p53-Armed Oncolytic Virotherapy Improves Radiosensitivity in Soft-Tissue Sarcoma by Suppressing BCL-xL Expression
Acta Med Okayama. 2024 Apr;78(2):151-161. doi: 10.18926/AMO/66924.ABSTRACTSoft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo a...
Source: Acta Med Okayama - April 30, 2024 Category: Universities & Medical Training Authors: Tadashi Komatsubara Hiroshi Tazawa Joe Hasei Toshinori Omori Kazuhisa Sugiu Yusuke Mochizuki Koji Demiya Aki Yoshida Tomohiro Fujiwara Toshiyuki Kunisada Yasuo Urata Shunsuke Kagawa Toshifumi Ozaki Toshiyoshi Fujiwara Source Type: research
p53-Armed Oncolytic Virotherapy Improves Radiosensitivity in Soft-Tissue Sarcoma by Suppressing BCL-xL Expression
Acta Med Okayama. 2024 Apr;78(2):151-161. doi: 10.18926/AMO/66924.ABSTRACTSoft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo a...
Source: Acta Medica Okayama - April 30, 2024 Category: General Medicine Authors: Tadashi Komatsubara Hiroshi Tazawa Joe Hasei Toshinori Omori Kazuhisa Sugiu Yusuke Mochizuki Koji Demiya Aki Yoshida Tomohiro Fujiwara Toshiyuki Kunisada Yasuo Urata Shunsuke Kagawa Toshifumi Ozaki Toshiyoshi Fujiwara Source Type: research
Targeting KRAS in pancreatic cancer
Oncol Res. 2024 Apr 23;32(5):799-805. doi: 10.32604/or.2024.045356. eCollection 2024.ABSTRACTPancreatic cancer has a dismal prognosis due to late detection and lack of efficient therapies. The Kirsten rat sarcoma virus (KRAS) oncogene is mutated in up to 90% of all pancreatic ductal adenocarcinomas (PDACs) and constitutes an attractive target for therapy. However, the most common KRAS mutations in PDAC are G12D (44%), G12V (34%) and G12R (20%) that are not amenable to treatment by KRAS G12C-directed cysteine-reactive KRAS inhibitors such as Sotorasib and Adagrasib that exhibit clinical efficacy in lung cancer. KRAS G12C mu...
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Sandra Stickler Barbara Rath Gerhard Hamilton Source Type: research
Emergency Department Use in Adolescent and Young Adult Cancer Early Survivors from 2006 to 2020
Conclusion: ED utilization declined as time from diagnosis elapsed, but higher utilization was associated with social determinants of health and cancer types.PMID:38682323 | DOI:10.1089/jayao.2023.0174 (Source: Ann Oncol)
Source: Ann Oncol - April 29, 2024 Category: Cancer & Oncology Authors: Karen J Wernli Eric C Haupt Neetu Chawla Thearis Osuji Ernest Shen Andrew B Smitherman Mallory Casperson Anne C Kirchhoff Bradley J Zebrack Theresa H M Keegan Lawrence Kushi Christopher Baggett Heydon K Kaddas Kathryn J Ruddy Candice A M Sauder Theodore W Source Type: research
Vastus lateralis flap for trochanteric sarcoma reconstruction following prior main pedicle dissection: A case report
Exp Ther Med. 2024 Apr 12;27(6):249. doi: 10.3892/etm.2024.12537. eCollection 2024 Jun.ABSTRACTThe reconstruction of trochanteric defects presents a challenge to the reconstructive surgeon. There have been a number of locoregional reconstructive options described in the literature. These include flaps based on the lateral circumflex femoral artery and its branches, such as the tensor fascia lata, vastus lateralis (VL), anterolateral thigh (ALT) flaps. The present case further complicated this challenge as the patient had multiple recurrences of a sarcoma overlying the trochanteric region, with previous surgical resections,...
Source: Experimental and Therapeutic Medicine - April 29, 2024 Category: General Medicine Authors: Zahir T Fadel Amani J Basaeed Mohammed B Ashi Hattan A Aljaaly Source Type: research
Expandable endoprostheses in skeletally immature patients: Where we are
World J Orthop. 2024 Apr 18;15(4):312-317. doi: 10.5312/wjo.v15.i4.312. eCollection 2024 Apr 18.ABSTRACTApproximately 45 percent of malignant bone tumors are seen under the age of 16 and one of the important results of growth plate sacrification in patients with immature skeletons is limb inequality. Until the early 1990s, the treatment options for these patients were rotationplasty or amputation. Multimodal approaches that combine imaging, chemotherapy, and surgical techniques have enabled the development of limb-preserving methods with satisfactory results. In order to overcome inequality problems, expandable prostheses ...
Source: World Journal of Orthopaedics - April 29, 2024 Category: Orthopaedics Authors: Recep Öztürk Source Type: research
Establishing biomarkers for soft tissue sarcomas
This article covers extensive recent research that has established novel potential biomarkers based on genomics, proteomics, and clinical characteristics. Validating and incorporating these biomarkers into clinical practice can improve prognosis, prediction of recurrence, and treatment response. Relevant literature was collected from PubMed, Scopus, and clinicaltrials.gov databases (November 2023).EXPERT OPINION: Currently, defining prognostic markers in soft tissue sarcomas remains challenging. More studies are required, especially to personalize treatment through advanced genetic profiling and analysis using individual t...
Source: Expert Review of Anticancer Therapy - April 29, 2024 Category: Cancer & Oncology Authors: Anna M Czarnecka Paulina Chmiel Piotr B łoński Piotr Rutkowski Source Type: research
Bone Sarcoma Survival in the US Military Health System: Comparison With the SEER Program
CONCLUSIONS: MHS beneficiaries with bone sarcoma may have longer survival than SEER patients. Our findings support the role of universal access to high-quality care in improving bone sarcoma outcomes.PMID:38684126 | DOI:10.5435/JAAOS-D-23-00897 (Source: The Journal of the American Academy of Orthopaedic Surgeons)
Source: The Journal of the American Academy of Orthopaedic Surgeons - April 29, 2024 Category: Orthopaedics Authors: Ashley B Anderson Eungjae Kim Amie B Park Kangmin Zhu Jie Lin Craig D Shriver Benjamin K Potter Source Type: research
Emergency Department Use in Adolescent and Young Adult Cancer Early Survivors from 2006 to 2020
Conclusion: ED utilization declined as time from diagnosis elapsed, but higher utilization was associated with social determinants of health and cancer types.PMID:38682323 | DOI:10.1089/jayao.2023.0174 (Source: Ann Oncol)
Source: Ann Oncol - April 29, 2024 Category: Cancer & Oncology Authors: Karen J Wernli Eric C Haupt Neetu Chawla Thearis Osuji Ernest Shen Andrew B Smitherman Mallory Casperson Anne C Kirchhoff Bradley J Zebrack Theresa H M Keegan Lawrence Kushi Christopher Baggett Heydon K Kaddas Kathryn J Ruddy Candice A M Sauder Theodore W Source Type: research
Undifferentiated Embryonal Sarcoma of the Liver with Epithelioid Features: A Case Report of an Exceptional Histological Heterogeneity among Rare Diseases
CONCLUSION: UESL is associated with a poor prognosis, especially in adults, but a comprehensive and multidisciplinary treatment based on radical resection and adjuvant therapy may provide a survival benefit. Surgical excision with negative margins remains mandatory to diagnose and treat UESL.PMID:38684493 | DOI:10.62713/aic.3374 (Source: Annali Italiani di Chirurgia)
Source: Annali Italiani di Chirurgia - April 29, 2024 Category: Surgery Authors: Alessia Kersik Greta Bracchetti Alessandro Bonomi Giorgio Bovo Maria Serena Cuttin Alessandro Germini Elson Gjoni Stefano Granieri Christian Cotsoglou Source Type: research
Vastus lateralis flap for trochanteric sarcoma reconstruction following prior main pedicle dissection: A case report
Exp Ther Med. 2024 Apr 12;27(6):249. doi: 10.3892/etm.2024.12537. eCollection 2024 Jun.ABSTRACTThe reconstruction of trochanteric defects presents a challenge to the reconstructive surgeon. There have been a number of locoregional reconstructive options described in the literature. These include flaps based on the lateral circumflex femoral artery and its branches, such as the tensor fascia lata, vastus lateralis (VL), anterolateral thigh (ALT) flaps. The present case further complicated this challenge as the patient had multiple recurrences of a sarcoma overlying the trochanteric region, with previous surgical resections,...
Source: Experimental and Therapeutic Medicine - April 29, 2024 Category: General Medicine Authors: Zahir T Fadel Amani J Basaeed Mohammed B Ashi Hattan A Aljaaly Source Type: research
Expandable endoprostheses in skeletally immature patients: Where we are
World J Orthop. 2024 Apr 18;15(4):312-317. doi: 10.5312/wjo.v15.i4.312. eCollection 2024 Apr 18.ABSTRACTApproximately 45 percent of malignant bone tumors are seen under the age of 16 and one of the important results of growth plate sacrification in patients with immature skeletons is limb inequality. Until the early 1990s, the treatment options for these patients were rotationplasty or amputation. Multimodal approaches that combine imaging, chemotherapy, and surgical techniques have enabled the development of limb-preserving methods with satisfactory results. In order to overcome inequality problems, expandable prostheses ...
Source: World Journal of Orthopaedics - April 29, 2024 Category: Orthopaedics Authors: Recep Öztürk Source Type: research
Establishing biomarkers for soft tissue sarcomas
This article covers extensive recent research that has established novel potential biomarkers based on genomics, proteomics, and clinical characteristics. Validating and incorporating these biomarkers into clinical practice can improve prognosis, prediction of recurrence, and treatment response. Relevant literature was collected from PubMed, Scopus, and clinicaltrials.gov databases (November 2023).EXPERT OPINION: Currently, defining prognostic markers in soft tissue sarcomas remains challenging. More studies are required, especially to personalize treatment through advanced genetic profiling and analysis using individual t...
Source: Expert Review of Anticancer Therapy - April 29, 2024 Category: Cancer & Oncology Authors: Anna M Czarnecka Paulina Chmiel Piotr B łoński Piotr Rutkowski Source Type: research
Bone Sarcoma Survival in the US Military Health System: Comparison With the SEER Program
CONCLUSIONS: MHS beneficiaries with bone sarcoma may have longer survival than SEER patients. Our findings support the role of universal access to high-quality care in improving bone sarcoma outcomes.PMID:38684126 | DOI:10.5435/JAAOS-D-23-00897 (Source: The Journal of the American Academy of Orthopaedic Surgeons)
Source: The Journal of the American Academy of Orthopaedic Surgeons - April 29, 2024 Category: Orthopaedics Authors: Ashley B Anderson Eungjae Kim Amie B Park Kangmin Zhu Jie Lin Craig D Shriver Benjamin K Potter Source Type: research
Emergency Department Use in Adolescent and Young Adult Cancer Early Survivors from 2006 to 2020
Conclusion: ED utilization declined as time from diagnosis elapsed, but higher utilization was associated with social determinants of health and cancer types.PMID:38682323 | DOI:10.1089/jayao.2023.0174 (Source: Ann Oncol)
Source: Ann Oncol - April 29, 2024 Category: Cancer & Oncology Authors: Karen J Wernli Eric C Haupt Neetu Chawla Thearis Osuji Ernest Shen Andrew B Smitherman Mallory Casperson Anne C Kirchhoff Bradley J Zebrack Theresa H M Keegan Lawrence Kushi Christopher Baggett Heydon K Kaddas Kathryn J Ruddy Candice A M Sauder Theodore W Source Type: research
