A Computational Study of Green Tea Extracts and their Derivatives as Potential Inhibitors for Squalene Monooxygenase
CONCLUSION: The results obtained from this study suggest that green tea polyphenols have the potential for inhibition of squalene monooxygenase, except for theasinensin A.PMID:38584555 | DOI:10.2174/0115734064280290240211170037 (Source: Molecular Medicine)
Source: Molecular Medicine - April 8, 2024 Category: Molecular Biology Authors: Kabelo Phuti Mokgopa Kevin A Lobb Tendamudzimu Tshiwawa Source Type: research
The association between trajectory of serum cholesterol, statin dosage, and the risk of recurrent biliary stone diseases
CONCLUSION: This study supports the potential benefits of statin use and the role of cholecystectomy in reducing the risk of recurrent biliary stone diseases.PMID:38589275 | DOI:10.1016/j.jfma.2024.04.003 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - April 8, 2024 Category: General Medicine Authors: Fai-Meng Sou Chien-Ning Hsu Yi-Chun Chiu Cheng-Kun Wu Lung-Sheng Lu Chung-Mou Kuo Shao-Ming Chiu Seng-Kee Chuah Yao-Hsu Yang Chih-Ming Liang Source Type: research
A Computational Study of Green Tea Extracts and their Derivatives as Potential Inhibitors for Squalene Monooxygenase
CONCLUSION: The results obtained from this study suggest that green tea polyphenols have the potential for inhibition of squalene monooxygenase, except for theasinensin A.PMID:38584555 | DOI:10.2174/0115734064280290240211170037 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - April 8, 2024 Category: Chemistry Authors: Kabelo Phuti Mokgopa Kevin A Lobb Tendamudzimu Tshiwawa Source Type: research
A Computational Study of Green Tea Extracts and their Derivatives as Potential Inhibitors for Squalene Monooxygenase
CONCLUSION: The results obtained from this study suggest that green tea polyphenols have the potential for inhibition of squalene monooxygenase, except for theasinensin A.PMID:38584555 | DOI:10.2174/0115734064280290240211170037 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - April 8, 2024 Category: Chemistry Authors: Kabelo Phuti Mokgopa Kevin A Lobb Tendamudzimu Tshiwawa Source Type: research
A Computational Study of Green Tea Extracts and their Derivatives as Potential Inhibitors for Squalene Monooxygenase
CONCLUSION: The results obtained from this study suggest that green tea polyphenols have the potential for inhibition of squalene monooxygenase, except for theasinensin A.PMID:38584555 | DOI:10.2174/0115734064280290240211170037 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - April 8, 2024 Category: Chemistry Authors: Kabelo Phuti Mokgopa Kevin A Lobb Tendamudzimu Tshiwawa Source Type: research
A Computational Study of Green Tea Extracts and their Derivatives as Potential Inhibitors for Squalene Monooxygenase
CONCLUSION: The results obtained from this study suggest that green tea polyphenols have the potential for inhibition of squalene monooxygenase, except for theasinensin A.PMID:38584555 | DOI:10.2174/0115734064280290240211170037 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - April 8, 2024 Category: Chemistry Authors: Kabelo Phuti Mokgopa Kevin A Lobb Tendamudzimu Tshiwawa Source Type: research
A Computational Study of Green Tea Extracts and their Derivatives as Potential Inhibitors for Squalene Monooxygenase
CONCLUSION: The results obtained from this study suggest that green tea polyphenols have the potential for inhibition of squalene monooxygenase, except for theasinensin A.PMID:38584555 | DOI:10.2174/0115734064280290240211170037 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - April 8, 2024 Category: Chemistry Authors: Kabelo Phuti Mokgopa Kevin A Lobb Tendamudzimu Tshiwawa Source Type: research
A Computational Study of Green Tea Extracts and their Derivatives as Potential Inhibitors for Squalene Monooxygenase
CONCLUSION: The results obtained from this study suggest that green tea polyphenols have the potential for inhibition of squalene monooxygenase, except for theasinensin A.PMID:38584555 | DOI:10.2174/0115734064280290240211170037 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - April 8, 2024 Category: Chemistry Authors: Kabelo Phuti Mokgopa Kevin A Lobb Tendamudzimu Tshiwawa Source Type: research
Establishment and validation of a CT-based prediction model for the good dissolution of mild chronic subdural hematoma with atorvastatin treatment
ConclusionThe imaging data-based prediction model has demonstrated great prediction accuracy for good hematoma dissolution in mild CSDH patients undergoing atorvastatin treatment. The study results emphasize the importance of imaging data evaluation in the management of CSDH patients. (Source: Neuroradiology)
Source: Neuroradiology - April 8, 2024 Category: Radiology Source Type: research
Drug intervention as an emerging concept for secondary prevention in patients with coronary disease
AbstractNon-culprit lesion-related coronary events are a significant concern in patients with coronary artery disease (CAD) undergoing coronary intervention. Since several studies using intra-coronary imaging modalities have reported a high prevalence of vulnerable plaques in non-culprit lesions at the initial coronary event, the immediate stabilization of these plaques by intensive pharmacological regimens may contribute to the reduction in the adverse events. Although current treatment guidelines recommend the titration of statin and other drugs to attain the treatment goal of low-density lipoprotein cholesterol (LDL-C) ...
Source: Cardiovascular Intervention and Therapeutics - April 8, 2024 Category: Cardiology Source Type: research
Impacts of ABCG2 loss of function variant (p. Gln141Lys, c.421 C > A, rs2231142) on lipid levels and statin efficiency: a systematic review and meta-analysis
This study investigates whether the... (Source: BMC Cardiovascular Disorders)
Source: BMC Cardiovascular Disorders - April 8, 2024 Category: Cardiology Authors: Yang Liu, Yuan Chen, Baozhu Wei, Hang Li, Yuanyuan Peng and Zhi Luo Tags: Research Source Type: research
High dose statin treatment reduces circulating Dickkopf-1 following acute myocardial infarction
Secreted glycoproteins of the Dickkopf (DKK) family modify Wnt signaling and may influence plaque destabilization but their modulation by statins in MI patients is not known. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 8, 2024 Category: Cardiology Authors: Thor Ueland, Noreen Butt, Tove Lekva, Stein Ørn, Cord Manhenke, Pål Aukrust, Alf Inge Larsen Source Type: research
Clinical effects of atorvastatin combined with conbercept in the treatment of patients with macular edema secondary to retinal vein occlusion and carotid plaque: study protocol for a prospective randomized controlled trial
Intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) drugs have been widely used in patients with macular edema (ME) secondary to retinal vein occlusion (RVO); however, recurrence is ... (Source: Trials)
Source: Trials - April 8, 2024 Category: General Medicine Authors: Bangtao Yao, Bei Wang, Jun Yang, Yan Geng, Hao Yu, Yuhui Liu, Gang Liu and Xiuying Wang Tags: Study protocol Source Type: research
Inhibition of PCSK9 with evolocumab modulates lipoproteins and monocyte activation in high-risk ASCVD subjects
CONCLUSIONS: This trial is the first to demonstrate that PCSK9 mAB with evolocumab can modulate circulating immune cell properties and highlights the importance of "stress" profiling of circulating immune cells that more clearly define immune contributions to ASCVD.PMID:38583289 | DOI:10.1016/j.atherosclerosis.2024.117529 (Source: Atherosclerosis)
Source: Atherosclerosis - April 7, 2024 Category: Cardiology Authors: Robert S Rosenson Ashley Tate Phyu Mar Olga Grushko Qinzhong Chen Sascha N Goonewardena Source Type: research
Inhibition of PCSK9 with evolocumab modulates lipoproteins and monocyte activation in high-risk ASCVD subjects
CONCLUSIONS: This trial is the first to demonstrate that PCSK9 mAB with evolocumab can modulate circulating immune cell properties and highlights the importance of "stress" profiling of circulating immune cells that more clearly define immune contributions to ASCVD.PMID:38583289 | DOI:10.1016/j.atherosclerosis.2024.117529 (Source: Atherosclerosis)
Source: Atherosclerosis - April 7, 2024 Category: Cardiology Authors: Robert S Rosenson Ashley Tate Phyu Mar Olga Grushko Qinzhong Chen Sascha N Goonewardena Source Type: research
