Adherence to Antithrombotic Treatment and Ischemic Stroke Recurrence in Egypt and Germany: A Comparative Analysis
Conclusions: The large stroke recurrence burden in Egypt may be partly explained by differing adherence to secondary preventative antithrombotic pharmacotherapy. Predictors of medication nonadherence have to be addressed to reduce stroke recurrence disparities.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - January 21, 2021 Category: Neurology Source Type: research

Increased Rates of Hemorrhages after Endovascular Stroke Treatment with Emergency Carotid Artery Stenting and Dual Antiplatelet Therapy
Conclusion: AIS patients receiving EST with acute CAS and consecutive tirofiban or dual antiplatelet therapy suffered from an increased risk of relevant secondary intracranial bleeding. After adjusting for confounders, tirofiban and dual antiplatelet therapy were associated with higher bleeding rates.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - January 20, 2021 Category: Neurology Source Type: research

Treatment with Diazepam in Acute Stroke Prevents Poststroke Seizures: A Substudy of the EGASIS Trial
Conclusion: We found that a 3-day treatment with diazepam after acute cortical anterior circulation stroke prevents the occurrence of seizures in the first 3 months following stroke.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - January 19, 2021 Category: Neurology Source Type: research

Multinational Survey of Current Practice from Imaging to Treatment of Atherosclerotic Carotid Stenosis
Conclusions: We found heterogeneity in current practices of carotid stenosis imaging and management in this worldwide survey with many respondents including vulnerable plaque imaging into their decision analysis despite the lack of proven benefit from clinical trials. This study highlights the need for new clinical trials using vulnerable plaque imaging to select high-risk patients despite maximal medical therapy who may benefit from procedural intervention.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - January 13, 2021 Category: Neurology Source Type: research

Influence of Including Patients with Premorbid Disability in Acute Stroke Trials: The HeadPoST Experience
Conclusions: Early poststroke functional impairment that exceeded premorbid levels was associated with worse 90-day outcome, and this association increased with greater premorbid functional impairment. Yet, including premorbid impaired patients in the HeadPoST did not materially affect the subsequent treatment effect.Clinical Trial Registration: HeadPoST is registered at http://www.ClinicalTrials.gov (NCT02162017).Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - January 12, 2021 Category: Neurology Source Type: research

Knowledge of Stroke Risk Factors and Signs in Parakou, a Northern City of Benin in West Africa
Conclusion: Knowledge of stroke risk factors and signs is low in northern Benin. Greater public education and awareness campaigns are required to address the burden of stroke.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - January 8, 2021 Category: Neurology Source Type: research

Does Body Mass Index Impact the Outcome of Stroke Patients Who Received Intravenous Thrombolysis?
Conclusions: After adjusting for confounding factors such as age, baseline National Institute of Health Stroke Scale (NIHSS), and comorbidities, obesity was not associated with an unfavorable functional outcome at discharge nor with a higher risk of sICH in patients with AIS treated with IVT.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - January 8, 2021 Category: Neurology Source Type: research

Efficacy and Safety of Timely Urgent Superficial Temporal Artery-to-Middle Cerebral Artery Bypass Surgery in Patients with Acute Ischemic Stroke: A Single-Institutional Prospective Study and a Pooled Analysis
Conclusions: Urgent STA-MCA bypass surgery can be regarded as a safe optional treatment to prevent cerebral infarct expansion and to improve clinical and radiological outcomes in highly selected patients.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - January 8, 2021 Category: Neurology Source Type: research

Prevalence of Mimics and Severe Comorbidity in Patients with Clinically Suspected Transient Global Amnesia
Conclusion: As approximately every tenth patient with suspected TGA either had an alternative diagnosis or a severe comorbidity, which had not been obvious at the time of admission, we consider in-patient treatment of all suspected TGA cases as appropriate, preferably in the setting of a stroke unit, as ischemic stroke was the by far most important diagnosis mimicking TGA.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - January 7, 2021 Category: Neurology Source Type: research

The Application of Tirofiban in the Endovascular Treatment of Acute Ischemic Stroke: A Meta-Analysis
Conclusions: The application of tirofiban in EVT of AIS may improve functional outcomes and reduce mortality at 3 months. Besides, tirofiban does not seem to increase the risk of symptomatic intracranial hemorrhage and intracranial hemorrhage, either in the anterior or posterior circulation stroke.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - January 5, 2021 Category: Neurology Source Type: research

A Meta-Analysis of Prognostic Factors in Patients with Posterior Circulation Stroke after Mechanical Thrombectomy
Conclusion: Our analysis indicates that hypertension, diabetes mellitus, or previous stroke correlate with poorer outcomes. Intriguingly, hyperlipidemia correlates with better prognosis. These factors may help inform triage decisions when considering MT for posterior circulation stroke patients. However, large, multicenter, randomized controlled trials are needed to validate these observations.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - December 30, 2020 Category: Neurology Source Type: research

Thrombectomy for Treatment of Acute Stroke in the COVID-19 Pandemic
This commentary will focus on the role of thrombectomy for the treatment of embolic stroke during the 2019 novel coronavirus disease (COVID-19). We will begin with review of recently promulgated guidelines for use of thrombectomy in COVID-19-associated stroke. We will then survey the reported experience of thrombectomy applied to treatment of large-vessel occlusion (LVO) stroke in COVID-19. We will conclude by discussing unusual challenges confronted by neuro-interventionalists seeking to perform thrombectomy in COVID-19 patients with acute LVO stroke.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - December 21, 2020 Category: Neurology Source Type: research

Ischemic Stroke in Patients with COVID-19 Disease: A Report of 10 Cases from Iran
Ischemic stroke seems to be one of the most serious neurologic complications in patients with COVID-19 infection. Herein, we report a series of 10 ischemic stroke patients with concomitant COVID-19 disease. Out of 10, 8 had large infarcts (3 massive middle cerebral artery, 2 basilar artery, 2 posterior cerebral artery, and 1 internal carotid artery infarct territory). Two had cardiogenic embolic stroke due to atrial fibrillation. Almost half of our patients did not have a vascular risk factor. Nine did not have fever and were diagnosed with COVID-19 upon admission for stroke. Stroke occurred in the first week of respirator...
Source: Cerebrovascular Diseases - December 15, 2020 Category: Neurology Source Type: research

Age and Outcome after Endovascular Treatment in Anterior Circulation Large-Vessel Occlusion Stroke: ETIS Registry Results
Conclusion: Patient age is strongly associated with functional outcome after EVT for acute ischemic stroke. The positive effect of thrombectomy persists in older age groups, even after adjustment for prognostic factors related to poor functional outcome. Stroke physicians should provide EVT irrespective of the patient ’s age.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - December 15, 2020 Category: Neurology Source Type: research

Association of Electrocardiographic P-Wave Markers and Atrial Fibrillation in Embolic Stroke of Undetermined Source
Conclusion: PTFV1 is associated with AF detection but not recurrent strokes in ESUS patients and can be a useful electrocardiographic marker for further risk stratification in ESUS patients.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - December 11, 2020 Category: Neurology Source Type: research

Impact of COVID-19 Pandemic on a Regional Stroke Thrombectomy Service in the United Kingdom
Conclusion: The COVID-19 pandemic has had a negative impact on the stroke admission numbers but not stroke thrombectomy rate, successful recanalization rate, or early neurological outcome. Internal delays actually improved during the COVID-19 pandemic. Further studies should examine the effects of the COVID-19 pandemic on longer term outcome.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - December 11, 2020 Category: Neurology Source Type: research

Incidence of Stroke and Ischemic Stroke Subtypes: A Community-Based Study in Brno, Czech Republic
Conclusions: The stroke incidence is lower than that previously reported for the CR and Eastern Europe probably reflecting socioeconomic changes in post-communistic countries in the region. These findings could contribute to stroke prevention strategies and influence health policies.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - December 10, 2020 Category: Neurology Source Type: research

< b > < i > MMP9 < /i > < /b > rs17576 Is Simultaneously Correlated with Symptomatic Intracranial Atherosclerotic Stenosis and White Matter Hyperintensities in Chinese Population
Conclusion:MMP9 rs17576 may be simultaneously associated with the risk of sICAS and WMHs.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - December 9, 2020 Category: Neurology Source Type: research

Contents Vol. 49, 2020
Cerebrovasc Dis 2020;49:I –X (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - December 9, 2020 Category: Neurology Source Type: research

Acknowledgements to Reviewers
Cerebrovasc Dis 2020;49:659 –661 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - December 9, 2020 Category: Neurology Source Type: research

White Matter Injury Is Associated with Reduced Manual Dexterity and Elevated Serum Ceramides in Subjects with Cerebral Small Vessel Disease
Conclusions: These results demonstrate that subcortical microstructural white matter disruption is associated with elevated serum ceramides and reduced manual dexterity in a population with cSVD. These findings suggest that injury to white matter tracts undermines neural networks, with functional consequences in a middle-aged population with cardiovascular risk factors.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - December 4, 2020 Category: Neurology Source Type: research

Explicit Diagnostic Criteria for Transient Ischemic Attacks Used in the Emergency Department Are Highly Sensitive and Specific
Conclusions: The data show that the EDCT in its modified version as proposed by us are a highly useful tool for clinicians. They display a high sensitivity and specificity to accurately diagnose TIAs in patients referred to the emergency department with a suspected TIA.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - December 4, 2020 Category: Neurology Source Type: research

Association between Intraplaque Hemorrhage and Vascular Remodeling in Carotid Arteries: The Plaque at RISK (PARISK) Study
Conclusion: After correcting for plaque size, plaques containing IPH had a smaller LA than plaques without IPH. However, RR was not different.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - December 3, 2020 Category: Neurology Source Type: research

Asia Pacific Stroke Conference 2020
Cerebrovasc Dis 2020;49(suppl 1):I –II (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - December 2, 2020 Category: Neurology Source Type: research

Asia Pacific Stroke Conference 2020. Abstracts of the Annual Conference of the asia Pacific Stroke Organization (APSO), Virtual Conference, Korea, December 4-6, 2020
Cerebrovasc Dis 2020;49:1 –149 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - December 2, 2020 Category: Neurology Source Type: research

Asia Pacific Stroke Conference 2020: Bringing Innovation to Stroke Care in Asia Pacific Countries
Cerebrovasc Dis 2020;49(suppl 1):III –IV (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - December 2, 2020 Category: Neurology Source Type: research

Pre-Stroke Glycemic Variability Estimated by Glycated Albumin Is Associated with Early Neurological Deterioration and Poor Functional Outcome in Prediabetic Patients with Acute Ischemic Stroke
Conclusion: Pre-stroke glycemic variability estimated by GA was associated with END occurrence and poor functional outcome after ischemic stroke in patients with prediabetes.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - December 1, 2020 Category: Neurology Source Type: research

Association of Admission Hyperglycemia with Clinical Outcomes in Japanese Patients with Acute Large Vessel Occlusion Stroke: A post hoc Analysis of the Recovery by Endovascular Salvage for Cerebral Ultra-Acute Embolism Japan Registry 2
Conclusions: Admission hyperglycemia in Japanese patients with large vessel occlusion stroke is associated with an unfavorable functional outcome at 90 days, mortality within 90 days, and the occurrence of SICH within 72 h.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - November 25, 2020 Category: Neurology Source Type: research

Detection of Atrial Fibrillation on Stroke Units: Look Harder, Look Longer, Look in More Sophisticated Ways
Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - November 23, 2020 Category: Neurology Source Type: research

Iron Measured in Nasal Exudate Samples as a New and Useful Biomarker in the Differential Diagnosis of Patients with Acute Stroke
Conclusions: Our findings suggest that iron levels in nasal exudate may be useful in the acute stage for the differential diagnosis between ischemic and hemorrhagic damage in acute stroke patients. They also open a potential field to study other biomarkers in nasal exudate in several neurological disorders. Clinical studies must be performed to confirm our results.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - November 20, 2020 Category: Neurology Source Type: research

Prediction of Functional Outcome in Patients with Acute Stroke by Measuring tRNA Derivatives
Conclusions: Stress-induced tRNA derivatives can detect brain tissue damage, predicting functional outcome in patients with ischemic stroke.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - November 18, 2020 Category: Neurology Source Type: research

Detection of Atrial Fibrillation on Stroke Units: Comparison of Manual versus Automatic Analysis of Continuous Telemetry
Conclusion: Automatic AF detection is highly specific, but sensitivity is relatively low. Results of this study suggest that automated computer-based AF detection should be rather complementary to manual ECG analysis than replacing it.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - November 18, 2020 Category: Neurology Source Type: research

Prestroke Physical Activity and Poststroke Cognitive Performance
Conclusion: Higher prestroke PA was associated with a better cognitive performance as measured by the SDMT at 1 and 6 months poststroke. We found no significant association between prestroke PA and functional outcome. Our results are encouraging and support further investigations of PA as a protective measure against poststroke cognitive impairment.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - November 11, 2020 Category: Neurology Source Type: research

Protective Effect of miR-340-5p against Brain Injury after Intracerebral Hemorrhage by Targeting PDCD4
Conclusion: miR-340-5p protects against brain injury after ICH. miR-340-5p might exert an anti-inflammatory effect during the occurrence of ICH via targeting PDCD4.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - November 11, 2020 Category: Neurology Source Type: research

Anticoagulation and Risk of Stroke Recurrence in Patients with Embolic Stroke of Undetermined Source Having No Potential Source of Embolism
Conclusions: This nonrandomized observational study suggests that anticoagulation therapy might be associated with a reduced risk of recurrent stroke compared with antiplatelet therapy in patients with ESUS in whom no potential source of embolism was identified. Further study should be performed in consideration of a potential source of embolism even in patients with ESUS.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - November 11, 2020 Category: Neurology Source Type: research

Reliability and Reproducibility of the Diameters Method in Rapid Determination of Acute Infarct Volume in Magnetic Resonance Diffusion-Weighted Imaging
Conclusions: The MD method was the best for achieving a rapid and excellent interobserver reliability for estimating infarct volume. Both OD and MD methods can quickly screen patients suitable for recanalization treatment and predict poor prognosis through threshold evaluation.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - November 11, 2020 Category: Neurology Source Type: research

Left Atrial Size and Ischemic Events after Ischemic Stroke or Transient Ischemic Attack in Patients with Nonvalvular Atrial Fibrillation
Conclusion: Severe LAE was associated with increased risk of ischemic events after ischemic stroke or TIA in patients with NVAF.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - November 11, 2020 Category: Neurology Source Type: research

Biomarkers of Unfavorable Outcome in Acute Ischemic Stroke Patients with Successful Recanalization by Endovascular Thrombectomy
Conclusions: The increased levels of MMP-9, tenascin-C, CRP, thioredoxin, and decreased levels of ADAMTS13 and gelsolin were independent predictors of futile recanalization in AIS patients after recanalization by EVT.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - October 26, 2020 Category: Neurology Source Type: research

The Minimum Distance May Affect Perioperative Complications and Completed Occlusions of Endovascular Treatment for Tandem Intracranial Aneurysms: A Multi-Institutional Retrospective Study
Conclusions: Both coiling and FDS can be utilized safely and can achieve similar clinical outcomes. FDS and LVIS are recommended for IAs that do not require embolization but cannot be prevented from being covered by stents. A multiple-session treatment may increase the treatment risk, and the minimum distance may affect the incidence of perioperative complications and completed occlusions. Further hemodynamic and prospective studies on such TAs in close proximity to one another are needed.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - October 26, 2020 Category: Neurology Source Type: research

C. Miller Fisher Stroke in the 20th Century
Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - October 22, 2020 Category: Neurology Source Type: research

Lacune and Large Perivascular Space: Two Kinds of Cavities Are of Different Risk Factors and Stroke Risk
Conclusions: The lack of association between large PVSs and cardiovascular risk factors or risk of stroke indicated a nonvascular pathogenic mechanism underlying large PVSs, suggesting the importance of distinguishing large PVSs from lacunes in clinical practice.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - October 22, 2020 Category: Neurology Source Type: research

Vascular Occlusion Evolution in Endovascular Reperfusion Candidates Transferred from Primary to Comprehensive Stroke Centers
Conclusion: REC at CSC arrival occurs exceptionally in patients with a documented LVO on PSC. Repeating a second vascular study before EVT would not be necessary in most patients. Despite its modest effect, tPA treatment at PSC was an independent predictor of REC.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - October 22, 2020 Category: Neurology Source Type: research

Publisher's Note
Cerebrovasc Dis 2020;49:459 –459 (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - October 20, 2020 Category: Neurology Source Type: research

Incidence and Prognostic Impact of Intracranial Hemorrhage after Endovascular Treatment for Acute Large Vessel Occlusion
Conclusions: The functional outcomes at 90 days were significantly worse in patients who developed ICH after receiving EVT for acute LVO, but the mortality was generally similar.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - October 20, 2020 Category: Neurology Source Type: research

Cerebral Perfusion and the Burden of Small Vessel Disease in Patients Referred to a Memory Clinic
Conclusion: Global CBF was not related to overall SVD burden or with individual SVD features in this memory clinic cohort, indicating that in this setting these lesions were not primarily due to cerebral hypoperfusion.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - October 19, 2020 Category: Neurology Source Type: research

Diet and Lifestyle as Risk Factors for Carotid Artery Disease: A Prospective Cohort Study
Conclusions: In conclusion, the present study found a trend toward a protective effect of higher intake of vegetables and fruit against incident CAD. More prospective studies investigating the association between diet and CAD and stroke are needed in order to give firm recommendations.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - October 19, 2020 Category: Neurology Source Type: research

Impact of COVID-19 on Patient Behavior to Stroke Symptoms in China
Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - October 8, 2020 Category: Neurology Source Type: research

High Prevalence of Moyamoya Syndrome in Appalachia
Conclusions: Moyamoya accounts for a substantial number of stroke admissions in Kentucky; these patients were more likely to develop an ischemic stroke rather than a hemorrhagic stroke. Autoimmune disorders were more prevalent in moyamoya patients than in the general population. The reduced frequency of traditional stroke risk factors within the Appalachian group suggests an etiology distinct to the population.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - October 7, 2020 Category: Neurology Source Type: research

Prognostic Significance of Hyponatremia in Acute Stroke: A Systematic Review and Meta-Analysis
Conclusions: The development of hyponatremia in the clinical course of stroke is associated with higher short-term mortality and a longer hospital stay. Although the causal relationship is unclear, hyponatremia could be a significant predictor of poor outcomes after stroke.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - October 5, 2020 Category: Neurology Source Type: research

Prediction of Poor Outcome in Intracerebral Hemorrhage Based on Computed Tomography Markers
Conclusions: CT markers of hypodensities, black hole sign, and island sign might predict poor outcome of ICH patients within 90 days.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - October 2, 2020 Category: Neurology Source Type: research