cGAS-STING pathway aggravates early cerebral ischemia-reperfusion injury in mice by activating NCOA4-mediated ferritinophagy

In conclusion, our results suggest that activation of the cGAS-STING pathway exacerbates CIRI at the early stage of CIR, which may be achieved by mediating NCOA4-mediated ferritinophagy.PMID:36343680 | DOI:10.1016/j.expneurol.2022.114269

Source: Experimental Neurology - November 7, 2022 Category: Neurology Authors: Bingyu Li Wei Wang Yanan Li Su Wang Hengjuan Liu Zhongyuan Xia Wenwei Gao Bo Zhao Source Type: research