Anticonvulsant effects of isopimpinellin and its interactions with classic antiseizure medications and borneol in the mouse tonic-clonic seizure model: an isobolographic transformation
CONCLUSIONS: The most intriguing interaction was that for ISOP + VPA, for which the addition of BOR evoked a transition from antagonism to synergy in the mouse MES model.PMID:37821793 | DOI:10.1007/s43440-023-00532-x (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 11, 2023 Category: Drugs & Pharmacology Authors: Jarogniew J Łuszczki Hubert Bojar Katarzyna Jankiewicz Magdalena Florek- Łuszczki Jaros ław Chmielewski Krystyna Skalicka-Wo źniak Source Type: research
Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish
CONCLUSION: Consequently, we conclude that, under the conditions employed in this study, NAC and ALC do not exhibit any significant effects on acute seizures in zebrafish.PMID:37814098 | DOI:10.1007/s43440-023-00536-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 9, 2023 Category: Drugs & Pharmacology Authors: Rafael Chitolina Carlos G Reis Thailana Stahlhofer-Buss Amanda Linazzi Radharani Benvenutti Matheus Marcon Ana P Herrmann Angelo Piato Source Type: research
Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish
CONCLUSION: Consequently, we conclude that, under the conditions employed in this study, NAC and ALC do not exhibit any significant effects on acute seizures in zebrafish.PMID:37814098 | DOI:10.1007/s43440-023-00536-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 9, 2023 Category: Drugs & Pharmacology Authors: Rafael Chitolina Carlos G Reis Thailana Stahlhofer-Buss Amanda Linazzi Radharani Benvenutti Matheus Marcon Ana P Herrmann Angelo Piato Source Type: research
Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish
CONCLUSION: Consequently, we conclude that, under the conditions employed in this study, NAC and ALC do not exhibit any significant effects on acute seizures in zebrafish.PMID:37814098 | DOI:10.1007/s43440-023-00536-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 9, 2023 Category: Drugs & Pharmacology Authors: Rafael Chitolina Carlos G Reis Thailana Stahlhofer-Buss Amanda Linazzi Radharani Benvenutti Matheus Marcon Ana P Herrmann Angelo Piato Source Type: research
Insulin in combination with pioglitazone prevents advanced cachexia in 256-Walker tumor-bearing rats: effect is greater than treatment alone and is associated with improved insulin sensitivity
CONCLUSIONS: The combined treatment with INS 18 U/kg + PIO 5 mg/kg was more effective in preventing advanced cachexia in TB rats than each treatment alone, emerging as the best approach, considering the lower dosage and higher efficacy. This combination completely preserved adipose mass and markedly reduced weight loss through a synergistic mechanism linked to improved insulin sensitivity. These findings provide new insights into the importance of drug combinations in effectively combating fat loss in advanced cachexia.PMID:37804392 | DOI:10.1007/s43440-023-00533-w (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 7, 2023 Category: Drugs & Pharmacology Authors: Daniele Romani Miksza Giuliana Regina Biazi Isabele Gon çalves Frasson Winny Beatriz de Souza Galia Laura Socio Ferraz Brenda Francisconi Diaz Mirian Ayumi Kurauti Carine Marmentini Cec ília Edna Mareze-Costa Sidney Barnab é Peres Priscila Cassolla Gis Source Type: research
Insulin in combination with pioglitazone prevents advanced cachexia in 256-Walker tumor-bearing rats: effect is greater than treatment alone and is associated with improved insulin sensitivity
CONCLUSIONS: The combined treatment with INS 18 U/kg + PIO 5 mg/kg was more effective in preventing advanced cachexia in TB rats than each treatment alone, emerging as the best approach, considering the lower dosage and higher efficacy. This combination completely preserved adipose mass and markedly reduced weight loss through a synergistic mechanism linked to improved insulin sensitivity. These findings provide new insights into the importance of drug combinations in effectively combating fat loss in advanced cachexia.PMID:37804392 | DOI:10.1007/s43440-023-00533-w (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 7, 2023 Category: Drugs & Pharmacology Authors: Daniele Romani Miksza Giuliana Regina Biazi Isabele Gon çalves Frasson Winny Beatriz de Souza Galia Laura Socio Ferraz Brenda Francisconi Diaz Mirian Ayumi Kurauti Carine Marmentini Cec ília Edna Mareze-Costa Sidney Barnab é Peres Priscila Cassolla Gis Source Type: research
Cytotoxic pathways activated by multifunctional thiosemicarbazones targeting sigma-2 receptors in breast and lung carcinoma cells
CONCLUSIONS: Our data suggest that FA4 is a promising compound that deserves to be further studied for lung and breast cancer treatment. However, the other multifunctional TSCs also hold promise for the development of therapies towards a personalized medicine approach. Indeed, the presence of the sigma-2 receptor-targeting moiety would lead to a more specific tumor delivery embracing the characteristics of individual tumor types.PMID:37796435 | DOI:10.1007/s43440-023-00531-y (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 5, 2023 Category: Drugs & Pharmacology Authors: Joanna Kopecka Alessandra Barbanente Daniele Vitone Fabio Arnesano Nicola Margiotta Paola Berchialla Mauro Niso Chiara Riganti Carmen Abate Source Type: research
Cytotoxic pathways activated by multifunctional thiosemicarbazones targeting sigma-2 receptors in breast and lung carcinoma cells
CONCLUSIONS: Our data suggest that FA4 is a promising compound that deserves to be further studied for lung and breast cancer treatment. However, the other multifunctional TSCs also hold promise for the development of therapies towards a personalized medicine approach. Indeed, the presence of the sigma-2 receptor-targeting moiety would lead to a more specific tumor delivery embracing the characteristics of individual tumor types.PMID:37796435 | DOI:10.1007/s43440-023-00531-y (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 5, 2023 Category: Drugs & Pharmacology Authors: Joanna Kopecka Alessandra Barbanente Daniele Vitone Fabio Arnesano Nicola Margiotta Paola Berchialla Mauro Niso Chiara Riganti Carmen Abate Source Type: research
Cytotoxic pathways activated by multifunctional thiosemicarbazones targeting sigma-2 receptors in breast and lung carcinoma cells
CONCLUSIONS: Our data suggest that FA4 is a promising compound that deserves to be further studied for lung and breast cancer treatment. However, the other multifunctional TSCs also hold promise for the development of therapies towards a personalized medicine approach. Indeed, the presence of the sigma-2 receptor-targeting moiety would lead to a more specific tumor delivery embracing the characteristics of individual tumor types.PMID:37796435 | DOI:10.1007/s43440-023-00531-y (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 5, 2023 Category: Drugs & Pharmacology Authors: Joanna Kopecka Alessandra Barbanente Daniele Vitone Fabio Arnesano Nicola Margiotta Paola Berchialla Mauro Niso Chiara Riganti Carmen Abate Source Type: research
Alpha-lipoic acid, apocynin or probiotics influence glutathione status and selected inflammatory parameters in C57/BL6 mice when combined with a low-fat diet
CONCLUSIONS: Supplementation of the tested compounds with LFD appears to have a positive influence on the glutathione redox status of pulmonary tissues and selected inflammatory parameters in mouse blood.PMID:37730940 | PMC:PMC10539412 | DOI:10.1007/s43440-023-00527-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 21, 2023 Category: Drugs & Pharmacology Authors: Paulina Kleniewska Rafa ł Pawliczak Source Type: research
Alpha-lipoic acid, apocynin or probiotics influence glutathione status and selected inflammatory parameters in C57/BL6 mice when combined with a low-fat diet
CONCLUSIONS: Supplementation of the tested compounds with LFD appears to have a positive influence on the glutathione redox status of pulmonary tissues and selected inflammatory parameters in mouse blood.PMID:37730940 | PMC:PMC10539412 | DOI:10.1007/s43440-023-00527-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 21, 2023 Category: Drugs & Pharmacology Authors: Paulina Kleniewska Rafa ł Pawliczak Source Type: research
Alpha-lipoic acid, apocynin or probiotics influence glutathione status and selected inflammatory parameters in C57/BL6 mice when combined with a low-fat diet
CONCLUSIONS: Supplementation of the tested compounds with LFD appears to have a positive influence on the glutathione redox status of pulmonary tissues and selected inflammatory parameters in mouse blood.PMID:37730940 | PMC:PMC10539412 | DOI:10.1007/s43440-023-00527-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 21, 2023 Category: Drugs & Pharmacology Authors: Paulina Kleniewska Rafa ł Pawliczak Source Type: research
Alpha-lipoic acid, apocynin or probiotics influence glutathione status and selected inflammatory parameters in C57/BL6 mice when combined with a low-fat diet
CONCLUSIONS: Supplementation of the tested compounds with LFD appears to have a positive influence on the glutathione redox status of pulmonary tissues and selected inflammatory parameters in mouse blood.PMID:37730940 | PMC:PMC10539412 | DOI:10.1007/s43440-023-00527-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 21, 2023 Category: Drugs & Pharmacology Authors: Paulina Kleniewska Rafa ł Pawliczak Source Type: research
Alpha-lipoic acid, apocynin or probiotics influence glutathione status and selected inflammatory parameters in C57/BL6 mice when combined with a low-fat diet
CONCLUSIONS: Supplementation of the tested compounds with LFD appears to have a positive influence on the glutathione redox status of pulmonary tissues and selected inflammatory parameters in mouse blood.PMID:37730940 | DOI:10.1007/s43440-023-00527-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 21, 2023 Category: Drugs & Pharmacology Authors: Paulina Kleniewska Rafa ł Pawliczak Source Type: research
Alpha-lipoic acid, apocynin or probiotics influence glutathione status and selected inflammatory parameters in C57/BL6 mice when combined with a low-fat diet
CONCLUSIONS: Supplementation of the tested compounds with LFD appears to have a positive influence on the glutathione redox status of pulmonary tissues and selected inflammatory parameters in mouse blood.PMID:37730940 | DOI:10.1007/s43440-023-00527-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 21, 2023 Category: Drugs & Pharmacology Authors: Paulina Kleniewska Rafa ł Pawliczak Source Type: research
