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Nutrition: Iron
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Total 471 results found since Jan 2013.
The Role of Ferroptosis in Nervous System Disorders
J Integr Neurosci. 2023 Jan 16;22(1):19. doi: 10.31083/j.jin2201019.ABSTRACTFerroptosis is distinct from other apoptotic forms of programmed cell death and is characterized by the accumulation of iron and lipid peroxidation. Iron plays a crucial role in the oxidation of lipids via the Fenton reaction with oxygen. Hence, iron accumulation causes phospholipid peroxidation which induces ferroptosis. Moreover, detoxification by glutathione is disrupted during ferroptosis. A growing number of studies have implicated ferroptosis in nervous system disorders such as depression, neurodegenerative disease, stroke, traumatic brain in...
Source: Journal of Integrative Neuroscience - February 1, 2023 Category: Neuroscience Authors: Lixia Du You Wu Zhongmin Fan Yi Li Xiaofeng Guo Zongping Fang Xijing Zhang Source Type: research
Elabela-APJ axis attenuates cerebral ischemia/reperfusion injury by inhibiting neuronal ferroptosis
Free Radic Biol Med. 2023 Jan 18:S0891-5849(23)00009-6. doi: 10.1016/j.freeradbiomed.2023.01.008. Online ahead of print.ABSTRACTFerroptosis is a form of non-apoptotic cell death caused by iron-dependent peroxidation of lipids. It contributes to ischemic stroke-induced neuronal damage. Elabela (ELA), a novel endogenous ligand for Apelin receptor (APJ), regulates oxidative stress and exerts a protective role in cardiovascular disease. However, the effect of ELA-APJ axis on cellular ferroptosis in cerebral ischemia/reperfusion (I/R) remains elusive. The present study showed that ELA and APJ were expressed on neurons and incre...
Source: Free Radical Biology and Medicine - January 21, 2023 Category: Biology Authors: Pengfei Xu Lingqi Kong Chunrong Tao Yuyou Zhu Juan Cheng Wenyu Li Nan Shen Rui Li Chao Zhang Li Wang Yan Zhang Guoping Wang Xinfeng Liu Wen Sun Wei Hu Source Type: research
Iron Chelation Therapy to Prevent Post-Stroke Cognitive Impairments: Role of Diabetes and Sex
Am J Physiol Heart Circ Physiol. 2023 Jan 6. doi: 10.1152/ajpheart.00004.2023. Online ahead of print.NO ABSTRACTPMID:36607799 | DOI:10.1152/ajpheart.00004.2023
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 6, 2023 Category: Physiology Authors: Siva S V P Sakamuri Venkata N Sure Prasad V G Katakam Source Type: research
