmacological Reports - August 4, 2023 Category: Drugs & Pharmacology Authors: Erasmia Rouka Rajesh M Jagirdar Ioannis Sarrigeorgiou Eleanna Pitaraki Sotirios I Sinis Charalambos Varsamas Eleftherios D Papazoglou Ourania S Kotsiou Peggy Lymberi Anastasios Giannou Chrissi Hatzoglou Konstantinos I Gourgoulianis Sotirios G Zarogiannis Source Type: research
