Low-dose colchicine for atherosclerosis: long-term safety
Eur Heart J. 2024 Apr 10:ehae208. doi: 10.1093/eurheartj/ehae208. Online ahead of print.ABSTRACTLow-dose colchicine (0.5 mg daily) is now FDA-approved for secondary prevention in patients with coronary disease and will be increasingly prescribed in clinical practice. In this State-of-the-Art Review, data were collated from contemporary systemic reviews of case reports, drug registries, and placebo-controlled trials that assessed specific issues of safety related to the continuous use of colchicine in a range of clinical settings to inform physicians, pharmacists, and patients of the absolute risks of continuous use of low-...
Source: Atherosclerosis - April 10, 2024 Category: Cardiology Authors: Stefan Mark Nidorf Eldad Ben-Chetrit Paul M Ridker Source Type: research
PCSK9i promoting the transformation of AS plaques into a stable plaque by targeting the miR-186-5p/Wipf2 and miR-375-3p/Pdk1/Yap1 in ApoE-/- mice
CONCLUSION: Aberrant miRNA expression may play a pivotal role in AS progression in murine models of AS. The subcutaneous administration of PCSK9i exerted anti-atherosclerotic effects by targeting the miR-186-5p/Wipf2 and miR-375-3p/Pdk1/Yap1 axes, thereby promoting the transition of AS plaques into a more stable form.PMID:38596793 | PMC:PMC11002805 | DOI:10.3389/fmed.2024.1284199 (Source: Atherosclerosis)
Source: Atherosclerosis - April 10, 2024 Category: Cardiology Authors: Yanlong Zhao Ning Liu Jifeng Zhang Lei Zhao Source Type: research
Role of statins in the management of dyslipidaemia
Indian Heart J. 2024 Mar;76 Suppl 1:S33-S37. doi: 10.1016/j.ihj.2023.11.267. Epub 2024 Apr 8.ABSTRACTBlood cholesterol has firmly been established as a crucial risk factor for the development of atherosclerotic cardiovascular disease (ASCVD) by elegant epidemiological studies. Naturally, means to reduce blood cholesterol level took the centerstage of research in this field. After initial lukewarm results with nicotinic acid, fibrates and some other agents, statins emerged as the most effective class of medicine to reduce blood cholesterol; in particular, the most atherogenic low density lipoprotein cholesterol (LDL-C). Als...
Source: Indian Heart J - April 10, 2024 Category: Cardiology Authors: Saumitra Ray Source Type: research
Familial hypercholesterolemia
Indian Heart J. 2024 Mar;76 Suppl 1:S108-S112. doi: 10.1016/j.ihj.2023.12.002. Epub 2024 Apr 8.ABSTRACTFamilial hypercholesterolemia is a common genetic disorder of autosomal inheritance associated with elevated LDL-cholesterol. It is estimated to affect 1:250 individuals in general population roughly estimated to be 5 million in India. The prevalence of FH is higher in young CAD patients (<55 years in men; <60 years in women). FH is underdiagnosed and undertreated. Screening during childhood and Cascade screening of family members of known FH patients is of utmost importance in order to prevent the burden of CAD. Ea...
Source: Indian Heart J - April 10, 2024 Category: Cardiology Authors: J P S Sawhney Kushal Madan Source Type: research
The clinical value of β-blockers in patients with stable angina
Curr Med Res Opin. 2024;40(sup1):33-41. doi: 10.1080/03007995.2024.2317443. Epub 2024 Apr 10.ABSTRACTStable angina, one manifestation of chronic coronary syndrome (CCS), is characterised by intermittent episodes of insufficient blood supply to the myocardium, provoking symptoms of myocardial ischaemia, particularly chest pain. These attacks usually occur during exercise or stress. Anti-ischaemic drugs are the mainstay of pharmacologic management of CCS with symptoms of angina. β-blockers reduce heart rate and myocardial contractility, thus reducing myocardial oxygen consumption. These drugs have been shown to ameliorate t...
Source: Current Medical Research and Opinion - April 10, 2024 Category: Research Authors: Paolo Palatini Jose R Faria-Neto Raul D Santos Source Type: research
Role of statins in the management of dyslipidaemia
Indian Heart J. 2024 Mar;76 Suppl 1:S33-S37. doi: 10.1016/j.ihj.2023.11.267. Epub 2024 Apr 8.ABSTRACTBlood cholesterol has firmly been established as a crucial risk factor for the development of atherosclerotic cardiovascular disease (ASCVD) by elegant epidemiological studies. Naturally, means to reduce blood cholesterol level took the centerstage of research in this field. After initial lukewarm results with nicotinic acid, fibrates and some other agents, statins emerged as the most effective class of medicine to reduce blood cholesterol; in particular, the most atherogenic low density lipoprotein cholesterol (LDL-C). Als...
Source: Atherosclerosis - April 10, 2024 Category: Cardiology Authors: Saumitra Ray Source Type: research
Low-dose colchicine for atherosclerosis: long-term safety
Eur Heart J. 2024 Apr 10:ehae208. doi: 10.1093/eurheartj/ehae208. Online ahead of print.ABSTRACTLow-dose colchicine (0.5 mg daily) is now FDA-approved for secondary prevention in patients with coronary disease and will be increasingly prescribed in clinical practice. In this State-of-the-Art Review, data were collated from contemporary systemic reviews of case reports, drug registries, and placebo-controlled trials that assessed specific issues of safety related to the continuous use of colchicine in a range of clinical settings to inform physicians, pharmacists, and patients of the absolute risks of continuous use of low-...
Source: Atherosclerosis - April 10, 2024 Category: Cardiology Authors: Stefan Mark Nidorf Eldad Ben-Chetrit Paul M Ridker Source Type: research
PCSK9i promoting the transformation of AS plaques into a stable plaque by targeting the miR-186-5p/Wipf2 and miR-375-3p/Pdk1/Yap1 in ApoE-/- mice
CONCLUSION: Aberrant miRNA expression may play a pivotal role in AS progression in murine models of AS. The subcutaneous administration of PCSK9i exerted anti-atherosclerotic effects by targeting the miR-186-5p/Wipf2 and miR-375-3p/Pdk1/Yap1 axes, thereby promoting the transition of AS plaques into a more stable form.PMID:38596793 | PMC:PMC11002805 | DOI:10.3389/fmed.2024.1284199 (Source: Atherosclerosis)
Source: Atherosclerosis - April 10, 2024 Category: Cardiology Authors: Yanlong Zhao Ning Liu Jifeng Zhang Lei Zhao Source Type: research
Role of statins in the management of dyslipidaemia
Indian Heart J. 2024 Mar;76 Suppl 1:S33-S37. doi: 10.1016/j.ihj.2023.11.267. Epub 2024 Apr 8.ABSTRACTBlood cholesterol has firmly been established as a crucial risk factor for the development of atherosclerotic cardiovascular disease (ASCVD) by elegant epidemiological studies. Naturally, means to reduce blood cholesterol level took the centerstage of research in this field. After initial lukewarm results with nicotinic acid, fibrates and some other agents, statins emerged as the most effective class of medicine to reduce blood cholesterol; in particular, the most atherogenic low density lipoprotein cholesterol (LDL-C). Als...
Source: Indian Heart J - April 10, 2024 Category: Cardiology Authors: Saumitra Ray Source Type: research
Familial hypercholesterolemia
Indian Heart J. 2024 Mar;76 Suppl 1:S108-S112. doi: 10.1016/j.ihj.2023.12.002. Epub 2024 Apr 8.ABSTRACTFamilial hypercholesterolemia is a common genetic disorder of autosomal inheritance associated with elevated LDL-cholesterol. It is estimated to affect 1:250 individuals in general population roughly estimated to be 5 million in India. The prevalence of FH is higher in young CAD patients (<55 years in men; <60 years in women). FH is underdiagnosed and undertreated. Screening during childhood and Cascade screening of family members of known FH patients is of utmost importance in order to prevent the burden of CAD. Ea...
Source: Indian Heart J - April 10, 2024 Category: Cardiology Authors: J P S Sawhney Kushal Madan Source Type: research
Role of statins in the management of dyslipidaemia
Indian Heart J. 2024 Mar;76 Suppl 1:S33-S37. doi: 10.1016/j.ihj.2023.11.267. Epub 2024 Apr 8.ABSTRACTBlood cholesterol has firmly been established as a crucial risk factor for the development of atherosclerotic cardiovascular disease (ASCVD) by elegant epidemiological studies. Naturally, means to reduce blood cholesterol level took the centerstage of research in this field. After initial lukewarm results with nicotinic acid, fibrates and some other agents, statins emerged as the most effective class of medicine to reduce blood cholesterol; in particular, the most atherogenic low density lipoprotein cholesterol (LDL-C). Als...
Source: Indian Heart J - April 10, 2024 Category: Cardiology Authors: Saumitra Ray Source Type: research
Familial hypercholesterolemia
Indian Heart J. 2024 Mar;76 Suppl 1:S108-S112. doi: 10.1016/j.ihj.2023.12.002. Epub 2024 Apr 8.ABSTRACTFamilial hypercholesterolemia is a common genetic disorder of autosomal inheritance associated with elevated LDL-cholesterol. It is estimated to affect 1:250 individuals in general population roughly estimated to be 5 million in India. The prevalence of FH is higher in young CAD patients (<55 years in men; <60 years in women). FH is underdiagnosed and undertreated. Screening during childhood and Cascade screening of family members of known FH patients is of utmost importance in order to prevent the burden of CAD. Ea...
Source: Indian Heart J - April 10, 2024 Category: Cardiology Authors: J P S Sawhney Kushal Madan Source Type: research
Atorvastatin causes developmental and behavioral toxicity in yellowstripe goby (Mugilogobius chulae) embryos/larvae via disrupting lipid metabolism and autophagy processes
Aquat Toxicol. 2024 Apr 6;271:106909. doi: 10.1016/j.aquatox.2024.106909. Online ahead of print.ABSTRACTAtorvastatin (ATV) is one of the most commonly prescribed lipid-lowering drugs detected frequently in the environment due to its high use and low degradation rate. However, the toxic effects of residual ATV in the aquatic environment on non-target organisms and its toxic mechanisms are still largely unknown. In the present study, embryos of a native estuarine benthic fish, Mugilogobius chulae, were employed to investigate the developmental and behavioral toxic effects of ATV including environmentally relevant concentrati...
Source: Aquatic Toxicology - April 9, 2024 Category: Toxicology Authors: Yufei Zhao Yimeng Wang Jinzhi Ren Weibo Gong Xiangping Nie Ying Peng Jianjun Li Chunni Duan Source Type: research
Assessing the structural stability and drug encapsulation efficiency of poly(ethylene glycol)-poly(L-lactic acid) nanoparticles loaded with atorvastatin calcium: Based on dissipative particle dynamics
This study aims to investigate the structural stability of drug-loading micelles formed by two diblock/triblock polymers with various block sequences through coarse-grained dissipative particle dynamics (DPD) simulations. From the perspectives of the binding strength of poly(L-lactic acid) (PLLA) and polyethylene glycol (PEG) in nanoparticles, hydrophilic bead surface coverage, and the morphological alteration of nanoparticles induced by shear force, the ratio of hydrophilic/hydrophobic sequence length has been observed to affect the stability of nanoparticles. We have found that for diblock polymers, PEG3kda-PLLA2kda has ...
Source: International Journal of Biological Macromolecules - April 9, 2024 Category: Biochemistry Authors: Yun Hao Feng Wei Xin Guo Zhuo Lin Li Liu Fu Hu Yue Liu Li Yue Jing Jianhao Wang Mohammad-Ali Shahbazi Bo Zhi Chen Xin Dong Guo Source Type: research
Update on cardiac imaging: A critical analysis
Clin Investig Arterioscler. 2024 Apr 8:S0214-9168(24)00022-6. doi: 10.1016/j.arteri.2024.03.001. Online ahead of print.ABSTRACTImaging is instrumental in diagnosing and directing the management of atherosclerosis. In 1958 the first diagnostic coronary angiography (CA) was performed, and since then further development has led to new methods such as coronary CT angiography (CTA), optical coherence tomography (OCT), positron tomography (PET), and intravascular ultrasound (IVUS). Currently, CA remains powerful for visualizing coronary arteries; however, recent studies show the benefits of using other non-invasive techniques. T...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Halia Shah Samina Alim Sonia Akther Mahnoor Irfan Jamolbi Rahmatova Aneesa Arshad Charlene Hui Ping Kok Syeda Anum Zahra Source Type: research
