Clinical recommendations for treatment of localized angiosarcoma: A consensus paper by the Italian Sarcoma Group
Angiosarcoma (AS) is a rare and aggressive vascular sarcoma. The current European Society of Medical Oncology (ESMO) clinical practice guidelines (CPGs) for the treatment of sarcomas apply to AS as well. However, AS aggressiveness and diverse tumor presentations differentiate it from other sarcomas, impacting clinical decisions. This is especially relevant in the context of localized disease, where considerations about the extent of surgery, the use of radiation therapy (RT), and the indication for neoadjuvant/adjuvant chemotherapy may vary. (Source: Cancer Treatment Reviews)
Source: Cancer Treatment Reviews - March 29, 2024 Category: Cancer & Oncology Authors: Elena Palassini, Giacomo Giulio Baldi, Sara Sulfaro, Marta Barisella, Giuseppe Bianchi, Domenico Campanacci, Marco Fiore, Marco Gambarotti, Massimiliano Gennaro, Carlo Morosi, Federico Navarria, Emanuela Palmerini, Claudia Sangalli, Marta Sbaraglia, Annal Tags: REVIEW Source Type: research
Cancers, Vol. 16, Pages 1355: Functional Classification of Fusion Proteins in Sarcoma
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Sarcomas comprise a heterogeneous group of malignant tumors of mesenchymal origin. More than 80 entities are associated with different mesenchymal lineages. Sarcomas with fibroblastic, muscle, bone, vascular, adipocytic, and other characteristics are distinguished. Nearly half of all entities contain specific chromosomal translocations that give rise to fusion proteins. These are mostly pathognomonic, and their detection by various molecular techniques supports histopathologic classification. Moreover, the fusion proteins act as oncogenic drivers, and their blockade represents a promising therapeutic approach. Th...
Source: Cancers - March 29, 2024 Category: Cancer & Oncology Authors: Marco Wachtel Didier Surdez Thomas G. P. Gr ünewald Beat W. Sch äfer Tags: Review Source Type: research
Safety, efficacy, and biological data of T cell-enabling oncolytic adenovirus TILT-123 in advanced solid cancers from the TUNIMO monotherapy phase I trial
CONCLUSIONS: TILT-123 was safe and able to produce anti-tumor effects in local and distant lesions in heavily pre-treated patients. Good tolerability of TILT-123 facilitates combination studies, several of which are ongoing (NCT04217473, NCT05271318, NCT05222932, NCT06125197).PMID:38546220 | DOI:10.1158/1078-0432.CCR-23-3874 (Source: Cell Research)
Source: Cell Research - March 28, 2024 Category: Cytology Authors: Santeri A Pakola Katriina J Peltola James H A Clubb Elise Jirovec Lyna Haybout Tatiana V Kudling Tuomo Alanko Riitta Korpisaari Susanna Juteau Marjut Jaakkola Jorma Sormunen Jukka Kemppainen Annabrita Hemmes Teijo Pellinen Mirte van der Heijden Dafne C A Source Type: research
Safety, efficacy, and biological data of T cell-enabling oncolytic adenovirus TILT-123 in advanced solid cancers from the TUNIMO monotherapy phase I trial
CONCLUSIONS: TILT-123 was safe and able to produce anti-tumor effects in local and distant lesions in heavily pre-treated patients. Good tolerability of TILT-123 facilitates combination studies, several of which are ongoing (NCT04217473, NCT05271318, NCT05222932, NCT06125197).PMID:38546220 | DOI:10.1158/1078-0432.CCR-23-3874 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - March 28, 2024 Category: Cancer & Oncology Authors: Santeri A Pakola Katriina J Peltola James H A Clubb Elise Jirovec Lyna Haybout Tatiana V Kudling Tuomo Alanko Riitta Korpisaari Susanna Juteau Marjut Jaakkola Jorma Sormunen Jukka Kemppainen Annabrita Hemmes Teijo Pellinen Mirte van der Heijden Dafne C A Source Type: research
Low NT5DC2 expression predicts favorable prognosis and suppresses soft tissue sarcoma progression via ECM-receptor interaction pathway
CONCLUSION: Low expression of NT5DC2 predicts a favorable prognosis in soft tissue sarcoma, and downregulated NT5DC2 expression can suppress sarcoma cell progression through the ECM-receptor interaction pathway.PMID:38547613 | DOI:10.1016/j.tranon.2024.101937 (Source: Translational Oncology)
Source: Translational Oncology - March 28, 2024 Category: Cancer & Oncology Authors: Zhen Huang Enjie Xu Xiaolong Ma Yongjie Wang Jiazhuang Zhu Kunpeng Zhu Jianping Hu Chunlin Zhang Source Type: research
Safety, efficacy, and biological data of T cell-enabling oncolytic adenovirus TILT-123 in advanced solid cancers from the TUNIMO monotherapy phase I trial
CONCLUSIONS: TILT-123 was safe and able to produce anti-tumor effects in local and distant lesions in heavily pre-treated patients. Good tolerability of TILT-123 facilitates combination studies, several of which are ongoing (NCT04217473, NCT05271318, NCT05222932, NCT06125197).PMID:38546220 | DOI:10.1158/1078-0432.CCR-23-3874 (Source: Cancer Control)
Source: Cancer Control - March 28, 2024 Category: Cancer & Oncology Authors: Santeri A Pakola Katriina J Peltola James H A Clubb Elise Jirovec Lyna Haybout Tatiana V Kudling Tuomo Alanko Riitta Korpisaari Susanna Juteau Marjut Jaakkola Jorma Sormunen Jukka Kemppainen Annabrita Hemmes Teijo Pellinen Mirte van der Heijden Dafne C A Source Type: research
ASO Visual Abstract: High Community-Level Social Vulnerability is Associated with Worse Recurrence-Free Survival Following Resection of Extremity and Truncal Soft-Tissue Sarcoma
Ann Surg Oncol. 2024 Mar 28. doi: 10.1245/s10434-024-15201-3. Online ahead of print.NO ABSTRACTPMID:38546800 | DOI:10.1245/s10434-024-15201-3 (Source: Ann Oncol)
Source: Ann Oncol - March 28, 2024 Category: Cancer & Oncology Authors: Raymond S Traweek Heather Lyu Russell G Witt Rebecca A Snyder Elise F Nassif David D Krijgh Jeffrey M Smith Gordon S Tilney Chun Feng Yi-Ju Chiang Keila E Torres Margaret J Roubaud Christopher P Scally Kelly K Hunt Emily Z Keung Alexander F Mericli Christ Source Type: research
Meta-Analysis of Incidence and Mortality of Firefighter Cancer: An Update on Emerging Science
CONCLUSIONS: The findings underscore the global cancer burden among firefighters, and indicate that geographically stratifying studies afford a more nuanced risk perspective. Further research should investigate why US firefighters exhibit higher cancer mortality rates compared to international counterparts.PMID:38546063 | DOI:10.31557/APJCP.2024.25.3.801 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - March 28, 2024 Category: Cancer & Oncology Authors: Sara A Jahnke Nattinee Jitnarin Christopher K Haddock Christopher Kaipust Walker S Carlos Poston Brittany S Hollerbach Carolyn Crisp Brittni Naylor Metoyer Source Type: research
Safety, efficacy, and biological data of T cell-enabling oncolytic adenovirus TILT-123 in advanced solid cancers from the TUNIMO monotherapy phase I trial
CONCLUSIONS: TILT-123 was safe and able to produce anti-tumor effects in local and distant lesions in heavily pre-treated patients. Good tolerability of TILT-123 facilitates combination studies, several of which are ongoing (NCT04217473, NCT05271318, NCT05222932, NCT06125197).PMID:38546220 | DOI:10.1158/1078-0432.CCR-23-3874 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - March 28, 2024 Category: Cancer & Oncology Authors: Santeri A Pakola Katriina J Peltola James H A Clubb Elise Jirovec Lyna Haybout Tatiana V Kudling Tuomo Alanko Riitta Korpisaari Susanna Juteau Marjut Jaakkola Jorma Sormunen Jukka Kemppainen Annabrita Hemmes Teijo Pellinen Mirte van der Heijden Dafne C A Source Type: research
Low NT5DC2 expression predicts favorable prognosis and suppresses soft tissue sarcoma progression via ECM-receptor interaction pathway
CONCLUSION: Low expression of NT5DC2 predicts a favorable prognosis in soft tissue sarcoma, and downregulated NT5DC2 expression can suppress sarcoma cell progression through the ECM-receptor interaction pathway.PMID:38547613 | DOI:10.1016/j.tranon.2024.101937 (Source: Translational Oncology)
Source: Translational Oncology - March 28, 2024 Category: Cancer & Oncology Authors: Zhen Huang Enjie Xu Xiaolong Ma Yongjie Wang Jiazhuang Zhu Kunpeng Zhu Jianping Hu Chunlin Zhang Source Type: research
Meta-Analysis of Incidence and Mortality of Firefighter Cancer: An Update on Emerging Science
CONCLUSIONS: The findings underscore the global cancer burden among firefighters, and indicate that geographically stratifying studies afford a more nuanced risk perspective. Further research should investigate why US firefighters exhibit higher cancer mortality rates compared to international counterparts.PMID:38546063 | DOI:10.31557/APJCP.2024.25.3.801 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - March 28, 2024 Category: Cancer & Oncology Authors: Sara A Jahnke Nattinee Jitnarin Christopher K Haddock Christopher Kaipust Walker S Carlos Poston Brittany S Hollerbach Carolyn Crisp Brittni Naylor Metoyer Source Type: research
