Decoding the Intricacies of Statin-Associated Muscle Symptoms

AbstractPurpose of ReviewHyperlipidemia is the major cardiovascular morbidity and mortality risk factor. Statins are the first-line treatment for hyperlipidemia. Statin-associated muscle symptoms (SAMS) are the main reason for the discontinuation of statins among patients. The purpose of this review is to guide clinicians to recognize the difference between self-limited and autoimmune statin myopathy in addition to the factors that potentiate them. Finally, treatment strategies will be discussed. This review mostly focuses on new data in the past 3 years.Recent FindingsRecent findings suggest that SAMS is a complex and multifactorial condition that involves mitochondrial dysfunction, oxidative stress, and immune-mediated mechanisms. Effective management of SAMS requires a thorough evaluation of the patient ’s symptoms, risk factors, and medication history, as well as consideration of alternative treatment options.SummaryWhile statins are effective in reducing the risk of cardiovascular events, their use is associated with a range of adverse effects, including SAMS.
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research