γ‑AApeptides as a New Class of Peptidomimetics: Design, Synthesis, and Applications
Curr Top Med Chem. 2021 Jul 27. doi: 10.2174/1568026621666210727160852. Online ahead of print.ABSTRACTPeptidomimetics are studied for medicinal application because of its ability to mimic hierarchical structures of peptides and proteins. To break the limitation and expand the peptidomimetics family, a new class of peptidomimetics based on peptide nucleic acids (PNAs) backbone - "γ-AApeptides" was developed. Compared with previous peptidomimetics, γ-AApeptides possess prominent advantages such as resistance to proteolytic degradation, enhanced chemodiversity, good selectivity and outstanding bioactivit...
Source: Topics in HIV Medicine - July 28, 2021 Category: Infectious Diseases Authors: Ma Su Yifan Zhu Wei Wang Feng Liu Huanqiu Li Source Type: research

γ‑AApeptides as a New Class of Peptidomimetics: Design, Synthesis, and Applications
Curr Top Med Chem. 2021 Jul 27. doi: 10.2174/1568026621666210727160852. Online ahead of print.ABSTRACTPeptidomimetics are studied for medicinal application because of its ability to mimic hierarchical structures of peptides and proteins. To break the limitation and expand the peptidomimetics family, a new class of peptidomimetics based on peptide nucleic acids (PNAs) backbone - "γ-AApeptides" was developed. Compared with previous peptidomimetics, γ-AApeptides possess prominent advantages such as resistance to proteolytic degradation, enhanced chemodiversity, good selectivity and outstanding bioactivit...
Source: Topics in HIV Medicine - July 28, 2021 Category: Infectious Diseases Authors: Ma Su Yifan Zhu Wei Wang Feng Liu Huanqiu Li Source Type: research

Interview-Rated Meaning and Survival over 17 Years in People Living with HIV
CONCLUSIONS: Meaning assessed by interview (both by interviewer- and transcript-rating) predicted greater survival over 17 years in PLWH, and did so above positive emotion. This adds to a literature that is primarily based on self-report questionnaires. Meaning may have beneficial effects for both psychological and physical health in PLWH.PMID:34267088 | DOI:10.1097/PSY.0000000000000963 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - July 16, 2021 Category: Infectious Diseases Authors: Gail Ironson Rachel Verhagen Beatriz da Rosa Emily Hylton Source Type: research

Reaching Absent and Refusing Individuals During Home-Based HIV Testing Through Self-Testing-at What Cost?
Conclusion: During home-based HIV testing in Lesotho, the secondary distribution of self-tests for persons absent or refusing to test during the visit reduced the costs per person tested and thus presents a promising add-on for such campaigns. Trial Registration:https://ClinicalTrials.gov/, identifier: NCT03598686.PMID:34268321 | PMC:PMC8276095 | DOI:10.3389/fmed.2021.653677 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - July 16, 2021 Category: Infectious Diseases Authors: Alain Amstutz Lineo Matsela Thabo Ishmael Lejone Mathebe Kopo Tracy Ren ée Glass Niklaus Daniel Labhardt Source Type: research

Interview-Rated Meaning and Survival over 17 Years in People Living with HIV
CONCLUSIONS: Meaning assessed by interview (both by interviewer- and transcript-rating) predicted greater survival over 17 years in PLWH, and did so above positive emotion. This adds to a literature that is primarily based on self-report questionnaires. Meaning may have beneficial effects for both psychological and physical health in PLWH.PMID:34267088 | DOI:10.1097/PSY.0000000000000963 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - July 16, 2021 Category: Infectious Diseases Authors: Gail Ironson Rachel Verhagen Beatriz da Rosa Emily Hylton Source Type: research

Reaching Absent and Refusing Individuals During Home-Based HIV Testing Through Self-Testing-at What Cost?
Conclusion: During home-based HIV testing in Lesotho, the secondary distribution of self-tests for persons absent or refusing to test during the visit reduced the costs per person tested and thus presents a promising add-on for such campaigns. Trial Registration:https://ClinicalTrials.gov/, identifier: NCT03598686.PMID:34268321 | PMC:PMC8276095 | DOI:10.3389/fmed.2021.653677 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - July 16, 2021 Category: Infectious Diseases Authors: Alain Amstutz Lineo Matsela Thabo Ishmael Lejone Mathebe Kopo Tracy Ren ée Glass Niklaus Daniel Labhardt Source Type: research

Interview-Rated Meaning and Survival over 17 Years in People Living with HIV
CONCLUSIONS: Meaning assessed by interview (both by interviewer- and transcript-rating) predicted greater survival over 17 years in PLWH, and did so above positive emotion. This adds to a literature that is primarily based on self-report questionnaires. Meaning may have beneficial effects for both psychological and physical health in PLWH.PMID:34267088 | DOI:10.1097/PSY.0000000000000963 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - July 16, 2021 Category: Infectious Diseases Authors: Gail Ironson Rachel Verhagen Beatriz da Rosa Emily Hylton Source Type: research

Reaching Absent and Refusing Individuals During Home-Based HIV Testing Through Self-Testing-at What Cost?
Conclusion: During home-based HIV testing in Lesotho, the secondary distribution of self-tests for persons absent or refusing to test during the visit reduced the costs per person tested and thus presents a promising add-on for such campaigns. Trial Registration:https://ClinicalTrials.gov/, identifier: NCT03598686.PMID:34268321 | PMC:PMC8276095 | DOI:10.3389/fmed.2021.653677 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - July 16, 2021 Category: Infectious Diseases Authors: Alain Amstutz Lineo Matsela Thabo Ishmael Lejone Mathebe Kopo Tracy Ren ée Glass Niklaus Daniel Labhardt Source Type: research

Interview-Rated Meaning and Survival over 17 Years in People Living with HIV
CONCLUSIONS: Meaning assessed by interview (both by interviewer- and transcript-rating) predicted greater survival over 17 years in PLWH, and did so above positive emotion. This adds to a literature that is primarily based on self-report questionnaires. Meaning may have beneficial effects for both psychological and physical health in PLWH.PMID:34267088 | DOI:10.1097/PSY.0000000000000963 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - July 16, 2021 Category: Infectious Diseases Authors: Gail Ironson Rachel Verhagen Beatriz da Rosa Emily Hylton Source Type: research

Reaching Absent and Refusing Individuals During Home-Based HIV Testing Through Self-Testing-at What Cost?
Conclusion: During home-based HIV testing in Lesotho, the secondary distribution of self-tests for persons absent or refusing to test during the visit reduced the costs per person tested and thus presents a promising add-on for such campaigns. Trial Registration:https://ClinicalTrials.gov/, identifier: NCT03598686.PMID:34268321 | PMC:PMC8276095 | DOI:10.3389/fmed.2021.653677 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - July 16, 2021 Category: Infectious Diseases Authors: Alain Amstutz Lineo Matsela Thabo Ishmael Lejone Mathebe Kopo Tracy Ren ée Glass Niklaus Daniel Labhardt Source Type: research

Interview-Rated Meaning and Survival over 17 Years in People Living with HIV
CONCLUSIONS: Meaning assessed by interview (both by interviewer- and transcript-rating) predicted greater survival over 17 years in PLWH, and did so above positive emotion. This adds to a literature that is primarily based on self-report questionnaires. Meaning may have beneficial effects for both psychological and physical health in PLWH.PMID:34267088 | DOI:10.1097/PSY.0000000000000963 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - July 16, 2021 Category: Infectious Diseases Authors: Gail Ironson Rachel Verhagen Beatriz da Rosa Emily Hylton Source Type: research

Reaching Absent and Refusing Individuals During Home-Based HIV Testing Through Self-Testing-at What Cost?
Conclusion: During home-based HIV testing in Lesotho, the secondary distribution of self-tests for persons absent or refusing to test during the visit reduced the costs per person tested and thus presents a promising add-on for such campaigns. Trial Registration:https://ClinicalTrials.gov/, identifier: NCT03598686.PMID:34268321 | PMC:PMC8276095 | DOI:10.3389/fmed.2021.653677 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - July 16, 2021 Category: Infectious Diseases Authors: Alain Amstutz Lineo Matsela Thabo Ishmael Lejone Mathebe Kopo Tracy Ren ée Glass Niklaus Daniel Labhardt Source Type: research

Interview-Rated Meaning and Survival over 17 Years in People Living with HIV
CONCLUSIONS: Meaning assessed by interview (both by interviewer- and transcript-rating) predicted greater survival over 17 years in PLWH, and did so above positive emotion. This adds to a literature that is primarily based on self-report questionnaires. Meaning may have beneficial effects for both psychological and physical health in PLWH.PMID:34267088 | DOI:10.1097/PSY.0000000000000963 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - July 16, 2021 Category: Infectious Diseases Authors: Gail Ironson Rachel Verhagen Beatriz da Rosa Emily Hylton Source Type: research

Reaching Absent and Refusing Individuals During Home-Based HIV Testing Through Self-Testing-at What Cost?
Conclusion: During home-based HIV testing in Lesotho, the secondary distribution of self-tests for persons absent or refusing to test during the visit reduced the costs per person tested and thus presents a promising add-on for such campaigns. Trial Registration:https://ClinicalTrials.gov/, identifier: NCT03598686.PMID:34268321 | PMC:PMC8276095 | DOI:10.3389/fmed.2021.653677 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - July 16, 2021 Category: Infectious Diseases Authors: Alain Amstutz Lineo Matsela Thabo Ishmael Lejone Mathebe Kopo Tracy Ren ée Glass Niklaus Daniel Labhardt Source Type: research

Interview-Rated Meaning and Survival over 17 Years in People Living with HIV
CONCLUSIONS: Meaning assessed by interview (both by interviewer- and transcript-rating) predicted greater survival over 17 years in PLWH, and did so above positive emotion. This adds to a literature that is primarily based on self-report questionnaires. Meaning may have beneficial effects for both psychological and physical health in PLWH.PMID:34267088 | DOI:10.1097/PSY.0000000000000963 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - July 16, 2021 Category: Infectious Diseases Authors: Gail Ironson Rachel Verhagen Beatriz da Rosa Emily Hylton Source Type: research

Reaching Absent and Refusing Individuals During Home-Based HIV Testing Through Self-Testing-at What Cost?
Conclusion: During home-based HIV testing in Lesotho, the secondary distribution of self-tests for persons absent or refusing to test during the visit reduced the costs per person tested and thus presents a promising add-on for such campaigns. Trial Registration:https://ClinicalTrials.gov/, identifier: NCT03598686.PMID:34268321 | PMC:PMC8276095 | DOI:10.3389/fmed.2021.653677 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - July 16, 2021 Category: Infectious Diseases Authors: Alain Amstutz Lineo Matsela Thabo Ishmael Lejone Mathebe Kopo Tracy Ren ée Glass Niklaus Daniel Labhardt Source Type: research

Interview-Rated Meaning and Survival over 17 Years in People Living with HIV
CONCLUSIONS: Meaning assessed by interview (both by interviewer- and transcript-rating) predicted greater survival over 17 years in PLWH, and did so above positive emotion. This adds to a literature that is primarily based on self-report questionnaires. Meaning may have beneficial effects for both psychological and physical health in PLWH.PMID:34267088 | DOI:10.1097/PSY.0000000000000963 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - July 16, 2021 Category: Infectious Diseases Authors: Gail Ironson Rachel Verhagen Beatriz da Rosa Emily Hylton Source Type: research

Reaching Absent and Refusing Individuals During Home-Based HIV Testing Through Self-Testing-at What Cost?
Conclusion: During home-based HIV testing in Lesotho, the secondary distribution of self-tests for persons absent or refusing to test during the visit reduced the costs per person tested and thus presents a promising add-on for such campaigns. Trial Registration:https://ClinicalTrials.gov/, identifier: NCT03598686.PMID:34268321 | PMC:PMC8276095 | DOI:10.3389/fmed.2021.653677 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - July 16, 2021 Category: Infectious Diseases Authors: Alain Amstutz Lineo Matsela Thabo Ishmael Lejone Mathebe Kopo Tracy Ren ée Glass Niklaus Daniel Labhardt Source Type: research

Interview-Rated Meaning and Survival over 17 Years in People Living with HIV
CONCLUSIONS: Meaning assessed by interview (both by interviewer- and transcript-rating) predicted greater survival over 17 years in PLWH, and did so above positive emotion. This adds to a literature that is primarily based on self-report questionnaires. Meaning may have beneficial effects for both psychological and physical health in PLWH.PMID:34267088 | DOI:10.1097/PSY.0000000000000963 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - July 16, 2021 Category: Infectious Diseases Authors: Gail Ironson Rachel Verhagen Beatriz da Rosa Emily Hylton Source Type: research

Reaching Absent and Refusing Individuals During Home-Based HIV Testing Through Self-Testing-at What Cost?
Conclusion: During home-based HIV testing in Lesotho, the secondary distribution of self-tests for persons absent or refusing to test during the visit reduced the costs per person tested and thus presents a promising add-on for such campaigns. Trial Registration:https://ClinicalTrials.gov/, identifier: NCT03598686.PMID:34268321 | PMC:PMC8276095 | DOI:10.3389/fmed.2021.653677 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - July 16, 2021 Category: Infectious Diseases Authors: Alain Amstutz Lineo Matsela Thabo Ishmael Lejone Mathebe Kopo Tracy Ren ée Glass Niklaus Daniel Labhardt Source Type: research

Interview-Rated Meaning and Survival over 17 Years in People Living with HIV
CONCLUSIONS: Meaning assessed by interview (both by interviewer- and transcript-rating) predicted greater survival over 17 years in PLWH, and did so above positive emotion. This adds to a literature that is primarily based on self-report questionnaires. Meaning may have beneficial effects for both psychological and physical health in PLWH.PMID:34267088 | DOI:10.1097/PSY.0000000000000963 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - July 16, 2021 Category: Infectious Diseases Authors: Gail Ironson Rachel Verhagen Beatriz da Rosa Emily Hylton Source Type: research

Reaching Absent and Refusing Individuals During Home-Based HIV Testing Through Self-Testing-at What Cost?
Conclusion: During home-based HIV testing in Lesotho, the secondary distribution of self-tests for persons absent or refusing to test during the visit reduced the costs per person tested and thus presents a promising add-on for such campaigns. Trial Registration:https://ClinicalTrials.gov/, identifier: NCT03598686.PMID:34268321 | PMC:PMC8276095 | DOI:10.3389/fmed.2021.653677 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - July 16, 2021 Category: Infectious Diseases Authors: Alain Amstutz Lineo Matsela Thabo Ishmael Lejone Mathebe Kopo Tracy Ren ée Glass Niklaus Daniel Labhardt Source Type: research

CROI 2021: Epidemiologic Trends in the HIV and SARS-CoV-2 Pandemics and HIV Prevention Research
Top Antivir Med. 2021 Apr-May;29(2):309-327.ABSTRACTAt the 2021 virtual Conference on Retroviruses and Opportunistic Infections ,several speakers described the disparities in both HIV and SARS-CoV-2 in-fections and outcomes in racial and ethnic minorities. A household survey suggested that there may have been more than 39 million SARS-CoV-2 infections in the United States by October 30, 2020, with an estimated infection fatality ratio of 0.64%; this compares with an estimated 7.3 million confirmed cases at that time. Several presentations found severe disruptions in HIV testing, prevention, and treatment services during CO...
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Susan Buchbinder Albert Liu Source Type: research

CROI 2021: Metabolic and Other Complications of HIV Infection or COVID-19
Top Antivir Med. 2021 Apr-May;29(2):328-333.ABSTRACTComorbid conditions have a major impact on the health, quality of life, and survival in people with HIV, particularly as they age. The 2021 Conference on Retroviruses and Opportunistic Infections featured excellent science related to specific comorbidities as well as multimorbidity. A number of presentations related to comorbidities in women with HIV reflected a new wave of research aimed at understanding how the epidemiology and pathogenesis of comorbidities may differ by sex. Weight gain related to antiretroviral therapy was also a major theme of the comorbidity abstrac...
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Sudipa Sarkar Todd T Brown Source Type: research

CROI 2021: Neurologic Complications of HIV-1 Infection or COVID-19
Top Antivir Med. 2021 Apr-May;29(2):334-343.ABSTRACTThe 2021 Conference on Retroviruses and Opportunistic Infections (CROI) featured a timely review of the neurologic complications of COVID-19 as well as new research findings on mechanisms by which SARS-CoV-2 may affect the brain. CROI included new and important findings about the neurologic complications of HIV-1, human polyomavirus 2 (also known as JC Virus), and cryptococcus. New long-term analyses of cognition in people with HIV-1 identified that cognitive decline over time is associated with multimorbidity, particularly diabetes, chronic lung disease, and vascular dis...
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Beau M Ances Albert M Anderson Scott L Letendre Source Type: research

CROI 2021: Tuberculosis, Opportunistic Infections, and COVID-19 Among People with HIV
Top Antivir Med. 2021 Apr-May;29(2):344-351.ABSTRACTTuberculosis (TB) remains a main driver of morbidity and mortality among people with HIV along with other opportunistic infections. This review summarizes key highlights related to TB, and other opportunistic infections in HIV as well as studies from the virtual 2021 Conference on Retroviruses and Oppoprtunitstic Infections evaluating outcomes among HIV-COVID-19 coinfected patients.PMID:34107204 | PMC:PMC8224244 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Andrew D Kerkhoff Diane V Havlir Source Type: research

Vaccination and Immunoprotection in People with HIV
This article summarizes a presentation by Steven C. Johnson, MD, at the International Antiviral Society-USA (IAS-USA) annual continuing education program held in New York, New York, in September 2019.PMID:34107205 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Steven C Johnson Source Type: research

Physical Function and Frailty in HIV
This article summarizes an International Antiviral Society-USA (IAS-USA) webinar presented by Kristine M. Erlandson, MD, MS, on July 24, 2020. This webinar is available on demand at https://www.iasusa.org/courses/on-demand-webinar-2020-erlandson/.PMID:34107206 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Kristine M Erlandson Source Type: research

Management and Prevention of HIV Among Transgender Adults
This article summarizes an International Antiviral Society-USA (IAS-USA) webinar presented by Asa E. Radix, MD, PhD, MPH, on August 18, 2020. This webinar is available on demand at https://www.iasusa.org/courses/on-demand-webinar-2020-radix/.PMID:34107207 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Asa E Radix Source Type: research

CROI 2021: Epidemiologic Trends in the HIV and SARS-CoV-2 Pandemics and HIV Prevention Research
Top Antivir Med. 2021 Apr-May;29(2):309-327.ABSTRACTAt the 2021 virtual Conference on Retroviruses and Opportunistic Infections ,several speakers described the disparities in both HIV and SARS-CoV-2 in-fections and outcomes in racial and ethnic minorities. A household survey suggested that there may have been more than 39 million SARS-CoV-2 infections in the United States by October 30, 2020, with an estimated infection fatality ratio of 0.64%; this compares with an estimated 7.3 million confirmed cases at that time. Several presentations found severe disruptions in HIV testing, prevention, and treatment services during CO...
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Susan Buchbinder Albert Liu Source Type: research

CROI 2021: Metabolic and Other Complications of HIV Infection or COVID-19
Top Antivir Med. 2021 Apr-May;29(2):328-333.ABSTRACTComorbid conditions have a major impact on the health, quality of life, and survival in people with HIV, particularly as they age. The 2021 Conference on Retroviruses and Opportunistic Infections featured excellent science related to specific comorbidities as well as multimorbidity. A number of presentations related to comorbidities in women with HIV reflected a new wave of research aimed at understanding how the epidemiology and pathogenesis of comorbidities may differ by sex. Weight gain related to antiretroviral therapy was also a major theme of the comorbidity abstrac...
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Sudipa Sarkar Todd T Brown Source Type: research

CROI 2021: Neurologic Complications of HIV-1 Infection or COVID-19
Top Antivir Med. 2021 Apr-May;29(2):334-343.ABSTRACTThe 2021 Conference on Retroviruses and Opportunistic Infections (CROI) featured a timely review of the neurologic complications of COVID-19 as well as new research findings on mechanisms by which SARS-CoV-2 may affect the brain. CROI included new and important findings about the neurologic complications of HIV-1, human polyomavirus 2 (also known as JC Virus), and cryptococcus. New long-term analyses of cognition in people with HIV-1 identified that cognitive decline over time is associated with multimorbidity, particularly diabetes, chronic lung disease, and vascular dis...
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Beau M Ances Albert M Anderson Scott L Letendre Source Type: research

CROI 2021: Tuberculosis, Opportunistic Infections, and COVID-19 Among People with HIV
Top Antivir Med. 2021 Apr-May;29(2):344-351.ABSTRACTTuberculosis (TB) remains a main driver of morbidity and mortality among people with HIV along with other opportunistic infections. This review summarizes key highlights related to TB, and other opportunistic infections in HIV as well as studies from the virtual 2021 Conference on Retroviruses and Oppoprtunitstic Infections evaluating outcomes among HIV-COVID-19 coinfected patients.PMID:34107204 | PMC:PMC8224244 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Andrew D Kerkhoff Diane V Havlir Source Type: research

Vaccination and Immunoprotection in People with HIV
This article summarizes a presentation by Steven C. Johnson, MD, at the International Antiviral Society-USA (IAS-USA) annual continuing education program held in New York, New York, in September 2019.PMID:34107205 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Steven C Johnson Source Type: research

Physical Function and Frailty in HIV
This article summarizes an International Antiviral Society-USA (IAS-USA) webinar presented by Kristine M. Erlandson, MD, MS, on July 24, 2020. This webinar is available on demand at https://www.iasusa.org/courses/on-demand-webinar-2020-erlandson/.PMID:34107206 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Kristine M Erlandson Source Type: research

Management and Prevention of HIV Among Transgender Adults
This article summarizes an International Antiviral Society-USA (IAS-USA) webinar presented by Asa E. Radix, MD, PhD, MPH, on August 18, 2020. This webinar is available on demand at https://www.iasusa.org/courses/on-demand-webinar-2020-radix/.PMID:34107207 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Asa E Radix Source Type: research

CROI 2021: Epidemiologic Trends in the HIV and SARS-CoV-2 Pandemics and HIV Prevention Research
Top Antivir Med. 2021 Apr-May;29(2):309-327.ABSTRACTAt the 2021 virtual Conference on Retroviruses and Opportunistic Infections ,several speakers described the disparities in both HIV and SARS-CoV-2 in-fections and outcomes in racial and ethnic minorities. A household survey suggested that there may have been more than 39 million SARS-CoV-2 infections in the United States by October 30, 2020, with an estimated infection fatality ratio of 0.64%; this compares with an estimated 7.3 million confirmed cases at that time. Several presentations found severe disruptions in HIV testing, prevention, and treatment services during CO...
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Susan Buchbinder Albert Liu Source Type: research

CROI 2021: Metabolic and Other Complications of HIV Infection or COVID-19
Top Antivir Med. 2021 Apr-May;29(2):328-333.ABSTRACTComorbid conditions have a major impact on the health, quality of life, and survival in people with HIV, particularly as they age. The 2021 Conference on Retroviruses and Opportunistic Infections featured excellent science related to specific comorbidities as well as multimorbidity. A number of presentations related to comorbidities in women with HIV reflected a new wave of research aimed at understanding how the epidemiology and pathogenesis of comorbidities may differ by sex. Weight gain related to antiretroviral therapy was also a major theme of the comorbidity abstrac...
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Sudipa Sarkar Todd T Brown Source Type: research

CROI 2021: Neurologic Complications of HIV-1 Infection or COVID-19
Top Antivir Med. 2021 Apr-May;29(2):334-343.ABSTRACTThe 2021 Conference on Retroviruses and Opportunistic Infections (CROI) featured a timely review of the neurologic complications of COVID-19 as well as new research findings on mechanisms by which SARS-CoV-2 may affect the brain. CROI included new and important findings about the neurologic complications of HIV-1, human polyomavirus 2 (also known as JC Virus), and cryptococcus. New long-term analyses of cognition in people with HIV-1 identified that cognitive decline over time is associated with multimorbidity, particularly diabetes, chronic lung disease, and vascular dis...
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Beau M Ances Albert M Anderson Scott L Letendre Source Type: research

CROI 2021: Tuberculosis, Opportunistic Infections, and COVID-19 Among People with HIV
Top Antivir Med. 2021 Apr-May;29(2):344-351.ABSTRACTTuberculosis (TB) remains a main driver of morbidity and mortality among people with HIV along with other opportunistic infections. This review summarizes key highlights related to TB, and other opportunistic infections in HIV as well as studies from the virtual 2021 Conference on Retroviruses and Oppoprtunitstic Infections evaluating outcomes among HIV-COVID-19 coinfected patients.PMID:34107204 | PMC:PMC8224244 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Andrew D Kerkhoff Diane V Havlir Source Type: research

Vaccination and Immunoprotection in People with HIV
This article summarizes a presentation by Steven C. Johnson, MD, at the International Antiviral Society-USA (IAS-USA) annual continuing education program held in New York, New York, in September 2019.PMID:34107205 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Steven C Johnson Source Type: research

Physical Function and Frailty in HIV
This article summarizes an International Antiviral Society-USA (IAS-USA) webinar presented by Kristine M. Erlandson, MD, MS, on July 24, 2020. This webinar is available on demand at https://www.iasusa.org/courses/on-demand-webinar-2020-erlandson/.PMID:34107206 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Kristine M Erlandson Source Type: research

Management and Prevention of HIV Among Transgender Adults
This article summarizes an International Antiviral Society-USA (IAS-USA) webinar presented by Asa E. Radix, MD, PhD, MPH, on August 18, 2020. This webinar is available on demand at https://www.iasusa.org/courses/on-demand-webinar-2020-radix/.PMID:34107207 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Asa E Radix Source Type: research

CROI 2021: Epidemiologic Trends in the HIV and SARS-CoV-2 Pandemics and HIV Prevention Research
Top Antivir Med. 2021 Apr-May;29(2):309-327.ABSTRACTAt the 2021 virtual Conference on Retroviruses and Opportunistic Infections ,several speakers described the disparities in both HIV and SARS-CoV-2 in-fections and outcomes in racial and ethnic minorities. A household survey suggested that there may have been more than 39 million SARS-CoV-2 infections in the United States by October 30, 2020, with an estimated infection fatality ratio of 0.64%; this compares with an estimated 7.3 million confirmed cases at that time. Several presentations found severe disruptions in HIV testing, prevention, and treatment services during CO...
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Susan Buchbinder Albert Liu Source Type: research

CROI 2021: Metabolic and Other Complications of HIV Infection or COVID-19
Top Antivir Med. 2021 Apr-May;29(2):328-333.ABSTRACTComorbid conditions have a major impact on the health, quality of life, and survival in people with HIV, particularly as they age. The 2021 Conference on Retroviruses and Opportunistic Infections featured excellent science related to specific comorbidities as well as multimorbidity. A number of presentations related to comorbidities in women with HIV reflected a new wave of research aimed at understanding how the epidemiology and pathogenesis of comorbidities may differ by sex. Weight gain related to antiretroviral therapy was also a major theme of the comorbidity abstrac...
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Sudipa Sarkar Todd T Brown Source Type: research

CROI 2021: Neurologic Complications of HIV-1 Infection or COVID-19
Top Antivir Med. 2021 Apr-May;29(2):334-343.ABSTRACTThe 2021 Conference on Retroviruses and Opportunistic Infections (CROI) featured a timely review of the neurologic complications of COVID-19 as well as new research findings on mechanisms by which SARS-CoV-2 may affect the brain. CROI included new and important findings about the neurologic complications of HIV-1, human polyomavirus 2 (also known as JC Virus), and cryptococcus. New long-term analyses of cognition in people with HIV-1 identified that cognitive decline over time is associated with multimorbidity, particularly diabetes, chronic lung disease, and vascular dis...
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Beau M Ances Albert M Anderson Scott L Letendre Source Type: research

CROI 2021: Tuberculosis, Opportunistic Infections, and COVID-19 Among People with HIV
Top Antivir Med. 2021 Apr-May;29(2):344-351.ABSTRACTTuberculosis (TB) remains a main driver of morbidity and mortality among people with HIV along with other opportunistic infections. This review summarizes key highlights related to TB, and other opportunistic infections in HIV as well as studies from the virtual 2021 Conference on Retroviruses and Oppoprtunitstic Infections evaluating outcomes among HIV-COVID-19 coinfected patients.PMID:34107204 | PMC:PMC8224244 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Andrew D Kerkhoff Diane V Havlir Source Type: research

Vaccination and Immunoprotection in People with HIV
This article summarizes a presentation by Steven C. Johnson, MD, at the International Antiviral Society-USA (IAS-USA) annual continuing education program held in New York, New York, in September 2019.PMID:34107205 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Steven C Johnson Source Type: research

Physical Function and Frailty in HIV
This article summarizes an International Antiviral Society-USA (IAS-USA) webinar presented by Kristine M. Erlandson, MD, MS, on July 24, 2020. This webinar is available on demand at https://www.iasusa.org/courses/on-demand-webinar-2020-erlandson/.PMID:34107206 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Kristine M Erlandson Source Type: research

Management and Prevention of HIV Among Transgender Adults
This article summarizes an International Antiviral Society-USA (IAS-USA) webinar presented by Asa E. Radix, MD, PhD, MPH, on August 18, 2020. This webinar is available on demand at https://www.iasusa.org/courses/on-demand-webinar-2020-radix/.PMID:34107207 (Source: Topics in HIV Medicine)
Source: Topics in HIV Medicine - June 9, 2021 Category: Infectious Diseases Authors: Asa E Radix Source Type: research