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Impact of COVID-19 on guillain-barre syndrome in India: A multicenter ambispective cohort study
Discussion: Results of this study revealed an overall reduction in the frequency of GBS during the pandemic. The lockdown likely reduced the risk for antecedent infections due to social distancing and improved hygiene, which may have resulted in the reduction of the frequency of GBS. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - December 3, 2022 Category: Neurology Authors: Yareeda Sireesha Ritu Shree Madhu Nagappa Anuja Patil Monika Singla MV Padma Srivastava RK Dhamija Neetha Balaram Abhishek Pathak Dileep Ramachandran Sujit Kumar Inder Puri Sudhir Sharma Samhita Panda Soaham Desai Priyanka Samal Aditya Choudhary Pamidimuk Source Type: research

Prevalence and risk factors of peripheral neuropathy in parkinson & #39;s disease
Conclusions: In our cohort, majority of the patients were in early-stage PD and around one-fifth and one-third of patients suffer from large and small fiber polyneuropathy, respectively. Large and small fiber neuropathy in PD is mainly associated with duration of disease, levodopa cumulative dose, and H and Y score. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - December 3, 2022 Category: Neurology Authors: Aparna Ramachandran James Jose V Abdul Gafoor Smita Das Neetha Balaram Source Type: research

Phenotypic pleiotropy in arginase deficiency: A single center cohort
Conclusion: Spastic diparesis, recurrent encephalopathy, presence of family history, and elevated serum arginine levels must alert the clinician to suspect arginase deficiency. Atypical presentations in our cohort include frequent metabolic crises and epileptic encephalopathy. Early identification and management will ensure a better neurodevelopmental outcome. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - December 3, 2022 Category: Neurology Authors: Narmadham K Bharathi Maya Mary Thomas Sangeetha Yoganathan Mahalakshmi Chandran Rekha Aaron Sumita Danda Source Type: research

Profiling cognitive impairment in mild COVID-19 patients: A case-control study at a secondary healthcare centre in the hilly region of North India
Conclusion: Our results have demonstrated that there is domain-wise cognitive impairment associated with mild COVID-19 disease. We recommend lowering the threshold of the MoCA to identify the early cognitive impairment and the inclusion of detailed cognitive assessment in post-COVID-19 follow-ups to initiate early cognitive rehabilitation among these patients. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - December 3, 2022 Category: Neurology Authors: Sanat Kumar Khanna Neelu Khanna Manoj Kumar Malav Himanshu Chhagan Bayad Akshay Sood Leena Abraham Source Type: research

Caregiver burden in caregivers of stroke survivors: A hospital-based study
Conclusion: CG burden increases with increased severity of stroke. Integrated stroke rehabilitation services should also address CGs issues along with patients. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - December 3, 2022 Category: Neurology Authors: Anand Kumar Ajay Kumar Yadav Varun Kumar Singh Abhishek Pathak Rameshwar Nath Chaurasia Vijaya Nath Mishra Deepika Joshi Source Type: research

The overlap in neuroimaging findings between idiopathic normal pressure hydrocephalus and progressive supranuclear palsy
Conclusions: We found that the neuroimaging features of iNPH and PSP highly overlapped between these patient groups. These results may provide indirect evidence regarding the coexistence of PSP and iNPH pathophysiology that has been deliberated in several recent reports. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - December 3, 2022 Category: Neurology Authors: Halil & #214;nder Bilge Kocer Aynur Turan Hayri Kertmen Selcuk Comoglu Source Type: research

Exploring novel word learning via fast mapping and explicit encoding in persons with temporal lobe epilepsy
Conclusion: Novel word learning via FM did not facilitate learning above EE in TLE patients or NC. But FM-based words could better overcome forgetting following overnight integration in RTLE and NC. Hence, it is possible that FM has the potential to improve retention of novel information following overnight integration in RTLE as in NC. However, its efficacy in improving retention in LTLE needs further evidence. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - December 3, 2022 Category: Neurology Authors: P Manju Mohan Ramshekhar N Menon Satyapal Puri Goswami Sanjeev V Thomas Ajith Cherian Ashalatha Radhakrishnan Source Type: research

Determinants of levodopa responsiveness in patients with vascular parkinsonism
Conclusions: Hypertension was the most common risk factor seen in patients with VaP. Those with isolated BG/thalamus infarcts demonstrated better levodopa responsiveness. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - December 3, 2022 Category: Neurology Authors: Sheetal Goyal Nitish Kamble MA Mukheem Mudabbir Amitabh Bhattacharya Ravi Yadav Pramod Kumar Pal Source Type: research

The clinical diagnostic utility of array CGH in children with syndromic microcephaly
Conclusion: This research highlights the contribution of submicroscopic chromosomal changes in the etiology of microcephaly in combination with developmental delay/facial dysmorphism/congenital anomalies (syndromic microcephaly). Our studies provide more insights into the benefits derived by using array CGH analysis in patients with syndromic microcephaly. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - December 3, 2022 Category: Neurology Authors: Manisha Goyal Mohammed Faruq Ashok Gupta Divya Shrivastava Uzma Shamim Source Type: research

Evaluation of non-motor symptoms in wilson disease using the parkinson & #39;s disease nonmotor symptoms questionnaire: A pilot cross-sectional study and critical assessment
Conclusions: Although many NMS of WD patients are picked up effectively with PD-NMS Quest, some of them need detail assessment including cognitive, behavioral, and psychiatric symptoms, drooling and dysphagia, sleep as well as autonomic disturbances. Questions pertaining to sexual activity may be omitted from the questionnaire. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - December 3, 2022 Category: Neurology Authors: Arka P Chakraborty Adreesh Mukherjee Sumanta Sarkar Uma Sinharoy Atanu Biswas Source Type: research

Predictors of seizures and associated functional outcome in a cerebral venous thrombosis cohort: An ambispective cohort study
Conclusion: Seizures at presentation occurred in 50% of patients with CVT which was associated with a parenchymal lesion in the brain. There was no association between seizure at presentation and clinical outcome. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - December 3, 2022 Category: Neurology Authors: Maneesh Shakywar Ayush Agarwal MV Padma Srivastava Rohit Bhatia Mamta B Singh Roopa Rajan Anu Gupta Awadh K Pandit Ajay Garg Jyoti Sharma Aakash Gupta Ashish Upadhyay Venugopalan Y Vishnu Source Type: research

Neurological manifestations in COVID-19 in three waves of the pandemic: An inpatient study from India
Conclusion: SARS-CoV-2 produces many central and peripheral nervous system manifestations. Encephalopathy was more common in first wave while acute symptomatic seizures were more common in third wave. Encephalopathy was most common neurological manifestation with progressively higher mortality with increased number of systemic comorbidities. Ischemic stroke was seen in patients who had vascular risk factors as well as in patients without them. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - December 3, 2022 Category: Neurology Authors: Rahul Kulkarni Dulari Gupta Shripad Pujari Vishal Deshpande Pravin Naphade Rushikesh Deshpande Source Type: research

Safety of recanalization therapy in acute ischemic stroke patients on direct oral anticoagulant therapy: An updated systematic review and meta-analysis
Yanxing Zhang, Huan Tang, Xiaohong Gui, Ye Du, Chenglong WuAnnals of Indian Academy of Neurology 2022 25(6):1036-1046 This review provides an updated assessment of the safety of recanalization therapy for Acute Ischemic Stroke (AIS) patients receiving direct oral anticoagulants (DOAC) therapy. We checked the literature for published observational from 1st January 1950 to 31st March 2021. The rate of symptomatic intracerebral hemorrhage (sICH), arterial recanalization rate, good functional recovery, and mortality at 3 months were investigated, and data were expressed as Risk ratio (RR) with a 95% confidence inte...
Source: Annals of Indian Academy of Neurology - December 3, 2022 Category: Neurology Authors: Yanxing Zhang Huan Tang Xiaohong Gui Ye Du Chenglong Wu Source Type: research

Nigrosome and neuromelanin imaging as tools to differentiate parkinson & #39;s disease and parkinsonism
Deblina Biswas, Rebecca Banerjee, Swagata Sarkar, Supriyo Choudhury, Pritimoy Sanyal, Mona Tiwari, Hrishikesh KumarAnnals of Indian Academy of Neurology 2022 25(6):1029-1035 Parkinson's disease (PD) lacks a definitive diagnosis due to a lack of pathological validation of patients at antemortem. The risk of misdiagnosis is high in the early stages of PD, often eluded by atypical parkinsonian symptoms. Neuroimaging and laboratory biomarkers are being sought to aid in the clinical diagnosis of PD. Nigrosome imaging and neuromelanin (NM)-sensitive magnetic resonance imaging (MRI) are the new emerging tools, both te...
Source: Annals of Indian Academy of Neurology - December 3, 2022 Category: Neurology Authors: Deblina Biswas Rebecca Banerjee Swagata Sarkar Supriyo Choudhury Pritimoy Sanyal Mona Tiwari Hrishikesh Kumar Source Type: research

An MRI based ischemic stroke classification & #8211; A mechanism oriented approach
James Jose, Joe JamesAnnals of Indian Academy of Neurology 2022 25(6):1019-1028 Oxfordshire Community Stroke Project and Trial of Org 10172 in acute stroke treatment are the commonly used ischemic stroke classification systems at present. However, they underutilize the newer imaging technologies. Diffusion-weighted magnetic resonance imaging (DW-MRI) of the brain can detect the site and extent of infarcts accurately. From the MRI patterns, the mechanisms of ischemic stroke can be inferred. We propose to classify ischemic infarcts into the following types based on their DW-MRI appearance: cortical territorial infarcts, str...
Source: Annals of Indian Academy of Neurology - December 3, 2022 Category: Neurology Authors: James Jose Joe James Source Type: research