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Serotonin receptor agonist and risk of paresthesia in migraine patients: A dose-response model-based (network) meta-analysis
Conclusions: This meta-analysis of reported placebo-controlled clinical trials suggests that the SUCRA probabilities for the manifestation of paresthesia are higher with Lasmiditan. The relative risk of paresthesia is higher with the use of Topiramate 200 mg, Lasmiditan 400 mg, and Zolmitriptan 10 mg. In addition, Lasmiditan exhibited a gradual dose-response of relative risk for the manifestation of paresthesia. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - September 9, 2022 Category: Neurology Authors: Sayed Aliul Hasan Abdi Shabihul Fatma Sayed Jamuna Bhaskar Source Type: research

Evaluation of asymptomatic carotid artery stenosis prior to coronary artery bypass grafting - A prospective observational study in North Indian population
Conclusion: The presence of significant carotid vessel stenosis in patients undergoing CABG in the Indian population has a stronger association with the chronicity of the coronary artery disease rather than the coronary atheroma load (as determined by the modified Gensini score). The presence of significant LM disease and coronary artery calcification may be useful in detecting high-risk patients for significant CAS during the pre-surgical workup. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - September 9, 2022 Category: Neurology Authors: Arghadip Bose Krishna Prasad Uma Debi Harkant Singh Prashant Panda Saurabh Mehrotra Source Type: research

Annual cost of care of Parkinson & #39;s Disease and its determinants in North India & #8211; A cost of illness study with patient perspective
Conclusion: Annual cost of care of Parkinson's disease is high and increases with the duration of the disease as well as the progression of the disease. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - September 9, 2022 Category: Neurology Authors: Vipin Ola Inder Puri Divya Goswami Deepti Vibha Garima Shukla Vinay Goyal Achal Srivastava Madhuri Behari Source Type: research

Cranial autonomic symptoms in migraine: An observational study
Conclusion: Our study showed that CASs in migraine is common and bilateral. Sunlight triggers headache in almost all CAS positive patients. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - September 9, 2022 Category: Neurology Authors: Ashutosh Tiwari Pradeep K Maurya Abdul Qavi Dinkar Kulshreshtha Anup K Thacker Ajai K Singh Source Type: research

Spinocerebellar ataxia 12 patients have better quality of life than spinocerebellar ataxia 1 and 2
Conclusions: Our study suggests that despite older age and comparable disease duration, SCA12 patients experience better QoL, less severe depression and ataxia versus SCA1 and SCA2. Severity of ataxia and depression are significant predictors of QoL among the three SCA types. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - September 9, 2022 Category: Neurology Authors: Surekha Dabla Divyani Garg Rajeev Aggarwal Nand Kumar Mohammad Faruq Roopa Rajan Garima Shukla Vinay Goyal Ravindra Mohan Pandey Achal Kumar Srivastava Source Type: research

Study Protocol: IMPETUS: Implementing a uniform stroke care pathway in medical colleges of India: IMPETUS Stroke
We present here a protocol to investigate the feasibility and fidelity of implementing a uniform stroke care pathway in medical colleges of India. Methods and Analysis: This is a multicentric, prospective, multiphase, mixed-method, quasi-experimental implementation study intended to examine the changes in a select set of stroke care-related indicators over time within the sites exposed to the same implementation strategy. We shall conduct process evaluation of the implementation process as well as evaluate the effect of the implementation strategy using the interrupted time series design. During implementation phase, educa...
Source: Annals of Indian Academy of Neurology - September 9, 2022 Category: Neurology Authors: Rohit Bhatia Partha Haldar Inder Puri MV Padma Srivastava Sanjeev Bhoi Menka Jha Anupam Dey Suprava Naik Satyabrata Guru Mamta Bhushan Singh VY Vishnu Roopa Rajan Anu Gupta Deepti Vibha Awadh Kishore Pandit Ayush Agarwal Manish Salunkhe Gunjan Singh Deeps Source Type: research

Propensity of stroke in standard versus various aortic arch variants: A 200 patients study
Conclusions: Standard aortic arch Type 2, bovine aortic arch Type A, and Type B are associated with an early age at stroke presentation. During routine carotid evaluation by CT or MR angiography in stroke patients, it would be better to evaluate the aortic arch as well, especially in young patients. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - September 9, 2022 Category: Neurology Authors: Swapnil Samadhiya Vijay Sardana Bharat Bhushan Dilip Maheshwari Seeta Ram Yadav Ravi Goyal Source Type: research

Predictors of early neurological deterioration following intravenous thrombolysis: Difference between risk factors for ischemic and hemorrhagic worsening
Conclusion: END occurs in one fifth of patients after intravenous thrombolysis; ENDi outnumbers ENDh. Proximal artery occlusion is a major predictor for END. Potentially modifiable risk factors include admission hyperglycemia and elevated blood pressures. Distinct factors characterize ENDh and ENDi and can guide prevention and management strategies. IScore identifies patients at risk for END. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - September 9, 2022 Category: Neurology Authors: Srikumar B Nair Deepthi Somarajan Rammohan K Pillai Keerthi Balachandran Sona Sathian Source Type: research

The genetic landscape of polymicrogyria
Jesmy James, Mary Iype, Mithran Omana Surendran, Ayyappan Anitha, Sanjeev V ThomasAnnals of Indian Academy of Neurology 2022 25(4):616-626 Polymicrogyria (PMG) is a relatively common complex malformation with cortical development, characterized by an exorbitant number of abnormally tiny gyri separated by shallow sulci. It is a neuronal migration disorder. Familial cases of PMG and the manifestation of PMG in patients with chromosomal aberrations and mutations indicate their important role of genetics in this disorder. The highly stereotyped and well-conserved nature of the cortical folding pattern in humans is suggestive ...
Source: Annals of Indian Academy of Neurology - September 9, 2022 Category: Neurology Authors: Jesmy James Mary Iype Mithran Omana Surendran Ayyappan Anitha Sanjeev V Thomas Source Type: research

Mechanical thrombectomy: Review
Chintan Prajapati, Vikram Huded, Niranjan Mahajan, Anirudh KulkarniAnnals of Indian Academy of Neurology 2022 25(4):606-615 Large vessel occlusion stroke contributes to disability and mortality out of proportion to its incidence. Over time it was noted that intravenous thrombolysis alone was not sufficient for this stroke type. Slowly, endovascular approach and mechanical clot retrieval have come out to be the biggest advances in the field of neurology as well as modern medicine. Although the careful selection of patients is needed as standardized by landmark trials. At the same time, thrombectomy is now being studied in ...
Source: Annals of Indian Academy of Neurology - September 9, 2022 Category: Neurology Authors: Chintan Prajapati Vikram Huded Niranjan Mahajan Anirudh Kulkarni Source Type: research

Cognition in trinucleotide repeat spinocerebellar ataxias: A review
Ayush Agarwal, Pankaj , Mohd Faruq, Ajay Garg, Achal K SrivastavaAnnals of Indian Academy of Neurology 2022 25(4):601-605 Spinocerebellar ataxias (SCAs) comprise a group of complex and heterogeneous hereditary neurodegenerative disorders characterized by cerebellar ataxia, with ophthalmoplegia, pyramidal and extrapyramidal features, peripheral neuropathy, motor neuron disease, pigmentary retinopathy, epilepsy, and dementia in varying proportions. Cognitive impairment is not frequent in SCAs but is rarely noticed since it gets camouflaged behind the exorbitant ataxic manifestations of the disease. The exact incidence and e...
Source: Annals of Indian Academy of Neurology - September 9, 2022 Category: Neurology Authors: Ayush Agarwal Pankaj Mohd Faruq Ajay Garg Achal K Srivastava Source Type: research

Fever, seizures and encephalopathy: From bush fires to firestorms
Prabhjot Kaur, Suvasini Sharma, Ramesh Konanki, Asuri N PrasadAnnals of Indian Academy of Neurology 2022 25(4):587-600 Fever-associated seizures and febrile encephalopathy are common neurological problems in children. Infections of the nervous system are responsible for the majority of cases. However, there is a spectrum of infection-associated and inflammatory conditions associated with the triad of fever, seizures, and encephalopathy. Apart from complex febrile seizures and febrile status epilepticus, fever infection-related epilepsy syndrome of childhood (FIRES), infantile hemiconvulsion hemiplegia epilepsy syndrome (I...
Source: Annals of Indian Academy of Neurology - September 9, 2022 Category: Neurology Authors: Prabhjot Kaur Suvasini Sharma Ramesh Konanki Asuri N Prasad Source Type: research

Management of wilson disease: The quest continues
Gautam Kamila, Biswaroop ChakrabartyAnnals of Indian Academy of Neurology 2022 25(4):585-586 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - September 9, 2022 Category: Neurology Authors: Gautam Kamila Biswaroop Chakrabarty Source Type: research

Quantifying quality of life after stroke
MV Padma Srivastava, Venugopalan Y VishnuAnnals of Indian Academy of Neurology 2022 25(4):583-584 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - September 9, 2022 Category: Neurology Authors: MV Padma Srivastava Venugopalan Y Vishnu Source Type: research

Prioritizing neuro-rehabilitation services in low-and middle-income countries: Needs, challenges and possible solutions
Alvee Saluja, Rajinder K DhamijaAnnals of Indian Academy of Neurology 2022 25(4):579-582 (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - September 9, 2022 Category: Neurology Authors: Alvee Saluja Rajinder K Dhamija Source Type: research