Clinical characteristics and outcomes for children, adolescents and young adults with “CIC‐fused” or “BCOR‐rearranged” soft tissue sarcomas: A multi‐institutional European retrospective analysis
ConclusionsPediatric patients often present with large tumors and metastatic disease, especially CIC sarcomas. Overall outcome is dismal. New treatment options are needed. (Source: Cancer Medicine)
Source: Cancer Medicine - May 22, 2023 Category: Cancer & Oncology Authors: Monika Sparber ‐Sauer,
Nadège Corradini,
Maria Carmen Affinita,
Giuseppe Maria Milano,
Gaelle Pierron,
Matthieu Carton,
Franck Tirode,
Daniel Pissaloux,
Rita Alaggio,
Christian Vokuhl,
Gianni Bisogno,
Pablo Berlanga,
Andrea Ferrari,
Daniel Tags: RESEARCH ARTICLE Source Type: research
Patterns of Failure in High-Grade Soft Tissue Sarcomas of the Extremities and Trunk Wall After Pre- or Postoperative Radiation Therapy
CONCLUSIONS: The majority of LRs occurred within the PTV suggesting that LR is most likely not a consequence of inadequate target volume definition, but rather of radioresistant tumor biology. To further improve local tumor control, future research on the potential of dose escalation with normal tissue sparing, STS subtype-specific tumor biology, radiosensitivity, and surgical technique is indicated.PMID:37213480 | PMC:PMC10196229 | DOI:10.1016/j.adro.2023.101224 (Source: Adv Data)
Source: Adv Data - May 22, 2023 Category: Epidemiology Authors: Siyer Roohani Felix Ehret Marta Kobus Anne Fl örcken Sven M ärdian Daniel Rau Silvan Wittenberg Armin Jarosch Robert Öllinger Daniel Zips David Kaul Source Type: research
Modeling the Effects of Phosphorylation on Phase Separation of the FUS Low-Complexity Domain
Biophys J. 2023 May 21:S0006-3495(23)00330-2. doi: 10.1016/j.bpj.2023.05.018. Online ahead of print.ABSTRACTAggregation of the RNA-binding protein fused in sarcoma (FUS) is a hallmark of neurodegenerative diseases. Phosphorylation of Ser/Thr in the FUS low-complexity domain (FUS-LC) may regulate phase separation of FUS and prevent pathological aggregation in cells. However, many details of this process remain elusive to date. In this work, we systematically investigated the phosphorylation of FUS-LC and the underlying molecular mechanism by molecular dynamics (MD) simulations and free energy calculations. The results clear...
Source: Biophysical Journal - May 22, 2023 Category: Physics Authors: Mingwei Li Guanglin Chen Zhiyong Zhang Source Type: research
Efficacy of anlotinib combined with radioiodine to treat scalp metastasis of papillary thyroid cancer: A case report and review of literature
CONCLUSION: The outcome of the present trial confirmed the potential of anlotinib therapy to treat scalp metastasis induced by PTC and point the way for the treatment of similar diseases in the future.PMID:37214573 | PMC:PMC10198115 | DOI:10.12998/wjcc.v11.i12.2839 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - May 22, 2023 Category: Cancer & Oncology Authors: Li-Yong Zhang Shao-Jun Cai Bo-Yan Liang Shou-Yi Yan Bo Wang Meng-Yao Li Wen-Xin Zhao Source Type: research
Modeling the Effects of Phosphorylation on Phase Separation of the FUS Low-Complexity Domain
Biophys J. 2023 May 21:S0006-3495(23)00330-2. doi: 10.1016/j.bpj.2023.05.018. Online ahead of print.ABSTRACTAggregation of the RNA-binding protein fused in sarcoma (FUS) is a hallmark of neurodegenerative diseases. Phosphorylation of Ser/Thr in the FUS low-complexity domain (FUS-LC) may regulate phase separation of FUS and prevent pathological aggregation in cells. However, many details of this process remain elusive to date. In this work, we systematically investigated the phosphorylation of FUS-LC and the underlying molecular mechanism by molecular dynamics (MD) simulations and free energy calculations. The results clear...
Source: Biophysical Journal - May 22, 2023 Category: Physics Authors: Mingwei Li Guanglin Chen Zhiyong Zhang Source Type: research
Efficacy of anlotinib combined with radioiodine to treat scalp metastasis of papillary thyroid cancer: A case report and review of literature
CONCLUSION: The outcome of the present trial confirmed the potential of anlotinib therapy to treat scalp metastasis induced by PTC and point the way for the treatment of similar diseases in the future.PMID:37214573 | PMC:PMC10198115 | DOI:10.12998/wjcc.v11.i12.2839 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - May 22, 2023 Category: Cancer & Oncology Authors: Li-Yong Zhang Shao-Jun Cai Bo-Yan Liang Shou-Yi Yan Bo Wang Meng-Yao Li Wen-Xin Zhao Source Type: research
Patterns of Failure in High-Grade Soft Tissue Sarcomas of the Extremities and Trunk Wall After Pre- or Postoperative Radiation Therapy
CONCLUSIONS: The majority of LRs occurred within the PTV suggesting that LR is most likely not a consequence of inadequate target volume definition, but rather of radioresistant tumor biology. To further improve local tumor control, future research on the potential of dose escalation with normal tissue sparing, STS subtype-specific tumor biology, radiosensitivity, and surgical technique is indicated.PMID:37213480 | PMC:PMC10196229 | DOI:10.1016/j.adro.2023.101224 (Source: Adv Data)
Source: Adv Data - May 22, 2023 Category: Epidemiology Authors: Siyer Roohani Felix Ehret Marta Kobus Anne Fl örcken Sven M ärdian Daniel Rau Silvan Wittenberg Armin Jarosch Robert Öllinger Daniel Zips David Kaul Source Type: research
Cancers, Vol. 15, Pages 2864: Pediatric Rhabdomyosarcomas of the Genitourinary Tract
Rellinger
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in the pediatric and adolescent population, with 350 new cases diagnosed each year. While they can develop anywhere in the body, the genitourinary tract is the second most common primary location for an RMS to develop. Overall survival has improved through the increased use of protocols and multidisciplinary approaches. However, the guidelines for management continue to change as systemic and radiation therapeutics advance. Given the relative rarity of this disease compared to other non-solid childhood malignancies, healthcare providers not directl...
Source: Cancers - May 22, 2023 Category: Cancer & Oncology Authors: Jennifer T. Castle Brittany E. Levy Derek B. Allison David A. Rodeberg Eric J. Rellinger Tags: Review Source Type: research
Primary cutaneous interdigitating dendritic cell sarcoma (IDCS): Report of a new case and literature review
We report herein a further case of an 81-year-old Caucasian woman who presented to the Dermatology Department to remove an asymptomatic skin papule in the left temporal region, clinically diagnosed as dermatofibroma. The overall pathological and immunohistochemical features supported the diagnosis of a malignant dendritic cell tumor, consistent of interdigitating dendritic cell sarcoma.PMID:37210770 | DOI:10.1016/j.prp.2023.154559 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - May 21, 2023 Category: Pathology Authors: E Dainese L Cimetti B Pozzi M Milani G Russo S Castelnuovo C V Vigan ò M Cerati S Uccella A Vanzati Source Type: research
High negative prediction for the Basel sarcoma score: Sonographic assessment of features suspicious of uterine sarcoma
CONCLUSION: BSS can help distinguishing between myomas and sarcomatous masses, with high NPV. Caution is required when >1 criterion is present. As a simple tool, it could easily be integrated into routine myoma sonographic examination and help develop standardized assessment of uterine masses for better preoperative triage.PMID:37210928 | DOI:10.1016/j.ygyno.2023.05.005 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 21, 2023 Category: Cancer & Oncology Authors: Alexandra Maria Knipprath-M észáros Alessandra Tozzi Annkathrin Butensch ön Hubertina Reina Andreas Schoetzau C éline Montavon Viola Heinzelmann-Schwarz Gwendolin Manegold-Brauer Source Type: research
Primary cutaneous interdigitating dendritic cell sarcoma (IDCS): Report of a new case and literature review
We report herein a further case of an 81-year-old Caucasian woman who presented to the Dermatology Department to remove an asymptomatic skin papule in the left temporal region, clinically diagnosed as dermatofibroma. The overall pathological and immunohistochemical features supported the diagnosis of a malignant dendritic cell tumor, consistent of interdigitating dendritic cell sarcoma.PMID:37210770 | DOI:10.1016/j.prp.2023.154559 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - May 21, 2023 Category: Pathology Authors: E Dainese L Cimetti B Pozzi M Milani G Russo S Castelnuovo C V Vigan ò M Cerati S Uccella A Vanzati Source Type: research
High negative prediction for the Basel sarcoma score: Sonographic assessment of features suspicious of uterine sarcoma
CONCLUSION: BSS can help distinguishing between myomas and sarcomatous masses, with high NPV. Caution is required when >1 criterion is present. As a simple tool, it could easily be integrated into routine myoma sonographic examination and help develop standardized assessment of uterine masses for better preoperative triage.PMID:37210928 | DOI:10.1016/j.ygyno.2023.05.005 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 21, 2023 Category: Cancer & Oncology Authors: Alexandra Maria Knipprath-M észáros Alessandra Tozzi Annkathrin Butensch ön Hubertina Reina Andreas Schoetzau C éline Montavon Viola Heinzelmann-Schwarz Gwendolin Manegold-Brauer Source Type: research
High negative prediction for the Basel sarcoma score: Sonographic assessment of features suspicious of uterine sarcoma
CONCLUSION: BSS can help distinguishing between myomas and sarcomatous masses, with high NPV. Caution is required when >1 criterion is present. As a simple tool, it could easily be integrated into routine myoma sonographic examination and help develop standardized assessment of uterine masses for better preoperative triage.PMID:37210928 | DOI:10.1016/j.ygyno.2023.05.005 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 21, 2023 Category: Cancer & Oncology Authors: Alexandra Maria Knipprath-M észáros Alessandra Tozzi Annkathrin Butensch ön Hubertina Reina Andreas Schoetzau C éline Montavon Viola Heinzelmann-Schwarz Gwendolin Manegold-Brauer Source Type: research
Cancers, Vol. 15, Pages 2854: Midterm Results of High-Dose-Rate Intraoperative Brachytherapy in the Treatment of Soft Tissue Sarcomas
Conclusion: The treatment regimen consisting of limb-preserving surgery, IORT and pre- or postoperative radiotherapy consistently shows excellent local control rates. (Source: Cancers)
Source: Cancers - May 21, 2023 Category: Cancer & Oncology Authors: Dietmar Dammerer Johannes Neugebauer Matthias Braito Moritz Wagner Markus Neubauer Lukas Moser Markus S üß Michael Liebensteiner David Putzer Tags: Article Source Type: research
Molecules, Vol. 28, Pages 4215: Thiocarbonyl Derivatives of Natural Chlorins: Synthesis Using Lawesson & rsquo;s Reagent and a Study of Their Properties
Molecules, Vol. 28, Pages 4215: Thiocarbonyl Derivatives of Natural Chlorins: Synthesis Using Lawesson’s Reagent and a Study of Their Properties
Molecules doi: 10.3390/molecules28104215
Authors:
Viktor Pogorilyy
Petr Ostroverkhov
Valeria Efimova
Ekaterina Plotnikova
Olga Bezborodova
Ekaterina Diachkova
Yuriy Vasil’ev
Andrei Pankratov
Mikhail Grin
The development of sulfur-containing pharmaceutical compounds is important in the advancement of medicinal chemistry. Photosensitizers (PS) that acquire new properties upon incorporation of sulfur-containing groups or individual sulfur atoms int...
Source: Molecules - May 20, 2023 Category: Chemistry Authors: Viktor Pogorilyy Petr Ostroverkhov Valeria Efimova Ekaterina Plotnikova Olga Bezborodova Ekaterina Diachkova Yuriy Vasil ’ev Andrei Pankratov Mikhail Grin Tags: Article Source Type: research
