Preclinical activity of selinexor in combination with eribulin in uterine leiomyosarcoma
In this study, we evaluated the effects of selinexor in combination with doxorubicin and eribulin in the LMS tumor model in vitro and in vivo. Treatment of selinexor combined with eribulin showed synergistic effects on tumor growth inhibition in SK-UT1 LMS-derived xenografts. Immunohistochemical assessment of the tumor tissues showed a significantly reduced expression of proliferation (Ki67) and XPO1 markers following combination therapy compared to the control group. Global transcriptome analyses on tumor tissue revealed that the combination therapy regulates genes from several key cancer-related pathways that are differe...
Source: Experimental Hematology and Oncology - September 15, 2023 Category: Cancer & Oncology Source Type: research
Primary cardiac sarcomas: A clinicopathologic study in a single institution with 25 years of experience with an emphasis on MDM2 expression and adjuvant therapy for prognosis
ConclusionOur study supports the use of adjuvant treatment in primary cardiac sarcoma, as it was associated with a significantly better overall survival rate. Further consideration of tumor histology may be important in determining the optimal use of adjuvant treatment for different types of sarcomas. Therefore, accurate diagnosis by MDM2 test is important condsidering patient's prognosis and treatment. (Source: Cancer Medicine)
Source: Cancer Medicine - September 14, 2023 Category: Cancer & Oncology Authors: Haeyon Cho,
In ‐Hye Song,
Uiree Jo,
Ji‐Seon Jeong,
Hyun Jung Koo,
Dong Hyun Yang,
Sung‐Ho Jung,
Joon Seon Song,
Kyung‐Ja Cho Tags: RESEARCH ARTICLE Source Type: research
Classic Kaposi sarcoma mimicking cellulitis in a middle-aged Asian man
Australas J Dermatol. 2023 Sep 14. doi: 10.1111/ajd.14159. Online ahead of print.NO ABSTRACTPMID:37706595 | DOI:10.1111/ajd.14159 (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - September 14, 2023 Category: Dermatology Authors: Patinya Pum-Im Leena Chularojanamontri Jomjit Chantharasamee Source Type: research
Myeloid sarcoma and pathological fracture: a case report and review of literature
Int J Hematol. 2023 Sep 14. doi: 10.1007/s12185-023-03656-1. Online ahead of print.ABSTRACTMyeloid sarcoma is a rare clinical entity that presents as an isolated proliferation of leukemic cells, concurrently with or at relapse of acute myeloid leukemia (AML), myelodysplastic syndromes/neoplasms (MDS), chronic myeloid leukemia (CML), and myeloproliferative neoplasm (MPN). Myeloid sarcoma disrupts the normal architecture of its surrounding tissues. When it forms in long bones, it can cause their pathological fracture. We recently experienced a rare case of MDS presenting with myeloid sarcoma in the femur that eventually resu...
Source: International Journal of Hematology - September 14, 2023 Category: Hematology Authors: Sho Takeyasu Ken Morita Seitaro Saito Masanori Toho Takashi Oyama Takafumi Obo Kazuki Taoka Arika Shimura Hiroaki Maki Eisuke Shibata Yusuke Watanabe Fumio Suzuki Liuzhe Zhang Hiroshi Kobayashi Munetoshi Hinata Mineo Kurokawa Source Type: research
RHAMM/hyaluronan inhibit β-catenin degradation, enhance downstream signaling, and facilitate fibrosarcoma cell growth
Mol Biol Rep. 2023 Sep 14. doi: 10.1007/s11033-023-08763-0. Online ahead of print.ABSTRACTIncreased hyaluronan deposition (HA) in various cancer tissues, including sarcomas, correlates with disease progression. The receptor for hyaluronic acid-mediated motility (RHAMM) expression is elevated in most human cancers. β-catenin is a critical downstream mediator of the Wnt signaling pathways, facilitating carcinogenic events characterized by deregulated cell proliferation. We previously showed that low molecular weight (LMW) HA/RHAMM/β-catenin signaling axis increases HT1080 fibrosarcoma cell growth. Here, focusing on mechani...
Source: Molecular Biology Reports - September 14, 2023 Category: Molecular Biology Authors: Aikaterini Berdiaki Lydia-Nefeli Thrapsanioti Eirini-Maria Giatagana Nikos K Karamanos Rashmin C Savani George N Tzanakakis Dragana Nikitovic Source Type: research
CT-based non-invasive identification of the most common gene mutation status in patients with non-small cell lung cancer
CONCLUSIONS: Our study demonstrates the potential of radiomics in the non-invasive identification of EGFR and KRAS mutation status, which may guide patients with non-small cell lung cancer to choose the most appropriate personalized treatment. This method can be used when biopsy will bring unacceptable risk to patients with NSCLC.PMID:37706584 | DOI:10.1002/mp.16744 (Source: Health Physics)
Source: Health Physics - September 14, 2023 Category: Physics Authors: Zongjian Chen Si Gao Changwei Ding Ting Luo Jiaqi Xu Shuang Xu Shu Li Source Type: research
RHAMM/hyaluronan inhibit β-catenin degradation, enhance downstream signaling, and facilitate fibrosarcoma cell growth
Mol Biol Rep. 2023 Sep 14. doi: 10.1007/s11033-023-08763-0. Online ahead of print.ABSTRACTIncreased hyaluronan deposition (HA) in various cancer tissues, including sarcomas, correlates with disease progression. The receptor for hyaluronic acid-mediated motility (RHAMM) expression is elevated in most human cancers. β-catenin is a critical downstream mediator of the Wnt signaling pathways, facilitating carcinogenic events characterized by deregulated cell proliferation. We previously showed that low molecular weight (LMW) HA/RHAMM/β-catenin signaling axis increases HT1080 fibrosarcoma cell growth. Here, focusing on mechani...
Source: Mol Biol Cell - September 14, 2023 Category: Molecular Biology Authors: Aikaterini Berdiaki Lydia-Nefeli Thrapsanioti Eirini-Maria Giatagana Nikos K Karamanos Rashmin C Savani George N Tzanakakis Dragana Nikitovic Source Type: research
Classic Kaposi sarcoma mimicking cellulitis in a middle-aged Asian man
Australas J Dermatol. 2023 Sep 14. doi: 10.1111/ajd.14159. Online ahead of print.NO ABSTRACTPMID:37706595 | DOI:10.1111/ajd.14159 (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - September 14, 2023 Category: Dermatology Authors: Patinya Pum-Im Leena Chularojanamontri Jomjit Chantharasamee Source Type: research
Myeloid sarcoma and pathological fracture: a case report and review of literature
Int J Hematol. 2023 Sep 14. doi: 10.1007/s12185-023-03656-1. Online ahead of print.ABSTRACTMyeloid sarcoma is a rare clinical entity that presents as an isolated proliferation of leukemic cells, concurrently with or at relapse of acute myeloid leukemia (AML), myelodysplastic syndromes/neoplasms (MDS), chronic myeloid leukemia (CML), and myeloproliferative neoplasm (MPN). Myeloid sarcoma disrupts the normal architecture of its surrounding tissues. When it forms in long bones, it can cause their pathological fracture. We recently experienced a rare case of MDS presenting with myeloid sarcoma in the femur that eventually resu...
Source: International Journal of Hematology - September 14, 2023 Category: Hematology Authors: Sho Takeyasu Ken Morita Seitaro Saito Masanori Toho Takashi Oyama Takafumi Obo Kazuki Taoka Arika Shimura Hiroaki Maki Eisuke Shibata Yusuke Watanabe Fumio Suzuki Liuzhe Zhang Hiroshi Kobayashi Munetoshi Hinata Mineo Kurokawa Source Type: research
RHAMM/hyaluronan inhibit β-catenin degradation, enhance downstream signaling, and facilitate fibrosarcoma cell growth
Mol Biol Rep. 2023 Sep 14. doi: 10.1007/s11033-023-08763-0. Online ahead of print.ABSTRACTIncreased hyaluronan deposition (HA) in various cancer tissues, including sarcomas, correlates with disease progression. The receptor for hyaluronic acid-mediated motility (RHAMM) expression is elevated in most human cancers. β-catenin is a critical downstream mediator of the Wnt signaling pathways, facilitating carcinogenic events characterized by deregulated cell proliferation. We previously showed that low molecular weight (LMW) HA/RHAMM/β-catenin signaling axis increases HT1080 fibrosarcoma cell growth. Here, focusing on mechani...
Source: Molecular Biology Reports - September 14, 2023 Category: Molecular Biology Authors: Aikaterini Berdiaki Lydia-Nefeli Thrapsanioti Eirini-Maria Giatagana Nikos K Karamanos Rashmin C Savani George N Tzanakakis Dragana Nikitovic Source Type: research
CT-based non-invasive identification of the most common gene mutation status in patients with non-small cell lung cancer
CONCLUSIONS: Our study demonstrates the potential of radiomics in the non-invasive identification of EGFR and KRAS mutation status, which may guide patients with non-small cell lung cancer to choose the most appropriate personalized treatment. This method can be used when biopsy will bring unacceptable risk to patients with NSCLC.PMID:37706584 | DOI:10.1002/mp.16744 (Source: Health Physics)
Source: Health Physics - September 14, 2023 Category: Physics Authors: Zongjian Chen Si Gao Changwei Ding Ting Luo Jiaqi Xu Shuang Xu Shu Li Source Type: research
Classic Kaposi sarcoma mimicking cellulitis in a middle-aged Asian man
Australas J Dermatol. 2023 Sep 14. doi: 10.1111/ajd.14159. Online ahead of print.NO ABSTRACTPMID:37706595 | DOI:10.1111/ajd.14159 (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - September 14, 2023 Category: Dermatology Authors: Patinya Pum-Im Leena Chularojanamontri Jomjit Chantharasamee Source Type: research
Myeloid sarcoma and pathological fracture: a case report and review of literature
Int J Hematol. 2023 Sep 14. doi: 10.1007/s12185-023-03656-1. Online ahead of print.ABSTRACTMyeloid sarcoma is a rare clinical entity that presents as an isolated proliferation of leukemic cells, concurrently with or at relapse of acute myeloid leukemia (AML), myelodysplastic syndromes/neoplasms (MDS), chronic myeloid leukemia (CML), and myeloproliferative neoplasm (MPN). Myeloid sarcoma disrupts the normal architecture of its surrounding tissues. When it forms in long bones, it can cause their pathological fracture. We recently experienced a rare case of MDS presenting with myeloid sarcoma in the femur that eventually resu...
Source: International Journal of Hematology - September 14, 2023 Category: Hematology Authors: Sho Takeyasu Ken Morita Seitaro Saito Masanori Toho Takashi Oyama Takafumi Obo Kazuki Taoka Arika Shimura Hiroaki Maki Eisuke Shibata Yusuke Watanabe Fumio Suzuki Liuzhe Zhang Hiroshi Kobayashi Munetoshi Hinata Mineo Kurokawa Source Type: research
Myeloid sarcoma and pathological fracture: a case report and review of literature
Int J Hematol. 2023 Sep 14. doi: 10.1007/s12185-023-03656-1. Online ahead of print.ABSTRACTMyeloid sarcoma is a rare clinical entity that presents as an isolated proliferation of leukemic cells, concurrently with or at relapse of acute myeloid leukemia (AML), myelodysplastic syndromes/neoplasms (MDS), chronic myeloid leukemia (CML), and myeloproliferative neoplasm (MPN). Myeloid sarcoma disrupts the normal architecture of its surrounding tissues. When it forms in long bones, it can cause their pathological fracture. We recently experienced a rare case of MDS presenting with myeloid sarcoma in the femur that eventually resu...
Source: International Journal of Hematology - September 14, 2023 Category: Hematology Authors: Sho Takeyasu Ken Morita Seitaro Saito Masanori Toho Takashi Oyama Takafumi Obo Kazuki Taoka Arika Shimura Hiroaki Maki Eisuke Shibata Yusuke Watanabe Fumio Suzuki Liuzhe Zhang Hiroshi Kobayashi Munetoshi Hinata Mineo Kurokawa Source Type: research
Myeloid sarcoma and pathological fracture: a case report and review of literature
Int J Hematol. 2023 Sep 14. doi: 10.1007/s12185-023-03656-1. Online ahead of print.ABSTRACTMyeloid sarcoma is a rare clinical entity that presents as an isolated proliferation of leukemic cells, concurrently with or at relapse of acute myeloid leukemia (AML), myelodysplastic syndromes/neoplasms (MDS), chronic myeloid leukemia (CML), and myeloproliferative neoplasm (MPN). Myeloid sarcoma disrupts the normal architecture of its surrounding tissues. When it forms in long bones, it can cause their pathological fracture. We recently experienced a rare case of MDS presenting with myeloid sarcoma in the femur that eventually resu...
Source: International Journal of Hematology - September 14, 2023 Category: Hematology Authors: Sho Takeyasu Ken Morita Seitaro Saito Masanori Toho Takashi Oyama Takafumi Obo Kazuki Taoka Arika Shimura Hiroaki Maki Eisuke Shibata Yusuke Watanabe Fumio Suzuki Liuzhe Zhang Hiroshi Kobayashi Munetoshi Hinata Mineo Kurokawa Source Type: research
