Case report: Primary sarcoma of the mandible with a novel SLMAP-BRAF fusion
Primary sarcomas of the jaw are very rare tumor with unclear mechanism of tumorigenesis. Identification of genetic alterations contributes to better understanding of tumorigenesis and extension of tumor spectrum, as well as potential therapeutic targets application. Herein, we firstly report a case of primary sarcoma in the mandible with novel SLMAP-BRAF fusion. Morphologically, the tumor was composed of histiocyte-like cells, larger epithelioid cells, spindle cells and osteoclast-like giant cells with moderate atypia. Focally, it mimicked tenosynovial giant cell tumor or biphasic synovial sarcoma, and even giant cell tumo...
Source: Frontiers in Oncology - March 28, 2024 Category: Cancer & Oncology Source Type: research
Incidence of second primary cancers in patients with retinoblastoma: a systematic review and meta-analysis
DiscussionThe findings of this review indicate that hereditary Rb patients have a significantly elevated risk of developing SPCs, whereas nonhereditary Rb patients do not show the same risk. Furthermore, significant differences were observed in the SIRs of different SPC types. Treatment techniques, specifically chemotherapy and radiation therapy, were associated with an increased risk of SPCs among hereditary Rb patients. These findings highlight the importance of radiation protection for Rb patients and the need for further research and tailored management strategies for this high-risk population. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 28, 2024 Category: Cancer & Oncology Source Type: research
Genes, Vol. 15, Pages 424: A Case Study of a Rare Undifferentiated Spindle Cell Sarcoma of the Penis: Establishment and Characterization of Patient-Derived Models
This study investigates a unique case of penile sarcoma, providing a comprehensive morphological and molecular analysis. Through the creation of experimental patient-derived models—including patient-derived xenograft (PDX), 3D, and monolayer primary cultures—we successfully replicated crucial molecular traits observed in the patient’s tumor, such as smooth muscle actin and CD99 expression, along with specific mutations in genes like TSC2 and FGFR4. These models are helpful in assessing the potential for an in-depth exploration of this tumor’s biology. This comprehensi...
Source: Genes - March 28, 2024 Category: Genetics & Stem Cells Authors: Ariane Cavalcante dos Santos Sousa Bruno Leonardo Nascimento Correa Fernandes Jeronimo Paulo Assis da Silva Paulo Roberto Stevanato Filho Luiza Bitencourt de Carvalho Terci Coimbra Adriano de Oliveira Beserra Ana Luiza Alvarenga Giovanna Maida Camila Toku Tags: Brief Report Source Type: research
Investigating the correlation between prominent viruses and hematological malignancies: a literature review
AbstractExtensive research has been conducted on the correlation between viral infections and hematological cancers ever since the identification of the Rous Sarcoma Virus as a cancer-causing agent. Numerous viruses, such as the Epstein-Barr virus, hepatitis B virus, hepatitis C virus, human immunodeficiency virus, human T-lymphotropic virus 1, and severe acute respiratory syndrome-related coronavirus 2, have been identified as potential contributors to the development and progression of cancer by disrupting normal cellular processes. Different viruses are associated with distinct forms of blood cancers, each exhibiting un...
Source: Medical Oncology - March 28, 2024 Category: Cancer & Oncology Source Type: research
Epithelioid angiosarcoma of the calf: a case report of an atypical imaging appearance
AbstractAngiosarcoma is an uncommon cause of soft tissue malignancy, accounting for approximately 2% of all soft tissue sarcomas. Of these, epithelioid angiosarcoma represents a morphologic subtype, where the malignant endothelial cells demonstrate a predominantly or exclusively epithelioid appearance. Overall, epithelioid angiosarcoma shares similar imaging characteristics to conventional angiosarcoma including a T1 hypointense to isointense and T2 hyperintense mass, which demonstrates avid enhancement, serpentine feeding vessels, and overlying skin thickening on MRI. The case herein describes a case of epithelioid angios...
Source: Skeletal Radiology - March 27, 2024 Category: Radiology Source Type: research
Best Overall Response-associated Signature to Doxorubicin in Soft Tissue Sarcomas: A Transcriptomic Analysis from ANNOUNCE
CONCLUSIONS: The refined REDSARC signature provides a potential tool to direct the application of doxorubicin in sarcomas and other malignancies. Validation and further refinement of the signature in other potentially subtype specific prospective cohorts is recommended.PMID:38536068 | DOI:10.1158/1078-0432.CCR-23-3936 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - March 27, 2024 Category: Cancer & Oncology Authors: Jiangang Liu David S Moura Robin L Jones Amit Aggarwal Ebert J Philip Andrew J Wagner Jennifer Wright Javier Mart ín-Broto William D Tap Source Type: research
Intraoperative Near-infrared Spectroscopy Can Predict Skin Flap Necrosis
CONCLUSION: These results further support the use of NIRS to objectively assess variations in skin flap oxygenation and tissue perfusion that are correlated with the development of postoperative SFN.PMID:38533520 | PMC:PMC10965202 | DOI:10.1097/GOX.0000000000005669 (Source: Cancer Control)
Source: Cancer Control - March 27, 2024 Category: Cancer & Oncology Authors: W F Hill K Kinaschuk C Temple-Oberle Source Type: research
Ewing Sarcoma-Chest Wall Reconstruction Following Resection of Rare Primary Chest Wall Tumor
We report the case of a 26-year-old man who was found to have a right lung mass extending into his anterolateral chest wall after presenting to the hospital for evaluation of unremitting chest pain. Biopsy was performed and the patient diagnosed with ES. After completion of neoadjuvant chemotherapy, the patient underwent resection of the right chest wall mass. The chest wall was reconstructed in a novel fashion with titanium plates and a reinforced tissue matrix patch. Due to a paucity of cases, no treatment or reconstruction algorithm currently exists for management of these malignancies.PMID:38532255 | DOI:10.1177/000313...
Source: The American Surgeon - March 27, 2024 Category: Surgery Authors: Ilya Sakharuk Thomas McKinley Gabrielle Moore Daniel Miller Source Type: research
The ultrasonography and pathological features of primary hepatic pleomorphic undifferentiated sarcoma
Med Ultrason. 2024 Mar 27;26(1):99-100. doi: 10.11152/mu-4340.ABSTRACTPMID:38537191 | DOI:10.11152/mu-4340 (Source: Medical Ultrasonography)
Source: Medical Ultrasonography - March 27, 2024 Category: Radiology Authors: Yuhan Bao Qingkai Meng Nina Qu Source Type: research
Best Overall Response-associated Signature to Doxorubicin in Soft Tissue Sarcomas: A Transcriptomic Analysis from ANNOUNCE
CONCLUSIONS: The refined REDSARC signature provides a potential tool to direct the application of doxorubicin in sarcomas and other malignancies. Validation and further refinement of the signature in other potentially subtype specific prospective cohorts is recommended.PMID:38536068 | DOI:10.1158/1078-0432.CCR-23-3936 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - March 27, 2024 Category: Cancer & Oncology Authors: Jiangang Liu David S Moura Robin L Jones Amit Aggarwal Ebert J Philip Andrew J Wagner Jennifer Wright Javier Mart ín-Broto William D Tap Source Type: research
Ewing Sarcoma-Chest Wall Reconstruction Following Resection of Rare Primary Chest Wall Tumor
We report the case of a 26-year-old man who was found to have a right lung mass extending into his anterolateral chest wall after presenting to the hospital for evaluation of unremitting chest pain. Biopsy was performed and the patient diagnosed with ES. After completion of neoadjuvant chemotherapy, the patient underwent resection of the right chest wall mass. The chest wall was reconstructed in a novel fashion with titanium plates and a reinforced tissue matrix patch. Due to a paucity of cases, no treatment or reconstruction algorithm currently exists for management of these malignancies.PMID:38532255 | DOI:10.1177/000313...
Source: The American Surgeon - March 27, 2024 Category: Surgery Authors: Ilya Sakharuk Thomas McKinley Gabrielle Moore Daniel Miller Source Type: research
The ultrasonography and pathological features of primary hepatic pleomorphic undifferentiated sarcoma
Med Ultrason. 2024 Mar 27;26(1):99-100. doi: 10.11152/mu-4340.ABSTRACTPMID:38537191 | DOI:10.11152/mu-4340 (Source: Medical Ultrasonography)
Source: Medical Ultrasonography - March 27, 2024 Category: Radiology Authors: Yuhan Bao Qingkai Meng Nina Qu Source Type: research
