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Nutrition: Iron

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Total 471 results found since Jan 2013.

A bibliometric analysis of cerebral microbleeds and cognitive impairment
CONCLUSION: This bibliometric analysis reveals a strong link between CMBs and cognitive impairment-related diseases and that specific brain networks were affected by CMBs. This provides further insights into the possible mechanisms and causes of CMBs and cognitive impairment. The direct and indirect damage (such as oxidative stress and neuroinflammation) to the brain caused by CMBs, destruction of the frontal-subcortical circuits, elevated Cystatin C levels, and iron deposition are involved in the occurrence and development of cognitive impairment. CMBs may be a potential marker for detecting, quantifying, and predicting c...
Source: Brain and Cognition - June 1, 2023 Category: Neurology Authors: Rui Yang Jia Li Yaya Qin Li Zhao Rong Liu Fanhui Yang Guohui Jiang Source Type: research

Epigenetic Regulation of Ferroptosis in Central Nervous System Diseases
AbstractFerroptosis, a newly identified form of cell death, is characterized by iron overload and accumulation of lipid reactive oxygen species. Inactivation of pathways, such as glutathione/glutathione peroxidase 4, NAD(P)H/ferroptosis suppressor protein 1/ubiquinone, dihydroorotate dehydrogenase/ubiquinol, or guanosine triphosphate cyclohydrolase-1/6(R)-l-erythro-5,6,7,8-tetrahydrobiopterin pathways, have been found to induce ferroptosis. The accumulating data suggest that epigenetic regulation can determine cell sensitivity to ferroptosis at both the transcriptional and translational levels. While many of the effectors ...
Source: Molecular Neurobiology - May 28, 2023 Category: Neurology Source Type: research

Iron, Ferroptosis, and Ischemic Stroke
AbstractOver 30 million people suffer from the consequences of ischemic stroke. The precise molecular mechanism of neuronal damage during ischemic stroke remains unclear; therefore, the effective treatment of post-ischemic stroke remains a critical challenge. Recently, iron has emerged as a crucial factor in post-reperfusion injuries, participating in cell peroxidation, excitotoxicity, and a distinctive cell death pathway, namely ferroptosis. Since iron is tightly regulated in the brain and important for brain functions, the imbalance of its metabolism, including its overload and deficiency, has been shown to impact ischem...
Source: Journal of Neurochemistry - March 13, 2023 Category: Neuroscience Authors: Jun Guo, Qing ‐zhang Tuo, Peng Lei Tags: REVIEW Source Type: research

Magnetically and Electrically Responsive Soft Actuator Derived from Ferromagnetic Bimetallic Organic Framework
In this work, a novel bimetallic metal-organic frameworks (MOFs) (NdFeMOFs) is developed via solvothermal synthesis method. The NdFeMOFs  shows superior electrochemical and magnetic properties after calcination, which enable their use as a dual responsive material under the external electrical and magnetic stimuli. The ability to accomplish the complex motions at ultralow input voltages and magnetic fields makes them a promising mat erial for robotic applications. With the developed electroactive and magnetoactive soft actuator, walking movement of a starfish robot is demonstrated. AbstractThe advancement in smart devices...
Source: Small - March 13, 2023 Category: Nanotechnology Authors: Pradeep Sambyal, Manmatha Mahato, Ashhad Kamal Taseer, Hyunjoon Yoo, Mousumi Garai, Van Hiep Nguyen, Syed Sheraz Ali, Il ‐Kwon Oh Tags: Research Article Source Type: research

Emerging role of miRNAs in the regulation of ferroptosis
Front Mol Biosci. 2023 Feb 15;10:1115996. doi: 10.3389/fmolb.2023.1115996. eCollection 2023.ABSTRACTFerroptosis is a kind of cell death which has distinctive features differentiating it from autophagy, necrosis and apoptosis. This iron-dependent form of cell death is described by an increase in lipid reactive oxygen species, shrinkage of mitochondria and decrease in mitochondrial cristae. Ferroptosis is involved in the initiation and progression of many diseases and is regarded as a hotspot of investigations on treatment of disorders. Recent studies have shown that microRNAs partake in the regulation of ferroptosis. The im...
Source: Atherosclerosis - March 6, 2023 Category: Cardiology Authors: Reza Mahmoudi-Lamouki Sepideh Kadkhoda Bashdar Mahmud Hussen Soudeh Ghafouri-Fard Source Type: research

Srs11-92, a ferrostatin-1 analog, improves oxidative stress and neuroinflammation via Nrf2 signal following cerebral ischemia/reperfusion injury
CONCLUSION: The findings imply that Fer-1 analog AA9 may be suitable for further translational studies for the protection of neuronal damage via Nrf2 signal pathway-mediated oxidative stress and neuroinflammation in stroke and others neurological diseases.PMID:36852441 | DOI:10.1111/cns.14130
Source: CNS Neuroscience and Therapeutics - February 28, 2023 Category: Neuroscience Authors: Yuhua Chen Wei He Hong Wei Cuicui Chang Lingjian Yang Jiao Meng Tianlin Long Quanhua Xu Chi Zhang Source Type: research

MRI for all: Cheap portable scanners aim to revolutionize medical imaging
.news-article__hero--featured .parallax__element{ object-position: 47% 50%; -o-object-position: 47% 50%; } The patient, a man in his 70s with a shock of silver hair, lies in the neuro intensive care unit (neuro ICU) at Yale New Haven Hospital. Looking at him, you’d never know that a few days earlier a tumor was removed from his pituitary gland. The operation didn’t leave a mark because, as is standard, surgeons reached the tumor through his nose. He chats cheerfully with a pair of research associates who have come to check his progress with a new and potentially revolutionary device they are testing. The cylind...
Source: Science of Aging Knowledge Environment - February 23, 2023 Category: Geriatrics Source Type: research

Role of lipocalin 2 in stroke
Neurobiol Dis. 2023 Feb 16:106044. doi: 10.1016/j.nbd.2023.106044. Online ahead of print.ABSTRACTStroke is the second leading cause of death worldwide; however, the treatment choices available to neurologists are limited in clinical practice. Lipocalin 2 (LCN2) is a secreted protein, belonging to the lipocalin superfamily, with multiple biological functions in mediating innate immune response, inflammatory response, iron-homeostasis, cell migration and differentiation, energy metabolism, and other processes in the body. LCN2 is expressed at low levels in the brain under normal physiological conditions, but its expression i...
Source: Neurobiology of Disease - February 22, 2023 Category: Neurology Authors: Ruo-Yu Zhao Peng-Ju Wei Xin Sun Dian-Hui Zhang Qian-Yan He Jie Liu Jun-Lei Chang Yi Yang Zhen-Ni Guo Source Type: research