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Total 471 results found since Jan 2013.

Ferroptosis: A new strategy for traditional Chinese medicine treatment of stroke
Biomed Pharmacother. 2022 Oct 10;156:113806. doi: 10.1016/j.biopha.2022.113806. Online ahead of print.ABSTRACTStroke is a serious threat to human survival and health due to its high morbidity and mortality. The pathological mechanism of stroke is complex and involves various regulated cell death (RCD) modalities such as autophagy, apoptosis and necroptosis. ferroptosis, a novel form of RCD characterised by iron-dependent accumulation of lipid peroxides and reactive oxygen radicals, has been found to be closely associated with the prognosis and outcome of stroke. At the same time, ferroptosis is also associated with other f...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 13, 2022 Category: Drugs & Pharmacology Authors: Yuan Lou Maoqiang Ma Yanan Jiang Haoqun Xu Zu Gao Lin Gao Yuan Wang Source Type: research

Activation of HIF-1α/VEGF-A pathway by deferoxamine ameliorates retinal hypoxia in a rat subarachnoid hemorrhage model
Conclusions Our findings suggest that modulating the application of deferoxamine may offer therapeutic approaches to alleviate retinal complications after SAH.
Source: NeuroReport - October 6, 2022 Category: Neurology Tags: Degeneration and Repair Source Type: research

Downregulation of ELAVL1 attenuates ferroptosis-induced neuronal impairment in rats with cerebral ischemia/reperfusion via reducing DNMT3B-dependent PINK1 methylation
ConclusionELAVL1 plays a critical role in protecting against ferroptosis-induced cerebral I/R and subsequent brain damage via DNMT3B/PINK1 axis, thus providing a new potential target for ischemic stroke treatment.
Source: Metabolic Brain Disease - September 29, 2022 Category: Neurology Source Type: research

Potential intervention target of atherosclerosis: Ferroptosis (Review)
Mol Med Rep. 2022 Nov;26(5):343. doi: 10.3892/mmr.2022.12859. Epub 2022 Sep 23.ABSTRACTAtherosclerosis (AS) is a chronic inflammatory disease of the blood vessels, which is mainly characterized by the form of atherosclerotic plaques and vascular endothelial injury. Its formation involves abnormal lipid metabolism, oxidative stress and inflammation, as well as other processes. AS is the direct cause of various acute cardiovascular and cerebrovascular diseases, such as acute myocardial infarction and acute ischemic stroke. Early intervention in the atherosclerotic inflammatory process and lesion progression is beneficial, an...
Source: Molecular Medicine Reports - September 23, 2022 Category: Molecular Biology Authors: Jia Li Ling Xu Yi Xuan Zuo Xue Qin Chang Hai Tao Chi Source Type: research

Mortality and Morbidity Effects of Long-Term Exposure to Low-Level PM < sub > 2.5 < /sub > , BC, NO < sub > 2 < /sub > , and O < sub > 3 < /sub > : An Analysis of European Cohorts in the ELAPSE Project
CONCLUSIONS: Long-term exposure to PM2.5, NO2, and BC was positively associated with natural-cause and cause-specific mortality in the pooled cohort and the administrative cohorts. Associations were found well below current limit values and guidelines for PM2.5 and NO2. Associations tended to be supralinear, with steeper slopes at low exposures with no indication of a threshold. Two-pollutant models documented the importance of characterizing the ambient mixture with both NO2 and PM2.5. We mostly found negative associations with O3. In two-pollutant models with NO2, the negative associations with O3 were attenuated to esse...
Source: Cancer Control - September 15, 2022 Category: Cancer & Oncology Authors: Brunekreef Bert Strak Maciej Chen Jie J Andersen Zorana Atkinson Richard Bauwelinck Mariska Bellander Tom Boutron Marie-Christine Brandt J ørgen Carey Iain Cesaroni Giulia Forastiere Francesco Fecht Daniela Gulliver John Hertel Ole Hoffmann Barbara de Ho Source Type: research

The mechanism of ferroptosis regulating oxidative stress in ischemic stroke and the regulation mechanism of natural pharmacological active components
Biomed Pharmacother. 2022 Oct;154:113611. doi: 10.1016/j.biopha.2022.113611. Epub 2022 Sep 5.ABSTRACTCerebrovascular diseases, such as ischemic stroke, pose serious medical challenges worldwide due to their high morbidity and mortality and limitations in clinical treatment strategies. Studies have shown that reactive oxygen species (ROS)-mediated inflammation, excitotoxicity, and programmed cell death of each neurovascular unit during post-stroke hypoxia and reperfusion play an important role in the pathological cascade. Ferroptosis, a programmed cell death characterized by iron-regulated accumulation of lipid peroxidation...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 9, 2022 Category: Drugs & Pharmacology Authors: Kailin Yang Liuting Zeng Xiao Yuan Shanshan Wang Anqi Ge Hao Xu Jinsong Zeng Jinwen Ge Source Type: research