GSE241970 Kaposi ’s Sarcoma-associated Herpesvirus Viral Protein Kinase Augments Cell Survival
Contributors : Xinjun Wu ; Zhigang Zhang ; Jason P Wong ; Ricardo Rivera-Soto ; Maria C White ; Aryan A Rai ; Blossom DamaniaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman umbilical vein endothelial cells (HUVECs) expressing vPK (HUVEC-vPK) have a survival advantage over control HUVEC under conditions of extrinsic- and intrinsic-mediated apoptosis. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - September 16, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Melanin-targeted [18F]-PFPN PET imaging may shed light for clear cell sarcoma
ConclusionMelanin-targeted [18F]-PFPN PET imaging is feasible for the diagnosis of CCS. Different imaging features were displayed on [18F]-PFPN and [18F]-FDG PET imaging, demonstrating the complementary role of the tracers. Combined use of the two imaging modalities would be preferred in patients with CCS.Clinical Trial RegistrationNCT05963035. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 16, 2023 Category: Nuclear Medicine Source Type: research
Lethal complication of a rare cardiac tumor
We present a case of a cardiac sarcoma, which was found during an autopsy performed with regard to medical malpractice, because the patient died due to a medical intervention. To report cases like this is important to gain more knowledge about possible complications regarding rare diseases. (Source: Forensic Science, Medicine, and Pathology)
Source: Forensic Science, Medicine, and Pathology - September 16, 2023 Category: Forensic Medicine Source Type: research
Melanin-targeted [18F]-PFPN PET imaging may shed light for clear cell sarcoma
ConclusionMelanin-targeted [18F]-PFPN PET imaging is feasible for the diagnosis of CCS. Different imaging features were displayed on [18F]-PFPN and [18F]-FDG PET imaging, demonstrating the complementary role of the tracers. Combined use of the two imaging modalities would be preferred in patients with CCS.Clinical Trial RegistrationNCT05963035. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 16, 2023 Category: Nuclear Medicine Source Type: research
New | phs003284.v1.p1 | Immune-Related Adverse Events after Immune Checkpoint Blockade-Based Therapy are Associated with Improved Survival in Advanced Sarcoma
Immune-Related Adverse Events after Immune Checkpoint Blockade-Based Therapy are Associated with Improved Survival in Advanced Sarcoma (study page |release notes) (Source: dbGaP, the database of Genotypes and Phenotypes)
Source: dbGaP, the database of Genotypes and Phenotypes - September 15, 2023 Category: Genetics & Stem Cells Tags: StudyRelease Source Type: research
Melanin-targeted [ < sup > 18 < /sup > F]-PFPN PET imaging may shed light for clear cell sarcoma
CONCLUSION: Melanin-targeted [18F]-PFPN PET imaging is feasible for the diagnosis of CCS. Different imaging features were displayed on [18F]-PFPN and [18F]-FDG PET imaging, demonstrating the complementary role of the tracers. Combined use of the two imaging modalities would be preferred in patients with CCS.CLINICAL TRIAL REGISTRATION: NCT05963035.PMID:37714979 | DOI:10.1007/s00259-023-06439-2 (Source: Molecular Medicine)
Source: Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Xiao Zhang Fei Kang Huaiyuan Zheng Yongkang Gai Jing Wang Xiaoli Lan Source Type: research
Network pharmacology and molecular docking to explore the mechanism of Sheng Xue Bao mixture against iron deficiency anemia
Medicine (Baltimore). 2023 Sep 15;102(37):e35012. doi: 10.1097/MD.0000000000035012.ABSTRACTBased on network pharmacology and molecular docking, we investigated the mechanism of action of Sheng Xue Bao mixture (SXBM) in treating iron deficiency anemia (IDA). We screened the HERB and traditional Chinese medicine systems pharmacology database and analysis platform databases to identify the active ingredients and targets of SXBM. The targets associated with "iron deficiency anemia" were collected from GeneCards, TTD, and OMIM databases. A component-target interaction network was constructed using Cytoscape 3.8.2. The protein-p...
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Yun Wang Huang Qinqin Haixia Wang Hongxu Zhang Xinhua Zhang Weiguo Liu Zhenhua Xiang Yuming Gu Source Type: research
Preclinical activity of selinexor in combination with eribulin in uterine leiomyosarcoma
In this study, we evaluated the effects of selinexor in combination with doxorubicin and eribulin in the LMS tumor model in vitro and in vivo. Treatment of selinexor combined with eribulin showed synergistic effects on tumor growth inhibition in SK-UT1 LMS-derived xenografts. Immunohistochemical assessment of the tumor tissues showed a significantly reduced expression of proliferation (Ki67) and XPO1 markers following combination therapy compared to the control group. Global transcriptome analyses on tumor tissue revealed that the combination therapy regulates genes from several key cancer-related pathways that are differe...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Sonam Mittal Ishaque Pulikkal Kadamberi Hua Chang Feng Wang Sudhir Kumar Shirng-Wern Tsaih Christopher J Walker Pradeep Chaluvally-Raghavan John Charlson Yosef Landesman Sunila Pradeep Source Type: research
A systematic review of recent phase-II trials in refractory or recurrent osteosarcoma: can we inform future trial design?
High-grade osteosarcoma is an aggressive bone sarcoma with a peak incidence in adolescence [1], with one-third of the patients experiencing disease progression/recurrence during or after first-line treatment consisting of multidrug chemotherapy and surgery of the primary tumor and metastatic lesions [2 –5]. At progression or recurrence, the 5-year overall survival (OS) is dismal, below 30%, with an extremely poor prognosis, unless a second complete surgical remission is achieved [2,3]. Despite many trials being performed, there is no established standard therapy besides surgery for recurrent/ref ractory osteosarcoma, nor...
Source: Cancer Treatment Reviews - September 15, 2023 Category: Cancer & Oncology Authors: Roelof van Ewijk, Morgane Cleirec, Nikolas Herold, Marie-C écile le Deley, Natasha van Eijkelenburg, Pascaline Boudou-Rouquette, Severine Risbourg, Sandra J. Strauss, Emanuela Palmerini, Kjetil Boye, Leo Kager, Stefanie Hecker-Nolting, Antonin Marchais, Tags: Systematic or Meta-analysis Studies Source Type: research
Preclinical activity of selinexor in combination with eribulin in uterine leiomyosarcoma
In this study, we evaluated the effects of selinexor in combination with doxorubicin and eribulin in the LMS tumor model in vitro and in vivo. Treatment of selinexor combined with eribulin showed synergistic effects on tumor growth inhibition in SK-UT1 LMS-derived xenografts. Immunohistochemical assessment of the tumor tissues showed a significantly reduced expression of proliferation (Ki67) and XPO1 markers following combination therapy compared to the control group. Global transcriptome analyses on tumor tissue revealed that the combination therapy regulates genes from several key cancer-related pathways that are differe...
Source: Experimental Hematology and Oncology - September 15, 2023 Category: Cancer & Oncology Source Type: research
KMT2A-rearranged sarcoma with unusual fusion gene CBX6::KMT2A::PYGO1
We report the case of a 47-year-old man with a spindle cell tumor arising from the subcutaneous tissue of the right anterior chest. The tumor harbored an unusual novel fusion gene,CBX6::KMT2A::PYGO1. Histologically, the tumor consisted of proliferating spindle-shaped cells with uniform nuclei, which varied in cell density and the amount of intervening collagen fibers. After 2 years and 8 months without postoperative treatment, the patient showed no recurrence or metastasis. Although highly likely irreproducible, tumors with theCBX6::KMT2A::PYGO1 fusion gene were morphologically somewhat different from those containing theY...
Source: Virchows Archiv - September 15, 2023 Category: Pathology Source Type: research
Viruses, Vol. 15, Pages 1935: E3 Ubiquitin Ligases in Gammaherpesviruses and HIV: A Review of Virus Adaptation and Exploitation
S. Ehrlich
For productive infection and replication to occur, viruses must control cellular machinery and counteract restriction factors and antiviral proteins. Viruses can accomplish this, in part, via the regulation of cellular gene expression and post-transcriptional and post-translational control. Many viruses co-opt and counteract cellular processes via modulation of the host post-translational modification machinery and encoding or hijacking kinases, SUMO ligases, deubiquitinases, and ubiquitin ligases, in addition to other modifiers. In this review, we focus on three oncoviruses, Epstein&ndash;Barr viru...
Source: Viruses - September 15, 2023 Category: Virology Authors: Jessica Oswald Mathew Constantine Adedolapo Adegbuyi Esosa Omorogbe Anna J. Dellomo Elana S. Ehrlich Tags: Review Source Type: research
Exploratory study of an anti-PD-L1/TGF- β antibody, TQB2858, in patients with refractory or recurrent osteosarcoma and alveolar soft part sarcoma: a report from Chinese sarcoma study group (TQB2858-Ib-02)
Novel and effective immunotherapies are required for refractory or recurrent sarcomas. Transforming growth factor-beta (TGF- β) is a diverse regulatory and fibrogenic protein expressed in multiple sarcoma tumo... (Source: BMC Cancer)
Source: BMC Cancer - September 15, 2023 Category: Cancer & Oncology Authors: Lu Xie, Xin Liang, Jie Xu, Xin Sun, Kuisheng Liu, Kunkun Sun, Yuan Li, Xiaodong Tang, Xianan Li, Xing Zhan, Xiaohui Niu and Wei Guo Tags: Research Source Type: research
Preclinical activity of selinexor in combination with eribulin in uterine leiomyosarcoma
In this study, we evaluated the effects of selinexor in combination with doxorubicin and eribulin in the LMS tumor model in vitro and in vivo. Treatment of selinexor combined with eribulin showed synergistic effects on tumor growth inhibition in SK-UT1 LMS-derived xenografts. Immunohistochemical assessment of the tumor tissues showed a significantly reduced expression of proliferation (Ki67) and XPO1 markers following combination therapy compared to the control group. Global transcriptome analyses on tumor tissue revealed that the combination therapy regulates genes from several key cancer-related pathways that are differe...
Source: Experimental Hematology and Oncology - September 15, 2023 Category: Cancer & Oncology Source Type: research
Primary cardiac sarcomas: A clinicopathologic study in a single institution with 25 years of experience with an emphasis on MDM2 expression and adjuvant therapy for prognosis
ConclusionOur study supports the use of adjuvant treatment in primary cardiac sarcoma, as it was associated with a significantly better overall survival rate. Further consideration of tumor histology may be important in determining the optimal use of adjuvant treatment for different types of sarcomas. Therefore, accurate diagnosis by MDM2 test is important condsidering patient's prognosis and treatment. (Source: Cancer Medicine)
Source: Cancer Medicine - September 14, 2023 Category: Cancer & Oncology Authors: Haeyon Cho,
In ‐Hye Song,
Uiree Jo,
Ji‐Seon Jeong,
Hyun Jung Koo,
Dong Hyun Yang,
Sung‐Ho Jung,
Joon Seon Song,
Kyung‐Ja Cho Tags: RESEARCH ARTICLE Source Type: research
