Modulation of atherosclerosis-related signaling pathways by Chinese herbal extracts: Recent evidence and perspectives
This article reviews the signaling pathways implicated in the pathogenesis of atherosclerosis and the advancements in research on TCM extracts for prevention and treatment, drawing on original articles from various databases including Google Scholar, Medline, CNKI, Scopus, and Pubmed. The objective is to furnish a reference for the clinical management of cardiovascular diseases.PMID:38577989 | DOI:10.1002/ptr.8203 (Source: Cell Research)
Source: Cell Research - April 5, 2024 Category: Cytology Authors: Changxing Liu Xinyi Guo Xulong Zhang Source Type: research
Physiologically based pharmacokinetics modeling and transporter proteomics to predict systemic and local liver and muscle disposition of statins
AbstractStatins are used to reduce liver cholesterol levels but also carry a dose-related risk of skeletal muscle toxicity. Concentrations of statins in plasma are often used to assess efficacy and safety, but because statins are substrates of membrane transporters that are present in diverse tissues, local differences in intracellular tissue concentrations cannot be ruled out. Thus, plasma concentration may not be an adequate indicator of efficacy and toxicity. To bridge this gap, we used physiologically based pharmacokinetic (PBPK) modeling to predict intracellular concentrations of statins. Quantitative data on transpor...
Source: CPT: Pharmacometrics and Systems Pharmacology - April 5, 2024 Category: Drugs & Pharmacology Authors: Luna Prieto Garcia,
Anna Vildhede,
Pär Nordell,
Christine Ahlström,
Ahmed B. Montaser,
Tetsuya Terasaki,
Hans Lennernäs,
Erik Sjögren Tags: ARTICLE Source Type: research
Comparative Safety and Efficacy of Low/Moderate-Intensity Statin plus Ezetimibe Combination Therapy vs. High-Intensity Statin Monotherapy in Patients with Atherosclerotic Cardiovascular Disease: An Updated Meta-Analysis
ConclusionThis meta-analysis demonstrated that the use of low/moderate-intensity statin combination therapy significantly reduced LDL-C levels compared with high-intensity statin monotherapy, making it preferable for patients with related risks. However, further trials are encouraged to evaluate potential adverse effects associated with combined therapy. (Source: American Journal of Cardiovascular Drugs)
Source: American Journal of Cardiovascular Drugs - April 5, 2024 Category: Cardiology Source Type: research
Decoding the Intricacies of Statin-Associated Muscle Symptoms
AbstractPurpose of ReviewHyperlipidemia is the major cardiovascular morbidity and mortality risk factor. Statins are the first-line treatment for hyperlipidemia. Statin-associated muscle symptoms (SAMS) are the main reason for the discontinuation of statins among patients. The purpose of this review is to guide clinicians to recognize the difference between self-limited and autoimmune statin myopathy in addition to the factors that potentiate them. Finally, treatment strategies will be discussed. This review mostly focuses on new data in the past 3 years.Recent FindingsRecent findings suggest that SAMS is a complex and mul...
Source: Current Rheumatology Reports - April 5, 2024 Category: Rheumatology Source Type: research
Statins Do Not Significantly Affect Oxidative Nitrosative Stress Biomarkers in the PREVENT Randomized Clinical Trial
Conclusions: Atorvastatin demonstrated very modest effects on oxidative/nitrosative stress biomarkers in this low cardiovascular risk population. Our findings provide potential mechanistic insight into the lack of effect of atorvastatin on LVEF in the PREVENT trial.PMID:38573708 | DOI:10.1158/1078-0432.CCR-23-3952 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 4, 2024 Category: Cancer & Oncology Authors: Igor Makhlin Biniyam G Demissei Ralph D'Agostino W Greg Hundley Camelia Baleanu-Gogonea Nicholas S Wilcox Anna Chen Amanda M Smith Nathaniel Sean O'Connell James Januzzi Glenn J Lesser Marielle Scherrer-Crosbie Borja Ib áñez W H Wilson Tang Bonnie Ky Source Type: research
Telmisartan-Induced Myotoxicity in Patients with Essential Hypertension
Turk Kardiyol Dern Ars. 2024 Apr;52(3):217-219. doi: 10.5543/tkda.2023.22893.ABSTRACTDrug-related muscular adverse effects are relatively common among certain groups of drugs, such as statins and steroids. However, these adverse effects are less well-known for angiotensin receptor blockers (ARBs). It is proposed that telmisartan and irbesartan may cause myotoxicity via increased Peroxisome Proliferator-Activated Receptor gamma (PPAR-gamma) activity. Herein, we present two hypertensive patients in whom telmisartan-induced myotoxicity was observed. Therefore, physicians should be aware that telmisartan, along with some other...
Source: Turk Kardiyoloji Dernegi arsivi - April 4, 2024 Category: Cardiology Authors: S üleyman Cihan Kara U ğur Canpolat Source Type: research
Statins Do Not Significantly Affect Oxidative Nitrosative Stress Biomarkers in the PREVENT Randomized Clinical Trial
Conclusions: Atorvastatin demonstrated very modest effects on oxidative/nitrosative stress biomarkers in this low cardiovascular risk population. Our findings provide potential mechanistic insight into the lack of effect of atorvastatin on LVEF in the PREVENT trial.PMID:38573708 | DOI:10.1158/1078-0432.CCR-23-3952 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 4, 2024 Category: Cancer & Oncology Authors: Igor Makhlin Biniyam G Demissei Ralph D'Agostino W Greg Hundley Camelia Baleanu-Gogonea Nicholas S Wilcox Anna Chen Amanda M Smith Nathaniel Sean O'Connell James Januzzi Glenn J Lesser Marielle Scherrer-Crosbie Borja Ib áñez W H Wilson Tang Bonnie Ky Source Type: research
Statins Do Not Significantly Affect Oxidative Nitrosative Stress Biomarkers in the PREVENT Randomized Clinical Trial
Conclusions: Atorvastatin demonstrated very modest effects on oxidative/nitrosative stress biomarkers in this low cardiovascular risk population. Our findings provide potential mechanistic insight into the lack of effect of atorvastatin on LVEF in the PREVENT trial.PMID:38573708 | DOI:10.1158/1078-0432.CCR-23-3952 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 4, 2024 Category: Cancer & Oncology Authors: Igor Makhlin Biniyam G Demissei Ralph D'Agostino W Greg Hundley Camelia Baleanu-Gogonea Nicholas S Wilcox Anna Chen Amanda M Smith Nathaniel Sean O'Connell James Januzzi Glenn J Lesser Marielle Scherrer-Crosbie Borja Ib áñez W H Wilson Tang Bonnie Ky Source Type: research
Patterns of Statin Therapy Use and Associated Outcomes in Older Veterans Across Kidney Function
CONCLUSION: This large cohort study did not reveal an association between the initiation of statin therapy and incident dementia. A survival benefit was seen in statin users compared to non-users. Prospective studies in more diverse populations including older adults will be needed to verify these findings.PMID:38574795 | DOI:10.1016/j.amjmed.2024.03.016 (Source: Atherosclerosis)
Source: Atherosclerosis - April 4, 2024 Category: Cardiology Authors: Grenita Gjyriqi Adam Gross Edith Burns Eugenia Gianos Mandeep Sidhu Roy Mathew Source Type: research
Colchicine for the Prevention of Cardiovascular Disease: Potential Global Implementation
Curr Cardiol Rep. 2024 Apr 4. doi: 10.1007/s11886-024-02049-y. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Targeting traditional cardiovascular risk factors is effective in reducing recurrent cardiovascular events, yet the presence of residual cardiovascular risk due to underlying systemic inflammation is a largely unaddressed opportunity. This review aims to comprehensively assess the evolving role of colchicine as a therapeutic approach targeting residual inflammatory risk in the context of those with coronary artery disease (CAD).RECENT FINDINGS: Inflammation plays a significant role in promoting atherosclerosis, a...
Source: Atherosclerosis - April 4, 2024 Category: Cardiology Authors: Robert S Zhang Brittany N Weber Diego Araiza-Garaygordobil Michael S Garshick Source Type: research
Biomedicine and pharmacotherapeutic effectiveness of combinatorial atorvastatin and quercetin on diabetic nephropathy: An in vitro study
CONCLUSION: Nevertheless, there is currently no existing literature that reports on the role of QCT as a combination renoprotective drug with statins in the context of diabetic nephropathy. Hence, these findings suggest that atorvastatin and quercetin may have clinical potential in treating diabetic nephropathy.PMID:38574626 | DOI:10.1016/j.biopha.2024.116533 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 4, 2024 Category: Drugs & Pharmacology Authors: Haleema Shahin Dh Rokeya Sultana Ashwini Prabhu Pavan S R Sourav Mohanto Vetriselvan Subramaniyan Source Type: research
Statins Do Not Significantly Affect Oxidative Nitrosative Stress Biomarkers in the PREVENT Randomized Clinical Trial
Conclusions: Atorvastatin demonstrated very modest effects on oxidative/nitrosative stress biomarkers in this low cardiovascular risk population. Our findings provide potential mechanistic insight into the lack of effect of atorvastatin on LVEF in the PREVENT trial.PMID:38573708 | DOI:10.1158/1078-0432.CCR-23-3952 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 4, 2024 Category: Cancer & Oncology Authors: Igor Makhlin Biniyam G Demissei Ralph D'Agostino W Greg Hundley Camelia Baleanu-Gogonea Nicholas S Wilcox Anna Chen Amanda M Smith Nathaniel Sean O'Connell James Januzzi Glenn J Lesser Marielle Scherrer-Crosbie Borja Ib áñez W H Wilson Tang Bonnie Ky Source Type: research
Telmisartan-Induced Myotoxicity in Patients with Essential Hypertension
Turk Kardiyol Dern Ars. 2024 Apr;52(3):217-219. doi: 10.5543/tkda.2023.22893.ABSTRACTDrug-related muscular adverse effects are relatively common among certain groups of drugs, such as statins and steroids. However, these adverse effects are less well-known for angiotensin receptor blockers (ARBs). It is proposed that telmisartan and irbesartan may cause myotoxicity via increased Peroxisome Proliferator-Activated Receptor gamma (PPAR-gamma) activity. Herein, we present two hypertensive patients in whom telmisartan-induced myotoxicity was observed. Therefore, physicians should be aware that telmisartan, along with some other...
Source: Turk Kardiyoloji Dernegi arsivi - April 4, 2024 Category: Cardiology Authors: S üleyman Cihan Kara U ğur Canpolat Source Type: research
Biomedicine and pharmacotherapeutic effectiveness of combinatorial atorvastatin and quercetin on diabetic nephropathy: An in vitro study
CONCLUSION: Nevertheless, there is currently no existing literature that reports on the role of QCT as a combination renoprotective drug with statins in the context of diabetic nephropathy. Hence, these findings suggest that atorvastatin and quercetin may have clinical potential in treating diabetic nephropathy.PMID:38574626 | DOI:10.1016/j.biopha.2024.116533 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 4, 2024 Category: Drugs & Pharmacology Authors: Haleema Shahin Dh Rokeya Sultana Ashwini Prabhu Pavan S R Sourav Mohanto Vetriselvan Subramaniyan Source Type: research
