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Total 393 results found since Jan 2013.

Near-infrared light-activatable siRNA delivery by microcapsules for combined tumour therapy
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Source: Artificial Cells, Blood Substitutes, and Biotechnology - March 12, 2018 Category: Biotechnology Authors: Yalan Rui Bo Pang Jinnan Zhang Yuxi Liu Huixin Hu Zicun Liu Sarah Ama Baidoo Chang Liu Yu Zhao Siwen Li Source Type: research

Preparation of PEGylated cationic nanoliposome-siRNA complexes for cancer therapy.
In conclusion, our novel PEGylated liposomes have high potential for systemic delivery of siRNA and can improve in vivo stability of free siRNA and also siRNA lipoplexes. PMID: 29475393 [PubMed - as supplied by publisher]
Source: Artificial Cells, Nanomedicine and Biotechnology - February 26, 2018 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

A dual targeting drug delivery system for penetrating blood brain barrier and selectively delivering siRNA to neurons for Alzheimer's disease treatment.
CONCLUSION: In conclusion, this study preliminarily demonstrated the ApoA-I and NL4 dual modified dendrimer nanoparticles were efficient carrier for siRNA delivery to AD bearing brain. PMID: 29484985 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Biotechnology - February 26, 2018 Category: Biotechnology Authors: Zhang C, Gu Z, Shen L, Liu X, Lin H Tags: Curr Pharm Biotechnol Source Type: research

Preparation of PEGylated cationic nanoliposome-siRNA complexes for cancer therapy
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Source: Artificial Cells, Blood Substitutes, and Biotechnology - February 24, 2018 Category: Biotechnology Authors: Fateme Haghiralsadat Ghasem Amoabediny Samira Naderinezhad Tymour Forouzanfar Marco N. Helder Behrouz Zandieh-Doulabi Source Type: research

In situ monitoring of PTHLH secretion in neuroblastoma cells cultured onto nanoporous membranes
Publication date: 1 June 2018 Source:Biosensors and Bioelectronics, Volume 107 Author(s): Alfredo de la Escosura-Muñiz, Marisol Espinoza-Castañeda, Alejandro Chamorro-García, Carlos J. Rodríguez-Hernández, Carmen de Torres, Arben Merkoçi In this work, we propose for the first time the use of anodic aluminum oxide (AAO) nanoporous membranes for in situ monitoring of parathyroid hormone-like hormone (PTHLH) secretion in cultured human cells. The biosensing system is based on the nanochannels blockage upon immunocomplex formation, which is electrically monitored through the voltammetric oxidation of Prussian blue nanop...
Source: Biosensors and Bioelectronics - February 11, 2018 Category: Biotechnology Source Type: research

Nanotechnology-Based Strategies for siRNA Brain Delivery for Disease Therapy.
Abstract Small interfering RNA (siRNA)-based gene silencing technology has demonstrated significant potential for treating brain-associated diseases. However, effective and safe systemic delivery of siRNA into the brain remains challenging because of biological barriers such as enzymatic degradation, short circulation lifetime, the blood-brain barrier (BBB), insufficient tissue penetration, cell endocytosis, and cytosolic transport. Nanotechnology offers intriguing potential for addressing these challenges in siRNA brain delivery in conjunction with chemical and biological modification strategies. In this review, ...
Source: Trends in Biotechnology - February 5, 2018 Category: Biotechnology Authors: Zheng M, Tao W, Zou Y, Farokhzad OC, Shi B Tags: Trends Biotechnol Source Type: research

KLF16 suppresses human glioma cell proliferation and tumourigenicity by targeting TFAM.
CONCLUSIONS: KLF16 is a key regulator of glioma cell proliferation by directly targeting TFAM. PMID: 29374989 [PubMed - as supplied by publisher]
Source: Artificial Cells, Nanomedicine and Biotechnology - January 31, 2018 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

VEGF siRNA delivery by a cancer-specific cell-penetrating peptide.
In this study, we investigated the efficacy of the cancer-specific CPP carrier BR2 to specifically transport siRNA to cancer-target cells. Our results showed that BR2 formed a complex with anti-vascular endothelial growth factor siRNA (siVEGF) that exhibited the appropriate size and surface charge for in vivo treatment. Additionally, the BR2-VEGF siRNA complex exhibited significant serum stability and high levels of gene-silencing effects in vitro. Moreover, the transfection efficiency of the complex into a cancer cell line was higher than that observed in non-cancer cell lines, resulting in downregulated intracellular VEG...
Source: Journal of Microbiology and Biotechnology - January 11, 2018 Category: Biotechnology Authors: Lee YW, Hwang YE, Lee JY, Sohn JH, Sung BH, Kim SC Tags: J Microbiol Biotechnol Source Type: research

Study of non-covalent interactions on dendriplex formation: Influence of hydrophobic, electrostatic and hydrogen bonds interactions.
Abstract The interaction of a double stranded small interference RNA (siRNA Nef) with cationic carbosilane dendrimers of generations 1-3 with two different ammonium functions at the periphery ([-NMe2R]+, R=Me, (CH2)2OH) has been studied by experimental techniques (zeta potential, electrophoresis, single molecule pulling experiments) and molecular dynamic calculations. These studies state the presence of different forces on dendriplex formation, depending on generation and type of ammonium group. Whilst for higher dendrimers electrostatic forces mainly drive the stability of dendriplexes, first generation compounds...
Source: Colloids and Surfaces - December 8, 2017 Category: Biotechnology Authors: Sánchez-Milla M, Pastor I, Maly M, Serramía MJ, Gómez R, Sánchez-Nieves J, Ritort F, Muñoz-Fernández MÁ, de la Mata FJ Tags: Colloids Surf B Biointerfaces Source Type: research

Enhancement of chemosensitivity by simultaneously silencing of Mcl-1 and Survivin genes using small interfering RNA in human myelomonocytic leukaemia.
Authors: Jafarlou M, Shanehbandi D, Dehghan P, Mansoori B, Othman F, Baradaran B Abstract Acute myeloid leukaemia (AML) is a genetically heterogeneous, severe and rapidly progressing disease triggered by blocking granulocyte or monocyte differentiation and maturation. Overexpression of myeloid cell leukaemia-1 (Mcl-1) and Survivin is associated with drug resistance, tumour progression and inhibition of apoptotic mechanisms in leukaemia and several cancers. In the present study, we examined the combined effect of etoposide and dual siRNA-mediated silencing of Mcl-1 and Survivin on U-937 AML cells. The AML cells were...
Source: Artificial Cells, Nanomedicine and Biotechnology - November 10, 2017 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Influence of the three ‐dimensional culture of human bone marrow mesenchymal stromal cells within a macroporous polysaccharides scaffold on Pannexin 1 and Pannexin 3.
This study provides new insights on the expression of pannexins in HBMSCs on a 3D microenvironment during the osteogenic differentiation, in vitro and in vivo.
Source: Journal of Tissue Engineering and Regenerative Medicine - November 1, 2017 Category: Biotechnology Authors: Julien Guerrero, Hugo Oliveira, Rachida Aid, Reine Bareille, Robin Siadous, Didier Letourneur, Yong Mao, Joachim Kohn, Jo ëlle Amédée Tags: RESEARCH ARTICLE Source Type: research

A fast and efficient protocol for small RNA extraction in Japanese plum and other Prunus species
Conclusion We propose this protocol as a reliable and reproducible small RNA isolation procedure for P. salicina and other Prunus species.
Source: Electronic Journal of Biotechnology - October 17, 2017 Category: Biotechnology Source Type: research

Identifying HIPK1 as target of miR-22-3p enhancing recombinant protein production from HEK 293 cell by using microarray and HTP siRNA screen.
Abstract Protein expression from human embryonic kidney cells (HEK 293) is an important tool for structural and clinical studies. It was previously shown that microRNAs (small, noncoding RNAs) are effective means for improved protein expression from these cells, and by conducting a high-throughput screening of the human microRNA library, several microRNAs were identified as potential candidates for improving expression. From these, miR-22-3p was chosen for further study since it increased the expression of luciferase, two membrane proteins and a secreted fusion protein with minimal effect on the cells' growth and ...
Source: Biotechnology Journal - October 7, 2017 Category: Biotechnology Authors: Inwood S, Buehler E, Betenbaugh M, Lal M, Shiloach J Tags: Biotechnol J Source Type: research