Liver Fibrosis, Sleep Apnea and Cardiovascular Events in Stroke Patients
Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - June 19, 2019 Category: Neurology Source Type: research

Collateral Automation for Triage in Stroke: Evaluating Automated Scoring of Collaterals in Acute Stroke on Computed Tomography Scans
In conclusion, ­e-CTA provides a real-time and fully automated approach to collateral scoring with the potential to improve consistency of image interpretation and to independently quantify collateral scores even without expert rater input.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - June 19, 2019 Category: Neurology Source Type: research

Outcomes after Thrombectomy in Belfast: Mothership and Drip-and-Ship in the Real World
Conclusions: Our analysis showed similar outcomes after thrombectomy in the MS and DS groups. For patients potentially eligible for thrombectomy, rapid access to the endovascular centre is essential to optimise both the number of patients treated and the outcomes achieved.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - June 18, 2019 Category: Neurology Source Type: research

Ivy Sign Predicts Ischemic Stroke Recurrence in Adult Moyamoya Patients without Revascularization Surgery
Conclusions: The ivy sign is associated with ischemic recurrence in adult MMD patients in a dose-response manner. It would be helpful for selecting high-risk patients who need revascularization surgery.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - June 18, 2019 Category: Neurology Source Type: research

Influence of the Extent of Intraventricular Hemorrhage on Functional Outcome and Mortality in Intracerebral Hemorrhage
Conclusions: Small amounts of intraventricular blood (Graeb score ≤2) not leading to obstructive hydrocephalus are not associated with unfavorable outcome or death after ICH. Thus, IVH per se should not be considered a binary variable in outcome prediction for ICH patients.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - June 18, 2019 Category: Neurology Source Type: research

Distal versus Proximal Middle Cerebral Artery Occlusion: Different Mechanisms
Conclusion: Proximal MCAO is more frequently associated with atherosclerosis, whereas distal MCAO is more frequently associated with cardioembolism. In proximal MCAO, the status of collateral flow presented by hyperintense vessel sign may affect the involvement of BG. In distal MCAO, distal migration of the embolus, which first impacted at the proximal MCA causing BG ischemia, may explain the high rate of HT by reperfusion injury. Hyperintense vessel sign and distal MCAO were independently associated with neurological improvement during admission.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - June 18, 2019 Category: Neurology Source Type: research

Relevance of Collaterals for the Success of Neuroprotective Therapies in Acute Ischemic Stroke: Insights from the Randomized URICO-ICTUS Trial
Conclusions: Collectively, the study found that collaterals were associated with the neuroprotective effect of uric acid therapy highlighting the importance of assessing collateral status in neuroprotection trials.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - June 4, 2019 Category: Neurology Source Type: research

Incidence and Risk Factors of the Watershed Shift Phenomenon after Superficial Temporal Artery-Middle Cerebral Artery Anastomosis for Adult Moyamoya Disease
Conclusions: The incidence of the WS phenomenon was as high as 10.9% after STA-MCA anastomosis for adult MMD. The clinical outcome of the WS phenomenon is generally favorable, but there is a potential risk for perioperative cerebral infarction. Thus, we recommend routine CBF measurement in the acute stage after revascularization surgery for adult MMD to avoid surgical complications, such as local CHP and cerebral ischemia, caused by the WS phenomenon. Concomitant detection of the WS phenomenon with local CHP is clinically important because blood pressure reduction to counteract local CHP may have to be avoided in the prese...
Source: Cerebrovascular Diseases - May 23, 2019 Category: Neurology Source Type: research

Sex-Related Differences in Management and Outcome of Acute Ischemic Stroke in Eligible Patients to Thrombolysis
Conclusions: We provided an exhaustive overview and real-life professional practices conditions in thrombolyzed AIS. Despite a later prehospital management in neurovascular units and more severe strokes at admission, women and men had both similar outcomes at hospital discharge and in 3-month survival, but women were associated to worst functional outcome at 3 months.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - May 23, 2019 Category: Neurology Source Type: research

Left Atrial Appendage Occlusion for Secondary Stroke Prevention in Patients with Atrial Fibrillation: Long-Term Results
Conclusion: Patients with prior stroke may be the preferred group for LAAC regardless of the presence or absence of contraindications for anticoagulant therapy. (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - May 23, 2019 Category: Neurology Source Type: research

Cerebral Vasospasm Due to Arteriovenous Malformation-Associated Hemorrhage: Impact of Bleeding Source and Pattern
Conclusion: SAH component and infratentorial location of ruptured AVMs may harbor a higher risk for CVS. Follow-up with angiographic imaging should be considered in patients with infratentorial AVM hemorrhage and delayed neurologic deterioration to rule out CVS.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - May 8, 2019 Category: Neurology Source Type: research

Direct Admission versus Secondary Transfer for Acute Stroke Patients Treated with Intravenous Thrombolysis and Thrombectomy: Insights from the Endovascular Treatment in Ischemic Stroke Registry
Conclusions: Our study suggests that LVO stroke patients directly admitted to a comprehensive stroke center present a higher chance of functional independence, especially when the distance between the primary stroke center and comprehensive stroke center is #x3e;12.5 miles or when the time between cerebral imaging and groin puncture is ≥140 min.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - May 7, 2019 Category: Neurology Source Type: research

Finger-Like Projections in Lobar Haemorrhage on Early Magnetic Resonance Imaging Is Associated with Probable Cerebral Amyloid Angiopathy
Conclusions: In acute LH patients, FLP and SAHE on acute/early subacute phase MRI are associated with probable CAA diagnosis. Larger LH volumes are associated with FLP and SAHE on MRI, and early performed MRI with FLP.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - May 7, 2019 Category: Neurology Source Type: research

Daily Habit of Water Intake in Patients with Cerebral Infarction before its Onset; Comparison with a Healthy Population: A Cross-Sectional Study
Conclusion: This study showed that daily NAD intake before CI onset in CI patients was less than that in healthy persons, indicating that sufficient intake of NAD may be protective for CI.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - May 5, 2019 Category: Neurology Source Type: research

Age- and Sex-Specific Risk Profiles and In-Hospital Mortality in 13,932 Spanish Stroke Patients
Conclusion: Although most of our findings were consistent with previous studies, it is important to take into account and highlight differences in in-hospital mortality between the sex and age group. Not to account for age-related differences between the sexes can give false results that may mislead management decisions. As most deaths in women were related to stroke, it is important to improve their early management, stroke code activation, access to stroke units and/or revascularisation therapies, especially in the older age groups.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - May 5, 2019 Category: Neurology Source Type: research

Genotype-Phenotype Correlation in Long-Term Cohort of Japanese Patients with Moyamoya Disease
Conclusions: The p.R4810K founder variant ofRNF213 affects the phenotype at disease onset. However, the optimal revascularization may be effective, regardless of the genotype, even for the homozygous variant, which has been thought to be the most pathogenic. This genotype may not strongly influence the long-term clinical manifestations or poor prognosis in MMD.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - April 15, 2019 Category: Neurology Source Type: research

Successful Reperfusion with Endovascular Therapy Has Beneficial Effects on Long-Term Outcome Beyond 90 Days
Conclusions: Successful reperfusion has further beneficial legacy effects on long-term outcomes beyond 90 days after stroke.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - April 15, 2019 Category: Neurology Source Type: research

Post-Stroke Blood-Brain Barrier Disruption and Poor Functional Outcome in Patients Receiving Thrombolytic Therapy
Conclusions: Post-stroke BBB disruption appears to be predictive of functional outcome irrespective of stroke size.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - April 15, 2019 Category: Neurology Source Type: research

Comparison Study of ASCO and TOAST Classification System in Chinese Minor Stroke Patients
Conclusion: Application of ASCO decreased the proportion of patients assigned to cause undermined category compared to TOAST system. Comprehensive characteristics of ASCO system might be helpful in the personalized therapy or secondary prevention for individual patients in the future.Cerebrovasc Dis 2019;47:95 –100 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - March 31, 2019 Category: Neurology Source Type: research

Air Pollution and Stroke: Is there Really a Significant Relationship
Cerebrovasc Dis 2019;47:101 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - March 31, 2019 Category: Neurology Source Type: research

Serum Albumin Is Negatively Associated with Hemorrhagic Transformation in Acute Ischemic Stroke Patients
Conclusions: Higher serum albumin is associated with lower HT risk in a dose-dependent manner in AIS patients younger than 60 years.Cerebrovasc Dis 2019;47:88 –94 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - March 22, 2019 Category: Neurology Source Type: research

Editorial
Cerebrovasc Dis 2019;47:I (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - March 21, 2019 Category: Neurology Source Type: research

A COACHS Nomogram to Predict the Probability of Three-Month Unfavorable Outcome after Acute Ischemic Stroke in Chinese Patients
Conclusions: The COACHS nomogram may be used to predict unfavorable outcome at 3 months after acute ischemic stroke in Chinese population. It may be also a reliable tool that is effective in its clinical utilization to risk-stratify acute stroke patients.Cerebrovasc Dis 2019;47:80 –87 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - March 21, 2019 Category: Neurology Source Type: research

Serotonergic Regulation and Cognition after Stroke: The Role of Antidepressant Treatment and Genetic Variation
Conclusion: There was no difference in cognition between citalopram and placebo-treated patients according to the genotype group. Our results indicate, however, that low expression SERT genotype may contribute to reduced cognitive function post stroke as placebo-treated patients with low SERT expression tended to score lower on the SDMT. The significant difference in SDMT scores between low and high expression patients was present only in the placebo-treated group, thereby warranting further exploration of the potential effect of early citalopram treatment on cognitive functioning. Our results are preliminary and need repl...
Source: Cerebrovascular Diseases - March 7, 2019 Category: Neurology Source Type: research

Endovascular Thrombectomy in the Elderly: Do Radiological and Clinical Outcomes Differ from Those in Younger Patients? A Prospective Single-Center Experience
Conclusions: EVT in the elderly resulted in equally notable neurological improvement as compared to younger patients. Although the elderly had a higher mortality rate and fewer favorable clinical outcomes at 3 month follow-up, a strict upper age limit for EVT seems unjustified.Cerebrovasc Dis 2019;47:65 –71 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - February 26, 2019 Category: Neurology Source Type: research

Renal Impairment Is Associated with Intracerebral Hemorrhage after Mechanical Thrombectomy in Vertebrobasilar Stroke
Conclusions: Patients with RD and acute vertebrobasilar stroke should be thoroughly monitored to prevent ICH after thrombectomy. Our results support performing mechanical thrombectomy in acute stroke patients with large vessel occlusions of the posterior circulation, irrespective of their renal function.Cerebrovasc Dis 2019;47:48 –56 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - February 15, 2019 Category: Neurology Source Type: research

Reduced Hypoxic Tissue and Cognitive Improvement after Revascularization Surgery for Chronic Cerebral Ischemia
Conclusions: Hypoxic tissue is reduced following the restoration of cerebral perfusion with revascularization surgery in patients with severe atherosclerotic stenosis of the cervical ICA. The reduction in hypoxic tissue is associated with cognitive improvement in such patients.Cerebrovasc Dis 2019;47:57 –64 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - February 15, 2019 Category: Neurology Source Type: research

Associations of High Intensities on Magnetization-Prepared Rapid Acquisition with Gradient Echo with Aortic Complicated Lesions in Ischemic Stroke Patients
Conclusions: High intensities on T1WI with MPRAGE in the aortic arch were significantly associated with the presence of ACLs. An evaluation of the aortic arch using MPRAGE may be useful for predicting ACLs.Cerebrovasc Dis 2019;47:15 –23 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - February 14, 2019 Category: Neurology Source Type: research

Impact of Baseline Features and Risk Factor Control on Cognitive Function in the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Trial
Conclusion: Cognitive impairment is common in patients with severe symptomatic intracranial atherosclerosis. Physical inactivity at baseline and during follow-up is a strong predictor of cognitive impairment.Cerebrovasc Dis 2019;47:24 –31 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - February 14, 2019 Category: Neurology Source Type: research

Liver Fibrosis, Not Steatosis, Associates with Long-Term Outcomes in Ischaemic Stroke Patients
Conclusions: This study found that the burden of liver fibrosis but not that of steatosis, assessed via TE, was an independent predictor of all-cause and cardiovascular mortality during long-term follow-up in patients with ischaemic stroke.Cerebrovasc Dis 2019;47:32 –39 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - February 14, 2019 Category: Neurology Source Type: research

One-Year Risk of Recurrent Stroke and Death Associated with Vertebrobasilar Artery Stenosis and Occlusion in a Cohort of 10,515 Patients
Conclusions: VBA stenosis or occlusion was relatively prevalent among patients with TIA or ischemic stroke and associated with higher risk of recurrent stroke and death in patients with ischemic stroke or TIA who had large artery atherosclerosis.Cerebrovasc Dis 2019;47:40 –47 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - February 14, 2019 Category: Neurology Source Type: research

Using the Region of Interest from Time-of-Flight Magnetic Resonance Angiography to Differentiate Between Intracranial Arterial Dissection and True Atherosclerotic Stenosis
Conclusion: The ROI difference value from 3D TOF MRA could help distinguish between dissection and atherosclerosis. If the ROI difference value from 3D TOF MRA is small (#x3c; 99.0), detailed testing should be performed to identify dissection.Cerebrovasc Dis 2019;47:8 –14 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - February 7, 2019 Category: Neurology Source Type: research

Contents Vol. 46, 2018
Cerebrovasc Dis 2018;46:I –VI (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - February 1, 2019 Category: Neurology Source Type: research

Risks of Acute Stroke Treatment in Patients with Cardiac Disease
Cerebrovasc Dis 2018;46:I (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - January 18, 2019 Category: Neurology Source Type: research

Returning to Unpaid Work after Stroke: The Psychosocial Outcomes in Stroke Cohort Study
Conclusions: More women are engaged in unpaid work before and at 12 months after stroke, but there is a reduction in the proportion of women returning to unpaid work at 12 months not seen in men. Consideration may need to be given to the development of rehabilitation strategies targeted at the specific needs of stroke survivors.Cerebrovasc Dis 2019;47:1 –7 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - January 17, 2019 Category: Neurology Source Type: research

Adenosine Deaminase Two and Immunoglobulin M Accurately Differentiate Adult Sneddon ’s Syndrome of Unknown Cause
Conclusion: Serum IgM levels might be used as a triage tool and plasma ADA2 activity performs perfectly as a diagnostic test for DADA2 in adult patients within the SnS spectrum. ADA2 activity in plasma also reliably distinguishes HHZ from HC.Cerebrovasc Dis 2018;46:257 –264 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - January 16, 2019 Category: Neurology Source Type: research

Intra-Plaque Vessels on Contrast-Enhanced Ultrasound Sonography Predict Carotid Plaque Histology
Conclusion: Vas-S values of 0 and 2 at 1 min indicated unruptured and healed plaques respectively. Thus, a Vas-S of 1 at 1 min is an indicator of a ruptured plaque. The intra-plaque vessel size on CEUS was significantly associated with carotid plaque histology, and may predict the process of plaque rupture and restoration.Cerebrovasc Dis 2018;46:265 –269 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - January 16, 2019 Category: Neurology Source Type: research

Thrombus Enhancement Is a Predictor of Clinical Outcome in Acute Ischemic Stroke after Mechanical Thrombectomy
Conclusions: CE of thrombi – especially in a range from over 18.4 to 40.35 Hounsfield Units – is an independent predictor of poor clinical outcome in patients undergoing MT due to acute middle cerebral artery occlusion.Cerebrovasc Dis 2018;46:270 –278 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - January 16, 2019 Category: Neurology Source Type: research

The Relationship between Blood Pressure Variability, Recanalization Degree, and Clinical Outcome in Large Vessel Occlusive Stroke after an Intra-Arterial Thrombectomy
Conclusions: Short-term BPV over 24 and 48 h after IAT in acute ischemic stroke patients was related to recanalization degree, and END occurrence, and may be an independent predictor of clinical outcome.Cerebrovasc Dis 2018;46:279 –286 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - January 16, 2019 Category: Neurology Source Type: research

Cholesterol Crystals in Embolic Debris are Associated with Postoperative Cerebral Embolism after Carotid Artery Stenting
Conclusions: Cholesterol crystals were common in the embolic debris from patients with postoperative ischemic lesions after CAS. These results suggest that inflammatory destabilization of the intraplaque lipid component is related to postprocedural DWI lesions.Cerebrovasc Dis 2018;46:242 –248 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - January 2, 2019 Category: Neurology Source Type: research

Baseline Characteristics and Readmissions after Cerebral Venous Sinus Thrombosis in a Nationally Representative Database
Conclusions: We provide baseline characteristics and readmission rates after CVST over a 1-year period. In-hospital mortality rate and association with pregnancy were lower than previously observed.Cerebrovasc Dis 2018;46:249 –256 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - January 2, 2019 Category: Neurology Source Type: research

Cervical Artery Dissection in Patients of African Ancestry
Conclusion: AA patients represent a smaller proportion of CeAD cases compared to young stroke cases at our center. AA patients suffering CeAD have higher prevalence of both vascular risk factors and frequency of the CeAD risk allele compared to EA patients. These findings suggest a complex interplay between traditional vascular risk factors and genetic predisposition underlying CeAD pathogenesis. Further prospective research is needed to clarify these associations and disparities.Cerebrovasc Dis 2018;46:218 –222 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - December 5, 2018 Category: Neurology Source Type: research

Left-Sided Atrial Septal Pouch as a Risk Factor of Cryptogenic Stroke: A Systematic Review and Meta-Analysis
Conclusion: Our meta-analysis demonstrated association between LSSP and cryptogenic stroke. In our univariate analysis, the risk of cryptogenic stroke is higher among patients with LSSP than in cases without the LSSP.Cerebrovasc Dis 2018;46:223 –229 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - December 5, 2018 Category: Neurology Source Type: research

A Systematic Review and Meta-Analysis of Molecular Biomarkers Associated with Early Neurological Deterioration Following Acute Stroke
Background: Early neurological deterioration (END) following acute stroke is associated with poorer long-term outcomes. Identification of patients at risk could assist early monitoring and treatment decisions. This review summarised the evidence describing non-radiological biomarkers for END.Summary: Electronic searches from January 1990 to March 2017 identified studies reporting a blood/cerebrospinal fluid (CSF)/urine biomarker measurement within 24 h of acute stroke and at least 2 serial assessments of clinical neurological status (#x3c; 24 h and #x3c; 7 days). Out of 12,895 citations, 82 studies were included, mostly fo...
Source: Cerebrovascular Diseases - December 5, 2018 Category: Neurology Source Type: research

The Management of Acute Ischemic Strokes and the Prevalence of Large Vessel Occlusion in Left Ventricular Assist Device
Conclusions: In-hospital strokes and acute LVOs are common in LVAD-associated AIS. Prompt evaluation with CTA and endovascular therapy should be pursued for these critically ill patients.Cerebrovasc Dis 2018;46:213 –217 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - December 4, 2018 Category: Neurology Source Type: research

Coincidence and Management of Non-Motor Stroke-Associated Risks (Dysphagia – Swallowing Deficits – Visual Neglect)
Cerebrovasc Dis 2018;46:I (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - November 15, 2018 Category: Neurology Source Type: research

Letter to the Article by Maus et al.: “Order of Treatment Matters in Ischemic Stroke: Mechanical Thrombectomy First, Then Carotid Artery Stenting for Tandem Lesions of the Anterior Circulation”
Cerebrovasc Dis 2018;46:210 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - November 12, 2018 Category: Neurology Source Type: research

Challenge of Attaining Flow Arrest in Anterior Circulation Tandem Occlusions in Large Vessel Ischemic Stroke: Wedged SAVE Technique
Cerebrovasc Dis 2018;46:211 –212 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - November 12, 2018 Category: Neurology Source Type: research

The Impact of Cerebral Atherosclerosis According to Location on Prognosis after Coronary Artery Bypass Grafting
Conclusions: Over 10 years of follow-up, cerebral atherosclerosis significantly associated with the development of adverse outcomes after CABG. The prognostic value of ICAS might be different from that of ECAS; immediate post-CABG stroke was more closely associated with ICAS, whereas there was a closer association between long-term post-CABG mortality and ECAS.Cerebrovasc Dis 2018;46:200 –209 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - November 8, 2018 Category: Neurology Source Type: research

Ten-Year Evaluation of the TOYOTA Prehospital Stroke Scale for Tissue Plasminogen Activator Intravenous Therapy in the Real World
Conclusions: The TOPSPIN is a simple prehospital stroke scale that includes an assessment of atrial fibrillation. Detection of atrial fibrillation in the prehospital stage may point to a higher probability of ischemic stroke.Cerebrovasc Dis 2018;46:184 –192 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - November 1, 2018 Category: Neurology Source Type: research