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Nutrition: Iron

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Total 471 results found since Jan 2013.

Safety and efficacy of iron supplementation after myocardial infarction in mice with moderate blood loss anaemia
ConclusionsIron supplementation 24  h after reperfusion of AMI is safe and reversed enlargement of end-systolic volume after AMI resulting in increased stroke volume and cardiac output. This highlights its potential as adjunctive treatment in anaemia with ID after reperfused AMI. Time point of iron application after reperfusion appe ars critical.
Source: ESC Heart Failure - October 12, 2021 Category: Cardiology Authors: Patricia Wischmann, Ramesh Chennupati, Isabella Solga, Felix Funk, Stefanie Becher, Norbert Gerdes, Stefan Anker, Malte Kelm, Christian Jung Tags: Original Research Article Source Type: research

Ferrostatin-1 Alleviates White Matter Injury Via Decreasing Ferroptosis Following Spinal Cord Injury
AbstractSpinal cord injury (SCI), a devastating neurological impairment, usually imposes a long-term psychological stress and high socioeconomic burden for the sufferers and their family. Recent researchers have paid arousing attention to white matter injury and the underlying mechanism following SCI. Ferroptosis has been revealed to be associated with diverse diseases including stroke, cancer, and kidney degeneration. Ferrostatin-1, a potent inhibitor of ferroptosis, has been illustrated to curb ferroptosis in neurons, subsequently improving functional recovery after traumatic brain injury (TBI) and SCI. However, the role...
Source: Molecular Neurobiology - October 12, 2021 Category: Neurology Source Type: research

Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke
Pharmacol Res. 2021 Oct 8:105933. doi: 10.1016/j.phrs.2021.105933. Online ahead of print.ABSTRACTIschemic stroke poses a significant health risk due to its high rate of disability and mortality. To address this problem, several therapeutic approaches have been proposed, including interruption targeting programmed cell death (PCD). Ferroptosis is a newly defined PCD characterized by iron-dependent accumulation of lipid peroxidation, and is becoming a promising target for treating numerous diseases. To explore the underlying mechanisms of the initiation and execution of ferroptosis in ischemic stroke, we established stroke m...
Source: Cell Research - October 11, 2021 Category: Cytology Authors: Chong Li Guangchi Sun Binglin Chen Lei Xu Yangfan Ye Jinyan He Zhongyuan Bao Pengzhan Zhao Zong Miao Lin Zhao Jingming Hu Yongping You Ning Liu Honglu Chao Jing Ji Source Type: research

Evaluation of brain iron content in Egyptian Patients with Sickle cell disease and its impact on Neurocognitive functions
ConclusionThe results of our study showed that even in cases of iron overload which affects vital organs as the liver, cardiac and brain iron overload don't occur.
Source: QJM - October 1, 2021 Category: Internal Medicine Source Type: research

Current Applications of Susceptibility Weighted Images in Pediatric Neurological Diseases
ConclusionIts high susceptibility for blood products, iron depositions, and calcifications makes susceptibility-weighted imaging an important additional sequence for the diagnostic workup of pediatric brain pathologic abnormalities that should be routinely added in our department. Compared with conventional MRI sequences, susceptibility-weighted imaging may show lesions with better detail and higher sensitivity. Familiarity with the pediatric susceptibility-weighted imaging signal variance is essential to prevent misdiagnosis.
Source: QJM - October 1, 2021 Category: Internal Medicine Source Type: research

Pyridoxal Isonicotinoyl Hydrazone Improves Neurological Recovery by Attenuating Ferroptosis and Inflammation in Cerebral Hemorrhagic Mice
Biomed Res Int. 2021 Sep 8;2021:9916328. doi: 10.1155/2021/9916328. eCollection 2021.ABSTRACTFerroptosis and inflammation induced by cerebral hemorrhage result in an excessive inflammatory response and irreversible neuronal injury. Alleviating ferroptosis might be an effective way to prevent neuroinflammatory injury and promote neural functional recovery. Pyridoxal isonicotinoyl hydrazine (PIH), a lipophilic iron-chelating agent, has been reported to reduce excess iron-induced cytotoxicity. However, whether PIH could ameliorate the effects of hemorrhagic stroke is not completely understood. In the present study, the preven...
Source: Biomed Res - September 20, 2021 Category: Research Authors: Hengli Zhang Min Wen Jiayu Chen Chaojie Yao Xiao Lin Zhongxiao Lin Junnan Ru Qichuan Zhuge Su Yang Source Type: research

Cerebrovascular Complications of Anemia
AbstractPurpose of the ReviewAnemia has been called the fifth cardiovascular risk factor. It is one of the most prevalent pathologies worldwide. In this article, we aimed to perform a narrative review of the main cerebrovascular complications of anemia and its influence on stroke prognosis.Recent FindingsBoth hypoproliferative anemia (thalassemia, iron deficiency anemia, etc.) and hyperproliferative anemia (sickle cell disease, paroxysmal nocturnal hemoglobinuria, hereditary spherocytosis, etc.) are associated to cerebrovascular disease ranging from transient ischemic attack to ischemic stroke and hemorrhagic stroke with b...
Source: Current Neurology and Neuroscience Reports - September 3, 2021 Category: Neuroscience Source Type: research

Dauricine alleviated secondary brain injury after intracerebral hemorrhage by upregulating GPX4 expression and inhibiting ferroptosis of nerve cells
In this study, we used the STRING protein database to predict the proteins that may be co-expressed with GPX4, and studied the ability of Dauricine(Dau) to up-regulate the expression of GPX4 against ferroptosis and neuroprotection after intracerebral hemorrhage in normal cells in vitro, glutathione peroxidase 4 (GPX4) knockdown cells and collagenase injection in vivo in mouse models of intracerebral hemorrhage. The results showed that glutathione reductase (GSR) was a possible co-expression protein with GPX4. Dau could up-regulate the expression of glutathione peroxidase 4 (GPX4) in intracerebral hemorrhage(ICH) model, nor...
Source: European Journal of Pharmacology - September 1, 2021 Category: Drugs & Pharmacology Authors: Chiwei Peng Xiang Fu Kaixuan Wang Ling Chen Beijiao Luo Ni Huang Yunfeng Luo Wei Chen Source Type: research

Iron chelation suppresses secondary bleeding after intracerebral hemorrhage in angiotensin II-infused mice
CONCLUSION: Iron overload plays a key role in secondary bleeding after ICH in Ang II-induced hypertensive mice. Iron chelation during the process of Ang II-induced hypertension suppresses secondary bleeding after ICH.PMID:34346561 | DOI:10.1111/cns.13706
Source: CNS Neuroscience and Therapeutics - August 4, 2021 Category: Neuroscience Authors: Jie Wang Xiao-Qin Tang Min Xia Cheng-Cheng Li Chao Guo Hong-Fei Ge Yi Yin Bo Wang Wei-Xiang Chen Hua Feng Source Type: research

B-po03-151 left atrial appendage occlusion as alternative approach for stroke prevention in hereditary hemorrhagic telangiectasia patients with atrial fibrillation
In this study, we evaluate the safety and efficacy of left atrial appendage occlusion (LAAO) for stroke prevention in HHT.
Source: Heart Rhythm - July 28, 2021 Category: Cardiology Authors: Mohammed Alghammass, Jad Aldanaf, Elizabeth Dranow, Kevin Whitehead Source Type: research

P-017 Evaluation of radiofrequency-induced heating in an X-ray and MR-visible interventional catheter at 3.0 T
ConclusionsInitial immersion tests suggest that the worst-case scenario for RF-induced heating of our guide catheter prototype occurs at 95 cm. During the period of our tests, our prototype remained safely under the maximum permitted temperature rise of +2°C/hr of exposure. This study suggests that our guide catheter may be retained during an intra-procedural MRI without the safety risk of RF-induced device heating over time to the patient.Disclosures B. Kilbride: None. J. Massachi: None. S. Ahn: None. K. Mueller: None. C. Jordan: None. A. Losey: None. A. Martin: None. T. Moore: None. M. Wilson: None. S. Hetts: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Kilbride, B., Massachi, J., Ahn, S., Mueller, K., Jordan, C., Losey, A., Martin, A., Moore, T., Wilson, M., Hetts, S. Tags: Oral poster abstracts Source Type: research

Development of Molecular Magnetic Resonance Imaging Tools for Risk Stratification of Carotid Atherosclerotic Disease Using Dual-Targeted Microparticles of Iron Oxide
AbstractIdentification of patients with high-risk asymptomatic carotid plaques remains a challenging but crucial step in stroke prevention. Inflammation is the key factor that drives plaque instability. Currently, there is no imaging tool in routine clinical practice to assess the inflammatory status within atherosclerotic plaques. We have developed a molecular magnetic resonance imaging (MRI) tool to quantitatively report the inflammatory activity in atherosclerosis using dual-targeted microparticles of iron oxide (DT-MPIO) against P-selectin and VCAM-1 as a smart MRI probe. A periarterial cuff was used to generate plaque...
Source: Translational Stroke Research - July 25, 2021 Category: Neurology Source Type: research

The Impact of Intravenous Iron Supplementation on Hematinic Parameters and Erythropoietin Requirements in Hemodialysis Patients
ConclusionHigh-dose intravenous iron (400  mg/week) can reduce the mean dose of rhEPO requirements and increase the TSAT index over a period of 6 months in hemodialysis patients. High-dose IV iron administration can decrease cardiovascular events in hemodialysis patients with iron deficiency anemia.
Source: Advances in Therapy - July 12, 2021 Category: Drugs & Pharmacology Source Type: research