Idebenone ameliorates statin-induced myotoxicity in atherosclerotic ApoE-/- mice by reducing oxidative stress and improving mitochondrial function
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 4:167157. doi: 10.1016/j.bbadis.2024.167157. Online ahead of print.ABSTRACTStatins are the first line of choice for the treatment for atherosclerosis, but their use can cause myotoxicity, a common side effect that may require dosage reduction or discontinuation. The exact mechanism of statin-induced myotoxicity is unknown. Previous research has demonstrated that the combination of idebenone and statin yielded superior anti-atherosclerotic outcomes. Here, we investigated the mechanism of statin-induced myotoxicity in atherosclerotic ApoE-/- mice and whether idebenone could counte...
Source: Atherosclerosis - April 6, 2024 Category: Cardiology Authors: Wenfei Yu Wenjing Wu Dandan Zhao Rui ZhangMD Kai Shao Haoyang Liu Chuanzhu Yan Pengfei Lin Source Type: research
Carotid Ultrasound Combined with Plasma Atherosclerosis Index (AIP) in the Severe Analysis of Coronary Heart Disease Treated with Atorvastatin
CONCLUSION: The combined assessment of AIP and carotid ultrasonography emerges as a promising approach for evaluating the severity of CHD. Notably, the multi-vessel disease group exhibited higher AIP levels compared to the single-vessel disease group, along with increased IMT and carotid artery stenosis. Our findings highlight a positive correlation between AIP and IMT, as well as between IMT and the degree of carotid stenosis. These associations underscore the potential of AIP, in conjunction with carotid ultrasonography parameters, as valuable indicators for gauging CHD severity. The clinical implications of these findin...
Source: Atherosclerosis - April 6, 2024 Category: Cardiology Authors: Bin Zhang Di Yang Min Xu Jian-Jun Wu Zhen-Hua Ling Source Type: research
Idebenone ameliorates statin-induced myotoxicity in atherosclerotic ApoE-/- mice by reducing oxidative stress and improving mitochondrial function
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 4:167157. doi: 10.1016/j.bbadis.2024.167157. Online ahead of print.ABSTRACTStatins are the first line of choice for the treatment for atherosclerosis, but their use can cause myotoxicity, a common side effect that may require dosage reduction or discontinuation. The exact mechanism of statin-induced myotoxicity is unknown. Previous research has demonstrated that the combination of idebenone and statin yielded superior anti-atherosclerotic outcomes. Here, we investigated the mechanism of statin-induced myotoxicity in atherosclerotic ApoE-/- mice and whether idebenone could counte...
Source: Biochimica et Biophysica Acta - April 6, 2024 Category: Biochemistry Authors: Wenfei Yu Wenjing Wu Dandan Zhao Rui ZhangMD Kai Shao Haoyang Liu Chuanzhu Yan Pengfei Lin Source Type: research
Carotid Ultrasound Combined with Plasma Atherosclerosis Index (AIP) in the Severe Analysis of Coronary Heart Disease Treated with Atorvastatin
CONCLUSION: The combined assessment of AIP and carotid ultrasonography emerges as a promising approach for evaluating the severity of CHD. Notably, the multi-vessel disease group exhibited higher AIP levels compared to the single-vessel disease group, along with increased IMT and carotid artery stenosis. Our findings highlight a positive correlation between AIP and IMT, as well as between IMT and the degree of carotid stenosis. These associations underscore the potential of AIP, in conjunction with carotid ultrasonography parameters, as valuable indicators for gauging CHD severity. The clinical implications of these findin...
Source: Alternative Therapies in Health and Medicine - April 6, 2024 Category: Complementary Medicine Authors: Bin Zhang Di Yang Min Xu Jian-Jun Wu Zhen-Hua Ling Source Type: research
Carotid Ultrasound Combined with Plasma Atherosclerosis Index (AIP) in the Severe Analysis of Coronary Heart Disease Treated with Atorvastatin
CONCLUSION: The combined assessment of AIP and carotid ultrasonography emerges as a promising approach for evaluating the severity of CHD. Notably, the multi-vessel disease group exhibited higher AIP levels compared to the single-vessel disease group, along with increased IMT and carotid artery stenosis. Our findings highlight a positive correlation between AIP and IMT, as well as between IMT and the degree of carotid stenosis. These associations underscore the potential of AIP, in conjunction with carotid ultrasonography parameters, as valuable indicators for gauging CHD severity. The clinical implications of these findin...
Source: Alternative Therapies in Health and Medicine - April 6, 2024 Category: Complementary Medicine Authors: Bin Zhang Di Yang Min Xu Jian-Jun Wu Zhen-Hua Ling Source Type: research
Carotid Ultrasound Combined with Plasma Atherosclerosis Index (AIP) in the Severe Analysis of Coronary Heart Disease Treated with Atorvastatin
CONCLUSION: The combined assessment of AIP and carotid ultrasonography emerges as a promising approach for evaluating the severity of CHD. Notably, the multi-vessel disease group exhibited higher AIP levels compared to the single-vessel disease group, along with increased IMT and carotid artery stenosis. Our findings highlight a positive correlation between AIP and IMT, as well as between IMT and the degree of carotid stenosis. These associations underscore the potential of AIP, in conjunction with carotid ultrasonography parameters, as valuable indicators for gauging CHD severity. The clinical implications of these findin...
Source: Alternative Therapies in Health and Medicine - April 6, 2024 Category: Complementary Medicine Authors: Bin Zhang Di Yang Min Xu Jian-Jun Wu Zhen-Hua Ling Source Type: research
The importance of LDL-C lowering in atherosclerotic cardiovascular disease prevention: Lower for longer is better
Am J Prev Cardiol. 2024 Mar 18;18:100649. doi: 10.1016/j.ajpc.2024.100649. eCollection 2024 Jun.ABSTRACTCumulative exposure to low-density lipoprotein cholesterol (LDL-C) is a key driver of atherosclerotic cardiovascular disease (ASCVD) risk. An armamentarium of therapies to achieve robust and sustained reduction in LDL-C can reduce ASCVD risk. The gold standard for LDL-C assessment is ultracentrifugation but in routine clinical practice LDL-C is usually calculated and the most accurate calculation is the Martin/Hopkins equation. For primary prevention, consideration of estimated ASCVD risk frames decision making regarding...
Source: Atherosclerosis - April 5, 2024 Category: Cardiology Authors: Omar Mhaimeed Zain A Burney Stacey L Schott Payal Kohli Francoise A Marvel Seth S Martin Source Type: research
Modulation of atherosclerosis-related signaling pathways by Chinese herbal extracts: Recent evidence and perspectives
This article reviews the signaling pathways implicated in the pathogenesis of atherosclerosis and the advancements in research on TCM extracts for prevention and treatment, drawing on original articles from various databases including Google Scholar, Medline, CNKI, Scopus, and Pubmed. The objective is to furnish a reference for the clinical management of cardiovascular diseases.PMID:38577989 | DOI:10.1002/ptr.8203 (Source: Cell Research)
Source: Cell Research - April 5, 2024 Category: Cytology Authors: Changxing Liu Xinyi Guo Xulong Zhang Source Type: research
Modulation of atherosclerosis-related signaling pathways by Chinese herbal extracts: Recent evidence and perspectives
This article reviews the signaling pathways implicated in the pathogenesis of atherosclerosis and the advancements in research on TCM extracts for prevention and treatment, drawing on original articles from various databases including Google Scholar, Medline, CNKI, Scopus, and Pubmed. The objective is to furnish a reference for the clinical management of cardiovascular diseases.PMID:38577989 | DOI:10.1002/ptr.8203 (Source: Atherosclerosis)
Source: Atherosclerosis - April 5, 2024 Category: Cardiology Authors: Changxing Liu Xinyi Guo Xulong Zhang Source Type: research
The importance of LDL-C lowering in atherosclerotic cardiovascular disease prevention: Lower for longer is better
Am J Prev Cardiol. 2024 Mar 18;18:100649. doi: 10.1016/j.ajpc.2024.100649. eCollection 2024 Jun.ABSTRACTCumulative exposure to low-density lipoprotein cholesterol (LDL-C) is a key driver of atherosclerotic cardiovascular disease (ASCVD) risk. An armamentarium of therapies to achieve robust and sustained reduction in LDL-C can reduce ASCVD risk. The gold standard for LDL-C assessment is ultracentrifugation but in routine clinical practice LDL-C is usually calculated and the most accurate calculation is the Martin/Hopkins equation. For primary prevention, consideration of estimated ASCVD risk frames decision making regarding...
Source: Atherosclerosis - April 5, 2024 Category: Cardiology Authors: Omar Mhaimeed Zain A Burney Stacey L Schott Payal Kohli Francoise A Marvel Seth S Martin Source Type: research
Evolution and outcomes of aortic dilations in giant cell arteritis
CONCLUSION: This study suggests that aortic inflammation, as well as atheromatous disease, might participate in the fast progression of aortic dilation in GCA.PMID:38580542 | DOI:10.1016/j.ejim.2024.03.038 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - April 5, 2024 Category: Internal Medicine Authors: Sophie Gallou Christian Agard Anael Dumont Samuel Deshayes Jonathan Boutemy Gw énola Maigné Nicolas Martin Silva Alexandre Nguyen R émi Philip Olivier Espitia Achille Aouba Hubert de Boysson Source Type: research
Modulation of atherosclerosis-related signaling pathways by Chinese herbal extracts: Recent evidence and perspectives
This article reviews the signaling pathways implicated in the pathogenesis of atherosclerosis and the advancements in research on TCM extracts for prevention and treatment, drawing on original articles from various databases including Google Scholar, Medline, CNKI, Scopus, and Pubmed. The objective is to furnish a reference for the clinical management of cardiovascular diseases.PMID:38577989 | DOI:10.1002/ptr.8203 (Source: Cell Research)
Source: Cell Research - April 5, 2024 Category: Cytology Authors: Changxing Liu Xinyi Guo Xulong Zhang Source Type: research
Physiologically based pharmacokinetics modeling and transporter proteomics to predict systemic and local liver and muscle disposition of statins
AbstractStatins are used to reduce liver cholesterol levels but also carry a dose-related risk of skeletal muscle toxicity. Concentrations of statins in plasma are often used to assess efficacy and safety, but because statins are substrates of membrane transporters that are present in diverse tissues, local differences in intracellular tissue concentrations cannot be ruled out. Thus, plasma concentration may not be an adequate indicator of efficacy and toxicity. To bridge this gap, we used physiologically based pharmacokinetic (PBPK) modeling to predict intracellular concentrations of statins. Quantitative data on transpor...
Source: CPT: Pharmacometrics and Systems Pharmacology - April 5, 2024 Category: Drugs & Pharmacology Authors: Luna Prieto Garcia,
Anna Vildhede,
Pär Nordell,
Christine Ahlström,
Ahmed B. Montaser,
Tetsuya Terasaki,
Hans Lennernäs,
Erik Sjögren Tags: ARTICLE Source Type: research
Comparative Safety and Efficacy of Low/Moderate-Intensity Statin plus Ezetimibe Combination Therapy vs. High-Intensity Statin Monotherapy in Patients with Atherosclerotic Cardiovascular Disease: An Updated Meta-Analysis
ConclusionThis meta-analysis demonstrated that the use of low/moderate-intensity statin combination therapy significantly reduced LDL-C levels compared with high-intensity statin monotherapy, making it preferable for patients with related risks. However, further trials are encouraged to evaluate potential adverse effects associated with combined therapy. (Source: American Journal of Cardiovascular Drugs)
Source: American Journal of Cardiovascular Drugs - April 5, 2024 Category: Cardiology Source Type: research
Decoding the Intricacies of Statin-Associated Muscle Symptoms
AbstractPurpose of ReviewHyperlipidemia is the major cardiovascular morbidity and mortality risk factor. Statins are the first-line treatment for hyperlipidemia. Statin-associated muscle symptoms (SAMS) are the main reason for the discontinuation of statins among patients. The purpose of this review is to guide clinicians to recognize the difference between self-limited and autoimmune statin myopathy in addition to the factors that potentiate them. Finally, treatment strategies will be discussed. This review mostly focuses on new data in the past 3 years.Recent FindingsRecent findings suggest that SAMS is a complex and mul...
Source: Current Rheumatology Reports - April 5, 2024 Category: Rheumatology Source Type: research
