Management of cutaneous tuberculosis in hand - Rare and disabling: A case report
CONCLUSION: Long-term complications of untreated CTB encompass significant contractures, scarring, and the onset of carcinomas and sarcomas. Prompt diagnosis facilitates timely and effective treatment, averting these sequelae and yielding high patient satisfaction.PMID:38608519 | DOI:10.1016/j.ijscr.2024.109631 (Source: Hand Surgery)
Source: Hand Surgery - April 12, 2024 Category: Surgery Authors: Hardisiswo Soedjana Betha Egih Riestiano Lisa Y Hasibuan Selvy Harianti Source Type: research
Disaggregation-Activated pan-COX Imaging Agents for Human Soft Tissue Sarcoma
Angew Chem Int Ed Engl. 2024 Apr 12:e202405525. doi: 10.1002/anie.202405525. Online ahead of print.ABSTRACTCancer stem cells are pivotal players in tumors initiation, growth, and metastasis. While several markers have been identified, there remain challenges particularly in heterogeneous malignancies like adult soft tissue sarcomas, where conventional markers are inherently overexpressed. Here, we designed BODIPY scaffold fluorescence probes (BD-IMC-1, BD-IMC-2) that activate via disaggregation targeting for cyclooxygenase (COX), a potential marker for CSCs in sarcoma in clinical pathology. Based on their structures, BD-IM...
Source: Angewandte Chemie - April 12, 2024 Category: Chemistry Authors: Kyung Tae Hong Seung Bin Park Dhiraj P Murale Jung Hoon Lee Jangsun Hwang Woo Young Jang Jun-Seok Lee Source Type: research
Financial burden of surgical treatment for retroperitoneal sarcoma
ConclusionsThe financial burden of surgical treatment for RPS is unexpectedly higher than that for GC. (Source: Surgery Today)
Source: Surgery Today - April 12, 2024 Category: Surgery Source Type: research
A case of primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion
Asian J Surg. 2024 Apr 10:S1015-9584(24)00623-7. doi: 10.1016/j.asjsur.2024.03.197. Online ahead of print.NO ABSTRACTPMID:38604870 | DOI:10.1016/j.asjsur.2024.03.197 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 11, 2024 Category: Surgery Authors: Zheng-Guo Xu Chao-Qun Wang Shi-Ping Lu Bi-Fei Huang Source Type: research
A case of primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion
Asian J Surg. 2024 Apr 10:S1015-9584(24)00623-7. doi: 10.1016/j.asjsur.2024.03.197. Online ahead of print.NO ABSTRACTPMID:38604870 | DOI:10.1016/j.asjsur.2024.03.197 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 11, 2024 Category: Surgery Authors: Zheng-Guo Xu Chao-Qun Wang Shi-Ping Lu Bi-Fei Huang Source Type: research
Nab-Paclitaxel for Relapsed AIDS-Related Kaposi Sarcoma -A Case Report
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - April 11, 2024 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Machine Learning as a Diagnostic and Prognostic Tool for Predicting Thrombosis in Cancer Patients: A Systematic Review
This study was conducted per Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Databases Medline, EMBASE, Cochrane, and ClinicalTrials.gov, were searched from inception to September 15, 2023, for studies evaluating the use of ML models for the prediction of thrombosis in cancer patients. Search terms “machine learning,” “artificial intelligence,” “thrombosis,” and “cancer” were used. Studies that examined adult cancer patients using any ML model were included. Two independent reviewers conducted study selection and data extraction. Three hundred citations were screened, of which...
Source: Seminars in Thrombosis and Hemostasis - April 11, 2024 Category: Hematology Authors: El-Sherbini, Adham H. Coroneos, Stefania Zidan, Ali Othman, Maha Tags: Review Article Source Type: research
Association between obesity and cancer risk in HIV-infected Asians
CONCLUSIONS: Obesity, which is one of the important health concerns in HIV management, was associated with an increased risk of non-AIDS-defining cancer but not AIDS-defining cancer.PMID:38597513 | DOI:10.1097/QAD.0000000000003904 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Yoonyoung Jang Taehwa Kim Yunsu Choi Kyoung Hwan Ahn Jung Ho Kim Hye Seong Youn Jeong Kim Shin-Woo Kim Jun Yong Choi Hyo Youl Kim Joon Young Song Hee Jung Choi Sang Il Kim Jang Wook Sohn BumSik Chin Bo-Youl Choi Boyoung Park Source Type: research
GSE261395 Immuno-Oncologic Profiling by Stage-Dependent Transcriptome and Proteome Analyses of Spontaneously Regressing Canine Cutaneous Histiocytoma [NanoString]
Contributors : Alina K Langenhagen ; Alexander F Haake ; Vladimir M Jovanovic ; Sandro Andreotti ; Michael Hummel ; Benjamin-Florian Hempel ; Achim D GruberSeries Type : Expression profiling by arrayOrganism : Canis lupus familiarisCanine cutaneous histiocytoma (CCH) is a tumor originating from dermal Langerhans cells, especially affecting young dogs. The common spontaneous regression of CCH makes it an interesting model in comparative oncology research. Previous studies have indicated that anti-tumor immune responses may be involved but details remain speculative to date. Here, we asked which specific immuno-oncologica...
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by array Canis lupus familiaris Source Type: research
GSE261387 Immuno-Oncologic Profiling by Stage-Dependent Transcriptome and Proteome Analyses of Spontaneously Regressing Canine Cutaneous Histiocytoma
Contributors : Alina K Langenhagen ; Alexander F Haake ; Vladimir M Jovanovic ; Sandro Andreotti ; Michael Hummel ; Benjamin-Florian Hempel ; Achim D GruberSeries Type : Expression profiling by high throughput sequencingOrganism : Canis lupus familiarisCanine cutaneous histiocytoma (CCH) is a tumor originating from dermal Langerhans cells, especially affecting young dogs. The common spontaneous regression of CCH makes it an interesting model in comparative oncology research. Previous studies have indicated that anti-tumor immune responses may be involved but details remain speculative to date. Here, we asked which speci...
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Canis lupus familiaris Source Type: research
Keeping an Eye Out for KS-IRIS: Kaposi Sarcoma in a Patient with Mpox
(Source: Journal of General Internal Medicine)
Source: Journal of General Internal Medicine - April 10, 2024 Category: Internal Medicine Source Type: research
Management of sotorasib-related adverse events and hepatotoxicities following anti-PD-(L)1 therapy: Experience with sotorasib in two French anti-cancer centers and practical guidance proposal
One of the most frequent oncogenic event in non-small cell lung cancer (NSCLC) is a glycine to cysteine substitution in position 12 in the V-ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) gene i.e., the KRASG12C mutation, detected in 13 % of the cases [1]. (Source: Lung Cancer)
Source: Lung Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Ali Chour, Cl émence Basse, Fanny Lebossé, Pierre-Emmanuel Bonte, Nicolas Girard, Michaël Duruisseaux Source Type: research
Cancers, Vol. 16, Pages 1447: Emerging Therapies in Kirsten Rat Sarcoma Virus (+) Non-Small-Cell Lung Cancer
Syrigos
Kirsten rat sarcoma virus (KRAS) is the most frequently found oncogene in human cancers, including non-small-cell lung cancer (NSCLC). For many years, KRAS was considered “undruggable” due to its structure and difficult targeting. However, the discovery of the switch II region in the KRAS-G12C-mutated protein has changed the therapeutic landscape with the design and development of novel direct KRAS-G12C inhibitors. Sotorasib and adagrasib are FDA-approved targeted agents for pre-treated patients with KRAS-G12C-mutated NSCLC. Despite promising results, the efficacy of these novel inhi...
Source: Cancers - April 9, 2024 Category: Cancer & Oncology Authors: Anastasia Karachaliou Elias Kotteas Oraianthi Fiste Konstantinos Syrigos Tags: Review Source Type: research
Habitat escalated adaptive therapy (HEAT): a phase 2 trial utilizing radiomic habitat-directed and genomic-adjusted radiation dose (GARD) optimization for high-grade soft tissue sarcoma
Soft tissue sarcomas (STS), have significant inter- and intra-tumoral heterogeneity, with poor response to standard neoadjuvant radiotherapy (RT). Achieving a favorable pathologic response (FPR ≥ 95%) from RT ... (Source: BMC Cancer)
Source: BMC Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Arash O. Naghavi, J. M. Bryant, Youngchul Kim, Joseph Weygand, Gage Redler, Austin J. Sim, Justin Miller, Kaitlyn Coucoules, Lauren Taylor Michael, Warren E. Gloria, George Yang, Stephen A. Rosenberg, Kamran Ahmed, Marilyn M. Bui, Evita B. Henderson-Jacks Tags: Study Protocol Source Type: research
Metabolic fingerprinting by nuclear magnetic resonance of hepatocellular carcinoma cells during p53 reactivation-induced senescence
NMR Biomed. 2024 Apr 8:e5157. doi: 10.1002/nbm.5157. Online ahead of print.ABSTRACTCellular senescence is characterized by stable cell cycle arrest. Senescent cells exhibit a senescence-associated secretory phenotype that can promote tumor progression. The aim of our study was to identify specific nuclear magnetic resonance (NMR) spectroscopy-based markers of cancer cell senescence. For metabolic studies, we employed murine liver carcinoma Harvey Rat Sarcoma Virus (H-Ras) cells, in which reactivation of p53 expression induces senescence. Senescent and nonsenescent cell extracts were subjected to high-resolution proton (1H)...
Source: Cancer Control - April 8, 2024 Category: Cancer & Oncology Authors: Philipp Knopf Jesus Pacheco-Torres Laimdota Zizmare Noriko Mori Flonne Wildes Benyuan Zhou Balaji Krishnamachary Yelena Mironchik Manfred Kneilling Christoph Trautwein Bernd J Pichler Zaver M Bhujwalla Source Type: research
