Robust mixed electron-photon radiation therapy planning for soft tissue sarcoma
CONCLUSION: For STS with subcutaneous involvement, MBRT offers statistically significant sparing of OARs without sacrificing target coverage when compared to VMAT. MBRT plans are deliverable on conventional linacs without the use of electron applicators, shortened source-to-surface distance (SSD) or bolus. This study shows that MBRT is a logistically feasible technique with clear dosimetric benefits.PMID:37681990 | DOI:10.1002/mp.16709 (Source: Health Physics)
Source: Health Physics - September 8, 2023 Category: Physics Authors: Veng Jean Heng Monica Serban Marc-Andr é Renaud Carolyn Freeman Jan Seuntjens Source Type: research
Robust mixed electron-photon radiation therapy planning for soft tissue sarcoma
CONCLUSION: For STS with subcutaneous involvement, MBRT offers statistically significant sparing of OARs without sacrificing target coverage when compared to VMAT. MBRT plans are deliverable on conventional linacs without the use of electron applicators, shortened source-to-surface distance (SSD) or bolus. This study shows that MBRT is a logistically feasible technique with clear dosimetric benefits.PMID:37681990 | DOI:10.1002/mp.16709 (Source: Health Physics)
Source: Health Physics - September 8, 2023 Category: Physics Authors: Veng Jean Heng Monica Serban Marc-Andr é Renaud Carolyn Freeman Jan Seuntjens Source Type: research
Case of unicystic ameloblastoma with review of literature
AbstractIntroductionAmeloblastoma is one of the most frequent benign odontogenic tumours of the jaw, accounting for approximately 10% of all tumours in the mandible and maxilla. It is a slow-growing, locally invasive tumour that causes painless swelling of the jaw or maxilla.DiagnosisAmeloblastoma is diagnosed through computerised tomography imaging and a biopsy. A biopsy can help distinguish ameloblastoma from other cancers, such as ossifying fibroma, osteomyelitis, giant cell tumour, cystic fibrous dysplasia, myeloma, and sarcoma.TreatmentAmeloblastoma is best treated with vigorous en bloc excision and concomitant repair...
Source: Oral Surgery - September 8, 2023 Category: ENT & OMF Authors: Sachinkumar Dahivelkar,
Shrikant B. Mali,
Aarti Mahajan,
Nilima Prakash Tags: REVIEW Source Type: research
GSE241949 KSHV Terminal Repeat Regulates Inducible Lytic Gene Promoters
Contributors : Yoshihiro Izumiya ; Kumar Ashish ; Clifford G TepperSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe Kaposi's sarcoma-associated herpesvirus (KSHV) genome consists of an approximately 140 kb unique coding region flanked by 30-40 copies of 0.8 kb terminal repeat (TR) sequence. KSHV genomes persist in latently infected cells as episomes via tethering to the host cell chromosomes, and KSHV latency associated nuclear antigen (LANA) plays a crucial role in latent episomal DNA replication and segregation during host cell mitosis by binding to TR. While TR's...
Source: GEO: Gene Expression Omnibus - September 8, 2023 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
Axitinib in patients with advanced/metastatic soft tissue sarcoma (Axi-STS): an open-label, multicentre, phase II trial in four histological strata
British Journal of Cancer, Published online: 08 September 2023; doi:10.1038/s41416-023-02416-6Axitinib in patients with advanced/metastatic soft tissue sarcoma (Axi-STS): an open-label, multicentre, phase II trial in four histological strata (Source: British Journal of Cancer)
Source: British Journal of Cancer - September 8, 2023 Category: Cancer & Oncology Authors: Penella J. Woll Piers Gaunt Charlotte Gaskell Robin Young Charlotte Benson Ian R. Judson Beatrice M. Seddon Maria Marples Nasim Ali Sandra J. Strauss Alexander Lee Ana Hughes Baljit Kaur David Hughes Lucinda Billingham Source Type: research
“Unusual Presentation of Epitheloid Dermatofibroma- Rare Case Report”
AbstractDermatofibroma is a commonly occurring cutaneous entity usually centered within the skin ’s dermis. Dermatofibromas are referred to as benign fibrous histiocytomas of the skin, superficial/cutaneous benign fibrous histiocytomas, or common fibrous histiocytoma. These mesenchymal cell lesions of the dermis clinically are firm subcutaneous nodules that occur on the extremities in the vas t majority of cases and may or may not be associated with overlying skin changes. A 20 years old male presented to ENT OPD, at a private hospital, with complaints of a huge mass over right side of face since 15 years, which was s...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - September 8, 2023 Category: ENT & OMF Source Type: research
Quantitative diffusion-weighted MRI response assessment in rhabdomyosarcoma: an international retrospective study on behalf of the European paediatric Soft tissue sarcoma Study Group Imaging Committee
ConclusionA significant change in the 5th percentile and the mean ADC after chemotherapy was observed. Strong heterogeneity was identified in DW-MRI acquisition protocols between centers and in individual patients.Graphical Abstract (Source: Pediatric Radiology)
Source: Pediatric Radiology - September 8, 2023 Category: Radiology Source Type: research
Clinical features and outcomes of infantile soft-tissue sarcoma: A multicenter retrospective study in Beijing
CONCLUSIONS: Infant-onset soft-tissue sarcoma is heterogeneous. The primary location of the abdominal or pelvic cavity of RMS and EWS was at a later stage and had a poorer prognosis. Multimodal therapy resulted in successful disease control for the majority of patients. Standardization of treatment protocols will facilitate care for such challenging conditions.PMID:37675711 | DOI:10.4103/jcrt.jcrt_1950_22 (Source: Cancer Control)
Source: Cancer Control - September 7, 2023 Category: Cancer & Oncology Authors: Shuai Zhu Na Xu Tian Zhi Yangxu Gao Dixiao Zhong Weiling Zhang Mei Jin Qing Sun Yao Xie Xiaolun Zhang Long Li Shengcai Wang Huanmin Wang Rong Liu Weihong Zhao Dongsheng Huang Xin Ni Xiaoli Ma Source Type: research
Gynecological carcinosarcomas: Overview and future perspectives
Bull Cancer. 2023 Sep 5:S0007-4551(23)00341-7. doi: 10.1016/j.bulcan.2023.07.005. Online ahead of print.ABSTRACTGynecologic carcinosarcoma (CS) are rare and aggressive tumors composed of high-grade carcinoma and sarcoma. Carcinosarcoma account for less than 5% of uterine and ovarian carcinoma and patients have poor outcome with a 5-year overall survival of less than 30%. In early-stage setting, the treatment mainstay is surgery and adjuvant chemoradiotherapy or adjuvant chemotherapy in uterine (UCS) and ovarian CS (OCS), respectively. In metastatic or advanced stage disease, chemotherapy is the rule with a lower response r...
Source: Bulletin du Cancer - September 7, 2023 Category: Cancer & Oncology Authors: Laetitia Collet Andrea Mar ía González López Cl émence Romeo Pierre M éeus Nicolas Chopin L éa Rossi Elise Rowinski Anne-Agathe Serre Corrinne Rannou Adrien Buisson Isabelle Treilleux Isabelle Ray-Coquard Source Type: research
Gynecological carcinosarcomas: Overview and future perspectives
Bull Cancer. 2023 Sep 5:S0007-4551(23)00341-7. doi: 10.1016/j.bulcan.2023.07.005. Online ahead of print.ABSTRACTGynecologic carcinosarcoma (CS) are rare and aggressive tumors composed of high-grade carcinoma and sarcoma. Carcinosarcoma account for less than 5% of uterine and ovarian carcinoma and patients have poor outcome with a 5-year overall survival of less than 30%. In early-stage setting, the treatment mainstay is surgery and adjuvant chemoradiotherapy or adjuvant chemotherapy in uterine (UCS) and ovarian CS (OCS), respectively. In metastatic or advanced stage disease, chemotherapy is the rule with a lower response r...
Source: Bulletin du Cancer - September 7, 2023 Category: Cancer & Oncology Authors: Laetitia Collet Andrea Mar ía González López Cl émence Romeo Pierre M éeus Nicolas Chopin L éa Rossi Elise Rowinski Anne-Agathe Serre Corrinne Rannou Adrien Buisson Isabelle Treilleux Isabelle Ray-Coquard Source Type: research
METTL16 controls Kaposi’s sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle
Cell Death & Disease, Published online: 06 September 2023; doi:10.1038/s41419-023-06121-3METTL16 controls Kaposi’s sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle (Source: Cell death and disease)
Source: Cell death and disease - September 6, 2023 Category: Internal Medicine Authors: Xinquan Zhang Wen Meng Jian Feng Xinghong Gao Chao Qin Pinghui Feng Yufei Huang Shou-Jiang Gao Source Type: research
Prediction of High Grade Soft Tissue Sarcoma Using A Combined Intratumoral and Peritumoral MRI Based Radiomics Nomogram
To develop an intratumoral and peritumoral MRI-based radiomics nomogram for predicting tumor grade to improve clinical treatment approach and long-term prognosis. (Source: Clinical Radiology)
Source: Clinical Radiology - September 6, 2023 Category: Radiology Authors: Yanping Dou, Xiangwen Li, Juan Tao, Yang Dong, Nan Xu, Shaowu Wang Source Type: research
Prediction of high-grade soft-tissue sarcoma using a combined intratumoural and peritumoural MRI-based radiomics nomogram
To develop an intratumoural and peritumoural magnetic resonance imaging (MRI)-based radiomics nomogram for predicting tumour grade to improve clinical treatment and long-term prognosis. (Source: Clinical Radiology)
Source: Clinical Radiology - September 6, 2023 Category: Radiology Authors: Y. Dou, X. Li, J. Tao, Y. Dong, N. Xu, S. Wang Source Type: research
Kaposi's Sarcoma in Children After Hematopoietic Stem Cell Transplantation: Two Cases of Rare Primary Tumor Localizations in the Lungs and Lymph Node
We describe 2 very rare cases of iatrogenic KS in children after hematopoietic stem cell transplant with isolated organ damage (case 1: lung; case 2: inguinal lymph node). KS is a potential complication of bone marrow transplant in pediatric patients and can occur in different age groups and at atypical sites.PMID:37669118 | DOI:10.1097/MPH.0000000000002745 (Source: Herpes)
Source: Herpes - September 5, 2023 Category: Infectious Diseases Authors: Il'ya Vladimirovich Sidorov Dmitriy Sergeevich Abramov Nataliia Alekseevna Strumila Larisa Nikolaevna Shelihova Ekaterina Andreevna Viktorova Dmitry Mikhailovich Konovalov Source Type: research
Kaposi's Sarcoma in Children After Hematopoietic Stem Cell Transplantation: Two Cases of Rare Primary Tumor Localizations in the Lungs and Lymph Node
We describe 2 very rare cases of iatrogenic KS in children after hematopoietic stem cell transplant with isolated organ damage (case 1: lung; case 2: inguinal lymph node). KS is a potential complication of bone marrow transplant in pediatric patients and can occur in different age groups and at atypical sites.PMID:37669118 | DOI:10.1097/MPH.0000000000002745 (Source: Herpes)
Source: Herpes - September 5, 2023 Category: Infectious Diseases Authors: Il'ya Vladimirovich Sidorov Dmitriy Sergeevich Abramov Nataliia Alekseevna Strumila Larisa Nikolaevna Shelihova Ekaterina Andreevna Viktorova Dmitry Mikhailovich Konovalov Source Type: research
