In memoriam: Dr. K K Sinha MD, FRCP, FICP, FIAN
Sudhir Kumar JhaAnnals of Indian Academy of Neurology 2019 22(3):365-366 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Sudhir Kumar Jha Source Type: research

Atlas of neurology (A case-based approach)
Subhash KaulAnnals of Indian Academy of Neurology 2019 22(3):364-364 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Subhash Kaul Source Type: research

Early-onset subacute sclerosing panencephalitis: Report of two cases and review of literature
Ananthanarayanan Kasinathan, Indar Kumar Sharawat, Shivan Kesavan, Renu Suthar, Naveen SankhyanAnnals of Indian Academy of Neurology 2019 22(3):361-363 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Ananthanarayanan Kasinathan Indar Kumar Sharawat Shivan Kesavan Renu Suthar Naveen Sankhyan Source Type: research

Pseudo hypsarrhythmia: An early marker of angelman syndrome
Ananthanarayanan Kasinathan, Sumeet Dhawan, Renu Suthar, Naveen SankhyanAnnals of Indian Academy of Neurology 2019 22(3):359-361 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Ananthanarayanan Kasinathan Sumeet Dhawan Renu Suthar Naveen Sankhyan Source Type: research

Hashimoto encephalopathy in children
Meenal Garg, Sunil Dutt Sharma, Abhishek Hajela, Piyush GuptaAnnals of Indian Academy of Neurology 2019 22(3):357-359 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Meenal Garg Sunil Dutt Sharma Abhishek Hajela Piyush Gupta Source Type: research

Acute influenza a virus-associated encephalitis with bilateral lateral geniculate body hemorrhagic infarction-complicating pregnancy
Goutham Kumar Puppala, Arvind N Prabhu, Shankar Prasad Gorthi, Vijay ChandranAnnals of Indian Academy of Neurology 2019 22(3):355-357 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Goutham Kumar Puppala Arvind N Prabhu Shankar Prasad Gorthi Vijay Chandran Source Type: research

Multiple cranial neuropathies in a patient with diabetes mellitus
Jomal Mathew, Madhukar Mohan, Ashok MenonAnnals of Indian Academy of Neurology 2019 22(3):353-355 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Jomal Mathew Madhukar Mohan Ashok Menon Source Type: research

Obesity, ethnicity and idiopathic intracranial hypertension
V Abdul Gafoor, B Smita, James JoseAnnals of Indian Academy of Neurology 2019 22(3):352-352 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: V Abdul Gafoor B Smita James Jose Source Type: research

Authors & #39; reply
Sucharita RayAnnals of Indian Academy of Neurology 2019 22(3):351-351 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Sucharita Ray Source Type: research

Clinical mimickers of amyotrophic lateral sclerosis-conditions we cannot afford to miss
Nishita Singh, Sucharita Ray, Achal SrivastavaAnnals of Indian Academy of Neurology 2019 22(3):351-351 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Nishita Singh Sucharita Ray Achal Srivastava Source Type: research

Pattern of idiopathic intracranial hypertension in Indian population
Asutosh Pal, Prasenjit Sengupta, Debsadhan Biswas, Chetana Sen, Avik Mukherjee, Sandip PalAnnals of Indian Academy of Neurology 2019 22(3):350-351 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Asutosh Pal Prasenjit Sengupta Debsadhan Biswas Chetana Sen Avik Mukherjee Sandip Pal Source Type: research

Mobile Phone & #8211;Induced vertebral artery dissection
Arunmozhimaran Elavarasi, Thekkumpurath Moyinul Haq, Thekkumpurath Thahira, Chiminikkara Bineesh, Lakshmana B KancharlaAnnals of Indian Academy of Neurology 2019 22(3):349-350 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Arunmozhimaran Elavarasi Thekkumpurath Moyinul Haq Thekkumpurath Thahira Chiminikkara Bineesh Lakshmana B Kancharla Source Type: research

The occurrence of metronidazole-induced encephalopathy in cancer patients: A hospital-based retrospective study
Conclusion: In cancer patients, MIE should be monitored in those with genitourinary cancer, especially with renal dysfunction. Longer duration with more cumulative dose also has a greater risk of MIE. Early consideration of MIE with prompt cessation of metronidazole may result in better outcome. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Jui-Ping Tsai Kevin Li-Chun Hsieh Tu-Hsueh Yeh Yuarn-Jang Lee Chun-Ren Wei Source Type: research

Clinico-investigative profile of hereditary spastic paraplegia in children
Conclusions: HSP is probably not uncommon. Recessive form of HSP is more frequently seen in children. Because of lack of awareness, there is delay in reaching the final diagnosis. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Mahesh Kamate Mayank Detroja Source Type: research

The risk of symptomatic intracranial hemorrhage after thrombolysis for acute stroke: Current concepts and perspectives
Conclusions: In addition to the already known risk factors considered in the standard protocols, an individualized evaluation of risks is needed to minimize the risk of brain hemorrhage after thrombolysis for ischemic stroke. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Pedro J Modrego Source Type: research

Extreme delta brush in anti N-Methyl-D-Aspartate encephalitis
Neeraj Balaini, Manoj Goyal, Ritu Shree, Vivek LalAnnals of Indian Academy of Neurology 2019 22(3):335-335 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Neeraj Balaini Manoj Goyal Ritu Shree Vivek Lal Source Type: research

Ischemic amnesia caused by bilateral fornix infarction: A rare entity
Madhavi Karri, Balakrishnan Ramasamy, Santhosh PerumalAnnals of Indian Academy of Neurology 2019 22(3):333-334 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Madhavi Karri Balakrishnan Ramasamy Santhosh Perumal Source Type: research

Isolated choroid plexus infarction presenting as psychomotor slowing
Jin San Lee, Eui Jong Kim, Sung Sang YoonAnnals of Indian Academy of Neurology 2019 22(3):332-333 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Jin San Lee Eui Jong Kim Sung Sang Yoon Source Type: research

An unusual combination of neurological manifestations and sudden vision loss in a child with familial hyperphosphatemic tumoral calcinosis
We report a child with hyperphosphatemia who presented with multiple episodes of neurologic dysfunction involving lower motor neuron facial nerve palsy along with sequential visual loss. He also had an episode of stroke. There was an extensive metastatic calcification of soft tissue and vasculature. Hyperphosphatemia with normal serum alkaline phosphatase, calcium, parathyroid hormone, and renal function was noted. He was managed with hemodialysis and sevelamer (3 months) without much success in reducing serum phosphate level, requiring continuous ambulatory peritoneal dialysis (3 years). Intact fibroblast growth factor 23...
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Lokesh Lingappa Shoji Ichikawa Amie K Gray Dena Acton Michael J Evans Rajsekara Chakravarthi Madarasu Ramesh Kekunnaya Sirisharani Siddaiahagari Source Type: research

Leukoencephalopathy in mitochondrial neurogastrointestinal encephalomyopathy-like syndrome with polymerase-gamma mutations
Hongyan Huang, Xinglong Yang, Ling Liu, Yanming XuAnnals of Indian Academy of Neurology 2019 22(3):325-327 Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) syndrome, caused by mutations in the thymidine phosphorylase gene, manifests as a multisystemic disorder characterized by severe gastrointestinal dysmotility, cachexia, ptosis and ophthalmoparesis, peripheral neuropathy, and leukoencephalopathy. These clinical manifestations, with the exception of leukoencephalopathy, are mimicked by MNGIE-like syndrome, linked to polymerase-gamma (POLG) gene. Here, we report a 49-year-old Chinese man with MNGIE-like syndr...
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Hongyan Huang Xinglong Yang Ling Liu Yanming Xu Source Type: research

Cryptococcal postinfectious inflammatory response syndrome in an immunocompetent host
Aarati Kulkarni, Vivek Jacob Philip, George K Varghese, Chintam Veerabhadraiah NagendraAnnals of Indian Academy of Neurology 2019 22(3):322-324 Cryptococcal-postinfectious inflammatory response syndrome (c-PIIRS) in an immunocompetent host is a rare entity. Unlike cryptococcal-immune reconstitution inflammatory syndrome, in c-PIIRS, macrophage clearance defect can be persistent, and the patient requires prolonged immunosuppressants to control inflammation. Early identification and treatment can reduce the mortality and morbidity in cryptococcal meningitis (CM). Here, we describe c-PIIRS in an apparently healthy individual...
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Aarati Kulkarni Vivek Jacob Philip George K Varghese Chintam Veerabhadraiah Nagendra Source Type: research

Survival of atypical rabies encephalitis
Chandrakant M Bokade, Vishal S Gajimwar, Rajkumar M Meshram, Swapnil B WathoreAnnals of Indian Academy of Neurology 2019 22(3):319-321 Rabies is a fatal zoonotic disease transmitted primarily by dogs, cats, and bats, which accounts for approximately 59,000 deaths globally per year. An 8-year-old boy from rural central India developed an atypical presentation of rabies following a street dog bite in spite of receiving postexposure prophylaxis and proper care of Category III wounds. A diagnosis of rabies was made on the basis of clinical background, neuroimaging finding, excess antibody titer, detection of rabies viral anti...
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Chandrakant M Bokade Vishal S Gajimwar Rajkumar M Meshram Swapnil B Wathore Source Type: research

Mineralizing angiopathy of lenticulostriate arteries with infantile basal ganglia infarct following minor head trauma: A case series
We report a clinical series of four infants who presented with the classical features of this distinct clinico-radiological entity. Clinical characteristics and risk factors at the time of stroke were described in detail. The long-term outcome on standard antiplatelet therapy is reported. None of the children had stroke recurrence during follow-up. The current literature on this clinico-radiological syndrome is reviewed in detail. In the typical cases, extensive etiological workup may not be warranted. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Neena Baby KP Vinayan Arun Grace Roy Source Type: research

Two South Indian children with KCNT1-related malignant migrating focal seizures of infancy & #8211; Clinical characteristics and outcome of targeted treatment with quinidine
We report the clinical characteristics of two south Indian children with KCNT1-related epileptic encephalopathy. Both of them had very high seizure burden which were resistant to antiepileptic and dietary therapy. Pharmacological response to quinidine in these children is described. Case 1 had 30% reduction in seizure burden at 20 mg/kg/day and 80% reduction at 36 mg/kg/day; case 2 had 30% reduction at 20 mg/kg/day. Serial electrocardiography was used to monitor the cardiotoxicity. Serum quinidine levels were not measured due to nonavailability. A critical review on the current status of targeted treatment of K...
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Abhijit Anil Patil KP Vinayan Arun Grace Roy Source Type: research

Is triamcinolone an easy and efficient way to treat meralgia paresthetica ? A cohort study
Conclusion: Triamcinolone acetonide injected locally seems to be an effective and safe treatment for refractory MP. A randomized control trial has been planned to look for efficacy and safety. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Arunmozhimaran Elavarasi Vinay Goyal Mamta Bhushan Singh MV Padma Srivastava Source Type: research

Increasing number of therapy sessions of repetitive transcranial magnetic stimulation improves motor development by reducing muscle spasticity in cerebral palsy children
Bablu Lal Rajak, Meena Gupta, Dinesh Bhatia, Arun MukherjeeAnnals of Indian Academy of Neurology 2019 22(3):302-307 Background: Repetitive TMS (rTMS), a non-invasive neuro-stimulation tool based on the principle of electromagnetic induction is recently being employed both for investigational and interventional purposes. The stimulating effect of rTMS on motor cortex areas of the brain leads to increased motor activity and decreased muscle tone in spastic cerebral palsy (CP) patients. Objective: This modulatory effect of rTMS is used in this study to evaluate its effect on motor function and spasticity by increasing the nu...
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Bablu Lal Rajak Meena Gupta Dinesh Bhatia Arun Mukherjee Source Type: research

Clinical profile, prognostic indicators, and therapeutic outcomes of pediatric opsoclonus-myoclonus-ataxia syndrome: A single-center experience from South India
Conclusion: A high index of suspicion in appropriate clinical circumstances and early aggressive immunomodulation might lead to a better outcome. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Karthik Muthusamy Maya Thomas Sangeetha Yoganathan Sniya Valsa Sudhakar Source Type: research

Prevalence and predictors of female sexual dysfunction in migraine
Conclusion: Sexual dysfunction is common in migraine with all domains of sexual function being affected. There is a significant negative correlation of sexual function with duration of acute episodes of headache and increasing frequency of migraine attacks per month. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: R Pradeep Harsha Sundarmurthy Vivek Karan Praveen Kulkarni Source Type: research

Memantine ameliorates migraine headache
Conclusion: Memantine (10 mg oral, once daily) is effective, well tolerated, and safe for patients with migraine. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Sundar Shanmugam Kranthi Karunaikadal Sathyanarayanan Varadarajan Muthuraj Krishnan Source Type: research

Cranial Autonomic symptoms, neck pain: Challenges in pediatric migraine
Conclusions: It is important for pediatricians and primary care physicians to be aware of the common nature of CASs and neck pain/stiffness in children with migraine to prevent unnecessary procedures. High frequency of migrain attacks was associated with high frequency of CAS and neck pain. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Zeliha Haytoglu Mihriban Ozlem Herguner Source Type: research

Association of serum levels of calcitonin gene-related peptide and cytokines during migraine attacks
Conclusions: In our study, we found migraine patients had a higher IL-6, IL-1β, and TNF level than healthy controls and the level of CGRP was related significantly with the level of IL-1β and IL-6. In conclusion, our results suggest that IL-1β and IL-6 may be involved in the pathogenesis of migraine attacks and CGRP related with the secretion of cytokines. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Dawei Han Source Type: research

Neurodegeneration with brain iron accumulation
Amit Batla, Chandana GaddipatiAnnals of Indian Academy of Neurology 2019 22(3):267-276 The term NBIA encompasses a heterogeneous group of inherited disorders characterized clinically by progressive extra pyramidal syndrome and pathologically by excessive iron deposition in brain, primarily affecting the basal ganglia (globus pallidus mainly).The hallmark of this syndrome is the age specific phenotypic presentation and intraphenotypic heterogeneity. NBIAs at present include ten subtypes with genes identified in nine subtypes. They form an important differential diagnosis for the phenotype of global developmental delay in i...
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Amit Batla Chandana Gaddipati Source Type: research

The Ape's Tail
Ajith CherianAnnals of Indian Academy of Neurology 2019 22(3):266-266 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Ajith Cherian Source Type: research

The neurologist and artificial intelligence: Titans at crossroads
Venugopalan Y Vishnu, Pulikottil Wilson VinnyAnnals of Indian Academy of Neurology 2019 22(3):264-266 Clinical judgment to reach final diagnosis has remained a challenge since time immemorial. The present times are witness to artificial intelligence (AI) and machine learning programs competing to outperform the seasoned physician in arriving at a differential diagnosis. We discuss here the possible roles of AI in neurology. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Venugopalan Y Vishnu Pulikottil Wilson Vinny Source Type: research

No evidence of disease activity (NEDA) in multiple sclerosis - Shifting the goal posts
Lekha PanditAnnals of Indian Academy of Neurology 2019 22(3):261-263 A combined endpoint measure to define no evidence of disease activity (NEDA) is becoming increasingly appealing in the treatment of multiple sclerosis (MS). Initial efforts using a 3 parameter NEDA monitored disease activity using clinical and MRI lesion data. Later refinements, introduced more recently, include brain atrophy measurement and cognitive function analysis in defining NEDA-4. Using these stringent criteria clearly differentiated the usefulness of different disease modifying agents (DMDs) in achieving and sustaining NEDA over time. This in tu...
Source: Annals of Indian Academy of Neurology - July 1, 2019 Category: Neurology Authors: Lekha Pandit Source Type: research

In Memorium: Prof. Jagjit S. Chopra, DCH, FRCP, PhD, FAMS, FIAN
Inder M S. Sawhney, Vijay K KakAnnals of Indian Academy of Neurology 2019 22(2):259-260 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - April 9, 2019 Category: Neurology Authors: Inder M S. Sawhney Vijay K Kak Source Type: research

Neuromuscular disorders
Muralidharan NairAnnals of Indian Academy of Neurology 2019 22(2):258-258 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - April 9, 2019 Category: Neurology Authors: Muralidharan Nair Source Type: research

Repeating acute-onset hemiballismus in association with distinct stroke regions in a single patient
Halil OnderAnnals of Indian Academy of Neurology 2019 22(2):255-257 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - April 9, 2019 Category: Neurology Authors: Halil Onder Source Type: research

Neuropsychiatric lupus: The devil is in the detail
Arunmozhimaran Elavarasi, Mamta B Singh, Padma Srivastava, Vinay GoyalAnnals of Indian Academy of Neurology 2019 22(2):253-255 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - April 9, 2019 Category: Neurology Authors: Arunmozhimaran Elavarasi Mamta B Singh Padma Srivastava Vinay Goyal Source Type: research

Mimickers of amyotrophic lateral sclerosis
Ayush Dubey, Shubham DubeyAnnals of Indian Academy of Neurology 2019 22(2):252-253 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - April 9, 2019 Category: Neurology Authors: Ayush Dubey Shubham Dubey Source Type: research

Recurrent stroke due to antiphospholipid syndrome remitted by immunotherapy, not by anticoagulation therapy: A case report and literature review
Jin-Mo Park, Kyung Yoon EahAnnals of Indian Academy of Neurology 2019 22(2):250-252 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - April 9, 2019 Category: Neurology Authors: Jin-Mo Park Kyung Yoon Eah Source Type: research

Comments on & #8220;Short-lasting, unilateral, neuralgiform headache attacks & #8221;
Ottar Sjaastad, Torbjorn FredriksenAnnals of Indian Academy of Neurology 2019 22(2):249-250 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - April 9, 2019 Category: Neurology Authors: Ottar Sjaastad Torbjorn Fredriksen Source Type: research

Esophageal atresia in a newborn born to a Parkinson & #39;s mother had L-Dopa/benserazide treatment during pregnancy
Mehmet Hamamci, Kaya Yucesoy, Nur Pekmezci, Zeynep Erdogan Cetin, Refah SayinAnnals of Indian Academy of Neurology 2019 22(2):248-249 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - April 9, 2019 Category: Neurology Authors: Mehmet Hamamci Kaya Yucesoy Nur Pekmezci Zeynep Erdogan Cetin Refah Sayin Source Type: research

Reversible spastic paraparesis
Ananthanarayanan Kasinathan, Indar Kumar Sharawat, Naveen Sankhyan, Sameer Vyas, Savita AttriAnnals of Indian Academy of Neurology 2019 22(2):246-247 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - April 9, 2019 Category: Neurology Authors: Ananthanarayanan Kasinathan Indar Kumar Sharawat Naveen Sankhyan Sameer Vyas Savita Attri Source Type: research

Heat hyperpyrexia-induced cerebellar degeneration and anterior horn cell degeneration: A rare manifestation
Vijay Sardana, Sunil Kumar Sharma, Sangeeta SaxenaAnnals of Indian Academy of Neurology 2019 22(2):244-245 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - April 9, 2019 Category: Neurology Authors: Vijay Sardana Sunil Kumar Sharma Sangeeta Saxena Source Type: research

Rivaroxaban: A possible cause of Guillain & #8211;Barre syndrome
Madhavi Karri, Balakrishnan Ramasamy, Santhosh PerumalAnnals of Indian Academy of Neurology 2019 22(2):242-244 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - April 9, 2019 Category: Neurology Authors: Madhavi Karri Balakrishnan Ramasamy Santhosh Perumal Source Type: research

Pharyngeal-cervical-brachial variant of Guillain & #8211;Barr & #233; syndrome following dengue infection: A rare syndrome with rare association
Rajendra Kumar Pandey, Rohit Kumar Jain, Syed Zammeer HussainAnnals of Indian Academy of Neurology 2019 22(2):240-241 Pharyngeal-cervical-brachial (PCB) variant is a rare localized variant of Guillain–Barré syndrome that presents with a rapidly progressive oropharyngeal and cervicopharyngeal weakness associated with areflexia in the upper limb. Here, we are describing a case of a 20-year-old female who had a preceding history of fever with thrombocytopenia that was found to be dengue ELISA positive. This was followed by rapidly progressive weakness of cervical, bulbar, and bilateral facial muscles along with ar...
Source: Annals of Indian Academy of Neurology - April 9, 2019 Category: Neurology Authors: Rajendra Kumar Pandey Rohit Kumar Jain Syed Zammeer Hussain Source Type: research

Long-segment myelitis, meningoencephalitis, and axonal polyneuropathy in a case of scrub typhus
Ruchika Tandon, Amit Kumar, Ajay KumarAnnals of Indian Academy of Neurology 2019 22(2):237-240 Scrub typhus, a mite-borne zoonotic disease, is endemic in several parts of India. It may cause multisystemic disease involving lungs, heart, spleen, liver, hematological system, and nervous system. Neurological involvement may include meningoencephalitis, cerebellitis, cranial nerve palsies, plexopathy, transverse myelitis, muscle dysfunction, neuroleptic malignant syndrome, parkinsonian syndrome, and Guillain–Barre syndrome. Here, we report a rare patient of scrub typhus, who developed meningoencephalitis followed by lon...
Source: Annals of Indian Academy of Neurology - April 9, 2019 Category: Neurology Authors: Ruchika Tandon Amit Kumar Ajay Kumar Source Type: research

Disseminated strongyloidiasis: Breaking brain barriers
We present a compendium of two immunocompromised patients, who were on high-dose steroids and presented with worsening neurological status. Cerebrospinal fluid analysis was notable for larvae of SS as diagnosed by direct visualization. A syndrome of SS hyperinfection with dissemination was made after stool, and sputum samples also revealed SS larvae. SS is an elusive disease and should be considered early on, especially in endemic regions like India. Early diagnosis and prompt initiation of antihelminthic therapy is indispensable for favorable outcomes. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - April 9, 2019 Category: Neurology Authors: Ivy Anne Sebastian Jeyaraj Durai Pandian Aroma Oberoi Mahesh Pundlik Kate Vineeth Jaison Smriti Bose Rajeshwar Sahonta Shavi Nagpal Indira Brar Source Type: research

Immunodeficiency, motor delay, and hypouricemia caused by a novel mutation of purine nucleoside phosphorylase gene in an Indian infant
We describe an 11-month-old boy who presented with recurrent respiratory infections from 6 months of age. His elder sister died at 10 months with severe septicemia and meningitis. The boy had a mild motor delay. Investigations revealed T cell deficiency and very low serum uric acid suggestive of purine nucleoside phosphorylase (PNP) deficiency – a rare variant of severe combined immunodeficiency disease. A novel homozygous missense mutation of c.597C>G(p. S199R) of exon 5 on PNP gene confirmed the diagnosis. We suggest that uric acid should be a part of investigation profile for unidentified motor delay, as recur...
Source: Annals of Indian Academy of Neurology - April 9, 2019 Category: Neurology Authors: Nikit Shah Lokesh Lingappa Ramesh Konanki Sirisha Rani Ramprasad Vedam Sakthivel Murugan Source Type: research