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Total 471 results found since Jan 2013.
A rare cause of stroke in young children: minor head trauma associated with mineralising lenticulostriate angiopathy in three patients
Paediatr Int Child Health. 2022 Apr 26:1-5. doi: 10.1080/20469047.2022.2066386. Online ahead of print.ABSTRACTAcute basal ganglia infarct following minor head trauma in association with mineralisation of lenticulostriate arteries is an increasingly recognised entity in childhood stroke. Three cases with a classical history and phenotypical features of mineralising angiopathy are described. Case 1 was a 2-year-old girl who presented with acute onset hemiparesis with a same-side upper motor neuron (UMN)-type facial palsy following minor head trauma. Case 2 was a 14-month-old boy who presented with a left side hemiparesis and...
Source: Paediatrics and international child health - April 26, 2022 Category: Pediatrics Authors: Kiruthiga Sugumar Aakash Chandran Chidambaram Bobbity Deepthi Sriram Krishnamurthy C G Delhikumar Source Type: research
Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions
Circ Res. 2022 Apr 15;130(8):1204-1229. doi: 10.1161/CIRCRESAHA.121.319949. Epub 2022 Apr 14.ABSTRACTIntracerebral hemorrhage (ICH) is a devastating form of stroke with high morbidity and mortality. This review article focuses on the epidemiology, cause, mechanisms of injury, current treatment strategies, and future research directions of ICH. Incidence of hemorrhagic stroke has increased worldwide over the past 40 years, with shifts in the cause over time as hypertension management has improved and anticoagulant use has increased. Preclinical and clinical trials have elucidated the underlying ICH cause and mechanisms of i...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Jessica Magid-Bernstein Romuald Girard Sean Polster Abhinav Srinath Sharbel Romanos Issam A Awad Lauren H Sansing Source Type: research
cPKC γ ameliorates ischemic injury in cultured neurons exposed to oxygen glucose deprivation/reoxygenation by inhibiting ferroptosis
In this study, primary cultured cortical neurons were used to establish 1h oxygen-glucose deprivation (OGD) and reoxygenation (R) 0-12h (i.e., 1h OGD/R 0-12h) as in vitro models of cell ischemia. After 1h OGD/R 0-12h, cyclooxygenase 2 (COX2) and acyl-CoA synthetase long-chain family member 4 (ACSL4) levels increased, and glutathione peroxidase 4 (GPx4) levels decreased significantly. Concurrently, GPx4 activity decreases, and iron levels increased. The inhibition of ferroptosis by Liproxstatin-1 ameliorated OGD-induced neuronal injury. Liproxstatin-1 administration prominently induced GPx4 expression and suppressed COX2 ex...
Source: Cell Research - April 14, 2022 Category: Cytology Authors: Haiping Wei Zhifeng Peng Yahong Chen Jia Guo Lixia Chen Kangmei Shao Source Type: research
