Increased prevalence of functional minor allele variants of drug metabolizing CYP2B6 and CYP2D6 genes in Roma population samples.
CONCLUSION: Our results demonstrate an increased minor allele frequency for CYP2B6 and CYP2D6 polymorphisms in Roma samples that implies clinical significance in this ethnic group. PMID: 25933954 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Weber A, Szalai R, Sipeky C, Magyari L, Melegh M, Jaromi L, Matyas P, Duga B, Kovesdi E, Hadzsiev K, Melegh B Tags: Pharmacol Rep Source Type: research

Anticonvulsant active inhibitor of GABA transporter subtype 1, tiagabine, with activity in mouse models of anxiety, pain and depression.
Abstract BACKGROUND: Tiagabine, a selective inhibitor of GABA transporter subtype 1 is used as an add-on therapy of partial seizures in humans but its mechanism of action suggests other potential medical indications for this drug. In this research we assess its pharmacological activity in several screening models of seizures, pain, anxiety and depression in mice. METHODS: For pharmacological tests tiagabine was administered intraperitoneally 60min before the assay. Behavioral tests were performed using models of chemically and electrically induced seizures, thermal acute pain and formalin-induced tonic pain. ...
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Sałat K, Podkowa A, Kowalczyk P, Kulig K, Dziubina A, Filipek B, Librowski T Tags: Pharmacol Rep Source Type: research

Ellagic acid enhances the antinociceptive action of venlafaxine in mouse acetic acid-induced pain: An isobolographic analysis.
CONCLUSION: The synergistic action of EA and VLF provides valuable tool referring to the management of visceral pain. PMID: 25933956 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Mansouri MT, Naghizadeh B, Ghorbanzadeh B Tags: Pharmacol Rep Source Type: research

Antidepressant-like effect of modafinil in mice: Evidence for the involvement of the dopaminergic neurotransmission.
CONCLUSION: Results show that modafinil induced an antidepressant property in TST and this effect apparently was mediated through interaction with the dopaminergic (D2 receptors) system. PMID: 25933957 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Mahmoudi J, Farhoudi M, Talebi M, Sabermarouf B, Sadigh-Eteghad S Tags: Pharmacol Rep Source Type: research

Clonidine intensifies memantine cutaneous analgesia in response to local skin noxious pinprick in the rat.
Abstract BACKGROUND: The purposes of this study were to evaluate the co-administration of clonidine with memantine and to determine whether it has a peripheral action in intensifying cutaneous analgesia. METHODS: Cutaneous analgesia was examined through inhibition of the cutaneous trunci muscle reflex in response to the local noxious pinprick in rats. Effect of the added subcutaneous clonidine to memantine on infiltrative cutaneous analgesia was assessed and compared with the local anesthetic lidocaine. RESULTS: On the 50% effective dose (ED50) basis, the rank of drug potency was memantine [4.05 (3.95-4....
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Wu BT, Chen KT, Liu KS, Chen YW, Hung CH, Wang JJ Tags: Pharmacol Rep Source Type: research

Evaluation of the role of NMDA receptor function in antidepressant-like activity. A new study with citalopram and fluoxetine in the forced swim test in mice.
CONCLUSIONS: The present literature data indicate that the antidepressant-like activity of conventional antidepressants is generally affected by the NMDA receptor, although by modulation from different sites of the complex. Thus, it supports the issue of the ability of NMDA receptor antagonists to enhance the antidepressant action in human depression. PMID: 25933959 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Wolak M, Siwek A, Szewczyk B, Poleszak E, Bystrowska B, Moniczewski A, Rutkowska A, Młyniec K, Nowak G Tags: Pharmacol Rep Source Type: research

Pharmacokinetics of cotinine in rats: A potential therapeutic agent for disorders of cognitive function.
CONCLUSIONS: Several important facts about the PK properties in rats suggested COT could be a potential pro-cognitive agent. Information about the pharmacokinetics of COT in rats revealed in this study is of great importance for the future studies on COT or potential COT analogs as agents for improving cognition. PMID: 25933960 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Li P, Beck WD, Callahan PM, Terry AV, Bartlett MG Tags: Pharmacol Rep Source Type: research

Long-term disease-modifying effect of the endocannabinoid agonist WIN55,212-2 in a rat model of audiogenic epilepsy.
CONCLUSIONS: This result suggests that short-term potentiation of the eCB system might modify the epileptogenic disease process in patients with a progressive course of epilepsy. PMID: 25933961 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Vinogradova LV, van Rijn CM Tags: Pharmacol Rep Source Type: research

Binge eating in pre-clinical models.
Abstract Obesity is a globally widespread disease. Approximately 35% of world population has the problem of inappropriate body weight due to sedentary lifestyle, excessive food consumption and the lack of physical activity. In the course of many years, several pharmacological anti-obesity drugs have been discovered. Most of them, however, possess severe side effects. Recent findings suggest that disturbed functioning of the reward system can be involved in the development of obesity. The data coming from clinical and animal studies provide new evidence that links excessive food consumption with compulsive behavior...
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Rospond B, Szpigiel J, Sadakierska-Chudy A, Filip M Tags: Pharmacol Rep Source Type: research

Effect of atorvastatin, a HMG-CoA reductase inhibitor in monosodium iodoacetate-induced osteoarthritic pain: Implication for osteoarthritis therapy.
CONCLUSION: Our study demonstrated that atorvastatin attenuates MIA-induced osteoarthritic pain and protect cartilage degradation through inhibition of oxidative stress suggesting its importance in osteoarthritic pain management. PMID: 25933963 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Pathak NN, Balaganur V, Lingaraju MC, Kant V, Kumar D, Kumar D, Sharma AK, Tandan SK Tags: Pharmacol Rep Source Type: research

Telmisartan decreases inflammation by modulating TNF-α, IL-10, and RANK/RANKL in a rat model of ulcerative colitis.
In this study, the antiinflammatory activity of telmisartan was tested in an acetic acid (10%) model of ulcerative colitis (UC) in rats. METHODS: Rats were given 1, 3, and 5mg/kg/day of telmisartan orally for 3 days before induction of UC. The same doses were also administered 2 and 24h after induction. Rats from the non-colitis and non-treated colitis groups were administered vehicle (saline, 5ml/kg) orally and another group received sulfasalazine (50mg/kg/day). Colons tissue was analyzed by macroscopic, by histopathology, by the immunohistochemical examination of RANKL/RANK pathway; by ELISA analysis of the levels o...
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Guerra GC, Araújo AA, Lira GA, Melo MN, Souto KK, Fernandes D, Silva AL, Júnior RF Tags: Pharmacol Rep Source Type: research

Anti-tumor potential of nitroxyl derivative Pirolin in the DMBA-induced rat mammary carcinoma model: A comparison with quercetin.
CONCLUSION: The attenuation of tumor progression by Pirolin was comparable with the action of quercetin. No negative changes were observed in the heart of animals after Pirolin treatment. Thus, its use in targeting deregulated redox pathways should be further studied. PMID: 25933965 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Tabaczar S, Domeradzka K, Czepas J, Piasecka-Zelga J, Stetkiewicz J, Gwoździński K, Koceva-Chyła A Tags: Pharmacol Rep Source Type: research

Subacute poisoning of mice with deltamethrin produces memory impairment, reduced locomotor activity, liver damage and changes in blood morphology in the mechanism of oxidative stress.
CONCLUSION: The results obtained indicate that liver and bone marrow, apart from the central nervous system (CNS) are damaged in the course of subacute poisoning with DEL. The possible common mechanism of the damage is oxidative stress. PMID: 25933966 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Nieradko-Iwanicka B, Borzęcki A Tags: Pharmacol Rep Source Type: research

The pharmacokinetic interaction between levofloxacin and sunitinib.
CONCLUSIONS: The study proved that there is a potential pharmacokinetic interaction between sunitinib and levofloxacin. The statistical analysis proved that the limited sample strategy can be applied for levofloxacin. PMID: 25933967 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Czyrski A, Kondys K, Szałek E, Karbownik A, Grześkowiak E Tags: Pharmacol Rep Source Type: research

Celecoxib reduces hyperalgesia and tactile allodynia in diabetic rats.
CONCLUSIONS: Data suggest that celecoxib produces an antihyperalgesic and antiallodynic effect in diabetic rats. These effects seem to result from activation of μ, δ and κ opioid receptors for antinociception and μ and δ for antiallodynia. Celecoxib could be useful to treat neuropathic pain in diabetic patients. PMID: 25933968 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Juárez-Rojop IE, Morales-Hernández PE, Tovilla-Zárate CA, Bermúdez-Ocaña DY, Torres-Lopez JE, Ble-Castillo JL, Díaz-Zagoya JC, Granados-Soto V Tags: Pharmacol Rep Source Type: research

Hypocholesterolemic and choleretic effects of three dimethoxycinnamic acids in relation to 2,4,5-trimethoxycinnamic acid in rats fed with a high-cholesterol/cholate diet.
CONCLUSIONS: 2,4,5-TMC (which has three methoxyls) had the highest hypocholesterolemic activity, while 3,4-DMC, which lacks the methoxyl in carbon 2 but conserves the two other methoxyls in an adjacent position, had the highest choleretic activity and a probable cholelitholytic activity. In methoxycinnamic acids with two methoxyls in non-adjacent positions (2,4-DMC and 3,5-DMC), the hypocholesterolemic and choleretic activities were not as evident. 2,4,5-TMC and 3,4-DMC, which did not cause liver damage during the treatment period, should be further explored as a hypocholesterolemic and choleretic compounds in humans. ...
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Serna M, Wong-Baeza C, Santiago-Hernández JC, Baeza I, Wong C Tags: Pharmacol Rep Source Type: research

Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 1. Chemical aspects and biological sources of oxidative stress in the brain.
Abstract Oxidative stress is a dysfunctional state of living cells, caused by the disturbance of the pro-/antioxidative equilibrium. This dynamic equilibrium, constitutive for all aerobic organisms, is an inevitable necessity of maintaining the level of oxidative factors on non-destructive value to the cell. Among these factors reactive oxygen species (ROS) and reactive nitrogen species (RNS) are the best known molecules. This review article shows the current state of knowledge on the chemical specificity, relative reactivity and main sources of ROS and RNS in biological systems. As a Part 1 to the report about th...
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Moniczewski A, Gawlik M, Smaga I, Niedzielska E, Krzek J, Przegaliński E, Pera J, Filip M Tags: Pharmacol Rep Source Type: research

Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism.
Abstract The pathophysiology of psychiatric diseases, including depression, anxiety, schizophrenia and autism, is far from being fully elucidated. In recent years, a potential role of the oxidative stress has been highlighted in the pathogenesis of neuropsychiatric disorders. A body of clinical and preclinical evidence indicates that psychiatric diseases are characterized by higher levels of oxidative biomarkers and with lower levels of antioxidant defense biomarkers in the brain and peripheral tissues. In this article, we review current knowledge on the role of the oxidative stress in psychiatric diseases, based ...
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Smaga I, Niedzielska E, Gawlik M, Moniczewski A, Krzek J, Przegaliński E, Pera J, Filip M Tags: Pharmacol Rep Source Type: research

Luteolin 8-C-β-fucopyranoside downregulates IL-6 expression by inhibiting MAPKs and the NF-κB signaling pathway in human monocytic cells.
Luteolin 8-C-β-fucopyranoside downregulates IL-6 expression by inhibiting MAPKs and the NF-κB signaling pathway in human monocytic cells. Pharmacol Rep. 2015 Jun;67(3):581-7 Authors: Lee YS, Kim MS, Lee DH, Kwon TH, Song HH, Oh SR, Yoon do Y Abstract Numerous studies have been suggested that derivatives can improve the effects of original substances. Therefore, we made luteolin derivative luteolin 8-C-β-fucopyranoside (LU8C-FP) for better anti-inflammatory and anti-cancer effects. In a previous study, we demonstrated that LU8C-FP inhibits invasion of human breast cancer cells via suppr...
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Lee YS, Kim MS, Lee DH, Kwon TH, Song HH, Oh SR, Yoon do Y Tags: Pharmacol Rep Source Type: research

Characterization and preliminary anticonvulsant assessment of some 1,3,4-thiadiazole derivatives.
CONCLUSIONS: 5-Butyl-2-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole and 5-heptyl-2-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole could become potentially favorable antiepileptic drugs, if the results from this study were to be extrapolated into clinical settings. PMID: 25933973 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Luszczki JJ, Karpińska M, Matysiak J, Niewiadomy A Tags: Pharmacol Rep Source Type: research

Effects of microinjection of histamine into the anterior cingulate cortex on pain-related behaviors induced by formalin in rats.
CONCLUSION: The results of the present study showed pain suppressing effects for histamine. Histamine H2 and H3, and to a lesser extent, H1 receptors might be involved in histamine-induced antinociception. Opioid receptors might be involved in suppressive effects of histamine and thioperamide. PMID: 25933974 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Hamzeh-Gooshchi N, Tamaddonfard E, Farshid AA Tags: Pharmacol Rep Source Type: research

Dawn of antioxidants and immune modulators to stop HIV-progression and boost the immune system in HIV/AIDS patients: An updated comprehensive and critical review.
Abstract In the last two decades, human immunodeficiency virus (HIV), the retrovirus responsible for the acquired immunodeficiency syndrome (AIDS), is one of the leading causes of morbidity and mortality, worldwide. Providing the optimum management of HIV/AIDS is a major challenge in the 21st century. Since, HIV-infected persons have an extended lifespan due to the development of effective antiretroviral therapies, malnutrition is becoming central factors of long-term survivors. The nutrition status of AIDS patients has a significant influence on the maintenance and optimal effectiveness of the immune system. Micr...
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Singh G, Pai RS Tags: Pharmacol Rep Source Type: research

Zinc sulphate: A reasonable choice for depression management in patients with multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial.
CONCLUSION: Therefore, the zinc supplementation is an appropriate choice for the depression management in patients with MS. PMID: 25933976 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Salari S, Khomand P, Arasteh M, Yousefzamani B, Hassanzadeh K Tags: Pharmacol Rep Source Type: research

n-3 Fatty acids as resolvents of inflammation in the A549 cells.
CONCLUSIONS: The results of the study have revealed the pro-inflammatory properties of AA, while the EPA and DHA had the opposite, resolving effect. Interestingly, FP-receptor inhibition by EPA and DHA demonstrated the unique role of the FP-receptor as a potential target for antagonists, in the diseases of inflammatory character. This study provides new information about n-3 fatty acids and their pro-resolving mediators, which can be used in the process of developing new anti-inflammatory drugs. PMID: 25933977 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Gdula-Argasińska J, Czepiel J, Woźniakiewicz A, Wojtoń K, Grzywacz A, Woźniakiewicz M, Jurczyszyn A, Perucki W, Librowski T Tags: Pharmacol Rep Source Type: research

Effect of chenodeoxycholic acid and sodium hydrogen sulfide in dinitro benzene sulfonic acid (DNBS) - Induced ulcerative colitis in rats.
CONCLUSION: The observed beneficial effects following CDCA may be due to its action through activation of CSE enzyme which leads to hydrogen sulfide generation. PMID: 25933978 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Goyal N, Rana A, Bijjem KR, Kumar P Tags: Pharmacol Rep Source Type: research

Brain concentrations of mGluR5 negative allosteric modulator MTEP in relation to receptor occupancy - Comparison to MPEP.
CONCLUSIONS: At behaviourally active dose MTEP produced complete mGluR5 receptor occupancy but over 50 times higher ECF concentrations than affinity for mGluR5 receptor in vitro. This difference is seems lower for other mGluR5 NAM compounds such as MPEP. A possibly explanation could be different distribution in body compartments of both agents leading to errors of estimation with the microdialysis technique or different pharmacological activity at the receptor. PMID: 25933979 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Nagel J, Greco S, Parsons CG, Flik G, Tober C, Klein KU, Danysz W Tags: Pharmacol Rep Source Type: research

β-Resorcylidene aminoguanidine (RAG) dilates coronary arteries in an endothelium-independent manner.
CONCLUSIONS: RAG is a strong vasodilator that exerts its effect via endothelium-independent mechanisms. PMID: 25933980 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Kazmierczak PA, Dobaczewski MP, Przygodzki T, Carsky J, Watala C Tags: Pharmacol Rep Source Type: research

Role of mTOR inhibitors in epilepsy treatment.
te;źwiak S Abstract In spite of the fact, that subsequent new antiepileptic drugs (AEDs) are being introduced into clinical practice, the percentage of drug-resistant epilepsy cases remains stable. Although a substantial progress has been made in safety profile of antiepileptic drugs, currently available substances have not been unambiguously proven to display disease-modifying effect in epilepsy and their mechanisms of action influence mainly on the end-stage phase of epileptogenesis, namely seizures. Prevention of epileptogenesis requires new generation of drugs modulating molecular pathways engaged in epilepto...
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Sadowski K, Kotulska-Jóźwiak K, Jóźwiak S Tags: Pharmacol Rep Source Type: research

Hydrogen sulfide in pharmacology and medicine - An update.
Abstract Hydrogen sulfide (H2S) is the endogenously produced gasotransmitter involved in the regulation of nervous system, cardiovascular functions, inflammatory response, gastrointestinal system and renal function. Together with nitric oxide and carbon monoxide, H2S belongs to a family of gasotransmitters. H2S is synthesized from l-cysteine and/or l-homocysteine by cystathionine β-synthase, cystathionine γ-lyase and cysteine aminotransferase together with 3-mercaptopyruvate sulfurtransferase. Significant progress has been made in recent years in our understanding of H2S biochemistry, signaling mechanis...
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Bełtowski J Tags: Pharmacol Rep Source Type: research

Zinc, future mono/adjunctive therapy for depression: Mechanisms of antidepressant action.
Abstract Affective disorders (depression) are considered as chronic illnesses leading to substantial disability, morbidity and mortality. While the etiology and pathophysiology of these diseases are still poorly recognized, the most important problems concerning them are low treatment response, treatment resistance and/or tolerance and risk of relapse. Recently published review articles have already demonstrated the important role of zinc in the pathophysiology and treatment of affective disorders, plus discussed the potential value of zinc as a marker of these diseases. This present concise review will update the...
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Nowak G Tags: Pharmacol Rep Source Type: research

Prospects of epileptogenesis prevention.
Abstract Epilepsy is a common neurologic disease, affecting about 1-2% of the population. In around 30% of patients with epilepsy, their seizures are not satisfactorily controlled and drug-resistant epilepsy constitutes a real therapeutic challenge. Consequently, there are efforts aimed at the inhibition of epileptogenesis, a process of converting a normal into an epileptic brain. Data on this problem have been mainly obtained in post-status epilepticus rodent models in which spontaneous seizure activity and behavioral disturbances develop over time. Among antiepileptic drugs, diazepam at high dose of 20mg/kg give...
Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Radzik I, Miziak B, Dudka J, Chrościńska-Krawczyk M, Czuczwar SJ Tags: Pharmacol Rep Source Type: research

MicroRNA Regulating Glutathione S-Transferase P1 in Prostate Cancer.
Abstract Glutathione S-transferase P1 (GSTP1), an enzyme involved in detoxification process, is frequently inactivated in prostate cancer due to epigenetic modifications. Through in silico analysis we identified a subset of miRNAs that are putative targets in regulating GSTP1. miRNAs are small endogenous non-coding RNA that are critical regulators of various physiologic and pathologic processes and their level of expression may play a precise role in early diagnosis and prognosis of cancer. These small molecules have been detected in a wide variety of human biological specimens including blood, serum, urine, ejacu...
Source: Pharmacological Reports - March 17, 2015 Category: Drugs & Pharmacology Authors: Singh S, Shukla GC, Gupta S Tags: Curr Pharmacol Rep Source Type: research

Impact of aliskiren on some hemostatic parameters in experimental arterial thrombosis in rats.
CONCLUSIONS: The presented results indicate that aliskiren inhibits hemostasis in the arterial thrombosis in rats. The antithrombotic effect is related with improvement of the fibrinolytic balance, and also depends on antiplatelet action. PMID: 25712636 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Hermanowicz JM, Buczko P, Tankiewicz-Kwedlo A, Hermanowicz A, Buczko W Tags: Pharmacol Rep Source Type: research

Differentiation of adult rat mesenchymal stem cells to GABAergic, dopaminergic and cholinergic neurons.
CONCLUSIONS: These new differentiation cocktails should be further investigated and in the next experiment only a part of MSCs that expressed the Cxcr4 receptor will be differentiated. We suppose that the Cxcr4(+) cells may differentiate more easily and as a result, we may achieve a homogenous population of one phenotype of neurons. PMID: 25712637 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Borkowska P, Fila-Danilow A, Paul-Samojedny M, Kowalczyk M, Hart J, Ryszawy J, Kowalski J Tags: Pharmacol Rep Source Type: research

Essential elements in depression and anxiety. Part II.
Abstract In this paper we continue to discuss the involvement of essential elements in depression and anxiety, and the possible mechanisms that link elements to the neurobiology underlying depression/anxiety. The present paper is focused on copper, selenium, manganese, iodine and vanadium. Different aspects of relationship between elements and depression or anxiety are reviewed, e.g. the association of the amount of an element in a diet or the serum level of an element and depressive or anxiety-like symptoms. Moreover, the relation of selected elements to the pathophysiology of depression or anxiety is discussed i...
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Młyniec K, Gaweł M, Doboszewska U, Starowicz G, Pytka K, Davies CL, Budziszewska B Tags: Pharmacol Rep Source Type: research

A review on Alzheimer's disease pathophysiology and its management: an update.
Abstract Alzheimer's disease acknowledged as progressive multifarious neurodegenerative disorder, is the leading cause of dementia in late adult life. Pathologically it is characterized by intracellular neurofibrillary tangles and extracellular amyloidal protein deposits contributing to senile plaques. Over the last two decades, advances in the field of pathogenesis have inspired the researchers for the investigation of novel pharmacological therapeutics centered more towards the pathophysiological events of the disease. Currently available treatments i.e. acetylcholinesterase inhibitors (rivastigmine, galantamine...
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Kumar A, Singh A, Ekavali Tags: Pharmacol Rep Source Type: research

Transcriptional and post-transcriptional regulation of CCN genes in failing heart.
CONCLUSION: CCN genes are activated in heart failure. Their regulation is multidimensional both transcriptional and posttranscriptional. The involved pathways include angiotensin II and IL-6. PMID: 25712640 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Bonda TA, Kożuch M, Litvinovich S, Bialuk I, Taranta A, Lipiec P, Szymczyk E, Musiał WJ, Winnicka MM, Kamiński KA Tags: Pharmacol Rep Source Type: research

Influence of nitric oxide synthase or cyclooxygenase inhibitors on cannabinoids activity in streptozotocin-induced neuropathy.
CONCLUSIONS: The results of this study seemed to indicate that the interaction between cannabinoid, COX-2 and NOS(s) systems might exist. Concomitant administration of small doses of CB1 and/or CB2 receptor agonists and COX-2 or NOS inhibitors can be effective in the alleviation of diabetic neuropathic pain. PMID: 25712641 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Bujalska-Zadrożny M, de Cordé A, Pawlik K Tags: Pharmacol Rep Source Type: research

Gambogic amide selectively upregulates TrkA expression and triggers its activation.
CONCLUSION: This study provides a novel mechanism of how gambogic amide regulates TrkA receptor, other than mimicking NGF in triggering TrkA activation. PMID: 25712642 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Shen J, Yu Q Tags: Pharmacol Rep Source Type: research

Current scenario in inflammatory bowel disease: Drug development prospects.
CONCLUSIONS: Preclinical research on the complex IBD puzzle coupled with an active and vibrant research agenda in recent decades which might reveal patterns of pharmacological interactions instead of single potential drug targets. The increased collaboration between pharmaceutical companies, basic researchers and clinical researchers has the potential to bring us closer to developing an optimum pharmaceutical approach for the treatment of IBD. PMID: 25712643 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Chandel S, Prakash A, Medhi B Tags: Pharmacol Rep Source Type: research

Protective effects of various dosage of Curcumin against morphine induced apoptosis and oxidative stress in rat isolated hippocampus.
CONCLUSIONS: These findings have demonstrated that Curcumin can act as an antioxidant and antiapoptotic agent against damage induced by morphine dependence. PMID: 25712644 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Motaghinejad M, Karimian M, Motaghinejad O, Shabab B, Yazdani I, Fatima S Tags: Pharmacol Rep Source Type: research

Synthesis and anticancer activity of 7-hydroxycoumarinyl gallates.
CONCLUSIONS: The novel compounds represent an excellent starting point for the further optimization and the design of therapeutically effective anti-cancerous drugs. PMID: 25712645 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Hejchman E, Taciak P, Kowalski S, Maciejewska D, Czajkowska A, Borowska J, Śladowski D, Młynarczuk-Biały I Tags: Pharmacol Rep Source Type: research

Antineoplastic effects of deoxypodophyllotoxin, a potent cytotoxic agent of plant origin, on glioblastoma U-87 MG and SF126 cells.
CONCLUSIONS: Taken together, our data demonstrated that DPT possesses a potent in vitro cytotoxic activity and exerts its effect via G2/M arrest and apoptosis. PMID: 25712646 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Guerram M, Jiang ZZ, Sun L, Zhu X, Zhang LY Tags: Pharmacol Rep Source Type: research

Low-dose ouabain administration increases Na(+),K(+)-ATPase activity and reduces cardiac force development in rats.
CONCLUSION: We suggest that the effects induced by ouabain in the isolated cardiac muscle could be related at least in part, to changes in NKA activity. PMID: 25712647 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Meira EF, Siman FD, Faria Tde O, Júnior RF, de Batista PR, Stefanon I, Vassallo DV, Padilha AS Tags: Pharmacol Rep Source Type: research

IL28B polymorphism (rs12979860) associated with clearance of HCV infection in Poland: Systematic review of its prevalence in chronic hepatitis C patients and general population frequency.
CONCLUSIONS: Events of spontaneous viral clearance can fully explain differences between genotype distributions in general population and chronic HCV subjects and a departure from the genetic equilibrium. This is the first study estimating the prevalence of IL28B rs12979860 SNP in the Southern Poland population based on a random representative sample. PMID: 25712648 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Kaczor MP, Seczyńska M, Szczeklik W, Sanak M Tags: Pharmacol Rep Source Type: research

Biofunctional studies of new 2-methoxyphenylpiperazine xanthone derivatives with α1-adrenolytic properties.
CONCLUSIONS: The results of the present study support the idea that the hypotensive activity of the studied compounds is related to their α1-adrenolytic properties. PMID: 25712649 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Rapacz A, Sapa J, Nowiński L, Mogilski S, Pytka K, Filipek B, Siwek A, Szkaradek N, Marona H Tags: Pharmacol Rep Source Type: research

The effects of valproate and olanzapine on the abnormal behavior of diacylglycerol kinase β knockout mice.
CONCLUSION: These results suggest that the abnormal behaviors of DGKβ KO mice is responsive to antimanic drugs, and that DGKβ KO mice are useful as an animal model of mania. PMID: 25712650 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Ishisaka M, Tsujii S, Mizoguchi T, Tsuruma K, Shimazawa M, Hara H Tags: Pharmacol Rep Source Type: research

Neuroprotective effect of noscapine on cerebral oxygen-glucose deprivation injury.
CONCLUSIONS: We concluded that noscapine had a neuroprotective effect, which could be due to its interference with multiple targets in the excitotoxicity process. These effects could be mediated partially by a decrease in NO production and the modulation of intracellular calcium levels. PMID: 25712651 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Vahabzadeh G, Rahbar-Roshandel N, Ebrahimi SA, Mahmoudian M Tags: Pharmacol Rep Source Type: research

Testicular effect of a mixture of 2-methoxyethanol and 2-ethoxyethanol in rats.
CONCLUSIONS: Marked testicular atrophy, decrease in epididymis and prostate weights are predominant effects of the repeated exposure to relatively low doses of ME and EE. A decrease in the total protein level, and protein sulfhydryl groups may be responsible for testicular atrophy. A significant depletion of non-protein sulfhydryl groups and occasionally elevated glutathione peroxidase activity may indicate that ME and EE resulted in disturbances of pro-oxidant/antioxidant balance. The study suggests that testicular toxicity in male rats co-exposed to ME and EE is mainly caused by the former compound. PMID: 25712652 [...
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Starek-Świechowicz B, Szymczak W, Budziszewska B, Starek A Tags: Pharmacol Rep Source Type: research

Genetic polymorphism of ABCB1 gene (C3435T) in patients with inflammatory bowel diseases. Is there any gender dependency?
Conclusions. The 3435CT genotype could be a risk factor for IBD and CD in men. The 3435TT genotype in males seems to be associated with the lower chance of IBD presence. PMID: 25712653 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - February 26, 2015 Category: Drugs & Pharmacology Authors: Jaźwińska-Tarnawska E, Jęśkowiak I, Waszczuk E, Mulak A, Głowacka K, Hurkacz M, Paradowski L, Zaleska Z, Wiela-Hojeńska A Tags: Pharmacol Rep Source Type: research