Establishment of a novel canine soft tissue sarcoma cell line and comparison of its characteristics with other soft tissue sarcoma cell lines
This study aimed to establish a new cell line, STS-YU1, derived from a recurrence of myxosarcoma in an 11-year-old mixed-breed dog. We examined STS-YU1 for in vitro cell proliferation, migration, anticancer drug sensitivity, transcriptome analysis using next-generation sequencing (RNA-seq), and in vivo tumorigenicity in mice and compared it with previously established STS cell lines, MUMA-G and A72. The cell proliferation and migration of STS-YU1 were higher than MUMA-G although MUMA-G only exhibited tumorigenicity in mice. STS-YU1 showed dose-dependent cytotoxicity to anticancer drugs, but with weak effects. RNA-seq analy...
Source: Cell Research - March 30, 2024 Category: Cytology Authors: Kyohei Miyanishi Masaya Igase Mami Murakami Yusuke Sakai Masashi Sakurai Kenji Tani Tomoki Motegi Takuya Mizuno Source Type: research
Extranodal follicular dendritic cell sarcoma presenting as colonic mass: A diagnostic and therapeutic challenge
J Cancer Res Ther. 2024 Jan 1;20(1):450-453. doi: 10.4103/jcrt.jcrt_1534_22. Epub 2023 Apr 8.ABSTRACTFolliclular dendritic cell sarcoma (FDCS) is an extremely rare neoplasm originating from folliclular dendritic cells, both nodally and extranodally. Its primary presentation as a large colonic mass is rare and can be misdiagnosed as epithelial tumor/soft tissue tumor both clinically and through histomorphology. Due to its rarity and limited consensus guidelines about its management, it presents as a diagnostic and therapeutic challenge for pathologists and oncologists. However, accurate diagnosis is imperative due to its di...
Source: Cell Research - March 30, 2024 Category: Cytology Authors: Sunil Pasricha Garima Durga Anila Sharma Ankush Jajodia Shivendra Singh Gurudutt Gupta Meenakshi Kamboj Venkata Pradeep Babu Koyyala Manoj Gupta Anurag Mehta Source Type: research
Clinical and histopathological spectrum of cranial small round cell tumors: An experience from a tertiary care center
CONCLUSIONS: SRCTs have a variable age of presentation. Their incidence in CNS is low as compared to other organ systems. On light microscopy, the histopathology of these lesions is overlapping, posing a great diagnostic dilemma for the pathologist. The use of ancillary techniques like immunohistochemistry helps in arriving at the correct diagnosis. Treatment strategy and tumor prognosis also vary along the entire spectrum of SRCT, thus making exact characterization essential for proper management.PMID:38554327 | DOI:10.4103/jcrt.jcrt_383_22 (Source: Cell Research)
Source: Cell Research - March 30, 2024 Category: Cytology Authors: Pooja Gupta Fouzia Siraj K B Shankar Manish Rawat Dipanker S Mankotia Vivek Yadav Amit Dagar Source Type: research
Ewing's sarcoma in adolescents and adults - 10-year experience from a tertiary cancer center in India
CONCLUSION: Treatment of EWS requires a multidisciplinary approach with radical surgery and/or radiation to control local disease and multiagent chemotherapy to control systemic disease. Long-term follow-up is essential because of disease relapse and treatment-related complications.PMID:38554302 | DOI:10.4103/jcrt.jcrt_775_22 (Source: Cell Research)
Source: Cell Research - March 30, 2024 Category: Cytology Authors: Geetha Narayanan Lakshmi H Kamala Sreejith G Nair Prakash N Purushothaman Aswin Kumar Jayasree Kattoor Source Type: research
Ewing's sarcoma in adolescents and adults - 10-year experience from a tertiary cancer center in India
CONCLUSION: Treatment of EWS requires a multidisciplinary approach with radical surgery and/or radiation to control local disease and multiagent chemotherapy to control systemic disease. Long-term follow-up is essential because of disease relapse and treatment-related complications.PMID:38554302 | DOI:10.4103/jcrt.jcrt_775_22 (Source: Cancer Control)
Source: Cancer Control - March 30, 2024 Category: Cancer & Oncology Authors: Geetha Narayanan Lakshmi H Kamala Sreejith G Nair Prakash N Purushothaman Aswin Kumar Jayasree Kattoor Source Type: research
ASO Author Reflections: Leveraging Preoperative Measurements to Predict Postoperative Outcomes in Thigh Soft Tissue Sarcomas
Ann Surg Oncol. 2024 Mar 29. doi: 10.1245/s10434-024-15242-8. Online ahead of print.NO ABSTRACTPMID:38553654 | DOI:10.1245/s10434-024-15242-8 (Source: Ann Oncol)
Source: Ann Oncol - March 30, 2024 Category: Cancer & Oncology Authors: Rami Elmorsi Alexander F Mericli Source Type: research
Cancers, Vol. 16, Pages 1365: Improved Metastatic-Free Survival after Systematic Re-Excision Following Complete Macroscopic Unplanned Excision of Limb or Trunk Soft Tissue Sarcoma
Conclusions: RE might be considered in patients with STS of limb or trunk, with UE with macroscopic complete resection performed out of a reference center, and also in originally defined R0 margin resections, to improve LRFS and MFS. Systematic RE should not be advocated for patients older than 70 years, or with tumors greater than 10 cm. (Source: Cancers)
Source: Cancers - March 30, 2024 Category: Cancer & Oncology Authors: Francois Gouin Audrey Michot Mehrdad Jafari Charles Honor é Jean Camille Mattei Alexandre Rochwerger Mickael Ropars Dimitri Tzanis Philippe Anract S ébastien Carrere Dimitri Gangloff Agn ès Ducoulombier C éleste Lebbe J érôme Guiramand Denis Waast F Tags: Article Source Type: research
Primary breast sarcomas: A 13 case-series study treated in university hospital in central Tunisia over a 25-year period
CONCLUSION: Breast sarcomas remain a very rare entity of aggressive tumors.The therapeutic approach is poorly codified. For this reason, the therapeutic decision should always be discussed in a multidisciplinary assessment.PMID:38552108 | DOI:10.3233/BD-230037 (Source: Breast Disease)
Source: Breast Disease - March 29, 2024 Category: Cancer & Oncology Authors: Fadoua Bouguerra Samia Kanoun Belajouza Emna Mziou Rym Zanzouri Hayfa Chahdoura Sabrine Tbessi Nadia Bouzid Sameh Tebra Mrad Source Type: research
Clinical recommendations for treatment of localized angiosarcoma: A consensus paper by the Italian Sarcoma Group
Angiosarcoma (AS) is a rare and aggressive vascular sarcoma. The current European Society of Medical Oncology (ESMO) clinical practice guidelines (CPGs) for the treatment of sarcomas apply to AS as well. However, AS aggressiveness and diverse tumor presentations differentiate it from other sarcomas, impacting clinical decisions. This is especially relevant in the context of localized disease, where considerations about the extent of surgery, the use of radiation therapy (RT), and the indication for neoadjuvant/adjuvant chemotherapy may vary. (Source: Cancer Treatment Reviews)
Source: Cancer Treatment Reviews - March 29, 2024 Category: Cancer & Oncology Authors: Elena Palassini, Giacomo Giulio Baldi, Sara Sulfaro, Marta Barisella, Giuseppe Bianchi, Domenico Campanacci, Marco Fiore, Marco Gambarotti, Massimiliano Gennaro, Carlo Morosi, Federico Navarria, Emanuela Palmerini, Claudia Sangalli, Marta Sbaraglia, Annal Tags: REVIEW Source Type: research
Cancers, Vol. 16, Pages 1355: Functional Classification of Fusion Proteins in Sarcoma
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Sarcomas comprise a heterogeneous group of malignant tumors of mesenchymal origin. More than 80 entities are associated with different mesenchymal lineages. Sarcomas with fibroblastic, muscle, bone, vascular, adipocytic, and other characteristics are distinguished. Nearly half of all entities contain specific chromosomal translocations that give rise to fusion proteins. These are mostly pathognomonic, and their detection by various molecular techniques supports histopathologic classification. Moreover, the fusion proteins act as oncogenic drivers, and their blockade represents a promising therapeutic approach. Th...
Source: Cancers - March 29, 2024 Category: Cancer & Oncology Authors: Marco Wachtel Didier Surdez Thomas G. P. Gr ünewald Beat W. Sch äfer Tags: Review Source Type: research
