Multimodality Imaging of Intimal Sarcoma Causing Both Severe Mitral Stenosis and Mitral Regurgitation
Turk Kardiyol Dern Ars. 2024 Apr;52(3):213-216. doi: 10.5543/tkda.2023.76062.ABSTRACTIntimal sarcomas (IS) are rare, malignant, rapidly progressive mesenchymal tumors that typically occur in the tunica intima of larger vessels, and they rarely involve the heart. IS are frequently misdiagnosed during the initial clinical presentation. This case report describes an uncommonly located IS, highlighting specific findings obtained through multimodality imaging.PMID:38573094 | DOI:10.5543/tkda.2023.76062 (Source: Turk Kardiyoloji Dernegi arsivi)
Source: Turk Kardiyoloji Dernegi arsivi - April 4, 2024 Category: Cardiology Authors: Duygu İnan Ay şe İrem Demirtola Funda Özlem Karabulut Sevil Tu ğrul Yavuz Nur B üyükpınarbaşılı Mehmet Yanarta ş Alev K ılıçgedik Source Type: research
Understanding quality of Life's challenges in sarcoma patients: A mixed-methods study
This study aimed to assess sarcoma patients' health-related quality of life and explore their experiences of living with the disease and their specific care requirements. (Source: European Journal of Oncology Nursing)
Source: European Journal of Oncology Nursing - April 4, 2024 Category: Cancer & Oncology Authors: Ana Maria Almeida, L ígia Lima, Teresa Martins Source Type: research
Neuroimaging-guided diagnosis of possible FTLD-FUS pathology: a case report
ConclusionsOur case highlights that despite the lack of specific FUS biomarkers the combination of clinical features and neuroimaging biomarkers can guide choosing the most likely differential diagnosis in a complex neurological case. Imaging in particular allowed an accurate measure of the topography and severity of neurodegeneration and the exclusion of AD-related pathology. (Source: EJNMMI Research)
Source: EJNMMI Research - April 4, 2024 Category: Radiology Source Type: research
Comprehensive radiotherapy for pediatric Ewing Sarcoma: Outcomes of a prospective proton study
Patients with Ewing sarcoma (EWS) are treated with combination therapy, which includes radiation therapy (RT) as a treatment option for the primary tumor site (local control). Historically, the best local control (LC) outcomes have been achieved with surgery alone or combination of surgery with adjuvant RT for patients with high risk factors such as positive tumor margins after surgery or poor response to adjuvant/ induction chemotherapy. Definitive RT is often reserved for large tumors in anatomical locations where surgical resection is considered to be too morbid [1 –3]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - April 4, 2024 Category: Radiology Authors: Julianna K. Bronk, Mary Frances McAleer, Susan L. McGovern, Yasmin Lassen-Ramshad, Akmal Safwat, Najat C. Daw, Nino Rainusso, Anita Mahajan, David R. Grosshans, Arnold C. Paulino Tags: Original Article Source Type: research
Validating Risk Prediction Models for Multiple Primaries and Competing Cancer Outcomes in Families With Li-Fraumeni Syndrome Using Clinically Ascertained Data
CONCLUSION: We describe a study that fills in the critical gap in knowledge for the utility of risk prediction models. Using a CCB cohort, our previously validated models have demonstrated good performance and outperformed the standard clinical criteria. Our study suggests that better risk counseling may be achieved by GCs using these already-developed mathematical models.PMID:38569124 | DOI:10.1200/JCO.23.01926 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 3, 2024 Category: Cancer & Oncology Authors: Nam H Nguyen Elissa B Dodd-Eaton Jessica L Corredor Jacynda Woodman-Ross Sierra Green Angelica M Gutierrez Banu K Arun Wenyi Wang Source Type: research
Validating Risk Prediction Models for Multiple Primaries and Competing Cancer Outcomes in Families With Li-Fraumeni Syndrome Using Clinically Ascertained Data
CONCLUSION: We describe a study that fills in the critical gap in knowledge for the utility of risk prediction models. Using a CCB cohort, our previously validated models have demonstrated good performance and outperformed the standard clinical criteria. Our study suggests that better risk counseling may be achieved by GCs using these already-developed mathematical models.PMID:38569124 | DOI:10.1200/JCO.23.01926 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 3, 2024 Category: Cancer & Oncology Authors: Nam H Nguyen Elissa B Dodd-Eaton Jessica L Corredor Jacynda Woodman-Ross Sierra Green Angelica M Gutierrez Banu K Arun Wenyi Wang Source Type: research
High-Grade Transformation and Carcinosarcoma
CONCLUSIONS.—: High-grade transformation occurs rarely but has a significant impact on prognosis and management. By microscopy, the high-grade area is usually a distinct nodule and shows solid and nested architecture, cellular atypia, high mitotic count, and necrosis. The molecular features are not well established. Carcinosarcoma almost always arises in a pleomorphic adenoma and likely follows an adenoma-carcinoma-sarcoma pathway.PMID:38569599 | DOI:10.5858/arpa.2023-0534-RA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 3, 2024 Category: Laboratory Medicine Authors: Anuj Verma Raja R Seethala He Wang Source Type: research
Validating Risk Prediction Models for Multiple Primaries and Competing Cancer Outcomes in Families With Li-Fraumeni Syndrome Using Clinically Ascertained Data
CONCLUSION: We describe a study that fills in the critical gap in knowledge for the utility of risk prediction models. Using a CCB cohort, our previously validated models have demonstrated good performance and outperformed the standard clinical criteria. Our study suggests that better risk counseling may be achieved by GCs using these already-developed mathematical models.PMID:38569124 | DOI:10.1200/JCO.23.01926 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 3, 2024 Category: Cancer & Oncology Authors: Nam H Nguyen Elissa B Dodd-Eaton Jessica L Corredor Jacynda Woodman-Ross Sierra Green Angelica M Gutierrez Banu K Arun Wenyi Wang Source Type: research
Validating Risk Prediction Models for Multiple Primaries and Competing Cancer Outcomes in Families With Li-Fraumeni Syndrome Using Clinically Ascertained Data
CONCLUSION: We describe a study that fills in the critical gap in knowledge for the utility of risk prediction models. Using a CCB cohort, our previously validated models have demonstrated good performance and outperformed the standard clinical criteria. Our study suggests that better risk counseling may be achieved by GCs using these already-developed mathematical models.PMID:38569124 | DOI:10.1200/JCO.23.01926 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 3, 2024 Category: Cancer & Oncology Authors: Nam H Nguyen Elissa B Dodd-Eaton Jessica L Corredor Jacynda Woodman-Ross Sierra Green Angelica M Gutierrez Banu K Arun Wenyi Wang Source Type: research
High-Grade Transformation and Carcinosarcoma
CONCLUSIONS.—: High-grade transformation occurs rarely but has a significant impact on prognosis and management. By microscopy, the high-grade area is usually a distinct nodule and shows solid and nested architecture, cellular atypia, high mitotic count, and necrosis. The molecular features are not well established. Carcinosarcoma almost always arises in a pleomorphic adenoma and likely follows an adenoma-carcinoma-sarcoma pathway.PMID:38569599 | DOI:10.5858/arpa.2023-0534-RA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 3, 2024 Category: Laboratory Medicine Authors: Anuj Verma Raja R Seethala He Wang Source Type: research
Long-Term Follow-Up of Combination Therapy with Sintilimab and Anlotinib in Gallbladder Follicular Dendritic Cell Sarcoma: A Rare Case Report
(Source: OncoTargets and Therapy)
Source: OncoTargets and Therapy - April 3, 2024 Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Molecules, Vol. 29, Pages 1597: Design, Synthesis, and Anti-Leukemic Evaluation of a Series of Dianilinopyrimidines by Regulating the Ras/Raf/MEK/ERK and STAT3/c-Myc Pathways
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Lei Huang
Yanmei Li
Although the long-term survival rate for leukemia has made significant progress over the years with the development of chemotherapeutics, patients still suffer from relapse, leading to an unsatisfactory outcome. To discover the new effective anti-leukemia compounds, we synthesized a series of dianilinopyrimidines and evaluated the anti-leukemia activities of those compounds by using leukemia cell lines (HEL, Jurkat, and K562). The results showed that the dianilinopyrimidine analog H-120 predominantly displayed the highest cytotoxic potential in HEL cells. It remarkably induced apoptosis of HEL...
Source: Molecules - April 3, 2024 Category: Chemistry Authors: Chaoyan Wang Bo Wang Yu Mou Xiang Liu Qiqing Chen Weidong Pu Qing Rao Chunlin Wang Jingrui Song Yubing Huang Longjia Yan Lei Huang Yanmei Li Tags: Article Source Type: research
Osteosarcoma of Mandible — A Case Report
AbstractAfter plasma cell neoplasia, osteosarcoma is the most common primary bone tumor which accounts for 20% of all sarcomas. A malignant tumor is characterized by the formation of bone or osteoid by tumor cells. Long bones are the most common site of involvement. In the jaw bones, approximately 5% of involvement with an incidence of 1 in 1.5 million persons per year. It develops in a broad range of ages but is more common in the third and fourth decades, slightly more often in the mandible than in the maxilla. In this case report, a 24-year-old male patient reported a mass in the left mandible for the past 1 week whic...
Source: Indian Journal of Surgical Oncology - April 3, 2024 Category: Cancer & Oncology Source Type: research
ACSL4 accelerates osteosarcoma progression via modulating TGF- β/Smad2 signaling pathway
In this study, we investigated the expression of ACSL4 in OS tissues using immunohistochemistry staining (IHC) staining of a human tissue microarray and in OS cells by qPCR assay. Our findings revealed a significant up-regulation of ACSL4 in both OS tissues and cells. To further understand its biological effects, we conducted a series of loss-of-function experiments using ACSL4-depleted MNNG/HOS and U-2OS cell lines, focusing on OS cell proliferation, migration, and apoptosis in vitro. Our results demonstrated that ACSL4 knockdown remarkably suppressed OS cell proliferation, arrested cells in the G2 phase, induced cell apo...
Source: Molecular and Cellular Biochemistry - April 2, 2024 Category: Biochemistry Authors: Xiaofeng Li Qianfen Chen Duo Zhao Jianshi Tan Rongbo Liao Yurong Gu Jinwei Zhu Huying Zhang Jian Xie Lu Chen Source Type: research
A case of retroperitoneal Ewing sarcoma
Asian J Surg. 2024 Apr 1:S1015-9584(24)00554-2. doi: 10.1016/j.asjsur.2024.03.126. Online ahead of print.NO ABSTRACTPMID:38565443 | DOI:10.1016/j.asjsur.2024.03.126 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 2, 2024 Category: Surgery Authors: Yizhi Chen Tianfeng Liu Jingping Chen Source Type: research
