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Total 471 results found since Jan 2013.
Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions
Circ Res. 2022 Apr 15;130(8):1204-1229. doi: 10.1161/CIRCRESAHA.121.319949. Epub 2022 Apr 14.ABSTRACTIntracerebral hemorrhage (ICH) is a devastating form of stroke with high morbidity and mortality. This review article focuses on the epidemiology, cause, mechanisms of injury, current treatment strategies, and future research directions of ICH. Incidence of hemorrhagic stroke has increased worldwide over the past 40 years, with shifts in the cause over time as hypertension management has improved and anticoagulant use has increased. Preclinical and clinical trials have elucidated the underlying ICH cause and mechanisms of i...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Jessica Magid-Bernstein Romuald Girard Sean Polster Abhinav Srinath Sharbel Romanos Issam A Awad Lauren H Sansing Source Type: research
Ferroptosis —A Novel Mechanism With Multifaceted Actions on Stroke
As a neurological disease with high morbidity, disability, and mortality, the pathological mechanism underlying stroke involves complex processes such as neuroinflammation, oxidative stress, apoptosis, autophagy, and excitotoxicity; but the related research on these molecular mechanisms has not been effectively applied in clinical practice. As a form of iron-dependent regulated cell death, ferroptosis was first discovered in the pathological process of cancer, but recent studies have shown that ferroptosis is closely related to the onset and development of stroke. Therefore, a deeper understanding of the relationship betwe...
Source: Frontiers in Neurology - April 11, 2022 Category: Neurology Source Type: research
Plaque Evaluation by Ultrasound and Transcriptomics Reveals BCLAF1 as a Regulator of Smooth Muscle Cell Lipid Transdifferentiation in Atherosclerosis
CONCLUSIONS: Plaque echogenicity correlated with enrichment of distinct molecular pathways and identified BCLAF1, previously not described in atherosclerosis, as the most significant gene. Functionally, BCLAF1 seems necessary for survival and transdifferentiation of SMCs into a macrophage-like phenotype. The role of BCLAF1 in plaque vulnerability should be further evaluated.PMID:35321563 | DOI:10.1161/ATVBAHA.121.317018
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 24, 2022 Category: Cardiology Authors: Urszula Rykaczewska Quanyi Zhao Peter Saliba-Gustafsson Mariette Lengquist Malin Kronqvist Otto Bergman Zhiqiang Huang Kent Lund Katarina Waden Vila Z Pons Kenneth Caidahl Josefin Skogsberg Vladana Vukojevic Jan H N Lindeman Joy Roy G öran K Hansson Ecka Source Type: research
Carbon Monoxide Protects Neural Stem Cells Against Iron Overload by Modulating the Crosstalk Between Nrf2 and NF- κB Signaling
Neurochem Res. 2022 Mar 8. doi: 10.1007/s11064-022-03537-9. Online ahead of print.ABSTRACTAlthough accumulating evidences have demonstrated pro-survival effects of CO against various insults, the precise mechanism explaining how neural stem cells (NSCs) are protected by CO also remains largely unknown. Here we report CO pro-survival effect on NSCs against iron overload was comparable to that obtained with pharmacological inhibitors of reactive oxygen species (ROS). Its pro-survival effect was accompanied by the inhibition of ROS and subsequent inhibition of NF-κB which is mediated through nuclear factor erythroid 2-relate...
Source: Neurochemical Research - March 8, 2022 Category: Neuroscience Authors: Xie Zhengxing Hu Aiying Zhang Zongqiang Miao Zengli Source Type: research
ACSL4 contributes to ferroptosis-mediated rhabdomyolysis in exertional heat stroke
CONCLUSIONS: These findings demonstrate an important role of ACSL4 in mediating ferroptosis activation in the development of RM following EHS and suggest that targeting ACSL4 may represent a novel therapeutic strategy to limit the skeletal muscle cell death and prevent RM after EHS.PMID:35243801 | DOI:10.1002/jcsm.12953
Source: Cancer Control - March 4, 2022 Category: Cancer & Oncology Authors: Sixiao He Ru Li Yanmei Peng Ziqing Wang Junhao Huang Hongen Meng Junxia Min Fudi Wang Qiang Ma Source Type: research
Iron promotes neurological function recovery in mice with ischemic stroke through endogenous repair mechanisms
In this study, we first observed that changes in iron metabolism occured during neurological function recovery in the mice with distal middle cerebral artery occlusion (dMCAO). Our data showed that plasticity changes due to endogenous repair mechanisms resulted in improvements in cerebral cortex function. These changes involved gliosis, synaptic function reconstruction, remyelination, and activation of neural stem cells. In order to examine the potential role of iron, we synthesized liposomal-encapsulated deferoxamine (DFO) nanoparticles to further explore the effect and the mechanism of iron on the recovery of neurologica...
Source: Free Radical Biology and Medicine - February 24, 2022 Category: Biology Authors: Xin Guo Xiaofang Jin Kang Han Shaomeng Kang Siyu Tian Xin Lv Mudi Feng Huiwen Zheng Yong Zuo Guodong Xu Ming Hu Jing Xu Peiyuan Lv Yan-Zhong Chang Source Type: research
Bibliometric Analysis of Ferroptosis in Stroke From 2013 to 2021
Conclusion: Further exploration of the mechanisms of crosstalk between ferroptosis and other programmed cell death may improve clinical applications and therapeutic effects against stroke. Scholars will also continue to pay attention to and be interested in the hot topic “ferroptosis in stroke”, to produce more exciting results and provide new insights into the bottleneck of stroke treatment.
Source: Frontiers in Pharmacology - February 21, 2022 Category: Drugs & Pharmacology Source Type: research
Dynamic Changes in Brain Iron Metabolism in Neonatal Rats after Hypoxia-Ischemia
The pathogenesis of hypoxic-ischemic white matter injury (WMI) in premature infants is still unclear, and the imbalance of cerebral iron metabolism may play an important role. Our study set out to investigate the changes in iron distribution, iron content and malondialdehyde (MDA) in disparate brain regions (parietal cortex, corpus callosum, hippocampus) within 84 days after hypoxia-ischemia (HI) in neonatal rats and to clarify the role of iron metabolism in WMI.
Source: Journal of Stroke and Cerebrovascular Diseases - February 10, 2022 Category: Neurology Authors: Ding-Wang Hu, Geng Zhang, Ling Lin, Xuan-Jing Yu, Feng Wang, Qing Lin Source Type: research
Extended Ischemic Recovery After Implantation of Human Mesenchymal Stem Cell Aggregates Indicated by Sodium MRI at 21.1 T
Transl Stroke Res. 2022 Feb 7. doi: 10.1007/s12975-021-00976-4. Online ahead of print.ABSTRACTExtended therapeutic application remains a significant issue in the use of stem cell therapies to treat ischemic stroke. Along these lines, neurological recovery in a rodent model of ischemic stroke was evaluated following implantation of human mesenchymal stem cell aggregates (hMSC-agg), labeled with micron-sized particles of iron oxide, directly into the lateral ventricle contralateral to the ischemic lesion hemisphere. Longitudinally, disease progression and response to hMSC-agg therapy were assessed by 1H and 23Na magnetic res...
Source: Cell Research - February 8, 2022 Category: Cytology Authors: Shannon Helsper F Andrew Bagdasarian Xuegang Yuan Kaya Xu Jea-Young Lee Jens T Rosenberg Cesario V Borlongan Teng Ma Samuel C Grant Source Type: research
Extended Ischemic Recovery After Implantation of Human Mesenchymal Stem Cell Aggregates Indicated by Sodium MRI at 21.1 T
AbstractExtended therapeutic application remains a significant issue in the use of stem cell therapies to treat ischemic stroke. Along these lines, neurological recovery in a rodent model of ischemic stroke was evaluated following implantation of human mesenchymal stem cell aggregates (hMSC-agg), labeled with micron-sized particles of iron oxide, directly into the lateral ventricle contralateral to the ischemic lesion hemisphere. Longitudinally, disease progression and response to hMSC-agg therapy were assessed by1H and23Na magnetic resonance imaging (MRI) at 21.1 T to investigate cellular localization, migration, and re...
Source: Translational Stroke Research - February 7, 2022 Category: Neurology Source Type: research
