Does the use of polymethyl-methacrylate cement after intralesional curettage of giant cell tumors of appendicular bone guarantee reduced local recurrence rates? A retrospective analysis
CONCLUSION: We found that the use of PMMA for bone defect reconstruction after intralesional curettage of GTCs in the appendicular skeleton did not ensure a reduced risk of local recurrence.PMID:37688488 | DOI:10.1177/10225536231202155 (Source: Journal of Orthopaedic Surgery)
Source: Journal of Orthopaedic Surgery - September 9, 2023 Category: Orthopaedics Authors: Thomas Colding-Rasmussen Peter F Horstmann Peter H J ørgensen Werner Hettwer Bjarne H Hansen Christian Nai En Tierp-Wong Michael M Petersen Source Type: research
Does the use of polymethyl-methacrylate cement after intralesional curettage of giant cell tumors of appendicular bone guarantee reduced local recurrence rates? A retrospective analysis
CONCLUSION: We found that the use of PMMA for bone defect reconstruction after intralesional curettage of GTCs in the appendicular skeleton did not ensure a reduced risk of local recurrence.PMID:37688488 | DOI:10.1177/10225536231202155 (Source: Journal of Orthopaedic Surgery)
Source: Journal of Orthopaedic Surgery - September 9, 2023 Category: Orthopaedics Authors: Thomas Colding-Rasmussen Peter F Horstmann Peter H J ørgensen Werner Hettwer Bjarne H Hansen Christian Nai En Tierp-Wong Michael M Petersen Source Type: research
GSE242360 Drosha-dependent microRNAs modulate FUS-mediated neurodegeneration in vivo
Contributors : Sukhleen Kour ; Tyler Fortuna ; Dhivyaa Rajasundaram ; Udai PandeySeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensMutations in Fused in Sarcoma (FUS) gene cause the familial and progressive form of amyotrophic lateral sclerosis (ALS). FUS is a nuclear RNA-binding protein involved in RNA processing and the biogenesis of a specific set of microRNAs. Here we report that Drosha and two previously uncharacterized Drosha-dependent miRNAs are strong modulators of FUS expression and prevent the cytoplasmic segregation of insoluble mutant FUS in vivo. We demonstrate that...
Source: GEO: Gene Expression Omnibus - September 9, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
Cancers, Vol. 15, Pages 4489: IGF2BP3 as a Prognostic Biomarker in Well-Differentiated/Dedifferentiated Liposarcoma
Conclusion: IGF2BP3 is highly expressed in a subset of WD/DD LPS. Across independent datasets, IGF2BP3 is also a biomarker of disease progression and worse survival. (Source: Cancers)
Source: Cancers - September 9, 2023 Category: Cancer & Oncology Authors: Kyle D. Klingbeil Jack Pengfei Tang Danielle S. Graham Serena Y. Lofftus Amit Kumar Jaiswal Tasha L. Lin Chris Frias Lucia Y. Chen Manando Nakasaki Sarah M. Dry Joseph G. Crompton Fritz C. Eilber Dinesh S. Rao Anusha Kalbasi Brian E. Kadera Tags: Article Source Type: research
Cancers, Vol. 15, Pages 4486: Prognostic Factors in Extremity Soft Tissue Sarcomas Treated with Radiotherapy: Systematic Review of the Literature
The objective of this systematic review is to analyze the available scientific data on prognostic factors concerning the characteristics of the patients, the disease and the treatments performed, as well as their potential complications, on studies with a median follow-up of 5 years at minimum. A search of articles following the “PRISMA method” and using the PubMed search engine was conducted to select the most relevant studies. Twenty-five articles were selected, according to preestablished criteria. This review provides a better understanding of the prognosis and disease outcome of these tumor...
Source: Cancers - September 9, 2023 Category: Cancer & Oncology Authors: Arthur Lebas Clara Le F èvre Waisse Waissi Isabelle Chambrelant David Brinkert Georges No ël Tags: Systematic Review Source Type: research
Robust mixed electron-photon radiation therapy planning for soft tissue sarcoma
CONCLUSION: For STS with subcutaneous involvement, MBRT offers statistically significant sparing of OARs without sacrificing target coverage when compared to VMAT. MBRT plans are deliverable on conventional linacs without the use of electron applicators, shortened source-to-surface distance (SSD) or bolus. This study shows that MBRT is a logistically feasible technique with clear dosimetric benefits.PMID:37681990 | DOI:10.1002/mp.16709 (Source: Health Physics)
Source: Health Physics - September 8, 2023 Category: Physics Authors: Veng Jean Heng Monica Serban Marc-Andr é Renaud Carolyn Freeman Jan Seuntjens Source Type: research
Robust mixed electron-photon radiation therapy planning for soft tissue sarcoma
CONCLUSION: For STS with subcutaneous involvement, MBRT offers statistically significant sparing of OARs without sacrificing target coverage when compared to VMAT. MBRT plans are deliverable on conventional linacs without the use of electron applicators, shortened source-to-surface distance (SSD) or bolus. This study shows that MBRT is a logistically feasible technique with clear dosimetric benefits.PMID:37681990 | DOI:10.1002/mp.16709 (Source: Health Physics)
Source: Health Physics - September 8, 2023 Category: Physics Authors: Veng Jean Heng Monica Serban Marc-Andr é Renaud Carolyn Freeman Jan Seuntjens Source Type: research
