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The Role of Ferroptosis in Nervous System Disorders
J Integr Neurosci. 2023 Jan 16;22(1):19. doi: 10.31083/j.jin2201019.ABSTRACTFerroptosis is distinct from other apoptotic forms of programmed cell death and is characterized by the accumulation of iron and lipid peroxidation. Iron plays a crucial role in the oxidation of lipids via the Fenton reaction with oxygen. Hence, iron accumulation causes phospholipid peroxidation which induces ferroptosis. Moreover, detoxification by glutathione is disrupted during ferroptosis. A growing number of studies have implicated ferroptosis in nervous system disorders such as depression, neurodegenerative disease, stroke, traumatic brain in...
Source: Journal of Integrative Neuroscience - February 1, 2023 Category: Neuroscience Authors: Lixia Du You Wu Zhongmin Fan Yi Li Xiaofeng Guo Zongping Fang Xijing Zhang Source Type: research
