The Unique Genetic Mutation Characteristics Based on Large Panel Next-Generation Sequencing (NGS) Detection in Multiple Primary Lung Cancers (MPLC) Patients
CONCLUSIONS: MPLC has a unique genetic mutation characteristic that differs from advanced patients and usually presents with low TMB. Comprehensive NGS helps to diagnose MPLC and guides the MPLC clinical treatment. ARID1A is significantly enriched in IA nodules containing micro-papillary/solid components, suggesting that these MPLC patients may have a poor prognosis.PMID:37188510 | DOI:10.24976/Discov.Med.202335175.14 (Source: Discovery Medicine)
Source: Discovery Medicine - May 15, 2023 Category: Research Authors: Zhu Liang Guoxiong Zeng Wang Wan Biao Deng Chunyuan Chen Fasheng Li Guanzhou Lin Yuying Lin Haitao Lin Guixi Mo Huilai Miao Source Type: research

GSE232072 Transcription effect of LY2835219 on the U2OS cell line expressing EWS-FLI1
Contributor : Pilong LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCancer-associated chromosomal rearrangements can result in the expression of numerous pathogenic fusion proteins. The mechanisms via which the fusion proteins contribute to oncogenesis are largely unknown and effective therapies for fusion-associated cancers are lacking. Here, we comprehensively scrutinized fusion proteins found in various cancers. We found that many fusion proteins are composed of phase separation-prone domains (PS) and DNA-binding domains (DBD), and these fusions have strong correlations with ab...
Source: GEO: Gene Expression Omnibus - May 15, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Ras family signaling pathway in immunopathogenesis of inflammatory rheumatic diseases
The Ras (rat sarcoma virus) is a GTP-binding protein that is considered one of the important members of the Ras-GTPase superfamily. The Ras involves several pathways in the cell that include proliferation, migration, survival, differentiation, and fibrosis. Abnormalities in the expression level and activation of the Ras family signaling pathway and its downstream kinases such as Raf/MEK/ERK1-2 contribute to the pathogenic mechanisms of rheumatic diseases including immune system dysregulation, inflammation, and fibrosis in systemic sclerosis (SSc); destruction and inflammation of synovial tissue in rheumatoid arthritis (RA)...
Source: Frontiers in Immunology - May 15, 2023 Category: Allergy & Immunology Source Type: research

Imaging findings of primary epithelioid sarcoma of adrenal gland: a case report and literature review
We reported a 69-year-old male with an adrenal ES. The tumor was completely resected, and two months later, positron emission tomography-computed tomography(PET/CT) noted recurrence at the tumor bed and multiple metastases. The patient has been treated with chemotherapy with good effects. We summarize the radiological findings and immunohistochemical indexes of primary epithelioid sarcoma of adrenal gland, which may be useful to promote disease awareness and help to distinguish among other lesions. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - May 15, 2023 Category: Cancer & Oncology Source Type: research

Parietal Peritoneum Interposition Tube Graft as an Autologous Substitute for the Reconstruction of Inferior Vena  cava Following Resection of Retroperitoneal Sarcoma
This study aimed to increase the awareness of surgical oncologists about the venous reconstruction technique using a large autologous peritoneal graft.An elderly male presented to our cancer center with a history of persistent abdominal pain. The computed tomography (CT) scan reported a large retroperitoneal mass involving the right kidney and the inferior vena cava (IVC). En bloc tumor resection with right nephrectomy and resection of the IVC extending from just above the bifurcation up to the origin of the renal veins was done. IVC reconstruction was performed using autologous parietal peritoneum tube graft. Harvesting t...
Source: Indian Journal of Surgical Oncology - May 15, 2023 Category: Cancer & Oncology Source Type: research

Multiple Kaposi's sarcoma nodules successfully treated by curettage and vincristine injections in the same session
Australas J Dermatol. 2023 May 13. doi: 10.1111/ajd.14075. Online ahead of print.NO ABSTRACTPMID:37178014 | DOI:10.1111/ajd.14075 (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - May 13, 2023 Category: Dermatology Authors: Lucia Brambilla Maria Alessandra Mattioli Athanasia Tourlaki Source Type: research

Multiple Kaposi's sarcoma nodules successfully treated by curettage and vincristine injections in the same session
Australas J Dermatol. 2023 May 13. doi: 10.1111/ajd.14075. Online ahead of print.NO ABSTRACTPMID:37178014 | DOI:10.1111/ajd.14075 (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - May 13, 2023 Category: Dermatology Authors: Lucia Brambilla Maria Alessandra Mattioli Athanasia Tourlaki Source Type: research

Cancers, Vol. 15, Pages 2749: Breaking the Invisible Barriers: Unleashing the Full Potential of Immune Checkpoint Inhibitors in Oncogene-Driven Lung Adenocarcinoma
g Lam The rapid development of targeted therapy paved the way toward personalized medicine for advanced non-small cell lung cancer (NSCLC). Lung adenocarcinoma (ADC) harboring actionable genetic alternations including epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), Kirsten rat sarcoma virus (ALK) and c-ros oncogene 1 (ROS1) treated with tyrosine kinase inhibitors (TKIs) incurred lesser treatment toxicity but better therapeutic responses compared with systemic chemotherapy. Angiogenesis inhibitors targeting vascular endothelial growth factor (VEGF) have also shown an increase in overall surviv...
Source: Cancers - May 13, 2023 Category: Cancer & Oncology Authors: Hoi-Hin Kwok Jiashuang Yang David Chi-Leung Lam Tags: Review Source Type: research