Overcoming Barriers to Implementation: Improving Incidental Coronary Calcium Reporting on Non-EKG Gated Chest CT Scans
The 2018 AHA/ACC Multisociety Blood Cholesterol Guideline1 states that the use of coronary artery calcium (CAC) scoring is reasonable to inform statin therapy decision-making in those borderline or intermediate-risk patients with uncertainty about the need for statin therapy after consideration of risk-enhancing factors. The basis for its use rests on its ability to improve discrimination and reclassify risk as compared to that derived from risk equations based on traditional atherosclerotic cardiovascular disease (ASCVD) risk factors. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - April 23, 2024 Category: Lipidology Authors: Jelani K. Grant, Amjad Bokhari, Aysswarya Manoharan, Margaret Koester, Michael Dangl, Miguel Martillo, Seamus P. Whelton, Seth S. Martin, Roger S. Blumenthal, Michael J. Blaha, David Eng, Joel Fishman, Carl E. Orringer Tags: Original Research Source Type: research
Effect of moxibustion on the SIRT1/FOXO3a signaling pathway in ApoE(-/-) mice with atherosclerosis
CONCLUSIONS: Moxibustion can reduce the body weight of AS model mice, regulate lipid levels, repair vascular intima, and alleviate endothelial damage. Its mechanism of action may be related to the regulation of the SIRT1/FOXO3a signaling pathway to improve oxidative damage.PMID:38649205 | DOI:10.13702/j.1000-0607.20230578 (Source: Atherosclerosis)
Source: Atherosclerosis - April 22, 2024 Category: Cardiology Authors: Zhao-Bo Yan Xian-Ming Wu Ning Zhang Zhi-Hong Yang Zhou Zhu Hua-Mei Yu Xiao-Qi Jia Xiao-Fang Yang Source Type: research
A retrospective study on the efficacy of Roxadustat in peritoneal dialysis patients with erythropoietin hyporesponsiveness
CONCLUSIONS: For PD patients with erythropoietin hyporesponsiveness, roxadustat can significantly improve renal anemia. The efficacy of roxadustat in improving renal anemia was not affected by baseline levels of hs-CRP0 and iPTH.PMID:38649158 | DOI:10.3904/kjim.2023.520 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 22, 2024 Category: Internal Medicine Authors: Jie Liu Shuang Li Fan Yang Tianyu Li Rui Li Yousuf Waheed Chen Meng Shulin Li Kun Liu Yanshan Tong Haisheng Xu Chuankuo Tian Xinglei Zhou Source Type: research
Assessing the causal associations of different types of statins use and knee/hip osteoarthritis: A Mendelian randomization study
This study comprehensively evaluated the causal relationship between different types of statins use and knee/hip osteoarthritis (OA) using a two-sample and multivariate Mendelian randomization (MR) method. MethodsMR analysis was conducted using publicly available summary statistics data from genome-wide association studies (GWAS) to assess the causal associations between total statins use (including specific types) and knee/hip OA. The primary analysis utilized the inverse variance-weighted (IVW) method, with sensitivity analysis conducted to assess robustness. Multivariable MR (MVMR) analysis adjusted for low-density lipo...
Source: PLoS One - April 22, 2024 Category: Biomedical Science Authors: Xin Chen Source Type: research
Cardio-protective effects of statins in patients undergoing anthracycline-based chemotherapy: An updated meta-analysis of randomized controlled trials
CONCLUSION: In this meta-analysis of RCTs, statins were significantly associated with a lower incidence of anthracycline-induced CTRCD and attenuated changes in the left ventricular end-systolic volume. Thus, our findings suggest that statins should be considered as a cardio-protection strategy for patients with planned anthracycline-based chemotherapy.PMID:38643042 | DOI:10.1016/j.ejim.2024.04.007 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - April 20, 2024 Category: Internal Medicine Authors: Nicole Felix Paula C Nogueira Isadora M Silva Thomaz Alexandre Costa Carlos Alberto Campello Carlos Stecca Renato D Lopes Source Type: research
Atorvastatin ‐induced intracerebral hemorrhage is inhibited by berberine in zebrafish
In this study, we aimed to investigate the protective action and mechanisms of berberine (BBR) against ATV-induced brain hemorrhage. We established an ICH model in zebrafish induced by ATV (2 μM) and demonstrated the effects of BBR (10, 50, and 100 μM) on ICH via protecting the vascular network using hemocyte staining and three transgenic zebrafish. BBR was found to reduce brain inflammation and locomotion injury in ICH-zebrafish. Mechanism research showed that ATV increased the l evels of VE-cadherin and occludin proteins but disturbed their localization at the cell membrane by abnormal phosphorylation, which decre...
Source: Journal of Applied Toxicology - April 20, 2024 Category: Toxicology Authors: Xin ‐Yan Liu,
Bo Chen,
Rui Zhang,
Miao‐Qing Zhang,
Yuan‐Yuan Ma,
Ying Han,
Jian‐Dong Jiang,
Jing‐Pu Zhang Tags: RESEARCH ARTICLE Source Type: research
How much data is enough data for imaging-guided PCI?
It is almost unanimously acknowledged that imaging guided percutaneous coronary intervention (PCI) improves outcomes, particularly in complex cases, where there's a mortality reduction of up to 50% [1,2]. Numerous studies have permeated the interventional landscape, that it is very difficult not to recommend intracoronary imaging when embarking on a more complex PCI. Just as no one questions the prescription of statins, for example, which reduce all-cause mortality by approximately 20 –30% (for both primary and secondary prevention) [3–5]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 20, 2024 Category: Cardiology Authors: Alexandru Achim Source Type: research
Dyslipidemia and heart failure: current evidence and perspectives of use of statins
Eur Rev Med Pharmacol Sci. 2024 Apr;28(7):2860-2877. doi: 10.26355/eurrev_202404_35929.ABSTRACTHeart failure (HF) is a condition with growing morbidity and mortality. Dyslipidemia in HF is not concentrated around hypercholesterolemia as in coronary artery disease. As a corollary, the robust benefits seen with statins across the spectrum of CAD have not been replicated in HF. Multiple potential pleiotropic effects of statins include anti-inflammatory, antioxidant, endothelial stabilization, antiapoptotic, anti-thrombotic, and modulation of the autonomic system apart from lipid lowering. These benevolent actions need to be c...
Source: Pharmacological Reviews - April 19, 2024 Category: Drugs & Pharmacology Authors: A Pradhan M Bhandari P Vishwakarma P Gualtieri L Di Renzo F Iellamo R Sethi M A Perrone Source Type: research
Safety of Monoclonal Antibodies Inhibiting PCSK9 in Pregnancy: Disproportionality Analysis in VigiBase ®
In conclusion, this study showed that, currently, there are no signals of increased reporting of spontaneous abortion with alirocumab and evolocumab compared with the full database and statins in VigiBase®. Notwithstanding, lack of disproportionality is not synonymous with safety and, as disproportionality analyses depend on the number of safety reports that progressively accumulate in VigiBase®, they should be repeated at regular intervals to confirm the results of the present study.PMID:38637956 | DOI:10.1002/cpt.3269 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - April 19, 2024 Category: Drugs & Pharmacology Authors: Roberta Noseda Francesca Bedussi Alice Panchaud Alessandro Ceschi Source Type: research
Dyslipidemia and heart failure: current evidence and perspectives of use of statins
Eur Rev Med Pharmacol Sci. 2024 Apr;28(7):2860-2877. doi: 10.26355/eurrev_202404_35929.ABSTRACTHeart failure (HF) is a condition with growing morbidity and mortality. Dyslipidemia in HF is not concentrated around hypercholesterolemia as in coronary artery disease. As a corollary, the robust benefits seen with statins across the spectrum of CAD have not been replicated in HF. Multiple potential pleiotropic effects of statins include anti-inflammatory, antioxidant, endothelial stabilization, antiapoptotic, anti-thrombotic, and modulation of the autonomic system apart from lipid lowering. These benevolent actions need to be c...
Source: European Review for Medical and Pharmacological Sciences - April 19, 2024 Category: Drugs & Pharmacology Authors: A Pradhan M Bhandari P Vishwakarma P Gualtieri L Di Renzo F Iellamo R Sethi M A Perrone Source Type: research
Metformin and statins reduce hepatocellular carcinoma risk in chronic hepatitis C patients with failed antiviral therapy
CONCLUSION: Metformin for DM and statins for HLP have chemopreventive effects on HCC risk in CHC patients who failed antiviral therapy. These findings emphasize the importance of personalized preventive strategies for managing patients with these clinical profiles.PMID:38637957 | DOI:10.3350/cmh.2024.0038 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - April 19, 2024 Category: Gastroenterology Authors: Pei-Chien Tsai Chung-Feng Huang Ming-Lun Yeh Meng-Hsuan Hsieh Hsing-Tao Kuo Chao-Hung Hung Kuo-Chih Tseng Hsueh-Chou Lai Cheng-Yuan Peng Jing-Houng Wang Jyh-Jou Chen Pei-Lun Lee Rong-Nan Chien Chi-Chieh Yang Gin-Ho Lo Jia-Horng Kao Chun-Jen Liu Chen-Hua L Source Type: research
Molecules, Vol. 29, Pages 1859: A Systematic Review of Statins for the Treatment of Nonalcoholic Steatohepatitis: Safety, Efficacy, and Mechanism of Action
Bing Liu
Nonalcoholic fatty liver disease (NAFLD) is the liver component of a cluster of conditions, while its subtype, nonalcoholic steatohepatitis (NASH), emerges as a potentially progressive liver disorder that harbors the risk of evolving into cirrhosis and culminating in hepatocellular carcinoma (HCC). NASH and cardiovascular disease (CVD) have common risk factors, but compared to liver-related causes, the most common cause of death in NASH patients is CVD. Within the pharmacological armamentarium, statins, celebrated for their lipid-modulating prowess, have now garnered attention for their expansive therapeutic ...
Source: Molecules - April 19, 2024 Category: Chemistry Authors: Shiqin Zhang Xiaoling Ren Bingzheng Zhang Tian Lan Bing Liu Tags: Review Source Type: research
Are there lost opportunities in chronic kidney disease? A region-wide cohort study
Conclusions
While we noted underdiagnosis and undertreatment of CKD in this large contemporary population, we also identified a substantial realisable potential to improve CKD outcomes and reduce its burden by treating patients early with guideline-directed pharmacological therapy. (Source: BMJ Open)
Source: BMJ Open - April 19, 2024 Category: General Medicine Authors: Sundström, J., Norhammar, A., Karayiannides, S., Bodegard, J., Gustafsson, S., Cars, T., Eriksson Svensson, M., Ärnlöv, J. Tags: Open access, Epidemiology Source Type: research
GlycA Levels Independently Predict Coronary Artery Calcium Incidence and Progression in the ELSA-Brasil Cohort (Brazilian Longitudinal Study of Adult Health)
Am J Cardiol. 2024 Apr 16:S0002-9149(24)00265-0. doi: 10.1016/j.amjcard.2024.03.041. Online ahead of print.ABSTRACTAtherosclerosis is an inflammatory disease. Coronary artery calcium (CAC) is a marker of atherosclerotic disease events and mortality risk. Elevated GlycA, an emerging marker of inflammation, is associated with a higher risk for coronary artery disease (CAD). However, there is conflicting evidence on whether GlycA predicts subclinical CAD progression. We hypothesized that GlycA can predict subclinical CAC incidence/progression in healthy individuals. We included 2,690 ELSA-Brasil cohort participants without ca...
Source: Atherosclerosis - April 18, 2024 Category: Cardiology Authors: Ronaldo C Fabiano Filho Giuliano Generoso Rhanderson Cardoso Steven R Jones Raul D Santos Peter P Toth Isabela M Bensenor Paulo A Lotufo Marcio S Bittencourt Source Type: research
Pragmatic Trial of Messaging to Providers About Treatment of Hyperlipidemia (PROMPT-LIPID): A Randomized Clinical Trial
CONCLUSIONS: With a real-time, targeted, individualized EHR alert as compared with usual care, the proportion of patients with atherosclerotic cardiovascular disease with LLT intensification was numerically higher but not statistically significant. Among clinicians who did not dismiss the alert, there was a > 2-fold increase in LLT intensification. EHR alerts, coupled with strategies to reduce clinician dismissal, may help address persistent gaps in LDL-C management.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04394715, https://www.clinicaltrials.gov/ct2/show/study/NCT04394715.PMID:38634282 |...
Source: Atherosclerosis - April 18, 2024 Category: Cardiology Authors: Nimish N Shah Lama Ghazi Yu Yamamoto Sanchit Kumar Melissa Martin Michael Simonov Ralph J Riello Iii Kamil F Faridi Tariq Ahmad F Perry Wilson Nihar R Desai Source Type: research
