Characteristic of Endometrial Stromal Sarcoma by Algorithm of Potential Biomarkers for Uterine Mesenchymal Tumor
Curr Issues Mol Biol. 2023 Jul 25;45(8):6190-6201. doi: 10.3390/cimb45080390.ABSTRACTThe benign tumor uterine leiomyoma (UL) develops from the smooth muscle tissue that constitutes the uterus, whereas malignant tumor uterine sarcoma develops from either the smooth muscle tissue or stroma and is different from UL and endometrial cancer. Uterine sarcoma is broadly classified into three types: uterine leiomyosarcoma, endometrial stromal sarcoma (ESS), and carcinosarcoma. Although uterine leiomyosarcoma and ESS are both classified as uterine sarcoma, they significantly differ in terms of their sites of occurrence, symptoms, an...
Source: Current Issues in Molecular Biology - August 25, 2023 Category: Molecular Biology Authors: Takuma Hayashi Kenji Sano Nobuo Yaegashi Kaoru Abiko Ikuo Konishi Source Type: research

Histopathologic "Evolution" in Pediatric Primary Intracranial High-Grade Sarcoma - a Key that Unlocked the Correct Diagnosis
We present a case of a 13-year-old female with a right-sided frontal hemorrhagic mass. Pathological work-up revealed an intra-cranial high-grade sarcoma, not otherwise specified (NOS). Despite receiving chemo-radiation, the lesion recurred after 9 months. This time, the sarcoma had evolved, showing distinct focal rhabdomyoblastic differentiation. Next-generation sequencing (NGS) based assay revealed variants p.E1705V, p.Y1417Ter in DICER1, and other mutations in KRAS and TP53 genes. The lesion was then diagnosed as spindle cell sarcoma with rhabdomyosarcoma-like features, DICER1 mutant. We propose that upfront molecular st...
Source: Annals of Clinical and Laboratory Science - August 25, 2023 Category: Laboratory Medicine Authors: Udit Naik Manish Shah David I Sandberg Rohan Samant Angshumoy Roy Meenakshi Bidwai Bhattacharjee Source Type: research

Bilateral Renal Auto-Transplantation for Retroperitoneal Sarcomas: Is It Underutilized?
We report a case of a large retroperitoneal liposarcoma, approximately 50 kg, encasing both kidneys, which was managed via a two-stage resection and staged renal auto-transplantation into the intra-peritoneal pelvis. The patient maintained normal renal function throughout, and remains disease free two years post-resection. Renal auto-transplantation with pelvic placement may facilitate improved margin-free resection. Renal relocation may allow the use of curative-intent ablative therapies such as radiofrequency ablation and radiation in cases of retroperitoneal recurrence.PMID:37623033 | PMC:PMC10453660 | DOI:10.3390/curro...
Source: Current Oncology - August 25, 2023 Category: Cancer & Oncology Authors: Tyler P Robinson Daniel P Milgrom Santosh Nagaraju William C Goggins Kannan P Samy Leonidas G Koniaris Source Type: research

Evaluation of clinical factors associated with early postoperative physical function and lower extremity functional impairment in patients with soft tissue sarcoma
CONCLUSIONS: The quadriceps and tibialis anterior muscles may affect physical dysfunction after surgery for STSs. Early postoperative rehabilitation should include the identification of resected muscles and functional improvement of residual muscles, possibly with orthotic support for knee extension and ankle dorsiflexion.PMID:37622737 | DOI:10.1080/09638288.2023.2249413 (Source: Disability and Rehabilitation)
Source: Disability and Rehabilitation - August 25, 2023 Category: Rehabilitation Authors: Takuya Fukushima Yusuke Okita Noriko Watanabe Shota Yokota Jiro Nakano Akira Kawai Source Type: research

Late lower extremity free flap vascular compromise and salvage in a Pediatric patient diagnosed with monophasic synovial sarcoma
We present the case of a 14-year-old with a late lower extremity free flap vascular compromise, along with the successful flap salvage.PMID:37622029 | PMC:PMC10446794 | DOI:10.1080/23320885.2023.2249092 (Source: Hand Surgery)
Source: Hand Surgery - August 25, 2023 Category: Surgery Authors: Shervin Zoghi Kelsey Millar Steven Thorpe Christopher O Bayne Source Type: research