Ovarian sarcoma a diagnostic dilemma & #8211; A case report
We report a case of an 8-year-old girl presenting with large abdominal mass and cachexia. Raised alpha-fetoprotein levels suggested germ cell tumor. Tru-cut biopsy histopathological report suggested a spindle cell tumor. The IHC staining suggested non rhabdomyosarcoma. As tumour was large and ovarian pediatric non rhabdomyosarcoma was not reported in the literature, we started on rhabdomyosarcoma neoadjuant regimen. Good response was noted for neoadjuvant chemotherapy, which was followed by complete surgical excision of the tumor and radiotherapy. At present, the overall outcome of the disease is dismal. Increased availabl...
Source: Journal of Indian Association of Pediatric Surgeons - September 5, 2023 Category: Surgery Authors: Prashant K Zulpi Akshay B Kalavant Anil B Halgeri P Priyanka Source Type: research
Molecules, Vol. 28, Pages 6450: Nortopsentins as Leads from Marine Organisms for Anticancer and Anti-Inflammatory Agent Development
Daniela Carbone
The marine environment is an excellent source of molecules that have a wide structural diversity and a variety of biological activities. Many marine natural products (MNPs) have been established as leads for anticancer drug discovery. Most of these compounds are alkaloids, including several chemical subclasses. In this review, we focus on the bis-indolyl alkaloid Nortopsentins and their derivatives with antiproliferative properties. Nortopsentins A–C were found to exhibit in vitro cytotoxicity against the P388 murine leukaemia cell line. Their structural manipulation provided a wide range ...
Source: Molecules - September 5, 2023 Category: Chemistry Authors: Camilla Pecoraro Francesca Terrana Giovanna Panzeca Barbara Parrino Stella Cascioferro Patrizia Diana Elisa Giovannetti Daniela Carbone Tags: Review Source Type: research
Argon-helium knife cryoablation plus programmed cell death protein 1 inhibitor in the treatment of advanced soft tissue sarcomas: there is no evidence of the synergistic effects of this combination therapy
ConclusionCryoablation combined with PD-1 inhibitors in the therapy of advanced STS is safe and can effectively shrink the cryoablation-target lesion. However, there is no evidence of the synergistic effects of this combination therapy. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - September 5, 2023 Category: Cancer & Oncology Source Type: research
RAS signaling and immune cells: a sinister crosstalk in the tumor microenvironment
The rat sarcoma virus (RAS) gene is the most commonly mutated oncogene in cancer, with about 19% of cancer patients carrying RAS mutations. Studies on the interaction between RAS mutation and tumor immune micr... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - September 5, 2023 Category: Research Authors: Yongting Liu, Bin Xie and Qiong Chen Tags: Review Source Type: research
Mutant HRas Signaling and Rationale for Use of Farnesyltransferase Inhibitors in Head and Neck Squamous Cell Carcinoma
Target Oncol. 2023 Sep 4. doi: 10.1007/s11523-023-00993-3. Online ahead of print.ABSTRACTHead and neck squamous cell carcinomas (HNSCCs) are often associated with poor outcomes, due at least in part to the limited number of treatment options available for those patients who develop recurrent and/or metastatic disease (R/M HNSCC). Even with the recent validation and approval of immunotherapies in the first-line setting for these patients, the need for the development of new and alternative precision medicine strategies with survival benefit is clear. Oncogenic alterations in the HRAS (Harvey rat sarcoma virus) proto-oncogen...
Source: Ann Oncol - September 4, 2023 Category: Cancer & Oncology Authors: Jiayu Wang Dana Al-Majid J Chad Brenner Joshua D Smith Source Type: research
Mutant HRas Signaling and Rationale for Use of Farnesyltransferase Inhibitors in Head and Neck Squamous Cell Carcinoma
Target Oncol. 2023 Sep 4. doi: 10.1007/s11523-023-00993-3. Online ahead of print.ABSTRACTHead and neck squamous cell carcinomas (HNSCCs) are often associated with poor outcomes, due at least in part to the limited number of treatment options available for those patients who develop recurrent and/or metastatic disease (R/M HNSCC). Even with the recent validation and approval of immunotherapies in the first-line setting for these patients, the need for the development of new and alternative precision medicine strategies with survival benefit is clear. Oncogenic alterations in the HRAS (Harvey rat sarcoma virus) proto-oncogen...
Source: Ann Oncol - September 4, 2023 Category: Cancer & Oncology Authors: Jiayu Wang Dana Al-Majid J Chad Brenner Joshua D Smith Source Type: research
Mutant HRas Signaling and Rationale for Use of Farnesyltransferase Inhibitors in Head and Neck Squamous Cell Carcinoma
AbstractHead and neck squamous cell carcinomas (HNSCCs) are often associated with poor outcomes, due at least in part to the limited number of treatment options available for those patients who develop recurrent and/or metastatic disease (R/M HNSCC). Even with the recent validation and approval of immunotherapies in the first-line setting for these patients, the need for the development of new and alternative precision medicine strategies with survival benefit is clear. Oncogenic alterations in theHRAS (Harvey rat sarcoma virus) proto-oncogene are seen in approximately 4 –8% of R/M HNSCC tumors. Recently, several preclin...
Source: Targeted Oncology - September 4, 2023 Category: Cancer & Oncology Source Type: research
PD-1, PD-L1, IDO, CD70 and microsatellite instability as potential targets to prevent immune evasion in sarcomas
Immunotherapy, Ahead of Print. (Source: Immunotherapy)
Source: Immunotherapy - September 4, 2023 Category: Allergy & Immunology Authors: Vasiliki Siozopoulou Evelien Smits Karen Zwaenepoel Jimmy Liu Abraham Pouliakis Patrick A Pauwels Elly Marcq Source Type: research
Pulmonary inflammatory leiomyosarcoma represents a potential diagnostic pitfall of DNA methylation-based classification of sarcomas: a case report
Pulmonary inflammatory leiomyosarcoma (PILMS) is a rare type of myogenic tumor with prominent lymphohistiocytic infiltration. Despite their histological similarities, PILMS is immunohistochemically and genetic... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - September 4, 2023 Category: Respiratory Medicine Authors: Takahiro Shibayama, Kaishi Satomi, Ryota Tanaka, Akihiko Yoshida, Kiyotaka Nagahama, Akimasa Hayashi, Takashi Hibiya, Kazuharu Suda, Masachika Fujiwara and Junji Shibahara Tags: Case Report Source Type: research
A Radiation Induced Low-Grade Myofibroblastic Sarcoma in the Retropectoral Area After Breast Conserving Surgery: A Case Report
In this report however, we present the clinical and radiological features of LGMFS in the retro pectoral area as a rare type of RT-induced sarcoma.PMID:37661085 | DOI:10.4048/jbc.2023.26.e36 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - September 3, 2023 Category: Cancer & Oncology Authors: Seo Young Park Hye Jung Kim Jeeyeon Lee Ji Yun Jeong Jungsup Byun Won Hwa Kim Byunggeon Park Jihoon Hong Source Type: research
A Radiation Induced Low-Grade Myofibroblastic Sarcoma in the Retropectoral Area After Breast Conserving Surgery: A Case Report
In this report however, we present the clinical and radiological features of LGMFS in the retro pectoral area as a rare type of RT-induced sarcoma.PMID:37661085 | PMC:PMC10475708 | DOI:10.4048/jbc.2023.26.e36 (Source: Journal of Breast Cancer)
Source: Journal of Breast Cancer - September 3, 2023 Category: Cancer & Oncology Authors: Seo Young Park Hye Jung Kim Jeeyeon Lee Ji Yun Jeong Jungsup Byun Won Hwa Kim Byunggeon Park Jihoon Hong Source Type: research
