Partial mGlu < sub > 5 < /sub > receptor NAM, M-5MPEP, induces rapid and sustained antidepressant-like effects in the BDNF-dependent mechanism and enhances (R)-ketamine action in mice

CONCLUSION: Partial mGlu5 receptor NAM, M-5MPEP, induced rapid and sustained antidepressant-like effects in the BDNF-dependent mechanism and enhanced (R)-ketamine action in mice, indicating both substances' convergent mechanisms of action and the possibility of their practical use in treating depression as RAAD.PMID:38632187 | DOI:10.1007/s43440-024-00588-3
Source: Pharmacological Reports - Category: Drugs & Pharmacology Authors: Source Type: research