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Nutrition: Iron

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Total 471 results found since Jan 2013.

Ferroptosis and cardiovascular disease: role of free radical-induced lipid peroxidation.
Authors: Chen X, Li X, Xu X, Li L, Liang N, Zhang L, Lv J, Wu YC, Yin H Abstract Cardiovascular disease (CVD), including heart attack, stroke, heart failure, arrhythmia, and other congenital heart diseases remain the leading cause of morbidity and mortality worldwide. The leading cause of deaths in CVD is attributed to myocardial infarction due to the rupture of atherosclerotic plaque. Atherosclerosis refers a condition when restricted or even blockage of blood flow occurs due to the narrowing of blood vessels as a result of the buildup of plaques composed of oxidized lipids. It is well-established that free radica...
Source: Free Radical Research - January 20, 2021 Category: Research Tags: Free Radic Res Source Type: research

Inhibiting ferroptosis: A novel approach for stroke therapeutics.
Abstract Stroke ranks as the second leading cause of death across the globe. Despite advances in stroke therapeutics, no US Food and Drug Administration (FDA)-approved drugs that can minimize neuronal injury and restore neurological function are clinically available. Ferroptosis, a regulated iron-dependent form of nonapoptotic cell death, has been shown to contribute to stroke-mediated neuronal damage. Inhibitors of ferroptosis have also been validated in several stroke models of ischemia or intracerebral hemorrhage. Herein, we review the therapeutic activity of inhibitors of ferroptosis in stroke models. We furth...
Source: Drug Discovery Today - January 4, 2021 Category: Drugs & Pharmacology Authors: Jin Y, Zhuang Y, Liu M, Che J, Dong X Tags: Drug Discov Today Source Type: research

The efficacy and safety of roxadustat treatment for anemia in patients with kidney disease: a meta-analysis and systematic review
ConclusionsRoxadustat has higher mean Hb level than placebo or EPO. Due to the short follow-up period and the lack of critical data, more RCTs are needed to prove long-term safety and effectiveness of roxadustat in the future.
Source: International Urology and Nephrology - January 3, 2021 Category: Urology & Nephrology Source Type: research

Recent advances in iron homeostasis and regulation -A focus on epigenetic regulation and stroke.
Authors: Shi H, Almutairi M, Moskovitz J, Xu YG Abstract Iron is an element with redox properties. It is active sites of many enzymes and plays an important role in various cellular and biological functions including ATP production and DNA synthesis. However, as a redox element, iron promotes free radical generation and lipid peroxidation, causing oxidative damage and cell death. Iron-mediated oxidation is a central player in ferroptosis, a type of cell death process that is different from apoptosis and necrosis. Thus, iron metabolism and homeostasis are sophisticatedly regulated. There has been exciting progress i...
Source: Free Radical Research - December 23, 2020 Category: Research Tags: Free Radic Res Source Type: research

Iron deficiency does not impair the outcome after elective coronary artery bypass and aortic valve procedures
ConclusionsThe majority of patients undergoing elective CABG or SAVR suffer from ID;  however, we found no significant differences in regard to MACCE and postoperative morbidity between ID and non‐ID patients.
Source: Journal of Cardiac Surgery - December 20, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Moritz B. Immohr, Yukiharu Sugimura, Hug Aubin, Philipp Rellecke, Udo Boeken, Artur Lichtenberg, Payam Akhyari Tags: ORIGINAL ARTICLE Source Type: research

Selective hand motor cortex lesions masquerading as & #8220;Pseudoperipheral Nerve Palsy & #8221;
Bhaskara P Shelley, Prakash Harishchandra, Acharya K DevadasAnnals of Indian Academy of Neurology 2020 23(5):688-693 Strategic cortical lesions involving the hand motor cortex (HMC) presenting acutely as distal upper limb pure motor weakness certainly do need to be differentiated on clinical grounds from “pseudoperipheral palsy.” This rare phenotype can imitate peripheral motor nerve deficits and should not be easily overlooked. The? isolated “central hand and finger weakness” presenting as an acute onset of varying combinations such as pseudomedian, pseudoradial,...
Source: Annals of Indian Academy of Neurology - December 8, 2020 Category: Neurology Authors: Bhaskara P Shelley Prakash Harishchandra Acharya K Devadas Source Type: research

Effects of Antimalarial Drugs on Neuroinflammation-Potential Use for Treatment of COVID-19-Related Neurologic Complications
AbstractThe SARS-CoV-2 virus that is the cause of coronavirus disease 2019 (COVID-19) affects not only peripheral organs such as the lungs and blood vessels, but also the central nervous system (CNS) —as seen by effects on smell, taste, seizures, stroke, neuropathological findings and possibly, loss of control of respiration resulting in silent hypoxemia. COVID-19 induces an inflammatory response and, in severe cases, a cytokine storm that can damage the CNS. Antimalarials have unique properti es that distinguish them from other anti-inflammatory drugs. (A) They are very lipophilic, which enhances their ability to cross ...
Source: Molecular Neurobiology - November 27, 2020 Category: Neurology Source Type: research

Iron chelators for acute stroke.
CONCLUSIONS: We identified two eligible RCTs for assessment. We could not demonstrate any benefit for the use of iron chelators in spontaneous intracerebral haemorrhage. The added value of iron-chelating therapy in people with ischaemic stroke or subarachnoid haemorrhage remains unknown. PMID: 33236783 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - November 24, 2020 Category: General Medicine Authors: Van der Loo LE, Aquarius R, Teernstra O, Klijn K, Menovsky T, van Dijk JMC, Bartels R, Boogaarts HD Tags: Cochrane Database Syst Rev Source Type: research

Iron Measured in Nasal Exudate Samples as a New and Useful Biomarker in the Differential Diagnosis of Patients with Acute Stroke
Conclusions: Our findings suggest that iron levels in nasal exudate may be useful in the acute stage for the differential diagnosis between ischemic and hemorrhagic damage in acute stroke patients. They also open a potential field to study other biomarkers in nasal exudate in several neurological disorders. Clinical studies must be performed to confirm our results.Cerebrovasc Dis
Source: Cerebrovascular Diseases - November 20, 2020 Category: Neurology Source Type: research

Investigation of the Relationship Between Breath Retention Time and Blood Parameters in Stroke Patients
Conclusion: Partial oxygen and carbon dioxide pressures and blood elements in the blood affect the breath holding time. People with high blood storage capacity and carbon dioxide and oxygen capacity can hold their breath longer. As a result, we think that the higher the hemoglobin and hematocrit levels in the blood, the longer the breath holding time can increase.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Yildiz, A., Mustafaoglu, R., Dincer, S. Tags: Clinical respiratory physiology, exercise and functional imaging Source Type: research

Epigenetic regulators of neuronal ferroptosis identify novel therapeutics for neurological diseases: HDACs, transglutaminases, and HIF prolyl hydroxylases.
Abstract A major thrust of our laboratory has been to identify how physiological stress is transduced into transcriptional responses that feed back to overcome the inciting stress or its consequences, thereby fostering survival and repair. To this end, we have adopted the use of an in vitro model of ferroptosis, a caspase-independent, but iron-dependent form of cell death (Dixon et al., 2012; Ratan, 2020). In this review, we highlight three distinct epigenetic targets that have evolved from our studies and which have been validated in vivo studies. In the first section, we discuss our studies of broad, pan-selecti...
Source: Neurobiology of Disease - October 27, 2020 Category: Neurology Authors: Rroji O, Kumar A, Karuppagounder SS, Ratan RR Tags: Neurobiol Dis Source Type: research

Iron bioavailability and cardiopulmonary function during ascent to very high altitude
More than one hundred million people reside worldwide at altitudes in excess of 2500 m above sea level. In the millions more who sojourn at high altitude for recreational, occupational or military pursuits, hypobaric hypoxia drives physiological changes affecting the pulmonary circulation, haematocrit and right ventricle (RV) [1]. Coincident with these, maximal left ventricular (LV) stroke volume (SV) falls [2], with a reduction of 20% reported after a 2-week stay at 4300 m [3]. A rise in heart rate (HR) compensates at rest and during submaximal exercise but is insufficient during maximal intensity exercise, cons...
Source: European Respiratory Journal - September 16, 2020 Category: Respiratory Medicine Authors: Holdsworth, D. A., Frise, M. C., Bakker-Dyos, J., Boos, C., Dorrington, K. L., Woods, D., Mellor, A., Robbins, P. A. Tags: Original Articles: Research letters Source Type: research

Improvement of a novel proposal for antioxidant treatment against brain damage occurring in ischemic stroke patients.
Abstract The underlying mechanism of cerebral injury occurring in patients with acute ischemic stroke involves a key pathophysiological role of oxidative stress. Thus, reactive oxygen species are related to the development of brain edema, calcium overload, mitochondrial dysfunction, excitotoxicity, iron release and inflammation. Nevertheless, although experimental studies have tested the use of antioxidants as an adjuvant therapy in this setting, clinical data and randomized trials are still lacking. Current approved pharmacological therapy is aimed at reperfusion strategies; however, the therapeutic window is lim...
Source: CNS and Neurological Disorders Drug Targets - September 9, 2020 Category: Drugs & Pharmacology Authors: Orellana-Urzúa S, Claps G, Rodrigo R Tags: CNS Neurol Disord Drug Targets Source Type: research

Deferoxamine Treatment Prevents Post-Stroke Vasoregression and Neurovascular Unit Remodeling Leading to Improved Functional Outcomes in Type 2 Male Diabetic Rats: Role of Endothelial Ferroptosis
This study aimed to determine the impact of iron chelation with deferoxamine (DFX) on (1) cerebral vascularization patterns and (2) functional outcomes after stroke in control and diabetic rats. After 8  weeks of type 2 diabetes induced by a combination of high-fat diet and low-dose streptozotocin, male control and diabetic animals were subjected to thromboembolic middle cerebral artery occlusion (MCAO) and randomized to vehicle, DFX, or tPA/DFX and followed for 14 days with behavioral tests. Vas cular indices (vascular volume and surface area), neurovascular remodeling (AQP4 polarity), and microglia activation were meas...
Source: Translational Stroke Research - August 31, 2020 Category: Neurology Source Type: research

The Evaluation of 68 Ga-Citrate PET/CT Imaging for Dihydroartemisinin in the Treatment of Rheumatoid Arthritis
ConclusionsThis study showed that the anti-inflammatory effect of the iron-responsive product DHA in arthritis can be monitored by an iron-like radioactive tracer (68Ga-citrate).
Source: Molecular Imaging and Biology - August 24, 2020 Category: Molecular Biology Source Type: research