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Nutrition: Iron

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Total 471 results found since Jan 2013.

Clot-targeted magnetic hyperthermia permeabilizes blood clots to make them more susceptible to thrombolysis
CONCLUSIONS: This study demonstrates that clot-targeted MH can enhance the thrombolysis of contracted human blood clots and can be safely applied to enhance the timeframe in which thrombolysis is effective.PMID:35950914 | DOI:10.1111/jth.15846
Source: Thrombosis and Haemostasis - August 11, 2022 Category: Hematology Authors: David Cabrera Maneea Eizadi Sharifabad Jacob A Ranjbar Neil D Telling Alan G S Harper Source Type: research

Heritability of R2* iron in the basal ganglia and cortex
CONCLUSIONS: Regional brain iron concentrations are mainly driven by genetic factors while environmental factors contribute to a certain extent. Brain iron levels in the basal ganglia and cortex are controlled by distinct sets of genes.PMID:35951362 | DOI:10.18632/aging.204212
Source: Aging - August 11, 2022 Category: Biomedical Science Authors: Edith Hofer Lukas Pirpamer Christian Langkammer Christian Tinauer Sudha Seshadri Helena Schmidt Reinhold Schmidt Source Type: research

A Systematic Review, Meta-Analysis, and Indirect Comparison of Blindly Adjudicated Cardiovascular Event Incidence with Ferric Derisomaltose, Ferric Carboxymaltose, and Iron Sucrose
CONCLUSIONS: Pooling data from four large-scale RCTs suggested that FDI was associated with significantly lower incidence of cardiovascular adverse events compared to both FCM and IS.PMID:35947351 | DOI:10.1007/s12325-022-02242-x
Source: Adv Data - August 10, 2022 Category: Epidemiology Authors: Richard F Pollock Philip A Kalra Paul R Kalra Fozia Z Ahmed Source Type: research

Molecules, Vol. 27, Pages 5100: Tetrahydrocurcumin-Related Vascular Protection: An Overview of the Findings from Animal Disease Models
nov Feng Wang Tetrahydrocurcumin (THC), one of the major metabolites of CUR, possesses several CUR-like pharmacological effects; however, its mechanisms of action are largely unknown. This manuscript aims to summarize the literature on the preventive role of THC on vascular dysfunction and the development of hypertension by exploring the effects of THC on hemodynamic status, aortic elasticity, and oxidative stress in vasculature in different animal models. We review the protective effects of THC against hypertension induced by heavy metals (cadmium and iron), as well as its impact on arterial stiffness and vascular r...
Source: Molecules - August 10, 2022 Category: Chemistry Authors: Li Zhang Changhu Li Sicheng Wang Dimiter Avtanski Nikola Hadzi-Petrushev Vadim Mitrokhin Mitko Mladenov Feng Wang Tags: Review Source Type: research

Prevalence and risk factors of stroke-related sarcopenia at the subacute stage: A case control study
ConclusionsOlder age, light weight, severer clinical conditions, cognitive impairment, and significantly decreased levels of albumin, RAG, creatinine, uric acid, red blood cell count, hemoglobin, prealbumin, iron, and creatine kinase are more significantly present in patients with SRS compared with those without SRS.
Source: Frontiers in Neurology - August 8, 2022 Category: Neurology Source Type: research

E-111 Analysis of intracerebral hemorrhage in n established mouse model
BackgroundKontos’ elucidated the theory that iron-mediated free radical production and subsequent oxidative damage was responsible for on-going cerebral degeneration within the infarct following ischemic stroke. The production of free radicals is likely tied to the generation of superoxide following reperfusion of the ischemic brain. Free radical production happens relatively soon after reperfusion but the time to oxidative damage of surrounding tissue is still unknown. It is well-established that ischemic stroke results in loss of autoregulation to cerebral tissues. Ischemic strokes have the potential to transform i...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Pendleton, N. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

E-205 In vitro evaluation of full-length, mr-safe interventional passive catheter markers at 3T
ConclusionAlthough worst-case artifacts were observed at 90°, they remained acceptable for use in guide catheters. Additionally, 20-mm marker separation could provide distinct artifacts down the length of a catheter during MRI-guided interventions, despite anatomic tortuosity. The phantom used in this study was shallow, which limited the ability to distinguish between real artifacts and those arising from the solution-air interface. Hence, accuracy of the degree of increased artifact may warrant further investigation. This study simulated worst-case orientations in vitro; more data should be collected in vivo using rea...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Kilbride, B., Jordan, C., Ahn, S., Mueller, K., Chu, A., Barry, D., Moore, T., Martin, A., Wilson, M., Hetts, S. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

Development of Molecular Magnetic Resonance Imaging Tools for Longitudinal Tracking of Carotid Atherosclerotic Disease Using Fast Imaging with Steady-State Precession
Transl Stroke Res. 2022 Jul 18. doi: 10.1007/s12975-022-01067-8. Online ahead of print.ABSTRACTIdentification of patients with high-risk asymptomatic carotid plaques remains a challenging but essential step in stroke prevention. Current selection criteria for intervention in carotid disease are still determined by symptomatology and degree of luminal stenosis. This strategy has been less effective in identifying the high-risk asymptomatic individual patients. Inflammation is the key factor that drives plaque instability causing clinical sequelae. Currently, there is no imaging tool in routine clinical practice to assess th...
Source: Atherosclerosis - July 20, 2022 Category: Cardiology Authors: Sung-Jin Park Wan Ying Chan Michael Ng Yiu Cho Chung Tze Tec Chong Kishore Bhakoo Joyce M S Chan Source Type: research

CDGSH iron sulfur domain 2 mitigates apoptosis, oxidative stress and inflammatory response caused by oxygen –glucose deprivation/reoxygenation in HT22 hippocampal neurons by Akt-Nrf2-activated pathway
AbstractCDGSH iron sulfur domain 2 (Cisd2) is known as a key determinant factor in maintaining cellular homeostasis. However, whether Cisd2 contributes to the mediation of neuronal injury during ischemic stroke has not been well stressed. This work focuses on investigating the role of Cisd2 in regulating neuronal injury caused by oxygen –glucose deprivation/reoxygenation (OGD/R). The dramatic down-regulation of Cisd2 was observed in hippocampal neurons suffering from OGD/R injury. In Cisd2-overexpressed neurons, OGD/R-induced neuronal apoptosis, oxidative stress and inflammation were prominently mitigated. Further invest...
Source: Metabolic Brain Disease - July 12, 2022 Category: Neurology Source Type: research

The Truth About Fasting and Type 2 Diabetes
Most fad diets don’t live up to the hype, let alone serious scientific scrutiny. But intermittent fasting seems to be an exception. These plans involve going without caloric foods or drinks for an extended period of time—anywhere from 16 hours to several days—and they have become increasingly popular. Research has also found them to be effective for weight loss. Doctors often advise people with Type 2 diabetes to lose weight, which can have beneficial effects on blood glucose and insulin sensitivity, as well as on the progression of the disease. For this and other reasons, experts are actively looking at ...
Source: TIME: Health - June 16, 2022 Category: Consumer Health News Authors: Markham Heid Tags: Uncategorized Diet & Nutrition freelance healthscienceclimate Source Type: news

Glutamine synthetase in human carotid plaque macrophages associates with features of plaque vulnerability: An immunohistological study
CONCLUSIONS: Our results link connect macrophage GLUL expression with carotid plaque features characterizing plaque vulnerability.PMID:35667160 | DOI:10.1016/j.atherosclerosis.2022.05.008
Source: Atherosclerosis - June 6, 2022 Category: Cardiology Authors: Pia Sorto Mikko I M äyränpää Jani Saksi Krista Nuotio Petra Ij äs Jarno Tuimala Pirkka Vikatmaa Lauri Soinne Petri T Kovanen Perttu J Lindsberg Source Type: research