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Nutrition: Iron
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Total 471 results found since Jan 2013.
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury
Neurochem Res. 2022 Nov 19. doi: 10.1007/s11064-022-03822-7. Online ahead of print.ABSTRACTFerroptosis is characterized by excessive accumulation of iron and lipid peroxides, which are involved in ischemia, reperfusion-induced organ injury, and stroke. Propofol, an anesthetic agent, has neuroprotective effects due to its potent antioxidant, anti-ischemic, and anti-inflammatory properties. However, the relationship between propofol and ferroptosis is still unclear. In the current study, we elucidated the role of ferroptosis in the neuroprotective effect of propofol in mouse brains subjected to cerebral ischemia reperfusion ...
Source: Neurochemical Research - November 19, 2022 Category: Neuroscience Authors: Gui-Bo Fan Yan Li Gao-Shuo Xu A-Yang Zhao Hong-Jiang Jin Si-Qi Sun Si-Hua Qi Source Type: research
Taurine attenuates neuronal ferroptosis by regulating GABA < sub > B < /sub > /AKT/GSK3 β/β-catenin pathway after subarachnoid hemorrhage
Free Radic Biol Med. 2022 Nov 16:S0891-5849(22)00965-0. doi: 10.1016/j.freeradbiomed.2022.11.003. Online ahead of print.ABSTRACTFerroptosis, characterized by lipid peroxidation and intracellular iron accumulation, has been reported to be involving in the pathophysiological of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Although taurine reportedly yields neuroprotective effects in multiple central neurological diseases and can attenuated neuron damage after stroke, its role in EBI after SAH remains unclear. The present study indicated that taurine levels in cerebrospinal fluid were significantly reduced in...
Source: Free Radical Biology and Medicine - November 19, 2022 Category: Biology Authors: Chengli Liu Peibang He Yujia Guo Qi Tian Jianfeng Wang Guijun Wang Zhan Zhang Mingchang Li Source Type: research
CROI 2022: neurologic complications of HIV-1, SARS-CoV-2, and other pathogens
Top Antivir Med. 2022 Oct-Nov;30(3):475-489.ABSTRACTThe 2022 Conference on Retroviruses and Opportunistic Infections featured new and important findings about the neurologic complications of HIV-1, COVID-19, and other infections. Long-term analyses identified that cognitive decline over time, phenotypic aging, and stroke are associated with various comorbidities in people with HIV. Neuroimaging studies showed greater neuroinflammation, white matter damage, demyelination, and overall brain aging in people with chronic HIV infection. Childhood trauma and exposure to environmental pollutants contribute to these neuroimaging f...
Source: Topics in HIV Medicine - November 8, 2022 Category: Infectious Diseases Authors: Albert M Anderson Scott L Letendre Beau M Ances Source Type: research
New insights in ferroptosis: Potential therapeutic targets for the treatment of ischemic stroke
In conclusion, ferroptosis, as a new form of cell death, plays a key role in ischemic stroke and is expected to become a new therapeutic target for this disease.
Source: Frontiers in Pharmacology - November 8, 2022 Category: Drugs & Pharmacology Source Type: research
cGAS-STING pathway aggravates early cerebral ischemia-reperfusion injury in mice by activating NCOA4-mediated ferritinophagy
In conclusion, our results suggest that activation of the cGAS-STING pathway exacerbates CIRI at the early stage of CIR, which may be achieved by mediating NCOA4-mediated ferritinophagy.PMID:36343680 | DOI:10.1016/j.expneurol.2022.114269
Source: Experimental Neurology - November 7, 2022 Category: Neurology Authors: Bingyu Li Wei Wang Yanan Li Su Wang Hengjuan Liu Zhongyuan Xia Wenwei Gao Bo Zhao Source Type: research
‘Intriguing’: Doctors suspect iron deficiency to blame for woman’s stroke while driving
Low levels of iron are associated with low levels of haemoglobin, a substance in the blood that carries oxygen around the body.
Source: Daily Express - Health - November 1, 2022 Category: Consumer Health News Source Type: news
