GSE243904 Antitumor effects of PRMT5 inhibition in sarcomas [RNA-seq]
Contributors : Stephanie Verbeke ; Aur élien Bourdon ; Jean-Philippe Guégan ; Laura Leroy ; Vanesssa Chaire ; Elodie Richard ; Alban Bessede ; Antoine ItalianoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPatients with advanced soft-tissue sarcomas (STSs) have few therapeutic options. Protein arginine methyltransferase 5 (PRMT5), an anticancer target, has been extensively investigated in recent years in epithelial tumors. To date, no data related to the biological role of PRMT5 inhibition and its potential effect as a treatment in STS have been reported. To investigate the...
Source: GEO: Gene Expression Omnibus - September 25, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Primary synovial sarcoma of the pleura in an 18 ‑year‑old male patient: A case report
Oncol Lett. 2023 Sep 12;26(4):461. doi: 10.3892/ol.2023.14048. eCollection 2023 Oct.ABSTRACTPrimary synovial sarcoma of the pleura (PSSP) is a rare disease. The present study reported the case of a patient (male; age, 18 years) with two tumors (7.8×2.8 cm and 6.5×5.8 cm) treated with surgery and chemotherapy. To the best of our knowledge, this is the first reported case of two tumors diagnosed as PSSP, which was confirmed by immunohistochemical staining. After six months of follow-up, the symptoms of dry cough and wheezing disappeared and all of the laboratory results were within normal limits. PSSP requires clinical sus...
Source: Oncology Letters - September 25, 2023 Category: Cancer & Oncology Authors: Yibing Zang Chengquan Ma Xiumei Xing Huimin Li Source Type: research
Treatment of Symptomatic Lymphedema in the Hand with Omental Flow-through Flap
Plast Reconstr Surg Glob Open. 2023 Aug 22;11(8):e5219. doi: 10.1097/GOX.0000000000005219. eCollection 2023 Aug.ABSTRACTVascularized lymph node transfer (VLNT) is a surgical option to improve physiologic lymphatic drainage. This technique transfers healthy vascularized lymphatic tissue from various available donor sites to the existing lymphatics of the affected area. Here, we present a successful case halting the size progression and reversing lymphedema symptoms in a patient treated with vascularized omental lymph node transfer. A 56-year-old man presented with stage III malignant sarcoma of his left medial upper arm. Tw...
Source: Hand Surgery - September 25, 2023 Category: Surgery Authors: Peaches A Dozier Adam J Reid Brian A Mailey Source Type: research
Primary synovial sarcoma of the pleura in an 18 ‑year‑old male patient: A case report
Oncol Lett. 2023 Sep 12;26(4):461. doi: 10.3892/ol.2023.14048. eCollection 2023 Oct.ABSTRACTPrimary synovial sarcoma of the pleura (PSSP) is a rare disease. The present study reported the case of a patient (male; age, 18 years) with two tumors (7.8×2.8 cm and 6.5×5.8 cm) treated with surgery and chemotherapy. To the best of our knowledge, this is the first reported case of two tumors diagnosed as PSSP, which was confirmed by immunohistochemical staining. After six months of follow-up, the symptoms of dry cough and wheezing disappeared and all of the laboratory results were within normal limits. PSSP requires clinical sus...
Source: Oncology Letters - September 25, 2023 Category: Cancer & Oncology Authors: Yibing Zang Chengquan Ma Xiumei Xing Huimin Li Source Type: research
GSE243759 Antitumor effects of PRMT5 inhibition in sarcomas
Contributors : Stephanie Verbeke ; Aur élien Bourdon ; Jean-Philippe Guégan ; Laura Leroy ; Vanesssa Chaire ; Elodie Richard ; Alban Bessede ; Antoine ItalianoSeries Type : Expression profiling by arrayOrganism : Homo sapiensPatients with advanced soft-tissue sarcomas (STSs) have few therapeutic options. Protein arginine methyltransferase 5 (PRMT5), an anticancer target, has been extensively investigated in recent years in epithelial tumors. To date, no data related to the biological role of PRMT5 inhibition and its potential effect as a treatment in STS have been reported. To investigate the therapeutic potenti...
Source: GEO: Gene Expression Omnibus - September 25, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE243758 Selective DNA-PK inhibition enhances chemotherapy and ionizing radiation activity in soft-tissue sarcomas
Conclusion: DNA-PK inhibition deserves clinical investigation to improve response to current therapies in patients with sarcoma (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - September 25, 2023 Category: Genetics & Stem Cells Tags: Other Homo sapiens synthetic construct Source Type: research
GSE241095 Bulk RNA-sequencing of normal and Kaposi sarcoma tissues from skin and gastrointestinal tract
Contributors : Joseph Ziegelbauer ; Takanobu Tagawa ; Guruswamy MaheshSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMatched tissue samples from 19 patients were harvested for total RNA and analyzed by bulk RNA-sequencing. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - September 25, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Genes, Vol. 14, Pages 1849: Oncomeric Profiles of microRNAs as New Therapeutic Targets for Treatment of Ewing & rsquo;s Sarcoma: A Composite Review
Genes, Vol. 14, Pages 1849: Oncomeric Profiles of microRNAs as New Therapeutic Targets for Treatment of Ewing’s Sarcoma: A Composite Review
Genes doi: 10.3390/genes14101849
Authors:
Mubashir Hassan
Saba Shahzadi
Amal Malik
Salah ud Din
Muhammad Yasir
Wanjoo Chun
Andrzej Kloczkowski
Ewing’s sarcoma is a rare type of cancer that forms in bones and soft tissues in the body, affecting mostly children and young adults. Current treatments for ES are limited to chemotherapy and/or radiation, followed by surgery. Recently, microRNAs have shown favourable results as latent diagnostic and ...
Source: Genes - September 23, 2023 Category: Genetics & Stem Cells Authors: Mubashir Hassan Saba Shahzadi Amal Malik Salah ud Din Muhammad Yasir Wanjoo Chun Andrzej Kloczkowski Tags: Review Source Type: research
Argon-helium knife cryoablation plus programmed cell death protein 1 inhibitor in the treatment of advanced soft tissue sarcomas: there is no evidence of the synergistic effects of this combination therapy
CONCLUSION: Cryoablation combined with PD-1 inhibitors in the therapy of advanced STS is safe and can effectively shrink the cryoablation-target lesion. However, there is no evidence of the synergistic effects of this combination therapy.PMID:37736543 | PMC:PMC10509548 | DOI:10.3389/fonc.2023.1185291 (Source: Cancer Control)
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Jiaqiang Wang Dengwei Zong Shuping Dong Shilei Gao Yonghao Yang Peng Zhang Xin Wang Weitao Yao Zhichao Tian Source Type: research
Activity of pazopanib in < em > EWSR1-NFATC2 < /em > translocation-associated bone sarcoma
Oncoscience. 2023 Sep 20;10:44-53. doi: 10.18632/oncoscience.587. eCollection 2023.ABSTRACTPazopanib is a multi-kinase inhibitor that is currently approved for treatment of advanced renal cell carcinoma and chemotherapy-refractory soft tissue sarcoma. In this case report, we discuss the case of a patient with a EWSR1-NFATC2 fusion positive bone sarcoma who had exceptional tumor control through using pazopanib and surgery for an overall duration exceeding 5 years. We also review the literature on EWSR1-NFATC2 translocation-associated sarcomas and use of pazopanib in bone sarcomas.PMID:37736255 | PMC:PMC10511123 | DOI:10.186...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Mohamed A Gouda Maria A Zarzour Ara A Vaporciyan Kalevi Kairemo Hubert H Chuang Vivek Subbiah Source Type: research
Loss of Chromosome 3q Is a Prognostic Marker in Fusion-Negative Rhabdomyosarcoma
CONCLUSION: The pathogenesis of STS including FN-RMS remains poorly understood, emphasizing the need for new therapeutic advances and adequate risk stratification. Our data demonstrate that loss of chr3q is associated with poor OS in FN-RMS, supporting it as an important tool for risk stratification.PMID:37738543 | DOI:10.1200/PO.23.00037 (Source: Ann Oncol)
Source: Ann Oncol - September 22, 2023 Category: Cancer & Oncology Authors: Carina A Dehner Robert C Bell Yang Cao Kevin He John S A Chrisinger Amy E Armstrong Marielle Yohe Jack Shern Angela C Hirbe Source Type: research
Mutation Profile via Next-Generation Sequencing in Patients with Colorectal Adenocarcinoma and Its Clinicopathological Correlation
CONCLUSION: It is necessary to have a comprehensive database of genomic alterations of colorectal carcinomas to interpret mutations more accurately clinically. There are no studies on the frequency of mutations in colorectal carcinomas in the Turkish population; thus, follow-up and treatment protocols are organized following the European and American databases and guidelines. A comprehensive study of the colorectal carcinoma patients' mutation profile in the Turkish patient cohort by the next-generation sequencing method will help to provide significant therapeutic, prognostic, and predictive data and design more successfu...
Source: The Turkish Journal of Gastroenterology - September 22, 2023 Category: Gastroenterology Authors: Sibel Osman Nesibe Kahraman Çetin İbrahim Halil Erdoğdu İbrahim Meteoğlu Source Type: research
Characterization and monitoring of nutritional risk and nutritional status in oncological patients admitted to an oncological surgery unit: A longitudinal study
CONCLUSION: this work reinforces the high prevalence of malnutrition in oncological patients and the need to systematically track cancer patients throughout their disease/treatment trajectory, from admission to the hospital, to the day of admission to inpatient unit, and subsequent follow-up. We also propose expedited referrals to different specialized centres in nutritional support for cancer patients from the first day of hospitalization. Assessment of patients should always be accompanied by active referral capacity to a specialized and duly trained nutritional care team that is quick, proactive, and responsive.PMID:377...
Source: Clinical Breast Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Filipe Gon çalves S ónia Cabral Ana Paula Moreira Joana Cunha Bruno Magalh ães Source Type: research
